국내 위해성 관리 계획 고찰

임숙,강주혜,박재현,김호정,이선희,최기환 한국에프디시규제과학회(구 한국에프디시법제학회) 2015 FDC법제연구 Vol.10 No.2

단일특징 분할 회귀트리의 학습성능 개선을 위한 회귀신경망

임숙,김성천,Lim, Sook,Kim, Sung-Chun 대한전자공학회 1996 전자공학회논문지-B Vol.b33 No.1

본 논문은 회귀트리에 기반을 둔 회귀 신경망을 제안한다. 회귀트리를 세 개의 계층을 갖는 전향 신경망에 사상하고, 첫 번째 계층에 다중특징 분할함수를 형성시켜 신경망이 보다 더 최적인 입력 공간의 분할을 갖도록 한다. 본 연구에서는 신경망 트레이닝을 위한 두 가지 지도 학습 알고리즘을 제안하여 단일특징 분할함수와 다중특징 분할함수에 실험한다. 실험결과, 제안된 회귀 신경망은 기존의 단일특징 분할 회귀트리 및 단일특징 분할 회귀신경망보다 학습능력이 우수함을 입증한다. 또한 본 논문에서 제안한 알고리즘이 학습 능력을 저하시키지 않으면서도 효과적으로 과성장한 회귀트리를 가지치기 할 수 있음을 보인다. In this paper, we propose regression neural networks based on regression trees. We map regression trees into three layered feedforward networks. We put multi feature split functions in the first layer so that the networks have a better chance to get optimal partitions of input space. We suggest two supervised learning algorithms for the network training and test both in single feature split and multifeature split functions. In experiments, the proposed regression neural networks is proved to have the better learning performance than those of the single feature split regression trees and the single feature split regression networks. Furthermore, we shows that the proposed learning schemes have an effect to prune an over-grown tree without degrading the learning performance.

압록강은 흐른다

임숙임 문예운동사 2017 수필시대 Vol.12 No.1·2

Citronellol 및 Thymol이 Candida albicans 세포막 조성에 미치는 영향

임숙,신승원 한국생약학회 2009 생약학회지 Vol.40 No.4

Phospholipids are crucially important in a cell membrane function and could thereby influence antibiotic susceptibility. In order to investigate the antifungal mechanism the total lipid was extracted from C. albicans treated with citronellol or thymol in concentration of their minimum inhibiting concentration and the changes in phospholipids composition were analyzed using ketoconazole as control. The cell growth and total lipid synthesis in cell walls of C. albicans were inhibited by treatment with citronellol. The levels of total lipids were decreased by 35.85% compared to the control. They also showed a significant decrease in the contents of phospholipid, phosphatidylcholine(PC), phosphatidyl ethanolamine(PE) and phosphatidylinositol( PI). As the result of GC assay for total fatty acid methyl esters of PC, PE and PI in C. albicans treated with citronellol, it was found that the major fatty acid composed of three phospholipid were palmitic acid, stearic acid and oleic a cid. Moreover, the pattern of the fatty acid compositions of PC, PE and PI were changed by the oil. Based on the results, the anti- Candida mechanism of citronellol or thymol might be closely associated with disrupting the permeability barriers of the fungal cell wall composition or construction.

홈페이지 분석 및 평가 미국 정보통신산업을 중심으로

임숙,Im, Suk 한국데이터베이스진흥원 1998 디지털콘텐츠 Vol.8 No.-

한국데이터베이스진흥센터 산하의 한국정보검색위원회에서 위원간의 연구의욕 고취와 새로운 검색 및 데이터베이스 관련 기술 보급을 위해 매월 연구발표회를 개최하고 있다. 본 코너는 매월 발표된 주제논문을 게재함으로써 정보검색과 관련된 정보를 제공하기 위해 마련된 것이다.

복수과 진료 환자의 중복 처방에 대한 분석 및 평가

이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1

In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.

