도인승기탕에 의한 당뇨병성 혈관장애 개선효과

이윤정,김언국,김혜윰,윤정주,이소민,이용표,이건목,강대길,이호섭,Lee, Yun Jung,Kim, Eon Kuk,Kim, Hye Yoom,Yoon, Jung Joo,Lee, So Min,Lee, Yong-Pyo,Lee, Geon Mok,Kang, Dae Gill,Lee, Ho Sub 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1

Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.

고지혈증 동물모델에서 홍삼과 천마 혼합투여에 의한 혈관 염증 개선연구

이윤정,김혜윰,윤정주,이소민,고정현,이호섭,최경민,강대길,Lee, Yun-Jung,Kim, Hye-Yoom,Yoon, Jung-Joo,Lee, So-Min,Kho, Joung-Hyun,Lee, Ho-Sub,Choi, Kyung-Min,Kang, Dae-Gill 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

Objectives : This experimental study was designed to investigate the inhibitory effects of combination with Korean red ginseng and Gastrodia rhizoma on vascular dysfunction in high-fat/cholesterol diet-induced hyperlipidemia. Methods : Sprague-Dawley rats were fed with 7.5% cocoa butter and 1.25% cholesterol for 10 weeks, with Panax ginseng (PG), and mixtures of Panax ginseng and Gastrodia rhizoma (PGM), respectively. Results : Chronic treatment with PG and PGM significantly decreased body weight. The aortic expression of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were markedly increased in hyperlipidemia rats. Interestingly, PGM significantly decreased cell adhesion molecules expression. However, there was no significant decrease in PG group. In addition, PG and PGM group inhibited high-fat/cholesterol diet-induced cytokine such as monocyte chemoattractant protein (MCP-1) mRNA expression. Furthermore, PG and PGM group significantly decreased c-reactive protein protein (CRP) level. Especially, PGM significantly accentuated the decrease of MCP-1 mRNA expression and CRP level. Conclusions : the present study provides an evidence that combination with Panax ginseng and Gastrodia rhizoma enhances anti-vascular protective effects through suppression of vascular inflammation in hyperlipidemic rats.

Salmonella typhimurium 에서 무산소 환경 유도유전자들에 대한 조절유전자들의 특성 및 클로닝

이윤정,방일수,이인수,이영록,박용근 ( Yun Joung Lee,Iel Soo Bang,In Soo Lee,Yung Nok Lee,Yong Keun Park ) 한국환경생물학회 1993 환경생물 : 환경생물학회지 Vol.11 No.2

New regulatory loci which participate in the anaerobic environment inducible gene(ani) expression in Salmonella typhimurium were identified. These regulators (oxr) showed negative regulatory effect on the anaerobiosis inducible operon fusions of this organism in aerobic environment (oxr 107 and oxr 108 to ani 2001, oxr 109 to ani 2007). They were identified as the trans-acting regulators, and increased β-galactosidase activity of ani-lacZ fusion strains up to about 10-240 fold in aerobic environment. By using the library of S. typhimurium chromosomal DNA, two negative regulators (oxr 101 and oxr 109) were cloned. The insert fragment of each clone, pPK32 for oxr 101 and pPK33 to oxr 109 were 7.8Kb and 9.3Kb, respectively. The recombinant plasmid pPK32 didn`t complement the mutation effect of oxr 101 on minimal media but rich media, pPK33 complemented the mutation effect of oxr 109 on both minimal and rich media.

의료계는 지금-간호사의 해외진출

이윤정,Lee, Yun-Jeong 대한간호협회 2006 대한간호 Vol.45 No.4

점검 : AI 안심해도 되는가! -세계 AI 발생현황과 AI 예방대책

이윤정,Lee, Yun-Jeong 대한양계협회 2010 월간 양계 Vol.42 No.9

무덥던 여름이 지나가고 조금씩 선선한 바람이 부는 계절이 돌아오고 있다. 더위에 지친 사람들과 동물들에게는 반가운 가을이지만, 조류인플루엔자(AI; Avian Influenza)라고 하는 질병 때문에라도 양계농가에서는 마냥 느긋하게 즐길 수만은 없는 계절이기도 하다. 우리나라는 2008년 5월 발생을 마지막으로 H5N1형의 고병원성 조류인플루엔자(HPAI)가 종식되어 현재는 HPAI 청정국 상태를 유지하고 있다. 하지만 세계적으로 HPAI 발생이 지속되고 있어 재유입의 가능성이 상존하고 있고, 이전 우리나라에서의 발생이 모두 봄 가을 철새 이동시기에 있었던 점, 그리고 인플루엔자 바이러스의 특성상 저온 환경에서 오래 생존할 수 있는 점 등을 생각하면 환경 온도가 낮은 가을에서 다음해 봄까지 기간이 아무래도 문제가 될 수 있는 시기라 하겠다. 따라서 본 원고에서는 우리나라 주변국을 중심으로 세계의 AI 발생현황을 알아보고 다가오는 계절에 대비하여 농가에서 지켜야 할 예방수칙에 대해 간략히 소개해 보고자 한다.

