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Promethazine이 사염화탄소에 의한 간손상에 미치는 영향
강진무 慶北大學校 醫科大學 1970 慶北醫大誌 Vol.11 No.2
The experiment was carried out to clarify the intriguing "protective" effects of promethazine on ultrastructural alterations in the hepatic cells exposed to carbon tetrachloride. The carbon tetrachloride and promethazine hydrochloride were administered into the albino rats, either singly or combined. carbon tetrachloride was given subcutaneously with a dose of 0.5ml per kg of body weight and promethazine was injected intraperitoneally with a dose of 25.0㎎ per kg of body weight. Hepatic lesions were examined histopathologically by the measure of both light and electron microscopes with the following concluions. 1. Light-microscopically, hepatic tissue of animals receiving carbon tetrachloride alone revealed marked degenerative changes and frank necrosis in the central zone of lobules, while the hepatic tissue of animals which received both carbon tetrachloride and promethazine revealed only minimal changes. Hepatic tissue of the animals fed only with basal diet or of those which received promethazine alone revealed no significant pathologic changes. 2. Electron-microscopically, hepatic cells affected by carbon tetrachloride revealed a wide range of ultrastructural changes. The nucleus-appears to be considerably active, and roughsurfaced endoplasmic reticulum revealed variable changes evidenced by swelling of this organel and shedding of ribosomes. The mitochondria later underwent swelling with loss of cristae. Animals which received both promethazine and carbon tetrachloride revealed relatively milder changes than in those which were treated only with carbon tetrachloride, and almost completely recovered within twentyfour hours. The animals which received promethazine alone revealed no significant ultrastructural changes in their hepatic cells. 3. promethazine, therefore, was thought to have significant protective effects upon hepatic injury produced by carbon tetrachloride.
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강진무 啓明大學校 醫科大學 1984 계명의대학술지 Vol.3 No.1
소아 급성 임파성백혈병은 좋은 protocol을 바탕으로한 화학요법제의 적절한 조합과 감염의 예방 및 적절한 치료로서 현재는 치유 가능한 질환으로 만들고 있다. 많은 연구 team 들은 5년간생존율 80%를 10년간생존율 80%로 만들것을 목적하고 있다.
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정순용,김팔동,차홍대,강진무 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.1
Breast feeding is recongnized as the ideal method of providing nutrition for the first year of life but infant needed additional supply of nutrition oher than milk from 5-6 months of life for providing good nutrition. The weaning diet should be started in proper time to fullfill these purpose. This study was carried out to find out present status of weaning in infant and to give a good guidelines to the mothers who take care of the infants who are ready to weaning diet. Five hundred mothers who visited well baby clinic of Dong San Hospital, Keimyung Univerity from January to JUly 1989 answered to the questions for weaning status. The results of the questions were analysed and obtained following results. Weaning was started at 3 months of age in 24.4% of the infants and 76.6% started between three and six months of age. Weaning was completed at 12 months in 59.0%, 47.6% of the mother offered commercial foods and 31.0% used home made foods. The beef(74.3%) was the most commoly used among meats. apple(55.8%) among fruits and spinach(53.8%) among vegetables. The main source of obtaining knowledge about weaning were the book on childcare(28.4%) and the newspaper or television(22.3%). The problem following weaning were mainly gastrointestinal symptoms such as diarrhea (21.7%), constipation (14.7%) and vomiting (9.2%)
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김명성,강진무 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.4
Since the clinical features of neonatal sepsis were reported by Dunham in 1933, there have been reported many studies for sepsis. Because of the variability of the symptoms and signs and rapid disease progression especially in early age group, the mortality rate of sepsis runs still high. This study was conducted on 81 case of sepsis in children under 1 year of age who were admitted at Pediatric department of Dongsan Medical Center of Keimyung University, School of Medicine between Jan. 1989 and Jul. 1992. The diagnosis of sepsis was made by clinical symptoms and the positive blood culture. The results were as follows : The Male to female ratio was 2.2 : 1 and 72 cases(86.7%) were under the age of 1 month. The clinical manifestations on admission were fever(65.4%), gastrointestinal symptoms(49.4%), poor feeding(35.8%), grunting(25.9%), lethargy(19.8%), and jaundice(17.3%), in order of frequency. Leukopenia(WBC count less than 5,000/㎣) was seen in 8 cases(9.9%) and 27 cases(33.3%) showed leukocytosis(WBC count more than 15,000/㎣). Thrombocytopenia(platelet count less than 150,000 /㎣)was found in 12 cases(14.8%). The associated diseases were pneumonia(22.2%), neonatal hyperbilirubinemia(17.3%), meningitis(8.6%), DIC(8.6%), local abscess(8.6%), in order of frequency. Of the 81 cases, gram positive organisms were isolated in 56 cases(69.1%) and gram negative organisms in 25 cases(30.9%). The principal organisms were Staphylococcus aureus(25.9%), E. coli(16.1%), Staphyloccus epidermidis(13.6%), group B hemolytic streptococcus(11.1%), enterococcus (8.6%), and enterobacter(8.6%). Gram positive organisms were sensitive to cephalothin(86.3%), clindamycin(79.5%), and erythromycin(76.0%) and resist to ampicillin. Gram negative organisms were sensitive to amilkacin(89.3%) and showed moderate sensitivity to gentamycin(53.6%). Staphylococcus aureus showed sensitivity to chloramphenicol(100%), clindamycin(90%) and erythrmycin(70%) and Staphylococcus epidermidis was sensitive to cephalothin(90%) and amikacin(90%). Cephalothin and erythromycin showed 100% sensitivity to group B streptococcus, and E. coli were sensitive to amikacin(93%). The mortality rate was 28.3%.
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김흥식,강진무 啓明大學校 醫科大學 1986 계명의대학술지 Vol.5 No.1
Authors experienced a case of Neurofibromatosis in a 13 years old boy who had over six large various shaped cafe-au-lait spots since birth. H also had scoliosis with intermittent exertional dyspnea and chest pain for about several months. Chest X-ray and chest C-T scan showed a mass in posterior mediastinum along 4th through 7th thoracic spine which had been confirmed as neurofibroma by biopsy. A brief review of literature was made.
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