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      • KCI등재후보

        1.5 T 자기공명영상기기에서 수소 자기공명분광법을 이용한 모델용액 내 포도당의 정량분석

        이경희,이정희,조순구,김용성,김형진,서창해,Lee, Kyung-Hee,Lee, Jung-Hee,Cho, Soon-Gu,Kim, Yong-Seong,Kim, Hyung-Jin,Suh, Chang-Hae 대한영상의학회 2002 대한영상의학회지 Vol.46 No.1

        목적: 1.5T 생체용 자기공명영상기기를 이용한 수소자기공명분광법으로 용액 내 물질의 정량분석에 대한 가능성을 알아보고자 하였다. 대상과 방법: 0.01%에서 50%까지의 여러 농도를 갖는 포도당+증류수 혼합액과 0.01%에서 20%까지의 여러 농도를 갖는 포도당+증류수+에탄올 혼합액의 모델용액을 만들어 생체용 자기공명영상기기와 시험관 nuclear magnetic resonance(NMR)분광기에서 각각 수소자기공명분광법을 시행하여 스펙트럼을 얻었다.스펙트럼 상에서 포도당 농도에 따른 포도당/물, (포도당+에탄올)/물, (포도당+에탄올)/에탄올 피크의 면적 비의 변화를 구하였고, 통계처리는 상관분석과 단순선형회귀분석을 시행하였고 회귀식을 산출 하였다.또한 생체용 자기공명영상기기를 이용하여 얻은 결과가 객관적인지 알아보기 위해 시험관 NMR 분광기에서 얻은 결과와의 상관관계를 분석하였다. 결과: 생체용 자기공명영상기기를 이용한 스펙트럼상 포도당/물, (포도당+에탄올)/물, (포도당+에탄올)/에탄올 피크의 면적 비는 포도당 농도변화에 대하에 일정하게 증가하는 통계적으로 의미 있는 변화를 보였고 그 결과에 따라 회귀식을 구할 수 있었다. 생체용 자기공명영상기기와 시험관 NMR 분광기를 이용하여 얻은 모든 결과에 대한 상관분석에서 통계적으로 의미 있는 상관관계를 보여 생체용 자기공명영상기기에서 얻은 수소자기공명분광 소견을 객관화 할 수 있었다. 따라서 생체용 자기공명영상기기를 이용하여 얻은 스펙트럼에서 용액 내 물질의 피크면적비를 구함으로써 농도를 정량할 수 있는 결과를 얻을 수 있었다. 결론: 생체용 자기공명영상기기를 이용하여 얻은 수소자기공명분광 스펙트럼에서도 시험관 NMR분광기로 얻은 스펙트럼과 마찬가지로 단순 포도당 용액, 포도당에 에탄올을 혼합한 용액에서 포도당/물, (포도당+에탄올)/물, (포도당+에탄올)/에탄올 피크의 면적 비를 측정함으로써 당의 정량분석이 가능하였다. 본 연구의 결과는 생체수소자기공명분광법이 환자의 체액에 대한 정량적 분석에 이용될 수 있다는 가능성을 시사한다고 생각한다. Purpose: To evaluate the feasibility of proton magnetic resonance spectroscopy ($^1H-MRS$) using a 1.5T magnetic resonance (MR) imager for quantification of the contents of model solutions. Materials and Methods: We prepared model solutions of dextrose+water and dextrose+water+ethanol at dextrose concentrations of 0.01% to 50% and 0.01% to 20%, respectively. Using these solutions and a 1.5T MR imager together with a high-resolution nuclear magnetic resonance (NMR) spectroscope, we calculated the ratios of dextrose to water peak, (dextrose+ethanol) to water peak, and (dextrose+ethanol) to ethanol peak, as seen on MR and NMR spectra, analysing the relationships between dextrose concentration and the ratios of peaks, and between the ratios of the peaks seen on MR spectra and those seen on NMR spectra. Results: Changes in the ratios between dextrose concentration and dextrose to water peak, (dextrose+ethanol) to water peak and (dextrose+ethanol) to ethanol peak, as seen on MR spectra, were statistically significant, and there was good linear regression. There was also close correlation between the ratios of the observed on MR and NMR spectra. The results depict the quantification of dextrose concentration according to the ratios of spectral peaks obtained by proton MRS at 1.5T. Conclusion: Using proton MRS at 1.5T, and on the basis of the ratios of spectcal peaks, it was possible to quantify the concentration of dextrose in model solutions of dextrose+water and dextrose+water+ethanol. The results of this study suggest that for quantifying the contents of biofluids, the use of low-tesla $^1H-MRS$ is feasible.

