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조기 성문암에 대한 경구강 레이저 미세수술의 장기 치료 성적
이승열,태경,곽진혜,홍성만,송창면,지용배 대한이비인후과학회 2022 대한이비인후과학회지 두경부외과학 Vol.65 No.12
Background and Objectives Traditionally, transoral laser microsurgery (TLM) is commonlyused to treat early glottic cancer. However, the long-term oncologic results have notbeen thoroughly investigated. Therefore, this study aimed to analyze long-term oncologic outcomesof TLM for early glottic cancer. Subjects and Method We retrospectively studied 132 patients who underwent TLM forearly glottis cancer from January 2001 to August 2020. We assessed overall and disease-freesurvival according to the T classification and types of cordectomy proposed by the EuropeanLaryngological Society in 2007. Results Of the 132 patients, 125 were male and 7 female. The mean age was 61.6±9.3 years. We found 5 (3.8%), 112 (84.8%), and 15 (11.3%) patients staged as CIS, T1, and T2, respectively. For the cordectomy types, there were 6 in type I, 22 in type II, 83 in type III, 6 in typeIV, 13 in type V, and 2 in type VI. Ten-year overall and disease-free survival rates were 99.2%and 87.1%, respectively. Overall and disease-free survival curves were not different accordingto different T classification and cordectomy types. Conclusion TLM is an excellent treatment modality for the long-term oncologic control ofearly glottic cancer.
혈소판유래성장인자를 함유한 Chitosan/Calcium Metaphosphate의 골조직재생효과에 관한 연구
이승열,설양조,이용무,이주연,이승진,김석영,구영,류인철,한수부,최상묵,정종평,Lee, Seung-Yeol,Seol, Yang-Jo,Lee, Yong-Moo,Lee, Ju-Yeon,Lee, Seung-Jin,Kim, Suk-Young,Ku, Young,Rhyu, In-Chul,Han, Soo-Boo,Choi, Sang-Mook,Chung, Chong-Pyou 대한치주과학회 2001 Journal of Periodontal & Implant Science Vol.31 No.1
Chitosan is biodegradable natural polymer that has been demonstrated its ability to improve wound healing, and calcium metaphosphate(CMP) is a unique class of phosphate minerals having a polymeric structure. In this study, chitosan/CMP and platelet derived growth factor(PDGF-BB) loaded chitosan/CMP sponges were developed, and the effect of the sponges on bone regeneration and their possibility as scaffolds for bone formation by three-dimensional osteoblast culture were examined. PDGF-BB loaded chitosan/CMP sponges were prepared by freeze-drying of a mixture of chitosan solution and CMP powder, and soaking in a PDGF-BB solution. Fabricated sponge retained its 3-dimensional porous structure with $100-200\;{\mu}m$ pores. The release kinetics of PDGF-BB loaded onto the sponge were measured in vitro with $^{125}I-labeled$ PDGF-BB. In order to examine their possibility as scaffolds for bone formation, fetal rat calvarial osteoblastic cells were isolated, cultured, and seeded into the sponges. The cell-sponge constructs were cultured for 28 days. Cell proliferation, alkaline phosphatase activity were measured at 1, 7, 14 and 28 days, and histologic examination was performed. In order to examine the effect on the healing of bone defect, the sponges were implanted into rat calvarial defects. Rats were sacrificed 2 and 4 weeks after implantation and histologic and histomorphometrical examination were performed. An effective therapeutic concentration of PDGF-BB following a high initial burst release was maintained throughout the examination period. PDGF-BB loaded chitosan/CMP sponges supported the proliferation of seeded osteoblastic cells as well as their differentiation as indicated by high alkaline phosphatase activities. Histologic findings indicated that seeded osteoblastic cells well attached to sponge matrices and proliferated in a multi-layer fashion. In the experiments of implantation in rat calvarial defects, histologic and histomorphometric examination revealed that chitosan/CMP sponge promoted osseous healing as compared to controls. PDGF-BB loaded chitosan/CMP sponge further echanced bone regeneration. These results suggested that PDGF-BB loaded chitosan/CMP sponge was a feasable scaffolding material to grow osteoblast in a three-dimentional structure for transplantation into a site for bone regeneration.
창업가의 무인결제시스템 도입의도에 미치는 영향에 관한 연구
이승열,김재홍,김재철 한국엔터프라이즈아키텍처학회 2022 정보기술아키텍처연구 Vol.19 No.3
최근 창업환경에서 많은 창업가 및 예비 창업가들은 무인결제시스템을 통하여 혁신을 시도하고있다. 본 연구에서는 기존의 창업과 향후 창업이 예상되는 예비 창업가들을 중심으로 무인결제시스템과 관련된 도입 하고자 하는 의도를 검토하고자 연구가설 및 설문을 설계 및 배포하여 자료를 수집하였다. 또한, 수집된 자료는 SPSS 26.0 통계패키지를 바탕으로 다중회귀분석을 통해 연구결과를 도출하였다. 본 연구결과를 요약하면 다음과 같다. 첫째, 무인결제시스템에 대한 창업가 및 예비 창업가의성과기대, 사회적 영향, 쾌락적 동기, 가격 효용, 친숙함 및 인지된 위험이 무인결제시스템에 유의한영향을 미치는 것으로 나타났다. 둘째, 무인결제시스템에 관한 노력기대, 촉진조건은 통합기술수용의선행 연구들과 다르게 유의하지 않은 연구결과가 도출되었다.
개인병사의 생존성 증대를 위한 생체신호 모니터링 기법의 설계 및 구현
이승열,박상훈,이춘우,김현준,채제욱,Lee, Seung-Youl,Park, Sang-Hoon,Lee, Choon-Woo,Kim, Hyun-Jun,Chae, Jae-Wook 한국군사과학기술학회 2013 한국군사과학기술학회지 Vol.16 No.6
Recently, personal health monitoring system using intelligent biosensors and equipments has been realized. This system can be adopted for soldier's biosignal monitoring system. In this paper, we propose a soldier biosignal monitoring system using personal biosensors, such as the ECG sensors and accelerometer.