우리나라 시 · 군 · 구 지역보건의료계획의 비전(Vision) 문구 분석

안치영(Chi-Young Ahn),김현수(Hyun-Soo Kim),김원빈(Won-bin Kim),오창훈(Chang-hoon Oh),홍지영(Jee-Young Hong),김은영(Eun-Young Kim),이무식(Moo-Sik Lee) 한국농촌의학 지역보건학회 2017 농촌의학·지역보건 Vol.42 No.1

지역보건의료계획서에서 비전은 각 지역의 보건의료계획을 나타내는 핵심요소임에도 불구하고 작성방법에 대한 구체적인 지침이 부재하여 각 지역의 비전은 매우 다양하게 표현되어 있다. 이에 이 연구에서는 제6기 지역보건의료계획에서 제시한 비전 문구를 보건소 유형별, 권역별로 분석하였다. 전국 229개 지역의 제6기 지역보건의료계획서의 비전 문구와 이와 관련된 미션, 전략체계도, 중장기 추진과제 등을 대상으로 하였다. 지역을 권역별 4개, 읍·면·동 구성에 따른 보건소 유형을 4개로 분류하였고, 각 지역 비전의 글자 수, 문장 평가, 단어 빈도, 문구 평가를 빈도분석과 카이제곱검정, 일원배치분산분석을 이용하여 분석하였다. 비전의 글자 수가 17자 이하인 보건소가 172개소(75.1%)였고, 보건소 유형별로 유의한 차이가 있었다(p<0.05). 문구에 대한 수사표현에서 비유법(37.1%)이, 한글 외에 표현 언어 사용에서는 특수문자(43.2%)가 많았으며, 보건소 유형별로 유의한 차이가 있었다(p<0.01). 비전에 사용된 단어들은 ‘건강’, ‘행복’, ‘함께’, ‘군민’ 또는 ‘시민’, ‘도시’, ‘100세’ 등이었다. 문구평가 점수에서는 특·광역시 및 수도권에서 가장 높았으며, 보건소 유형 및 권역별로 유의한 차이를 보였다(p<0.05). 보건소 유형별로 과정 및 평가 영역, 공유가능성 등에서 유의한 차이가 있었다(p<0.01). 방향성은 충청권, 수도권 순으로 권역별로 유의한 차이가 있었으며(p<0.01), 미래지향성 및 공유가능성은 영남권이 가장 높아 권역별로 유의한 차이가 있었다(p<0.01). 비전은 지역보건의료계획에 가장 중요 요소 중 하나이다. 이 연구는 지역사회 특성별로 비전의 설정이 다름을 확인하였으며, 이러한 결과를 통하여 지역보건의료계획 등 보건소 비전 수립시 참고가 될 수 있는 기초적인 자료가 될 것으로 판단된다. Objectives: In this study, we analyzed vision statements of the 6th community health plan of local government in Korea. Methods: We examined vision statements letters, missions and strategy plans, and long-term missions of 6th community health plans of 229 local government in Korea. We also analyzed the numbers of vision letters, sentence examination, word frequency, each vision statement with frequency analysis, chi-square test, and one-way ANOVA. Results: Among 229 local government, 172(75.1%) of local government had the number of letters (Korean) less than 17 of vision statements, and there were a significant differences according to type of community health centers (p<0.05). Figuration (37.1%) were the most used in an expression of vision statement sentence, and special characters (43.2%) were the most used language except Korean. The most commonly used words of vision statement in order of frequency were ‘health’, ‘happiness’, ‘with’, ‘citizen’, ‘city’, ‘100 years old’ etc. Chungcheong provinces and Daejeon metropolitan city had a highest score in directionality on phrase evaluation, and there were a significant differences according to regional classes of local government (p<0.01). Gyeongsang provinces, Ulsan, Daegu, and Busan metropolitan cities had a highest score in future orientation and sharing possibilities on phrase evaluation, and there were a significant differences according to regional classes of local government (p<0.01). Conclusions: Vision is one of the most important component of community health plan. We need more detailed ‘vision statement guideline’ and the community health care centers of local government should effort to make more clear and complete their vision.

복수과 진료 환자의 중복 처방에 대한 분석 및 평가

이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1

In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.

