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보중익기탕가미방으로 치료한 만성 비세균성전립선염환자의 자각증상 및 백혈구수치변화에 대한 치험 1례
조철준,구창모,김진원,이승진,선중기,박양춘,배한호,이정은,한영주,임도희,Cho Cheol-Jun,Koo Chang-Mo,Kim Jin-Won,Lee Seung-Jin,Sun Jung-Ki,Park Yang-Chun,Bae Han-Ho,Lee Joung-Eun,Han Young-Joo,Lim Do-Hui 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1
The chronic non-bacterial prostatis disease is relatively incurable, chronic and recurrent. Due to its prostatis barrier, chronic non-bacterial prostatis disease is difficult to be penetrated with Medicine. Nevertheless, we obtained the desired results using the method of iki action by Bojungiki-tang. The purpose of this study is to evaluate the effect of treatment and change of WBC numerical index using Bojungiki-tang. We investigated one chronic non-bacterial prostatis disease for about one year with NIH chronic prostatis symptom index, expressed prostatic secretion(EPS). After the treatment, symptom index score was decreased from 27 to 1. Also WBC numerical index by EPS test was decreased to zero. These results indicate that oriental medical therapy is effective in treating chronic non-bacterial prostatis disease. Therefore further study of the effect of herb-medicine is necessary.
황금이 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향
조철준,임도희,황지호,양수영,박양춘,Cho, Cheol-Jun,Lim, Do-Hee,Hwang, Ji-Ho,Yang, Soo-Young,Park, Yang-Chun 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1
objective : The purpose of this research is to examine the effects of Scutellaria Radix(SR) extract on immune cells and cytokines in ovalbumin(OVA)-induced asthmatic mice. Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 9 weeks. In this experiment, one group was not treated, and the other group was treated with SR extract for six weeks(five times per week) and analyzed by ELISA and flow cytometer. Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-13 in BALF (bronchoalveolar lavage fluid) compared with that of control group. However,$IFN{\gamma}$ in the SR group increased significantly compared with that of control group. Additionally, the population of $CD3e^-/CCR3^+,\;CD69^+/CD3e^+,\;IgE^+/B220^+,\;CD11b^+/Gr-1^+$ cells in the SR group decreased compared with that of control group. conclusion : The results of this study support a role for SR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing $IFN{\gamma}$, Which helps prevent such reactions.
뇌척수액 백혈구 증가증이 없는 장바이러스 뇌수막염 소아들의 임상적 특징
조철준,남명수,김용욱,김경심,조형민,김 령,장해인,김은영 조선대학교 의학연구원 2018 The Medical Journal of Chosun University Vol.43 No.2
The aim of this study was to investigate the factors associated with cerebrospinal fluid (CSF) pleocytosis in pediatric enteroviral meningitis. A retrospective analysis of the medical records was performed in 281 patients under 18 years of age who were diagnosed with enteroviral meningitis by reverse transcription-polymerase chain reaction (RT-PCR) at Kwangju Christian Hospital from January to December 2016. Clinical symptoms and laboratory findings were compared according to the presence or absence of CSF pleocytosis. 112 children (39.9%) did not have CSF pleocytosis. When we compared the group of meningitis without pleocytosis and the group with pleocytosis, age were younger (< 2years), and the interval between onset of symptoms and the time of lumbar puncture was shorter (<24 hours), peripheral white blood cell counts were lower, but C-reactive protein (CRP) was higher in the group of meningitis without pleocytosis. Enteroviral meningitis should not be excluded even if CSF pleocytosis is not seen in patients. And enterovirus CSF RT-PCR should be performed with high suspicion in children younger than 2 years.
신생아에서 담도 폐쇄증으로 오인된 Jagged1 (JAG1) 유전자 분석에 의해 확진된 Alagille 증후군 1례
윤희정,조철준,김용욱,김은영,조형민,김영,장해인,김경심 대한신생아학회 2017 Neonatal medicine Vol.24 No.3
Alagille syndrome is a complex autosomal dominant disorder secondary to defects in the Notch signaling pathway, primarily caused by mutations in the Jagged1 (JAG1) gene. The liver, heart, skeleton, face and eyes are the body parts most commonly involved. Alagille syndrome may mimic other causes of high gamma-glutamyl transferase (GGT)-linked cholestasis, most notably biliary atresia in the neonatal period. Infants with Alagille syndrome are occasionally misdiagnosed as cases with biliary atresia due to variations in clinical features that might be expressed in early infancy. We describe a case of Alagille syndrome mimicking biliary atresia, identified by sequencing analysis of the JAG1 gene in a newborn. During counseling, family members of the patient have also been found to demonstrate various phenotypes and levels of disease severity of Alagille syndrome.
