음이온성 지질을 포함한 지질나노입자의 제조 및 물리적 특성

이정은,김은혜,임덕휘,정석현,정규성,신병철,Lee, Jung-Eun,Kim, Eun-Hye,Lim, Deok-Hwi,Jung, Suk-Hyun,Jeong, Kyu-Sung,Shin, Byung-Cheol 대한화학회 2008 대한화학회지 Vol.52 No.3

커플모래놀이치료가 대학생의 자아분화와 이성관계만족에 미치는 효과

이정은(Jung0-Eun Lee),박지영(Ji-yeong Park),박부진(Boo-Jin Park) 가정과삶의질학회 2013 가정과삶의질연구 Vol.31 No.6

한약 치료를 시행한 트리메틸아민뇨증 환자 1례 증례보고

이정은,한성준,이엄지,이재형,남성욱,하나연,김진성,Lee, Jung-eun,Han, Seong-jun,Lee, Eom-jee,Lee, Jae-hyung,Nam, Seong-uk,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2

Objective: This case reports on the efficacy of herbal medicine treatment for trimethylaminuria.Method: A 29-year-old female Korean patient with trimethylaminuria received herbal medicine treatment for three months. We evaluated her symptoms with the methacholine challenge test and OralChroma.Results: The odor intensity shown in the methacholine challenge test demonstrated improvement.Conclusion: Herbal medicine treatment could improve trimethylaminuria symptoms.

부모의 양육태도가 섭식장애의 발병과 심각도에 미치는 영향

이정은,이정현,정영철,박준영,남궁기,박동화,김경란,Lee, Jung Eun,Lee, Jung-Hyun,Jung, Young-Chul,Park, Jun Young,Kee, Namkoong,Park, Dong Wha,Kim, Kyung Ran 한국정신신체의학회 2015 정신신체의학 Vol.23 No.1

연구목적 한국에서 신경성 식욕부진증과 신경성 폭식증을 진단받은 환자 군에서 부모 양육태도의 차이와 각 아형에서 부모 양육태도의 차이가 발병 나이와 섭식장애 증상의 심각도에 미치는 영향을 알아보고자 하였다. 방 법 167명의 섭식장애 환자(신경성 식욕부진증, N=49 ; 신경성 폭식증, N=118)를 대상으로 하였다. 자가보고식 설문지인 부모 양육행동 척도(Parental Behavior Inventory, PBI)를 시행하여 환자가 인식하는 부모님의 양육행동을 측정하였으며, 섭식장애 검사 개정판(The Eating disorder Inventory-2, EDI-2)를 통하여 증상의 심각도를 평가하였다. 결 과 신경성 식욕부진증 환자를 발병 나이에 따라 분류하였을 때, 16세 이후에 발병한 군보다 16세 이전에 조기 발병한 경우 낮은 아버지의 애정, 높은 아버지의 합리적 설명, 낮은 어머니의 과잉간섭을 보고하였다. 섭식장애 증상의 심각도(EDI-2)는 신경성 식욕부진증과 신경성 폭식증에서 어머니의 애정, 합리적 설명과 음의 상관관계를 나타내었다. 단계별 회귀분석을 시행하였을 때, 아버지의 애정, 어머니의 과잉기대와 합리적 설명이 신경성 식욕부진증의 발병 나이에 중요한 영향을 준다는 것을 확인할 수 있었으며, 두 집단에서 모두 어머니의 애정이 높을 수록 EDI-2의 점수가 낮은 것으로 나타났다. 결 론 섭식장애 환자의 평가 및 치료에서 가족의 기능과 인식된 부모의 양육태도가 중요한 역할을 할 수 있겠다. 본 연구 결과는 아버지의 양육방식이 섭식장애 발병나이에 미치는 영향을 밝힘으로써 이제까지 상대적으로 부족하게 평가되었던 아버지 역할의 중요성을 확인하였다. 이뿐 아니라, 섭식장애 증상의 심각도와 어머니의 애정과의 관련성을 확인함으로써 가족 기능에 대한 평가가 치료에 필수적임을 입증하였다. 앞으로 본 연구 결과에 대한 해석 및 적용을 위한 후속 연구들이 필요하겠다. Objectives:To determine the influence of parental behaviors on the onset and severity of eating disorders, this study compared aspects of perceived parental styles, according to eating disorder subtypes and age at onset in Korean women with eating disorders. Methods:One hundred and sixty-seven patients with eating disorders[Anorexia Nervosa (AN), N=49; Bulimia Nervosa(BN), N=118] were recruited for this study. Perceived parent behaviors were assessed with Parental Behavior Inventory(PBI) self-rating scale. The study subjects also completed the Eating Disorder Inventory -2 (EDI-2) to assess the severity of eating disorder symptoms. Results:In anorexia nervosa, early onset group(<16 years) reported low paternal affection and high paternal rational expression, low maternal interference than group with age at onset over 16 years. The severity of eating disorder symptoms was negatively associated with mother affection and rational expression in two subtypes of eating disorder(AN and BN). On stepwise regression analysis, paternal affection and maternal over-protection were associated with age of onset only in AN group and maternal affection was associated with the severity of symptoms in both groups of eating disorder. Conclusions:Considering the role of family function and perceived parental styles could help improve the management of eating disorders. These results emphasize the importance of fathers' role in the eating disorder on the age of onset, a relatively unexplored area of eating disorder research. Also, we investigated the importance of mothers' affection on the severity of symptoms.