일 도시 여고생의 음주관련 요인에 관한 연구

김주형,김은경,김효정,문현숙,오선민,박나경,신혜정,이경원,이지선,최연옥,최진희,한유정,현수인 대한간호학회정신간호학회 2002 정신간호학회지 Vol.11 No.1

This study was designed to examine the factors associated with alcohol consumption among the Korean high schools girls. 283 female students were sampled from two high school in Seoul, Korea. They were given questionnaires and were asked to fill in and return them during a class hours. The factors included in the questionnaire were analyzed to see their contributions to alcohol consumption using chi-square. Alcohol consumption was associated with lower school performance(p=.001). High alcohol expectancies increased alcohol consumption(p=.000); however, depression did not show a statistically significant relationship to alcohol consumption. Mothers' alcohol consumption, having many alcohol consuming friends and watching TV commercials picturing alcohol were found to be associated with alcohol consumption, p=.049, .000, .000. respectively. Results may imply that alcohol consumption may not be a coping behavior of the depressed high school girls. Parents in Korea should be more concerned about alcohol consumption and its impacts on their daughters. Media effects on alcohol consumption need to be stressed and deserve attention from the public.

로타바이러스 원내 감염과 지역사회 획득 감염의 비교 연구

유재성,진현주,강호석,오지은 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Purpose: This study was performed to investigate the epidemiologic and clinical characteristics of rotaviral infection, the most common nosocomial gastroenteritis. Method: We retrospectively reviewed the records of 983 patients who were diagnosed as rotavirus gastroenteritis from January 2006 to March 2010. We divided them into two groups: group A for community-acquired rotavirus infection (N=810), group B for nosocomial infection (N=173). We investigated the characteristics of both groups. Results: The percentage of nosocomial infection among rotavirus gastroenteritis was 18% in our study. Rotaviral infection in both groups was more common in winter. The average age (±SD) of group A and B was 25.8±23.3 and 17.8±15.7 months old, respectively. The average hospital days (±SD) were 4.3±2.0 days for group A and 9.0±3.5 days for group B. Nosocomial infection symptoms of group B started at 4.6±1.7 hospital days on average. Fever, vomiting, abdominal pain, convulsion, elevation of serum CRP (C-reactive protein) or AST (Aspartate aminotransferase) were observed more common in group A than B. Conclusion: The nosocomial rotavirus infection rate did not decrease as we expected in spite of our effort of strict hygiene control. Nosocomial infection showed more favorable prognosis than community-acquired infection but demanded longer days of hospitalization and more cost.

Relationship of Circadian Rhythm in Behavioral Characteristics and Lipid Peroxidation of Brain Tissues in Mice

Chi Eun Oh(Chi Eun Oh),Hyun Ju Lim(Hyun Ju Lim),Jeounghyun Park(Jeounghyun Park),Eunsoo Moon(Eunsoo Moon),Ji Kyoung Park(Ji Kyoung Park) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4

Objective: This study aimed to explore the relationship among several indices of circadian rhythms and lipid peroxidation of brain tissue in mice. Methods: After entrainment of 4-week-old mice, one group was disrupted their circadian rhythms for three days and the other group for seven days (n = 10, respectively). After a recovery period, the Y-maze test, the elevated plus maze test, the tail suspension test, and the forced swimming test were conducted. To assess lipid peroxidation in brain tissue, thiobarbituric acid reactive substances were measured in the cortex, hippocampus, and cerebellum. Results: When circadian rhythms were disrupted and adapted back to their original rhythm, the recovery time of the 7-day disruption group (median 3.35 days) was significiantly faster than one of the 3-day disruption group (median 4.87 days). In the group with a 7-day disruption, mice that had recovered their rhythms early had higher malondialdehyde levels in their hippocampus compared to those with delayed recovery. The entrainment of circadian rhythms was negatively correlated with the malondialdehyde level of brain tissue. The behavioral test results showed no differences depending on the disruption durations or recovery patterns of circadian rhythms. Conclusion: These results suggest that disruption types, recovery patterns, and the entrainment of circadian rhythms are likely to affect oxidative stress in adolescents or young adult mice. Future study is needed to confirm and specify these results on the effects of circadian rhythms on oxidative stress and age-dependent effects.