      • SCOPUSKCI등재

        보완대체의료에 관한 간호사들의 태도 조사

        이경희,박경민,Lee, Kyung-Hee,Park, Kyung-Min 한국지역사회간호학회 2000 지역사회간호학회지 Vol.11 No.1

        Complementary & Alternative Medicine(CAM) have become increasingly popular with health care consumer in recent years. The nurse's attitude and beliefs about CAM will influence the response. to the patient's demands and inquiries. The purpose of this study is to evaluate the attitude and beliefs of nurses about CAM. The study was performed in 600 nurses from October to December in 1999 : Nurses were working one university hospital & one general hospital were located in TaeGu city. and two general hospitals located in Kyung Buk city. The study used specially designed questionnaire to 600 nurses, and analyzed by using descriptive statistics, ANOVA data based on 460 completed questionnaire. The findings of the study are as following. 1. The credible forms of subject about CAM were ranked acupunture (66.1%). herbal medicine(56.5%), Sooji chim (50.4%) et al. 2. In the credibility of subject about CAM there were not significant difference by age. clinical career, marriage, health status. The most reason of positive credibility was 'Being human perspective and spiritual supporting'. While the most reason of negative credibility was 'the lack of science test and doubt of disease treatment'. 3. In the experienced rate of subject about CAM there were significant difference not by health status but by age($x^2$=10.096, p= .006), clinical career($x^2$=7.648 p= .022), marriage($x^2$=9.317. p= .002). In the satistied rate of subject about CAM there were not significant difference by age, clinical career, marriage, health status 4. The most usable forms of subject about CAM in nurse's practice was Music therapy(55.9%), and ranked massage (50.9%), acupressure(32.8%). Sooji chim (27.8%) et al.

      • KCI등재

        LPS로 유발된 대식세포의 염증반응에 대한 청상보하탕(淸上補下湯)의 효과

        이경희,김홍렬,정희재,이형구,Lee, Kyung-Hee,Kim, Hong-yeoul,Jung, Hee-Jae,Lee, Hyung-Koo 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1

        Background and Objective : Chungsangboha-tang (CSBHT) has analgesic, sedative, anti-convulsive and anti-histamine effects, so it alleviates the symptoms of asthma. For the comparison of anti-inflammatory effect(s) on CSBHT, PD098059 was used as a negative control. Materials and Methods : This study emphasized THP-1 cells, which had been well characterized as a human monocytic leukemic cell line. The cells resemble monocytes with respect to several criteria and can be differentiated into macrophage-like cells by treatment with PMA. By using the MTS assay, it was possible to prove the safety of CSBHT. Results : Results shows that the CSBHT did not affected cell survival within $10^{1}$ ng/ml to $10^{5}$ ng/ml. Especially, $10^{5}$ ng/ml CSBHT treated cells show 70% deduction of $TNF-{\alpha}$ gene expression against that of LPS treated group. Furthermore, $IL-1{\beta}$, IL-6, IL-8, IL-10 and $TNF-{\alpha}$ levels are down-regulated when treated with CSBHT with concentrations up to 100 ug/ml on monocyte-derived macrophages. Interestingly, CSBHT-treated samples showed that overall transcriptional activities were down-regulated to 20% of that of PD098059 ($TNF-{\alpha}$ inhibitor). At protein level, the expression of $TNF-{\alpha}$ showed similar results as that of transcriptional activity. Results show that the protein level decreased more in the CSBHT-treated group (487 ${\pm}$ 87 pg/ml) than in the LPS-treated group (703 ${\pm}$ 103 pg/ml). In addition, the protein level of IL-8 in the CSBHT treated-group (9.84 ${\pm}$ 3.28 ng/ml) decreased similar as the expression of the control and PD098059-treated groups. Conclusion : CSBHT affects immune response, especially allergic responses and suppression of inflammatory reaction. The results provide us an alternative way to care for clinical inflammatory diseases, not only asthma but also the other possible general inflammatory and allergic diseases.

      • KCI등재
      • Some Properties of an RNA Ligase from Rhodosporidium toruloides

        이경희,정연희,남정이,박인원,Lee, Kyung-Hee,Joung, Yean-Hee,NamShin, Jeong-E.,Park, In-Won Korean Society for Biochemistry and Molecular Biol 1987 한국생화학회지 Vol.20 No.2