1mW의 전력소모를 갖는 8-bit 100KSPS Cyclic 구조의 CMOS A/D 변환기

이정은,송민규,Lee, Jung-Eun,Song, Min-Kyu 대한전자공학회 1999 電子工學會論文誌, C Vol.c36 No.9

This paper describes a design of an 8-bit 100KSPS 1mW CMOS A/D Converter. Using a novel systematic offset cancellation technique, we reduce the systematic offset voltage of operational amplifiers. Further, a new Gain amplifier is proposed. The proposed A/D Converter is fabricated with a $0.6{\mu}m$ single-poly triple-metal n-well CMOS technology. INL and DNL is within ${\pm}1LSB$, and SNR is about 43dB at the sampling frequency of 100KHz. The power consumption is $980{\mu}W$ at +3V power supply. 본 논문에서는 1mW의 낮은 전력소모를 갖는 8-bit 100KSPS CMOS A/D 변환기를 설계, 제작하였다. Cyclic 구조를 갖는 A/D 변환기에서 발생하는 연산증폭기의 시스템적인 offset 전압을 효과적으로 감소시키기 위해, 새로운 시스템적인 offset 전압 제거 기술을 제안하였다. 또한 기존 Gain 증폭기에서 발생하는 오차를 감소시키기 위해 완전 차동 구조의 Gain 증폭기를 설계하였다. 제안된 A/D 변환기는 $0.6{\mu}m$ single-poly triple-metal n-well CMOS 공정을 사용하여 제작되었으며, +3V 단일 공급전압에서 DNL과 INL은 ${\pm}1LSB$ 이내로 측정되었고, 100KHz의 샘플링 주파수에서 43dB의 SNR를 갖는다. 측정된 최대전력소모는 $980{\mu}W$로 나타났다.

아버지의 미취학자녀 돌봄시간 변화 추이 분석(2004-2019)

이정은,서지원,Lee, Jung-eun,Seo, Jiwon 한국가족자원경영학회 2021 가족자원경영과 정책 Vol.25 No.3

Recently, the importance of the fathers role in the care of young children has been emphasized in Korea for the balance of childcare responsibilities between mothers and fathers. This study investigates the trends in paternal childcare in Korea over the last 15 years. Childcare is divided into primary and developmental care and fathers's Childcare time and participation rates are inverstigated for dual- and single-income households. Data are collected from the four waves of the five-yearly Statistics of Korea Life Time Surveys between 2004(t₁) and 2019(t₄) including the workday time diaries of fathers with preschool children(n₁=2,264, n₂=1,242, n₃=959, n₄=952). Three major results are identified. First, paternal childcare time and participation rates have increased with dual-income fathers spending 24 more minutes a day with their young child(ren) in 2019 than in 2004, which is nearly double. Second, in the analysis of fathers' childcare time use and participation rates comparing primary and developmental care, primary care is found to have increased more than developmental care, especially among dual income fathers: this further exhibits a reversed relation between primary and developmental care over time. Third, the determinants of paternal childcare time are fathers' age, market labor time, commuting time, gender equality consciousness, and education. In particular, market labor time was significant in all four waves, while gender equality consciousness is only significant for single-income fathers. Based on these results, a specific agenda is provided for family-friendly policies to improve the balance of childcare roles between fathers and mothers, especially encouraging increased(significant and sufficient) participation of fathers in primary care activities.