기술위험 거버넌스에서의 역할분담: 영국과 한국의 방사성폐기물 관리 공론화 사례

이윤정,Lee, Yun Jeong 기술경영경제학회 2016 Journal of Technology Innovation Vol.24 No.4

과학기술 전문가가 근거를 제시하고 정책관료가 결정을 내리던 기존의 정책결정체계와는 달리, 불확실성과 이해관계 대립으로 특징지어지는 기술위험 영역에서 참여적 의사결정방법이 바람직한 모델로 상정되어왔다. 이어 여러 가지 정책실험이 이루어졌다. 그러나 의사결정과정에 있어서 '누가 어떤 역할을 할 것인가'에 대해서는 여전히 다양한 견해가 존재한다. 본 연구는 기술위험 거버넌스에 대한 사회적 배경이 다른 두 나라인 영국과 한국에서 각각 수행된 방사성폐기물 관리방안 모색을 위한 공론화 프로그램을 역할분담의 관점에서 분석한다. 본고는 영국과 한국의 공론화 프로그램이 전개되는 과정에서 다양한 참여자 그룹이 어떻게 정의되고, 어떠한 근거로 역할이 상정되며, 적용된 의사결정방법은 무엇인지에 관해 논의한다. 공론화과정의 사례연구를 통해 많은 기술선진 민주주의 사회에서 지지 받고 있는 '참여를 통한 의사결정'이라는 기술위험 거버넌스의 규범이자 방법론이 실제 각기 다른 정치사회 환경에서 어떻게 구현되는 지를 살펴본다. 방사성폐기물 관리와 공론화에 대한 오랜 경험을 가진 영국과의 비교분석은 한국의 방사성폐기물 관리정책과 나아가 기술위험 거버넌스를 위한 정책도구를 정교화 하는 데 기여할 것이다. In order to deal with uncertainty and conflicting interests in technological risk policy-making, various participatory decision-making models have been practiced. This participatory approach is an alterative to the traditional process of science and technology policy-making where scientific experts provide evidence and government officials make decisions. However, there still remain different opinions on who should play what kind of role in decision-making process. Therefore this paper examines the division of labour in the public deliberations for radioactive waste management policy carried out in the UK and Korea. It discusses the ways in which various actors are defined, and the rationales are employed for allocating actors to certain roles and participatory methods. In so doing, this paper unfolds the ways in which the participatory decision-making process for risk governance is delivered in real policy context. Similarities and differences revealed in the division of labour of two cases contribute to development of radioactive waste management policy and the policy instruments for risk governance.

경계 차감 클러스터링에 기반한 클러스터 개수 추정 화자식별

이윤정,최민정,서창우,한헌수,Lee, Youn-Jeong,Choi, Min-Jung,Seo, Chang-Woo,Hahn, Hern-Soo 한국음향학회 2007 韓國音響學會誌 Vol.26 No.5

본 논문에서는 화자식별을 위한 특징벡터의 새로운 클러스터링 방법을 제안한다. 제안된 방법은 클러스터 센터에 대한 초기값 설정과 클러스터 개수에 대한 사전 정보 없이 클러스터링이 가능하다. 각 클러스터 센터는 경계 차감 클러스터링 알고리즘으로 한 번에 한 개의 클러스터 센터가 추가됨으로써 순차적으로 구해지며, 클러스터 개수는 클러스터간의 상호관계를 조사하여 결정된다. 인공 생성 데이터 및 TIMIT 음성을 이용하여 실험한 결과로부터 제안된 방법이 기존의 방법보다 우수함을 확인하였다. In this paper we propose a new clustering algorithm that performs clustering the feature vectors for the speaker identification. Unlike typical clustering approaches, the proposed method performs the clustering without the initial guesses of locations of the cluster centers and a priori information about the number of clusters. Cluster centers are obtained incrementally by adding one cluster center at a time through the boundary subtractive clustering algorithm. The number of clusters is obtained from investigating the mutual relationship between clusters. The experimental results for artificial datum and TIMIT DB show the effectiveness of the proposed algorithm as compared with the conventional methods.