        Rhodosporidium toruloides의 무세포 추출물에서 새로운 RNA 연결효소의 활동성을 검출하였다. 이 효소계는 합성 UG의 5'-인산에 2'-, 3'-, 또는 고리형 2' : 3'-누클레오티드를 잇따라 결합시킴으로써 $N_nU_{16}G$(n= 1,2,3,...)을 합성시키는 것을 관찰하였다. 합성 올리고누클레오티드와의 연결반응은 2'-포스포모노에스테르, 3',5'-포스포디에스테르 중간체 결합의 형성에 의해서 진행한다. 이 RNA 연결효소는 그의 최대 활동성을 위해서 ATP와 $Mg^{2+}$을 필요로 한다. 흥미있는 것은, 무세포 추출물을 Micrococcus 에서 얻은 핵산가수분해효소로 처리하면 효소 활동성이 없어지지만, 데옥시리보 핵산가수분해효소로 처리한 경우에는 활동성에 영향을 미치지 않는다. 이것은 이 RNA 연결효소가 그의 연결작용에 RNA 성분을 필요로 함을 가리킨다. A novel RNA ligase activity has been detected in a cell-free extract from Rhodosporidium toruloides. The enzyme system was found to successively join 2'-, 3'-, or cyclic 2' : 3'-nucleotide to the 5'-phosphate of synthetic $U_{16}G$, leading to the synthesis of $N_{n}U_{16}G$(n=1,2,3...). The ligation of the nucleotides with synthetic oligonucleotide was found to proceed by forming 2'-phosphomonoester, 3',5'-phospho diester intermediate linkage. The RNA ligase requires ATP and $Mg^{2+}$ for its maximum activity. Interestingly, treatment of the cell- free extract with micrococcal nuclease but not with deoxyribonuclease abolishes the enzyme activity, indicating that the RNA ligase requires an RNA component(s) for its ligation activity.

      • KCI등재후보

        물리치료과 학생의 자아개념과 정신건강에 관한 연구

        이경희,김기원,Lee, Kyung-Hee,Kim, Gi-Won 대한물리치료학회 2008 대한물리치료학회지 Vol.20 No.4

        Purpose: To investigate the relationship between self-concept and mental health of physical therapy students. Methods: We recruited 179 currently enrolled college freshman, sophomores, and juniors studying physical therapy. The instruments used for this study were Rosenberg's Self-esteem Scale, Choi Chung Hoon's Perceeptual Orientation Scale, and the Mental Health Test modified by Lee. Results: The mean self-concept score was 3.97, a positive self concept, and the mean mental health score was 1.04. The mean dimension score for mental health ranged from: r=0.79$\sim$r=1.29. The relationship between self-concept and the mental health showed a negative correlation (r=-0.693, p<0.01). Conclusion: Modifications to the current program may improve self-concept and the mental health of physical therapy students.

      • KCI등재

        0.1% 클로르헥시딘과 탄툼액을 이용한 구강간호가 기관내관을 삽입한 중환자실 환자의 구강상태 및 구강내 세균 발생에 미치는 효과

        이경희,박해경,김지혜,Lee, Kyung-Hee,Park, Hae-Kyung,Kim, Ji-Hye 한국중환자간호학회 2010 중환자간호학회지 Vol.3 No.2

        Purpose: The purpose of this pilot study was to investigate the effect of oral care using 0.1% chlorhexidine and tantum solution on oral status and incidence of oral pathogens among intubated ICU patients. Methods: The study subjects were 26 intubated patients of MICU in a university hospital. Oral care was provided with 0.1% chlorhexidine solution to the experimental group (n=12) and with tantum solution to the control group (n=14), 3 times a day for 6 days. After the intervention, the oral status of each subject was checked using structured method, and oral swab culture was done to count colonized bacterial pathogens. Results: The mean oral status score of experimental group was significantly higher than that of control group (U=42.50, p=.031). The mean incidence of oral pathogens in experimental group was smaller than that of control group, but the difference was not statistically significant. Conclusion: The oral care with 0.1% chlorhexidine solution is more effective than with tantum solution for improving oral status of intubated ICU patients. However, additional studies with larger sample size will be needed to figure out it's effects on the incidence of oral pathogens.

      • KCI등재

        치매의 진단과 치료

        이경희,김철용,김성학,Lee, Kyung-Hee,Kim, Chul-Yong,Kim, Seong-Hak 대한물리치료과학회 2002 대한물리치료과학회지 Vol.9 No.3

        This research recognized about general ancient temple of Alzheimer dementia. Research of cause of Alzheimer dementia is progressing up to now. Age, education, melancholia, estrogen, woman, smoking, thyroid gland disease, aluminum etc. are danger factor of an Alzheimer dementia. Familyish factor was proved in some degree by gene. Medicine in early patient's case imbecility some measure progress late in degree develop. However, ceilinged thing is true in treatment of Alzheimer dementia up to now, and must help so that their quality of life may can rise and laws of physical therapist must help to keep function in everyday life.

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