급성 호흡기 바이러스 감염이 가와사키병에 미치는 영향에 관한 연구
이화랑,조철준,김용욱,김경심,김은영,김령,장해인,조형민 조선대학교 의학연구원 2018 The Medical Journal of Chosun University Vol.43 No.2
The aim of this study was to determine the effect of acute respiratory viral infection on Kawasaki disease. From July 2016 to June 2018, among the patients who underwent respiratory virus screening at the Kwangju Christian Hospital, those diag-nosed 88 patients with Kawasaki disease were enrolled in this study. The effects of acute respiratory viral infection on Ka-wasaki disease were compared according to whether 2nd intravenous immunoglobulin (IVIG) treatment was administered or not, and whether coronary artery complications occurred. Respiratory virus was detected in 44 out of 88 patients. 2nd IVIG treatment rates were 16% (n=7) and 27% (n=12) in the virus positive group and the virus negative group, respectively (p>0.05). The incidence of coronary artery complications was 11% (n=5) and 25% (n=11) in the virus positive group and the virus negative group, respectively (p>0.05). There was no statistically significant correlation between the 2nd IVIG admin-istration and coronary artery complications following the detection of respiratory virus in patients with Kawasaki disease. We think it is necessary to actively study the effects of acute respiratory viral infection on Kawasaki disease through large-scale studies of multiple centers in the future.
杏蘇湯 및 加味八味丸이 呼吸器 杯狀細胞로부터의 뮤신 分泌에 미치는 영향
임도희,이정은,한영주,황지호,조철준,배한호,박양춘,채은영 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
The intent of this study is to investigate whether two oriental medical prescriptions named haengsotang(HST) and gami-palmihwan (GPMH) significantly effect mucin release from cultured hamster tracheal surface epithelial(HTSE) cells. Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of HST or GPMH to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of HST and GPMH on contractility of isolated tracheal smooth muscle were investigated. The results are consistant with the following assertions : (1) HST significantly inhibited mucin release from cultured HTSE cells, without cytotoxicity ; (2) GPMH did not effect mucin release without cytotoxicity; (3) HST and GPMH did not effect contractility of isolated tracheal smooth muscle. These results suggest a need for further investigation of HST and its components, for its potential in oriental medicine prescriptions and novel agents that effectively regulate (inhibit) mucin secretion from airway goblet cells.
행소탕(杏蘇湯) 및 가미팔미환(加味八味丸)이 호흡기(呼吸器) 배상세포(杯狀細胞)로부터의 뮤신 분비(分泌)에 미치는 영향
임도희,이정은,한영주,황지호,조철준,배한호,채은영,박양춘,Lim, Do-Hee,Lee, Joung-Eun,Han, Young-Joo,Hwang, Ji-Ho,Cho, Cheol-Jun,Bae, Han-Ho,Chae, Eun-Young,Park, Yang-Chun 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
The intent of this study is to investigate whether two oriental medical prescriptions named haengsotang(HST) and gami-palmihwan(GPMH) significantly effect mucin release from cultured hamster tracheal surface epithelial(HTSE) cells, Confluent HTSE cells were metabolically radiolabeled with $^3H-glucosamine$ for 24 hrs and chased for 30 min in the presence of HST or GPMH to assess the effect of each agent on $^3H-mucin$ release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of HST and GPMH on contractility of isolated tracheal smooth muscle were investigated. The results are consistant with the following assertions: (1) HST significantly inhibited mucin release from cultured HTSE cells, without cytotoxicity; (2) GPMH did not effect mucin release without cytotoxicity; (3) HST and GPMH did not effect contractility of isolated tracheal smooth muscle. These results suggest a need for further investigation of HST and its components, for its potential in oriental medicine prescriptions and novel agents that effectively regulate (inhibit) mucin secretion from airway goblet cells.