다낭성신질환, 한의학으로 어떻게 접근할 것인가? (동의보감을 중심으로-증례보고)

이정은,한영주,임도희,박양춘,배한호,Lee, Jung-Eun,Han, Young-Joo,Lim, Do-Hee,Park, Yang-Chun,Bae, Han-Ho 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4

Objective : This study was designed to evaluate the extent of effectivness of no mind-therapy (Korean traditional Qigong) on ADPKD. Method : ADPKD patient were observed for one year, given no Western Treatments, and treated only Josik(調息), Joki(調氣)(Korean traditional therapy). Results : 1. The general condition of patient improved and there were specific symtoms that ceased. 2. Hypertention patient showed a lowering of blood pressure. Conclusion : These results suggest a role for no mind-therapy in treatement of ADPKD.

Phase II Study of Induction Irinotecan + Cisplatin Chemotherapy Followed by Concurrent Irinotecan + Cisplatin Plus Twice-Daily Thoracic Radiotherapy

이정은,박희선,정성수,김주옥,조문준,김진환,이충식,김선영,Lee, Jeong Eun,Park, Hee Sun,Jung, Sung Soo,Kim, Ju Ock,Cho, Moon June,Kim, Jin Hwan,Lee, Choong Sik,Kim, Sun Young The Korean Academy of Tuberculosis and Respiratory 2007 Tuberculosis and Respiratory Diseases Vol.63 No.2

배경: Irinotecan hydrochloride는 topoisomerase I inhibitor로서 소세포 폐암에 효과적인 약제로 알려져 있다. Irinotecan은 cisplatin과 더불어 방사선감작물질로 작용하기도 한다. 본 연구는 이전에 치료받은 경험이 없는 제한성 병기의 소세포 폐암 환자에서 irinotecan과 cisplatin(IP)의 방사선 동시화학요법의 효과를 평가하기 위하여 시행되었다. 방법: 2002년 12월부터 2004년 11월까지 충남대학교 병원에서 새로이 제한성 병기의 소세포 폐암으로 진단된 24명의 환자들을 대상으로 하였다. Irinotecan $60mg/m^2$을 제 1일과 제 8일째 투여하였고 cisplatin $60mg/m^2$을 제 1일째 투여하였으며 매 3주 간격으로 시행되었다. 제 3차 항암화학요법을 시작하는 날과 동시에 과다 분할방사선 치료(twice-daily thoracic irradiation; 45 Gy total)을 시작하였다. 예방적 전 뇌 방사선 조사(Prophylactic cranial irradiation)가 방사선 동시화학요법이 끝난 후 완전반응(complete response)을 나타낸 환자에서 시행되었다. 제 2차 항암요법과 제 6차 항암요법이 끝난 후에 흉부 전산화 단층촬영과 기관지경 등을 통한 병기의 재평가가 이루어졌다. 결과: 병기의 재평가는 19명의 환자에게 이루어졌다. 중앙 추적관찰기간은 12.5개월이고 전체 99회의 항암치료가 시행되었다. 평균 한 환자당 5.2회의 항암치료가 시행되었다. 실제 용량강도는 cisplatin $19.6mg/m^2$/week과 irinotecan $38.2mg/m^2$/week이었다. 9명의 환자가 완전반응을 보였고 10명의 환자가 부분반응(partial response)을 보여서 전체 반응률은 95%였다. 3에서 4도의 혈액학적 독성은 백혈구 감소증(35% of cycles), 빈혈(7% of cycles), 혈소판 감소증(7% of cycles) 등으로 나타났다. 3에서 4도의 비 혈액학적 독성은 설사(5% of cycles)였다. 3에서 4도의 방사선 식도염(10% of patients)을 제외하고는 과다 분할 방사선 치료를 이용한 방사선 동시 화학요법의 기존의 방법과 독성 면에서는 큰 차이가 없었다. 치료와 관련된 사망은 관찰되지 않았다. 평가가 가능한 환자들에서 1년 생존율과 2년 생존율은 각각 89% (16/18)와 47% (9/18)였다. 결론: 3주 간격으로 시행된 irinotecan과 cisplatin을 이용한 과다분할 방사선 동시 요법은 제한성 병기의 소세포 폐암 환자에서 부작용은 높지 않으면서 효과적인 치료법으로 고려될 수 있을 것이다. Background: Irinotecan hydrochloride, a topoisomerase I inhibitor, is effective against small-cell lung cancer. Irinotecan also can act as a potential radiation sensitizer along with cisplatin. To evaluate efficacy and toxicity of irinotecan plus cisplatin (IP) with concurrent thoracic radiotherapy, we conducted a phase II study of IP followed by concurrent IP plus hyperfractionated thoracic radiotherapy in patients with previously untreated limited-stage small-cell lung cancer. Methods: Twenty-four patients with previously untreated small-cell lung cancer were enrolled onto the study since November 2004. Irinotecan $60mg/m^2$ was administered intravenously on days 1 and 8 in combination with cisplatin $60mg/m^2$ on day1 every 21 days. From the first day of third cycle, twice-daily thoracic irradiation (total 45 Gy) was given. Prophylactic cranial irradiation was given to the patients who showed complete remission after concurrent chemoradiotherapy. Restaging was done after second and sixth cycle with chest CT and/or bronchosocpy. Results: Up to November 2004, 19 patients were assessable. The median follow-up time was 12.5 months. A total of 99 cycles (median 5.2 cycles per patient) were administered. The actual dose intensity values were cisplatin $19.6mg/m^2$/week and irinotecan $38.2mg/m^2$/week. Among the 19 patients, the objective response rate was 95% (19 patients), with 9 patients (47%) having a complete response (CR). The major grade 3/4 hematological toxicities were neutropenia (35% of cycles), anemia (7% of cycles), thrombocytopenia (7% of cycles). Febrile neutropenia was 4% of cycles. The predominant grade 3/4 non-hematological toxicities was diarrhea (5% of cycles). Toxicities was not significantly different with concurrent administration of irinotecan and cisplatin with radiotherapy, except grade 3/4 radiation esophagitis (10% of patients). No treatment-related deaths were observed. The 1-year and 2-year survival rate of eligible patients was 89% (16/18) and 47% (9/18), respectively. Conclusion: Three-week schedule of irinotecan plus cisplatin followed by concurrent IP plus hyperfractionated thoracic radiotherapy is an effective treatment for limited disease small-cell lung cancer, with acceptable toxicity.

