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오구멘틴^(R)시럽과 메피롤^(R)시럽 혼합액의 안전성 평가
방현경,연은숙,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.2
A study was carried out using HPLC to determine the chemical stability of Augmentin^(R) oral suspension (Amoxicillin and Potassium Clavulanate) and Mephirol^(R) syrup (Sobrerol and S-Carboxylmethycysteine) mixture, stored at 2~8℃ over a period of 7days. Augmentin^(R) suspension is reported to be stable for at least 7days in a refrigerator. Our main objective was to study its stability in Augmentin^(R) suspension and Mephirol^(R) syrup mixture. During the study period, amoxicillin component was found to be more stable than the clavulanate. But in a tendency, there were little difference between the Augementin^(R) suspension and the mixture. An increase in the pH of the samples was also observed as an increase in Mephirol^(R) syrup ratio. Despite the pH increase, no additional HPLC peaks were noted. On the basis these results, it is suggested that likewise the Augmentin^(R) suspension. Augmentin^(R) suspension and Mephirol^(R) syrup mixture is stable for 7days in a refrigerator.
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김운학,한은경,이나영,임은형,강진숙,최귀령 한국병원약사회 2000 병원약사회지 Vol.17 No.1
The influence of busulfan plasma concentration on outcome of bone marrow transplantation was examined in 10 patients transplanted. All patients received the same regiment of busulfan, 4㎎/㎏/day orally. Plasma concentrations of busulfan during the administration were measured at sampling time. As a result, means of half life, Kd, first-dose AUC, Cpss_(av??), Cpss_(peak) and Cpss_(trough) were 2.184hr, 0.352hr^(-1), 8,876ng·h/㎖, 2,548ng/㎖, 4,161ng/㎖ and 935ng/㎖, respectively. Of patients with high Cpss_(trough) (>1,000ng/㎖), three patients developed increased liver function test value. One patient (Cpss-(trough) 2,002ng/㎖) developed veno-occlusive disease. There was no significant association of plasma concentration with graft vs host disease, infection, regimen-related toxicity. We assume that high Cpss_(trough) may be associated with an increase risk of veno-occlusive disease.
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이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1
In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.
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