뇌경색 환자의 당뇨병성 고지혈증에 대한 오적산가감방(五積散加減方) 호전 1례
한승혜,정병주,우성호,김병철,김용호,서호석,황규동,조철준,남효익,김진원,Han, Seung-Hea,Jeong, Byeong-Ju,Woo, Sung-Ho,Kim, Byung-Chul,Kim, Yong-Ho,Seo, Ho-Seok,Hwang, Gyu-Dong,Cho, Cheol-Jun,Nam, Hyo-Ick,Kim, Jin-Won 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1
Hyperlipidemia is one of the major factors causing the atherosclerosis of coronary arteries and well-documented modifiable risk factors of stroke, especially of the ischemic type. For Insulin-Dependent Diabetes Mellitus sufferers, if blood sugar is appropriately maintained, lipid and lipoprotein are normal, but if blood sugar is inappropriately maintained or clinical Diabetic nephropathy induces metabolic disorder of lipid, then Total cholesterol, low density lipoprotein cholesterol, triglyceride and very low density lipoprotein cholesterol levels go up and high density lipoprotein levels go down. The purpose of this study is to evaluate the effect of treatment with Ojeok-san and to observe the changes in Fasting Blood Sugar(FBS), 2 Hours Postprandial Blood Sugar(PP2h), Haemoglobin A1c(HbA1c), Total Cholesterol(T-Chol) and Triglyceride(TG). After the treatment, Fasting Blood Sugar decreased from 149mg/dl to 89mg/dl. 2 Hours Postprandial Blood Sugar decreased from l85mg/dl to 110mg/dl. Haemoglobin A1c decreased from 6.3% to 5.7%. Total Cholesterol decreased from 268mg/dl to 217mg/dl. And Triglyceride decreased from 438mg/dl to 265mg/dl. These results support a role for oriental medical therapy in treating Diabetic Hyperlipidemia. Further case studies of herbal treatment of this ailment are needed.
한영주,이정은,임도희,황지호,배한호,박양춘,조철준,Han Young-Joo,Lee Jung-Eun,Lim Do-Hee,Hwang Ji-Ho,Bae Han-Ho,Park Yang-Chun,Jo Chul-Jun 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Lung abscess is often ocuured by aspiration of infectious secretion in stroke patients that has symptom of dysphagia. So we studied the effects of combined eastern and western treatment in lung abscess patient combined with stroke. We performed both antibiotic therapy and herbal medication in a lung abscess patient. We compared a chest x-ray film of early stage of disease with a film of after stage of disease, also compared change of symptom-cough, sputum, flank pain, blood phlem. After dispending antibiotic therapy and herbal medication, a lung abscess patient improved symptoms and in result of chest x-ray. The above results suggest that combined eastern and western trearment can have good effects on improving symptoms of a lung abscess patient.
성상신경절차단술로 제어되지 않은 대상포진후 신경통환자 치험 1예
이정은,배한호,한영주,임도희,채은영,조철준,박양춘,Lee, Jung-Eun,Bae, Han-Ho,Han, Young-Joo,Lim, Do-Hee,Chae, Eun-Young,Jo, Chul-Jun,Park, Yang-Chun 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
Post-herpetic neuralgia(PHN) is a chronic pain syndrome associated with the reactivation of a primary infection with varicella zoster virus(chinken pox), which leads to a chronic infection of dorsal root ganglia. The most common risk factor for shingles and its potential sequela, PHN, is advanced age. For a significant number of patients, the pain following healing of shingles can persist for months to years. If this pain, classified as PHN, persists longer than one month. PHN often leads to depression, disrupted sleep, decreased productivity, and utilization of health care. We treated a 60 year-old female patient who suffered pain and headache after Stellate Ganglion Blocks(SGB). In identifying points for differentiation of syndrom(辨證), this subject was diagnosed as Yangmyeong Merdian wind-heat syndrom(陽明經風熱證) and was administered Seungmagalgeuntanggamibang(revised Shengmagalgen-tang, 升麻葛根湯加味方). To ease pain, Western medication was administered as well. After fourteen days of treatment, pain and other symptoms improved.