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당뇨 합병증과 군령탕 구성성분의 네트워크 약리학 분석 및 효능 예측
윤정주,김혜윰,태애림,이호섭,강대길 대한한의학방제학회 2024 大韓韓醫學方劑學會誌 Vol.32 No.1
Objectives : GunRyeong-Tang(GRT) is a traditional herbal prescription that combines Oryeongsan and Sagunja-tang. This study employed network analysis methods on the components of GRT and target genes related to diabetes complications to predict the improvement effects of GRT on diabetes complications. Methods : The collection of active compounds of GRT and related target genes involved the utilization of public databases and the PubChem database. We selected diabetes complication-related genes using GeneCards and confirmed their correlation through comparative analysis with the target genes of GRT. We constructed a network using Cytoscape 3.9.1 and conducted topological analysis. To predict the mechanism, we performed functional enrichment analysis based on Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results : Through network analysis, 234 active compounds and 1361 related genes were collected from GRT. A total of 9,136 genes related to diabetes complications were collected, and 1,039 target genes overlapping with the components of GRT were identified. The core genes of this network were TP53, INS, AKT1, ALB, and EGFR. In addition, GRT significantly reduced the H9c2 cell size and the expression of myocardial hypertrophy biomarkers (ANP, BNP), which were increased by high glucose (HG). Conclusions : Through this study, we were able to predict the activity and mechanism of action of GRT on diabetes and diabetic complications, and confirmed the potential of GRT as a treatment for diabetes complications through the effect of GRT on improving myocardial hypertrophy for diabetic cardiomyopathy.
태권도를 통한 이슬람권 선교의 여정: 밀의 '사회학적 상상력'을 중심으로
윤정주 횃불트리니티신학대학원대학교 한국이슬람연구소 2024 Muslim - Christian Encounter Vol.17 No.1
This study is an examination of how the author, a Taekwondo missionary, was able to enter, settle, and integrate into the Islamic world with relative ease. The author uses Mills’ sociological imagination to explore this through various theories of social integration and theories of different forms of capital: symbolic, cultural, and social capital. It is shown that the possession of symbolic capital, which is conferred by the symbolism of being a Korean Taekwondo master, cultural capital, which embodies the culture of Taekwondo, as well as the acquisition of social capital, which expands the network of social connections, facilitated the entry into the Islamic world, settlement and integration into the local community, and the development of missionary work. In terms of methodology, this study employs firstly, literature review, and secondly, autoethnography, which is a qualitative methodology in the social sciences, in order to analyze and interpret the author’s own empirical narrative with sociological theory, then draw conclusions. In short, through the lens of the sociology of sports, the author aims to reveal how Taekwondo mission can serve as a bridgehead for Islamic mission that require a creative approach.