비중격만곡증 환자의 눈물주머니코안연결술의 임상예후

이윤정,문상원,조희윤,정진혁,Yoon Jung Lee,M,D,Sang-Won Moon,M,D,Hee Yoon Cho,M,D,Jin-Hyeok Jeong,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: Septal deviation has few subjective symptoms. However, a difficulty remains in doing DCR (dacryocystorhinostomy) in these patients. We investigate the clinical course of DCR in patients with a septal deviation. Methods: Acquired nasolacrimal duct-obstructed patients who had undergone DCR with septal deviation from 2003 to 2006 in our hospital were retrospectively analyzed. We measured the septal distance using paranasal computed tomography taken preoperatively and compared the sex and age of patients, the kinds of operations, outcome of surgery, and ocular and nasal complications in our analysis. Results: Twenty-two eyes of 22 patients with a mean age of 55.3 years (range 29~74) were analyzed (4 males, 18 females). Mean septal distance was 4.84 mm (range 2.18~6.99 mm). Nineteen eyes had endonasal DCR, and three had external DCR. Two had DCR combined with septoplasty. Three had septoplasty as a secondary operation, Nasal complication was synechiae in 9 eyes. DCR success was seen in 15 eyes, and DCR failure in 7 eyes. Septal distance was not correlated with DCR success but was correlated with nasal complication (Mann-Whitney test, p=0.003) Conclusions: In the case of DCR with septal deviation, the surgical technique used will need to minimize the mucosal injury and ensure appropriate nasal correction to prevent future complications.

사체를 이용한 아래눈꺼풀지방의 해부학적 연구

이윤정,강일봉,신선영,백두진,Yoon Jung Lee,M,D,Il Bong Kang,M,D,Sun Young Shin,M,D,Doo Jin Paik,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: This study investigated the anatomy of infraorbital fat and the relationship between surrounding structures and infraorbital fat. Methods: Forty-one orbits from adult Korean cadavers were dissected. Among them 20 orbits were male and 21 orbits were female. The cadavers were perfused and embalmed in formalin solution. The skin and orbicularis oculi muscle were dissected to expose the arrangement and compartments of infraorbital fat. A punctal probe was used to find a deeper fat compartment lying under the another compartment. The width of each compartment and the distances from the inferior orbital rim and from the lower lid margin to the topmost point of each compartment were measured using a digital caliper. The distance from the top of the medial compartment and lower lid margin to the first appearance of the inferior oblique muscle, located between the medial and the central fat compartments, were measured, respectively. Results: The width of the medial compartment was 11.49±2.54 mm, the central compartment was 21.78±5.69 mm, and the lateral compartment was 17.94±4.99 mm. The distance from the inferior orbital rim to the medial compartment was 8.13±2.72 mm, to the central compartment was 9.91±3.44 mm, to the lateral compartment was 9.58±3.76 mm. The distance from the lower lid margin to the medial compartment was 5.55±1.22 mm, to the central compartment was 7.09±3.22 mm, and to the lateral compartment was 5.41±3.07 mm. The distance from the inferior oblique muscle to the medial compartment was 9.09±2.63 mm, and to the lower lid margin was 13.60±2.27 mm. Conclusions: Our study evaluates the normal anatomy of the infraorbital fat compartments in Korean patients and suggests a useful index for lower blepharoplasty and lower orbital surgery.

집합주택단지의 옥외공간에 있어서 고령자 이바쇼(居場所)의 특징고찰 - 일본 치바현(千葉縣)의 카시와시(柏市) 토요시키다이(豊四季台)단지를 대상으로 -

이윤정,변경화,유창균,Lee, Yunjeong,Byun, Kyeonghwa,Yoo, Changgeun 한국주거학회 2015 한국주거학회 논문집 Vol.26 No.6

The purpose of this study is to analyze the characteristics of exterior spaces used by the elderly of housing complex. The exterior spaces are used for going out in everyday life with the view point that the elderly have to go out from the inside home in order to prevent isolating the elderly from local community. For that Toyoshikidai housing complex in Kashiwa city of Chiba prefecture, Japan is selected and carried out questionnaire survey and field survey targeting residents. The results are following as. For spatial characteristics, the location installed benches, location occupied in one part by roof, wall, or plants, place connecting to moving flow of the aged, and an open expanse getting safety from vehicle are taken advantages for the elderly. For using benches, the elderly of 70.1% do not have experience using benches installed in all those places. The the biggest reason is that they are not tired. However, 36.8% of the elderly are using benches in order to take a rest and 20.8% of them are using benches in order to talk with the other people. Bench is ibasho of the elderly.