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A Case of Ovarian Microinvasive Mucinous Carcinoma and Co-existent Angiosarcoma
허진형,이윤희,김광일,김태헌,강혜윤,안희정,윤보성,성석주,박현,김지영 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.1
Primary ovarian angiosarcoma is very rare with only 27 cases reported so far in the medical literature. We report here on a rare case of ovarian microinvasive mucinous carcinoma that was coexistent with angiosarcoma in a 54-year-old woman. The tumor was a 26×19×10 cm-sized multilocular cystic mass with a 4×3 cm-sized solid hematoma-like nodule in the center. Microscopically, it was composed mostly of mucinous tumor of various grades from borderline to microinvasive carcinoma. The hematoma-like area turned out to be an angiosarcoma, composed of pleomorphic cells that formed slit-like spaces, spindle cells that formed short fascicles and anastomosing vascular channels with atypical endothelial cells. All these cells were positive for CD31, CD34 and factor VIII-related antigen. The patient developed peritoneal and pleural metastases, which were angiosarcoma and mucinous carcinoma, respectively. We believe this case is only the fourth example of an ovarian collision tumor of angiosarcoma and surface epithelial tumor.
이태호,허진형,정주연,이지훈,박동수,김태헌 연세대학교의과대학 2021 Yonsei medical journal Vol.62 No.8
Purpose: Eph receptors are differentially expressed in numerous malignant tumors. This study intended to analyze the roles ofEphB receptors (EphB2, B3, and B4) in urinary bladder cancer. Materials and Methods: Tissue microarray-based immunohistochemical analysis was used to investigate the expression patternsof EphB2, EphB3, and EphB4 in 154 bladder cancer specimens. Immunohistochemical staining was conducted examining theextent of stained cells and staining intensity. EphB was considered to be highly expressed when the intensity of staining was morethan moderate in >25% of cells in the tissue section. Small interfering RNA (siRNA) was used to knock down EphB expression inbladder cancer cell lines (T24, 5637) to determine the effects of EphB on tumor cell invasion, proliferation, and migration. Results: EphB receptors (B2, B3, and B4) were detected in 40.9% (EphB2, 63/154), 71.4% (EphB3, 110/154), and 53.2% (EphB4,82/154) of bladder cancer specimens. Low expression of EphB2, B3, and B4 receptors were significantly associated with higher tumorgrade (EphB2, p<0.001; EphB3, p=0.032; EphB4, p<0.001) and muscular invasion (EphB2, p=0.002; EphB3, p=0.009; EphB4,p<0.001). No obvious correlation was observed with other clinicopathological variables, such as age, sex, recurrence, lymph nodeinvolvement, metastasis, and overall survival. Inactivation of EphB receptors by siRNA transfection increased cell viability, tumorcell invasion, proliferation, and migration in comparison with untransfected cancer cells. Conclusion: Low expression of EphB receptors (B2, B3, and B4) can be a predictive marker for muscular invasion of bladder cancer.
홍종의,임대근,허진형,유찬기 대한이비인후과학회 2011 대한이비인후과학회지 두경부외과학 Vol.54 No.5
Leiomyoma is the most common benign neoplasm of the uterus and gastrointestinal tract, but it is rare in the oral cavity. Also, its occurrence in the tongue is very rare because there is so little smooth muscle tissue present in this region. Clinically, oral leiomyoma usually grows slowly and is generally a non-ulcerated, small (1 to 2 cm), painless, sessile, firm and superficial nodule like lesion, although several authors have reported painful lesions. The diagnosis and treatment of oral leiomyoma is possible with complete surgical excision and histological studies by special stains. Recently, we experienced a 42-year-old woman with 6 month history of protruding tongue mass. She underwent surgical excision and the final pathological result confirmed it to be vascular leiomyoma. We report this case with a review of the related literatures.
Eosinophilic Infiltration in the Liver: Unusual Manifestation of Hepatic Segmental Involvement
이현주,김대중,허진형,김경아,윤상욱,이종태 대한자기공명의과학회 2012 Investigative Magnetic Resonance Imaging Vol.16 No.1
Eosinophilic infiltration in the liver is not a rare disease and it is usually presented as multiple, small, ill defined, oval or round, low attenuated lesions on portal phase of computed tomography. We reported case of hepatic eosinophilic infiltration in the liver, as an unusual manifestation of segmental involvement.
김홍중,홍종의,허진형,유찬기 대한이비인후과학회 부산,울산,경남 지부회 2009 임상이비인후과 Vol.20 No.1
An osteoma is a benign bone tumor that commonly is seen in the mandible or maxilla in the head and neck region, but is rare in the soft tissue in the head and neck, such as tongue. Recently we experienced a case of tongue osteoma. A 16-year-old woman presented with about 11cm sized, nodular, firm mass. The mass was observed on the left side of the dorsum of the tongue. According to the medical record, when she was undergone tonsillectomy and adenoidectomy 7 years ago, there was the mass at the same site of the tongue at that time. It appears that the mass was enlarged slowly over the past 7 years. Surgical excision was done after physical exam and magnetic resonance image. Histologically, the lesion was compact bone with osteocytes and haversian system and the bone was surrounded by fibrous connective tissue and stratified squamous epithelium. So the lesion was diagnosed as ‘osteoma of the tongue’. (J Clinical Otolaryngol 2009;20:110-114)
소아에서 생긴 혈성 유두 분비물을 동반한 관내 유두종: 증례 보고
정진영,육지현,고경희,허진형 대한영상의학회 2008 대한영상의학회지 Vol.59 No.3
관내 유두종은 유방의 양성 종양인 유두종의 가장 흔한 아형으로 대부분 주 유관(major duct) 에서 발생하는 단일 종괴로 나타난다. 흔히 유두 분비물을 동반하고 주로 30세에서 55세 사이의 연령에 발생한다. 소아의 관내 유두종은 매우 드물어 제한적으로 보고되어 있다. 저자들은 혈성 유두 분비물을 동반한 11세 여아의 관내 유두종에 대해 영상소견과 함께 보고하고자 한다.