성상신경절차단술로 제어되지 않은 대상포진후 신경통환자 치험 1예

이정은,배한호,한영주,임도희,채은영,조철준,박양춘,Lee, Jung-Eun,Bae, Han-Ho,Han, Young-Joo,Lim, Do-Hee,Chae, Eun-Young,Jo, Chul-Jun,Park, Yang-Chun 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Post-herpetic neuralgia(PHN) is a chronic pain syndrome associated with the reactivation of a primary infection with varicella zoster virus(chinken pox), which leads to a chronic infection of dorsal root ganglia. The most common risk factor for shingles and its potential sequela, PHN, is advanced age. For a significant number of patients, the pain following healing of shingles can persist for months to years. If this pain, classified as PHN, persists longer than one month. PHN often leads to depression, disrupted sleep, decreased productivity, and utilization of health care. We treated a 60 year-old female patient who suffered pain and headache after Stellate Ganglion Blocks(SGB). In identifying points for differentiation of syndrom(辨證), this subject was diagnosed as Yangmyeong Merdian wind-heat syndrom(陽明經風熱證) and was administered Seungmagalgeuntanggamibang(revised Shengmagalgen-tang, 升麻葛根湯加味方). To ease pain, Western medication was administered as well. After fourteen days of treatment, pain and other symptoms improved.

간질발작(癎疾發作)환자 치험 1예

이정은,황지호,임도희,한영주,배한호,정인철,박양춘,Lee, Jung-Eun,Hwang, Ji-Ho,Lim, Do-Hee,Han, Young-Joo,Bae, Han-Ho,Jeong, In-Chul,Park, Yang-Chun 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2

Epilepsy is a neurological condition that from time to time produces brief disturbances in the normal electrical functions of the brain, Normal brain function is made possible by millions of tiny electrical charges passing between nerve cells in the brain and to all parts of the body. They may affect a person's consciousness, bodily movements or sensations for a short time. These physical changes are called epileptic seizures. These clinical data, gathered an epileptic seizure whose main symptom was convulsion, was analyzed. This clinical report pertains to a 51 year-old man who suffered an epileptic seizure and after effects of weakness. He was treated with ChongsimOndamTang(淸心溫膽湯). The cheif symptom, epileptic seizure, disappeared and general conditions improved after Korean medical treatments, so this is reported as a potential treatment.