Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

응급실에서 기관내 삽관후 발생한 후두육아종 1례

조남수,김용배,조수형,송민엽,송성용 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.1

Endotracheal intubation has been used widely for the maintenance of airway in the emergency patient and CPR in the acute airway obstruction patient and to treat respiratory insufficiency. Endotracheal intubation has many advantages but it may cause several complications which rate about 4% of endotracheal intubation patient. Among these complications, laryngeal granuloma is a relatively rare complication arising about 1 case per 10,000∼20,000 cases. Authors report a case of laryngeal granuloma which developed after endotracheal intubation required during emergency treatment. Case: A 55-year old female patient visited Chosun University Hospital Emergency Room complaining of dyspnea, cyanosis and sweating on Feb. 8th 1995. According to past history, she had a little obesity, dyspnea on exercise and mild hypertension. At arrival, blood pressure was 240/110mmHg, pulse rate 150 rates/min, respiratory rate 12/min, body temperature 36.5℃ and cyanosis with sweating on whole body was observed. And the mental state was semicoma. At 5 minutes after arrival, sudden respiratory arrest developed and immediate endotracheal intubation which emergency treatment was performed it was difficult to intubate endotracheally due to short neck and obesity. At 1 hour after arrival, general condition of the patient recovered well and extubation was done. The patient was transferred to internal medicine department and discharged after 12 days of medical treatment. At 2 months after discharge, the patient felt a progressive hoarseness and foreign body sensation of larynx. She was diagnosed as laryngeal granuloma at ENT department of Chosun University. She underwent the surgical operation and discharged in good health after 7 days of admission.

용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

住宅平面作成의 體系化에 관한 硏究 : Graph 理論을 利用한 Generative System의 作成 및 內部空間의 解決方案을 中心으로

趙鏞秀 동아대학교 공과대학 부설 한국자원개발연구소 1987 硏究報告 Vol.11 No.1

For systemizing the design of residential floor plans, the graph theory was introduced to the generative system of previous study, and this could be more logically reestablished than the previous of it, Variations of possible plan graphs could be produced, which would be the database of this model. Basic theory of an algorithm for the practical productions of main space and auxiliary space which is the spine of the framework of this system was also possibly arranged.

대기압 스트리머 코로나방전특성 및 이산화탄소 전환특성

조문수,김학규,곽동주,신용섭 경성대학교 공학기술연구소 2001 공학기술연구지 Vol.8 No.-

Deep interests have been paid on the application of non-thermal plasma technique th solve the environmental pollution problems. CO_2 is one of the severe pollutants which cause the acid rain and global warming. In this study, in order to improve the conversion efficiency of CO_2, the streamer corona discharge plasma and barrier discharge plasma reactors were made, and the conversion characteristics of CO_2 by the corona discharge plasma and some discharge characteristics of these discharge chambers are studied experimentally.

응급 수술에 대한 기술통계학적 고찰 : 한 종합병원의 1개년을 중심으로 This statistical data derived from our hospital for one year

조남수,김용배,소금영 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

해부학 실습에 의한 의과대학생들의 formaldehyde 폭로 정도와 formaldehyde 과민반응에 대한 조사연구

조수현,김헌,남윤정,김용대 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1

Formaldehyde induces not only irritation symptoms of eyes and respiratory tract but hypersensitivity reactions, such as contact dermatitis, allergic rhinitis, and asthma. To estimate the levels of exposure to formaldehyde during cadaver dissection in anatomy laboratory and to investigate the prevalence rates of irritation symptoms, allergic rhinitis and bronchial asthma, air concentrations of formaldehyde within cadaver dissection room were measured, and self-administrative questionnaire and enzyme linked immunosorbent assay(ELISA) were performed upon medical(n=182) and premedical students(n=69). For measurement of air formaldehyde level, chromotropic acid method(NIOSH method 3500) was used. Formaldehyde was conjugated to human serum albumin, and used as antigen in ELISA after identification of conjugation with immunoelectrophoresis. Prevailing symptoms during cadaver dissection were soreness of eyes or throat(92.9%), lacrimation(74.3%), rhinorrhea(49.7%), and sneezing(32.2%). Mean titers of IgE and IgG antibodies specific to formaldehyde-human serum albumin conjugate(F-HSA) of medical students were higher than those of premedical students. However, there was no case whose titers of anti-F-HSA antibody were higher than the twice of those of anti-HSA antibody or higher than the twice of the mean titers of premedical students. These results suggest that medical students were exposed to relatively high concentration of formaldehyde, but few asthma or allergic rhinitis were induced by formaldehyde exposure during cadaver dissection practice.

企業이미지 向上을 위한 CIP에 관한 硏究 (Ⅲ) : 導入事例槪論을 中心으로 (Ⅰ)

曺溶秀 진주여자전문대학 1993 論文集 Vol.16 No.-

CIP(corporate identity program) which began to develop on the basis of the cognizance that the post-industial society is the period of CIP boom, is appearing as an important factor in the development of corporation. The present stydy was concerned with the investigation of the entity with the cognition and the conception of CIP, which have developed continuously, in the introductory aspect. The case of introduction was described at the aspect of corporate image, that of marketing, that of communication, and that of corporate culture. And this study also described the factors influencing the case of CIP introduction in the basis of the conception of each aspect, and predicted the future CIP. Frist, in the aspect of corporate image, the necessity of image strategy and its methodology of CIP strategy was introduced, which was much influencing the change of CIP cognition. Second, the social change bring about the change of market which represent in the diversity of consumer's need. As the result of it, the change of cognition for marketing is also the claim of the present period. This appears as the cause of many changes in the introduction case of CIP. This study compared and analyzed the changing marketing strategy and the change of cognition to the introduction case of CIP, and also suggested its methodology. Third, the change of communication cognition and the introduction case of CIP according to it was compared and analyed. Especially, the cause which CIP orienting design factor changes into the factors of other conception(for example, communication, corporate culture etc.) was traced, and the diversity of CIP methodology in the basis of the cognition and others according to the developing human sense was suggested. Fourth, it is considered that the future CIP, one of the CIP introduction cases, would much affect on the aspect of corporate culture. The factors suggested above was compared with each other, and the outline of the CIP introduction case also described in detail. The case of U.S.A., that of Japan, and that of Korea will be compared and analyzed in the following research.

Polytrop Blue B에 依한 徵量 Ti의 吸光度定量에 關한 硏究

趙誠烋,鄭鐘南,金英洙 朝鮮大學校 工科大學 1974 論文集 Vol.3 No.-

Polytrop Blue B Was proved to help determine Spectrophotometrically even little bit amount of titanium from 0.02 to 1.6 ppm. We dropped 5ml of 4.8×10??M polytrop Blue B solution in to 30ml of the titanium solution, and that PH was adjusted to 3.20 with o.25M sodium acetate solution and 0.25M perchloric acid. After the dilution to 50ml with water, we measured the absorbance at 573mμ. 3hours' standing did not change a bit in the absorbance. Interference was noticed from iron, aluminum, Oxalate ion very small amount of E D T A. The mole ratio of titanium to polytrop Blue B. in the complex under given condition was 1 : 1.