청동기시대 석제 목공구의 변천과 생업경제

임숙(Sook Im) 한국상고사학회 2022 한국상고사학보 Vol.118 No.118

본고는 남한지역 청동기시대 유적에서 출토된 석제 목공구를 통계적으로 분석하여 변천 양상을 살펴보고, 이를 청동기시대 생업경제와 관련시켜 이해해보고자 한 것이다. 청동기시대 목공구는 돌도끼, 대팻날자귀, 돌끌, 턱자귀, 홈자귀로 신석기시대보다 기종이 다양해졌다. 이러한 목공구 자료들을 시기(전기, 중기, 후기)와 문화유형(미사리유형, 가락동유형, 역삼동-흔암리유형, 검단리유형, 천전리유형, 송국리유형)에 따라 분석하였다. 그 결과 목공구의 크기 및 조성비가 시기와 문화유형에 따라 달라졌으며, 청동기시대 생업경제에 대한 연구결과들과도 관련되는 것을 확인하였다. 청동기시대 전기에는 목공구 조성비에서 돌도끼의 비중이 가장 높고, 크기가 크다는 점에서 신석기시대와 비슷하다. 그래서 청동기시대 전기의 생업 활동은 신석기시대와 상당히 유사했을 것으로 생각된다. 청동기시대 중기의 검단리유형, 천전리유형, 송국리유형의 목공구는 크기와 조성비가 서로 다르게 나타났다. 그래서 비슷한 시기에 유행하였지만, 지역과 생업 활동의 특성이 목공구의 크기와 조성비에 영향을 미친 것으로 생각된다. 검단리유형의 목공구는 청동기시대 전기의 전통을 강하게 유지하며, 천전리유형은 신석기시대부터 청동기시대 전기까지 이어지는 돌도끼의 감소와 자귀류의 증가 현상이 점진적으로 이어진다. 그러나 송국리유형에서는 돌도끼와 대팻날자귀의 크기 차이가 뚜렷해지고, 돌도끼의 비중이 급감하는 대신 대팻날자귀의 비중이 급증하면서 청동기시대 전기와는 전혀 다른 획기적인 변화를 보인다. 이러한 양상은 송국리유형이 청동기시대 전기는 물론 중기의 다른 문화유형들과도 구분되는 생업 활동을 기반으로 해서 새로운 사회에 진입한 것을 반영하는 것으로 생각된다. 이로 보아, 청동기시대 목공구의 크기와 조성비의 변화는 당시의 생업경제와 밀접하게 관련된 것으로 생각된다. Woodworking tools made of stone during the Bronze Age include stone axes, flat-adze, stone chisels, pillar-shaped adze, and grooved adze. Woodworking tools can be divided into periods that can be broadly classified into the first, middle, and late periods, and cultural types that include localities such as Misari assemblage, Garakdong type, Yeoksamdong assemblage, Heunamri assemblage, Songgukri assemblage, Geomdanri assemblage, and Cheonjeonri assemblage. Changes in the assemblages of woodworking tools by period, cultural type, and woodworking tools are in line with the existing Bronze Age research on the livelihood and Economy. As a result of the analy sis, the s tone axes of the early Bronze Age were s imilar in s ize to those of the Neolithic Age. Therefore, in the early Bronze Age, the Livelihood and Economy related to the use of woodworking tools would have been similar to that of the Neolithic Age. Woodworking tools of Geomdanri assemblage, Cheonjeonri assemblage, and Songgukri assemblage in the middle of the Bronze Age were all different in size and assemblages. Woodworking tools of the Geomdanri assemblage maintain electrical tradition. The Cheonjeonri assemblage maintains the phenomenon of decreasing stone axes leading to the early Neolithic and Bronze Age and increasing the flat-adze. As for the Songgukri assemblage, the difference in size between the stone axe and the blade of the flat-adze. In addition, the composition ratio of the stone axe is greatly reduced, and the composition ratio of the flat-adze of the plane is greatly increased. This aspect means that the Songgukri assemblage has entered a new society based on the living environment, which is distinguished from other cultural assemblages in the early and mid-term. As described above, changes in the size and assemblage of woodworking tools in the Bronze Age are closely related to the living environment.

증후 종속성의 결정과 계산

임숙(Lim Sook),엄정국(Jung-Kook Um) 한국정보과학회 1989 한국정보과학회 학술발표논문집 Vol.16 No.2

지지도를 가진 논리 프로그래밍에서, 명제간의 종속성이 존재하는 지식 베이스를 가정하였을 때, 추론을 위한 증후결합에 있어 내부적 모순이 내포되므로, 정확한 지지도 구하기위해 반드시 정규인자를 고려하여 결과 지지도를 산출하여야 한다. 본 논문에서는 불완전 세계를 지식 베이스로 가정하고, 불확실성 개념을 표현, 기술하고, 위의 문제점을 파악 하였다. 특히 불확실성을 지원하는, 증후이론을 이용하여, 위의 문제영역에 적합한 의사결정을 제공하는 이론적모델과 방법을 제시하였다.

Candida 속 진균에 대한 Cyntbophogon citratus 정유와 항진균제의 병용효과

임숙;신승원 德成女子大學校 藥學硏究所 2011 藥學論文誌 Vol.22 No.-

The antibacterial activities of the essential oil fraction of Cymbopogon citratus and its main component, citral were assessed by disk diffusion and micro-broth-dilution tests against Candida species. C. citratus oil and its main components showed significant inhibition in micrcrdilution and disk diffusion test against C. albicans, C. tropicalis, and C. utilis. The minimum inhibiting concentrations (MICs) ranged from 0.5 mg/mL to 2 mg/mL. The combined effects of C. citratus oil and citral with ketoconazole were evaluated using a checkerboard microtiter assay. Essential oil fractions of C. citratus and citral exhibited significant synergistic or additive effects with ketoconazole resulting fractional inhibitory concentration (FIC) indices in the range of 0.07 to 0.56. In conclusion, a combination of ketoconazole and the essential oil of C. citratus may reduce the minimum dose of ketoconazole and its side effects

세포 배양에 의한 baccatin Ⅲ의 생산 연구

신승원,류리,임숙 德成女子大學校 藥學硏究所 1997 藥學論文誌 Vol.8 No.1

The semi-synthesis of taxol using the biosynthetic precursor, baccatin Ⅲ, is one of the suggested alternative methods for economical production of taxol. The purpose of the study is to establish the high yielding culture system purchasing the development of the method for the economical production of baccatin Ⅲ. In this study, the regulation of biosynthetic metabolism in cell suspension culture system of Taxus cuspidata was experimented by feeding biosynthetic precursors of baccatin Ⅲ and other diterpenes, using the fast growing and highly productive callus lines which were selected in the previous experiments as the result of cultures for five years. The production of baccatin Ⅲ in the cultured cells was analysed by HPLC.