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우리나라 군지역의 고령화 위기와 동태성의 인과순환적 구조분석
최남희 ( Nam Hee Choi ),이종근 ( Jong Kun Lee ),김근세 ( Keun Sei Kim ),이명식 ( Myung Suk Lee ) 한국시스템다이내믹스학회 2014 한국시스템다이내믹스 연구 Vol.15 No.1
This research primarily aims at analyzing major crises originating from marginalizing population, especially in counties. In addition, based on the system dynamics approaches, it pays attention to divulging causal loop structure which has been rather strengthened by diverse interactions among key variables. Judging from simulation works, even though Korea is exposed to unprecedented aging trends over decades, its counter response seems inadequate and insufficient, mostly dismissing a series of impact embedded in the aging dynamics. This research statistically confirms that demographic marginalization trends have already begun in the villages within Eup and Myon counties. Furthermore, this research pinpoints out the fact that it would be almost impossible for majority of villages within Eup and Myon counties to escape from going out of existence in the course of time, as they tend to be entrapped vicious cycle of marginalization or extinction.
한국인 갑상선 유두암에서 ret 암 전구 유전자 재배열 ( ret/PTC) 의 발현빈도 및 그 임상적 의의
이명식,김성훈,양정현,김광원,민용기,김동준,정재훈,김경아,김병준,이문규,남석진,함종렬,이회정 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.1
Background: The prevalence of ret/PTC rearrangement in papillary thyroid carcinomas has been found to have wide variance in different populations. Recent studies, however, have been reporting no significant geographical difference between Asian and Western countries. In addition, there are some arguments about the correlation of ret/PTC expression with clinical aggressiveness. We have performed this study in order to examine the prevalence of ret/PTC-1, -2 and -3 rearrangements in korean papillary throid carcinomas and to ascertain its clinical relevance. Methods: Fourteen thyroid tumors histologically confirmed to be papillary carcinomas were included in this study. To find rearrangements, we adopted RT-PCR and automated direct sequencing. Initial and follow-up clinical data were obtained form the patients medical records. The plasmid containing ret/PTC-2, and 3 was kindly provided by Dr. Ahn (Ulsan University, Seoul Choonang Hospital). Results: We identified one tumors containing ret/PTC-1(1/14, 7.1%), and two containing ret/PTC-2 (2/14, 14.2%), and could not find ret/PTC-3 rearrangement in other patients (0/11). There was no significant correlation of ret/PTC with clinical aggressiveness. Conclusion: We found that the prevalence of ret/PTC rearrangement (3/14, 21.4%) in papillary thyroid carcinomas from Korea was similar to those recently reported in other nations. ret/PTC rearrangement may not affect biological behaviors of papillary thyroid carcinomas (J Kor Soc Endocrinol 14:532, 1999).
갑상선 결절에서 초음파 촬영의 진단적 의의에 관한 연구
이문호,이명철,김주완,조보연,고창순,이종석,오연상,이명식,윤종현 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1
The effeciency of combined application of isotope scan and ultrasonography of thyroid was assessed in 91 patients with thyroid nodule. Malignancy rates were 35.5%, 18.8%, & 0% in solid, complex & cystic nodule group, respectively. No statistically significant co-relationship was found between isotope scan finding & ultrasonographic finding. Malignant nodules were found, only in cold solid nodule group & in cold complex nodule group, and rate of malignant nodule was different between them (45.8% in co1d solid nodule group & 20.7% in cold complex nodule group). Difference between the rate of cystic change in benign & malignant nodule observed in our study (59.2% vs. 35.3%) was thought to explain at least partly the statistically different rate of malignant nodule in cold solid nodule & cold complex nodule group. No difference in the boundarycondition, echogenicity & distribution of internal echo existed between benign nodule group & malignant nodule group.
원발성 부갑상선 기능항진증의 종양 위치 선정을 위한 진단 검사법의 유용성 비교
이석인,이명철,조보연,이홍규,고창순,민헌기,박용수,이명식,오승근,김성연,박재형 대한내분비학회 1992 Endocrinology and metabolism Vol.7 No.1
To compare the preoperative localization procedures, a total of 30 parathyroid tumors were scanned preoperatively using 99Tc-201Tl subtraction scan, high-resolution ultrasonography and computerized tomography (CT). Twenty-three cases of radionuclide scintigraphy, 20 cases of ultrasonography and 29 cases of CT have been taken in 22 cases of parathyroid adenoma, 3 cases of parathyroid hyperplasia and a case of parathyroid cancer. 1) The sensitivities of parathyroid scintigraphy, sonography and CT in detecting parathyroid tumors were 869p, 609p and 7496, while the specificities of respective diagnostic modality were 92Zo, 92F and 9896. 2) Preoperative localization of parathyroid tumors appeared related not only to the volume of the tumor, but also to the position of the tumor. Ultrasonagraphy and CT were not as sensitive as parathyroid scintigraphy in detecting the tumor located in the left lower lobe of parathyroid gland. 3) Common errors in localizing the tumors were easily made in cases with the volume of tumor less than 1 cm', with the tumor surrounded by the normal architecture or the false tumor mimicking parathyroid gland, and with the abnormal thyroid gland nearby, Neck CT was a specific method for the preoperative localization especially in case of the tumors involving more than 2 parathyroid glands. 99Tc-201Tl parathyroid scintigraphy was useful for the localization of parathyroid adenomas and hyperplastic glands and the sensitivity of it exceeded that of either ultrasonography or CT. It will be necessary to evaluate the applicability of the preoperative localization modalities extensively in case of, at least, hyperparathyroidism of the primary or persistent types. (J Kor Soc Endocrino 17:52-60, 1992)