Purification of high purity docosahexaenoic acid from Schizochytrium sp. SH103 using preparative-scale HPLC

Oh Chi-Eun,Kim Gap-Jin,Park Seung-Jin,Choi Seunghoon,Park Min-Joo,Lee O-Mi,서정우,손홍주 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.5

High purity polyunsaturated fatty acids (> 95%) are essential for the synthesis of specialized pro-resolving lipid mediators (SPMs), such as protectins, resolvins, and maresins, which are used for clinical application. To date, high purity (> 95%) eicosapentaenoic acid (EPA; C20:5n3) and docosahexaenoic acid (DHA; C22:6n3) have been produced through various manufacturing steps using fish oil. In this study, we optimized preparative high performance liquid chromatography (HPLC) process to purify high-purity DHA ethyl ester (DHAee; > 98%) from oleaginous microalgae Shizochytrium sp. SH103 containing at least 34% DHA content. The purity and yield of DHA were determined by reverse phase chromatography with changing the mobile phase velocity, loading amount, and mobile phase composition. On a semi-preparative scale, optimal DHA separation in isocratic elution was obtained with a mobile phase velocity of 0.5 mL/min, a loading amount of 10 mg/mL, and mobile phase composition of methanol/water (96:4, v/v), wherein the purity of DHA was 98.5%. This separation was scaled up to a preparative column, resulting in 99.0% DHA fraction with a yield of 79.8%. This result suggests that a large amount of high purity DHA can be produced from microalgae when scaling up a preparative column to an industrial column.

Four months of rifampicin monotherapy for latent tuberculosis infection in children

Oh Chi Eun,Menzies Dick 대한소아청소년과학회 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.5

Diagnosing and treating latent tuberculosis infection (LTBI) is an important part of efforts to combat tuberculosis (TB). The Korean guidelines for TB published in 2020 recommend 2 LTBI regimens for children and adolescents: 9 months of daily isoniazid (9H) and 3 months of daily isoniazid plus rifampicin. Isoniazid for 6–12 months has been used to effectively treat LTBI in children for over 50 years. However, a long treatment period results in poor patient compliance. This review summarizes pediatric data on the treatment completion rate, safety, and efficacy of 4 months of daily rifampicin (4R) and evaluates the pharmacokinetics and pharmacodynamics of rifampicin in children. The 4R regimen has a higher treatment completion rate than the 9H regimen and equivalent safety in children. The efficacy of preventing TB is also consistent with that of 9H when summarizing reports published to date. A shorter treatment period could increase patient compliance and, therefore, prevent TB in more patients. By using an effective, safe, and highly compliant regimen for the treatment of children with LTBI, we would become one step closer to our goal of eradicating TB.

Machine Learning Algorithms for the Prediction of Locomotor Activity by an Infrared Motion Detector on the Sleep-wake States in Mice

Yoo Rha Hong(Yoo Rha Hong),Kyungwon Kim(Kyungwon Kim),Eunsoo Moon(Eunsoo Moon),Jeonghyun Park(Jeonghyun Park),Chi Eun Oh(Chi Eun Oh),Jung Hyun Lee(Jung Hyun Lee),Min Yoon(Min Yoon) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Even though studies using machine learning on sleep-wake states have been performed, studies in various conditions are still necessary. This study aimed to examine the performance of the prediction model of locomotor activities on sleep-wake states using machine learning algorithms. Methods: The processed data using moving average of locomotor activities were used as predicting features. The sleep-wake states were used as true labels. The prediction models were established by machine learning classifiers such as support vector machine with radial basis function (SVM-RBF), linear discriminant analysis (LDA), naïve Bayes, and random forest (RF). The prediction model was evaluated by a six-fold cross validation. Results: The SVM-RBF and RF showed acceptable performance within a window of moving average from 480 to 1,200 seconds. The highest accuracy (0.869) was shown by the RF at the interval of 480 seconds. Meanwhile, the highest area under the curve (0.939) was shown by LDA at the interval of 870 seconds. Conclusion: This study suggested that the prediction model on sleep-wake state using machine learning could show an improvement of the model performance when using moving average with raw data. The prediction model using locomotor activity can be useful in research on sleep-wake state.

PET IMAGING OF DOPAMINE TRANSPORTERS IN THE HUMAN BRAIN IN HEALTH AND PARKINSON ` S DISEASE WITH [f - 18] β - CIT - FP

Chi, Dae Yoon,Oh, Seung Jun,Choe, Yearn Seong,Choi, Yong,Kim, Sang Eun,Kim, Byung Tae,Choi, Joon Young,Kim, Gyeong Moon 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.2

3 - AND 4 - [F - 18] FLUOROMETHYLBENZYLSULFONATE ESTERS : INTERMEDIATES FOR INTRODUCTION OF F - 18 INTO AMINES AND AMIDES

Chi, Dae Yoon,Oh, Seung Jun,Choe, Yearn Seong,Choi, Yong,Kim, Sang Eun,Lee, Kyung Han,Kim, Byung Tae 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.2