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Effect of a Flavon Extracted from Artemisia absinthium onCollagen Induced Arthritis in Mice
최경민,황대환,신경미,윤도영*,김동수 대한소아청소년과학회 2004 Clinical and Experimental Pediatrics (CEP) Vol.47 No.6
Purpose:In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods:DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies and a stimulation index of the splenocytes of the mice were measured. IL-10 and TNF-α in the supernatants of the mice sera were measured by ELISA. mRNA expression for IL-10 and TNF-α in the splenocytes were tested. Results:Flavon extracted from Artemisia absinthium appears to be an effective suppressor of CIA in mice. The serum anti-collagen antibody level and stimulation index of the cultured splenocytes showed no significant differences among the three experimental groups. Also serum IL-10 and TNF-α levels did not show any significant differences among the three experimental groups. An increased expression of mRNA for IL-10 was observed in the splenocytes treated with flavon. Conclusion:With these results, flavon extracted from Artemisia absinthium appears to have a suppressive effect of CIA. The mechanism of the suppressive effect of flavon extracted from Artemisia absinthium may be from a stimulation of IL-10 production. Artemisia absinthium (애엽)에서 추출한 Flavon이 마우스에서 Collagen InducedArthritis에 미치는 영향연세대학교 의과대학 소아과학교실, 한국과학기술연구소*최경민·황대환·신경미·윤도영*·김동수목 적 : 애엽에서 추출한 flavon이 마우스에서 유발된 CIA의 염증을 억제하는 효과를 조사하고자 하였다.방 법 : DBA/1 mouse에서 chicken type II collagen을 피내주사하였고, 접종 3주 후부터 flavon을 경구투여하였다. 세 실험군에서 관절염의 발생과 관절염 지수를 측정하였으며, 항콜라겐항체와 비장세포의 자극지수를 측정하였다. ELISA를 이용하여 IL-10과 TNF-α의 농도를 측정하였다. 비장세포에서의 IL-10과 TNF-α의 mRNA 표현을 조사하였다.결 과 : 애엽에서 추출한 flavon은 마우스의 CIA에 대한 억제 효과를 지닌다. 실험군간의 혈청내 항콜라겐항체 농도와 배양된 비장세포에서의 자극지수에는 통계적으로 의미있는 차이는 없었다. 뿐만 아니라 세 실험군간의 혈청 IL-10과 TNF-α 농도의 통계적으로 의미있는 차이도 관찰되지 않았다. Flavon을 투여한 마우스의 비장세포에서 IL-10의 mRNA 표현이 증가되어 있음이 관찰되었다.
최경민,김정원,김승우 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.11
Organizing hematoma occurs in many locations and simulate neoplasms. They have similar histologic features such as having a central mass of blood, granulation tissue, and dense, fibrous tissue at the periphery. There have been sporadic reports of organizing hematoma found not only in the soft tissue but also in the brain, adrenal gland, lung and maxillary sinus. We report a case of nontraumatic organizing hematoma encountered in a child -on the supraclavicular fossa. To our knowledge it is a site that has not been previously reported.
최경민 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.5
The mumps virus is a single-stranded, non-segmented, negativesense RNA virus belonging to the Paramyxoviridae family. Mumps is characterized by bilateral or unilateral swelling of the parotid gland. Aseptic meningitis is a common complication, and orchitis is also common in adolescents and adult men. Diagnosis is based on clinical findings, but because of high vaccination coverage,clinical findings alone are not sufficient for diagnosis, and laboratory confirmation is needed. Mumps is preventable by vaccination,but despite high vaccination coverage, epidemics occur in several countries, including Korea. Many hypotheses are suggested for these phenomena. In this review, we investigate the reason for the epidemics, optimal methods of diagnosis, and surveillance of immunization status for the prevention of future epidemics.
Recommendation for the use of newly introduced Tdap vaccine in Korea
최경민,김경효,김예진,김종현,박수은,이환종,은병욱,조대선,최은화,홍영진 대한소아청소년과학회 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.4
Pertussis is an acute respiratory infection characterized by paroxysmal cough and inspiratory whoop for over 2 weeks. The incidence of pertussis has decreased markedly after the introduction of DTwP/DTaP vaccine, but the incidence of pertussis has increased steadily among young infant and among adolescents and adults in many countries. Td vaccine was used in this age group but the increase in pertussis has lead to the development of a Tdap vaccine. The Tdap vaccine is a Td vaccine with a pertussis vaccine added and is thought to decrease the incidence and transmission of pertussis in the respective age group. In Korea, two products are approved by the KOREA FOOD & DRUG ADMINISTRATION, which are ADACEL^TM (Sanofi-Pasteur, Totonto,Ontario, Canada) and BOOSTRIX^Ⓡ (GlaxoSmithKline Biologicals,Rixensart, Belgium) for those aged between 11-64. This report summarizes the recommendations approved by the Committee on Infectious Diseases, the Korean Pediatric Society.
최경민,양재경,박응로,배진우,서용기,이성택,Choi, Kyung-Min,Yang, Jae-Kyung,Park, Eung-Roh,Bae, Jin-Woo,Seo, Yong-Ki,Lee, Sung-Taik 유기성자원학회 1997 유기물자원화 Vol.5 No.1
5-Aminolevulinic acid (ALA) 생합성의 $C_5$ 경로의 전구물질인 L-glutamic acid가 Rhodospirillum rubrum N-1 새포내에서 ALA 생산의 역할을 검토하였다. Lascelles의 기본배지에 L-glutamic acid와 levulinic acid (LA)를 각각 30, 20 mM 첨가배양으로써 균체외 ALA 생산성이 40배 증가(76 mg/l)하였다. 한편 $C_4$ 경로의 기질인 glycine과 succinic acid를 대수기 중기에 각각 60 mM 첨가함으로써, 균의 증식은 억제되었으나 균체외의 ALA는 52 mg/l에 달하였다. The role of L-glutamic acid, a precursor of $C_5$ ALA biosynthetic pathway, on the production of 5-aminolevulinic acid (ALA) has been described in cells of Rhodospirillum rubrum N-1. To the Lascelles basal medium the addition of both 30 mM L-glutamicacid and 20 mM levulinic acid (LA) provided to increase the extracellular ALA yield up to 40 fold (76 mg/l). By the addition of both 60 mM glycine and succinic acid, precursorsof $C_4$ ALA biosynthetic pathway, at middle log phase of cell growth ALA yield was increased 27 fold (52 mg/l) although the celt growth was inhibited to a certain extent.
최경민,김승우,김춘동 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.3
Osseous choristoma rarely occurs, but when it does, the oral cavity of the head and neck lesion is the most common site. It appears as a mass of normal bony structure, consisting of mature osteocytes in an ectopic position. Appearing as a calcification of thyroid mass on radiologic examinations,it could be a benign lesion, chronic inflammation, or carcinoma; the final diagnosis can only be obtained by a pathologic confirmation. Histologically, the lesions show a well-circumscribed mass of vital bone. The treatment of choice is surgical excision. We report a case of osseous choristoma that occurred on the thyroid gland. To our knowledge, such has not been reported previously as a site of osseous choristoma. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:187-9