황금(黃芩)과 구성 화합물의 약리작용에 대한 고찰

이건석,박민희,천목은,홍진우,조수인,Lee, Keon-Suk,Park, Min-Hee,Cheon, Mog-Eun,Hong, Jin-Woo,Cho, Su-In 대한예방한의학회 2011 대한예방한의학회지 Vol.15 No.2

Objective : Scutellaria baicalensis is one of the most popular and multi-purpose herb in traditional medicine. It is also useful for its practicability to cultivate in Korea. The purpose of this study is to contribute to researches and applications of scutellaria baicalensis by analyzing and reviewing international researches on the compositions and the effects of scutellaria baicalensis. Methods : This study analyzed 146 articles from PubMed by searching with the keyword "Scutellaria baicalensis", "Huang quin", "Baical Skullcap", "Huang qin", "baical skullcap root", "ogon", "Hwanggeum" and "Hwangkeum", published within the last 10 years(from 2000 to 2009). We reviewed the 146 articles on Scutellaria baicalensis and its active constituents in terms of 'Active constituents', 'Experimental studies', 'Clinical studies', 'Drug interaction', 'Side Effects/Toxicity' and 'Pharmacokinetics'. Results : The active constituents of Scutellaria baicalensis are flavonoids such as baicalein, baicalin, wogonin and oroxylin-A. It is reported that scutellaria baicalensis and its active compounds have antiinflammatory activity, antitumor activity, antioxidant activity, antiviral and antibiotic activity, neuroprotective effects, hepatoprotective effects and cardiovascular effect. Conclusions : This study is aimed to summarize the results obtained within the last 10 years and to contribute to following researches and applications of Scutellaria baicalensis.

대학생의 자살위험도와 MMPI-2의 관계

이건석,이혜경,김석현,장은영,김대호,Lee, Kounseok,Lee, Hye Kyung,Kim, Seok Hyeon,Jang, Eun-Young,Kim, Daeho 대한불안의학회 2015 대한불안의학회지 Vol.11 No.2

Objectives : The Minnesota Multiphasic Personality Inventory (MMPI) is a commonly used psychological test measuring personality and psychopathology in both clinical and non-clinical population. This study was to evaluate characteristic MMPI-2 profile associated with the risk of suicide among college students. Methods : We analyzed the survey response of 2,964 college students who participated in a health survey from a school health center at a national university in 2011. Those who endorsed any of six items on the suicidaity module of MINI were classified as a suicide risk group and remaining students who did not as a control group. Then we compared the Patient Health Questionnaire (PHQ-9) score, the MMPI-2 Clinical scales and Restructured Clinical (RC) scales. To evaluate the correlation RC scales with suicidality score, Pearson correlation analysis was performed. Results : The suicide risk group was 464 students, and the control group was 2,500. The classification result of suicidality, 255 (8.6%) students were low-risk group, 149 (4.8%) students were moderate-risk group and 60 (2.0%) students were high-risk group. In the suicide risk group, VRIN, F scale, Clinical scale and RC scales were significantly higher. In the control group L, K and S scales were significantly higher. Suicidality score has significant correlation with all RC scales. Conclusion : In the suicide risk group, overall psychopathology was higher than the control group. Taken together, features of depressive symptom, antisocial behavior, aggressiveness, introversion may indicate the risk of suicide in college students. These results display both clinical and public health implications for clinicians and school health professionals.

불안장애 환자를 대상으로 한 한국판 상태불안척도의 요인분석

이건석,배활립,김대호,Lee, Koun-Seok,Bae, Hwal-Lip,Kim, Dae-Ho 대한불안의학회 2008 대한불안의학회지 Vol.4 No.2

Objective : Brief screening for anxiety symptoms in clinical practice can further facilitate the diagnosis and evaluation of anxiety disorders. This study examined the factorial validity of the Korean version of the State-Trait Inventory (STAI)-Form X, one of the most frequently used self-report questionnaires for anxiety. Methods : Data from the STAI and Beck Depression Inventory were obtained from a consecutive sample of 200 outpatients diagnosed with DSM-IV anxiety disorders at a psychiatric unit of a university hospital. The factor structures of the State and Trait Scales were assessed using exploratory factor analysis. Results : Three-factor components, including 'State anxiety present', 'State anxiety absent' and 'Selfconfidence', were extracted from the State Scale, explaining 59% of the total variance. A four-factor solution involving 'Trait anxiety and depression present', 'Trait anxiety and depression absent', 'Anxiety proneness' and 'Stability' (59% of total variance) was extracted from the Trait Scale. The internal consistency of the STAI and factors were satisfactory. There were significant correlations between depressive symptoms and factors of the STAI. Conclusion : The STAI-form X showed factorial validity for Korean patients with anxiety disorders. However, our finding that this anxiety scale also measures depressive symptoms should be interpreted with caution.

매개변수 적용범위를 확장한 배관 곡관부에 용접 부착된 원형관 이음부의 이차응력지수

이건석,문승재,Lee, Kun-Suk,Moon, Seong-Jae 한국플랜트학회 2019 플랜트 저널 Vol.15 No.4

배관계를 지지하는 목적으로 자주 사용되는 일체형 용접부착물은 응력집중효과로 인한 국부응력을 유발시켜 종종배관의 파손을 일으키기 때문에 사용에 각별한 주의를 요구하고 있다. 국내 원자력 발전소 배관 곡관부에 부착된 원형관의 국부응력 평가는 EPRI TR-107453에 따라 평가하고 있지만, 이의 적용에는 배관과 부착물의 크기에 관한 특정 매개변수 범위의 제한사항이 있다. 이 논문에서는 유한요소해석을 활용하여 모델들의 치수를 기반으로 한 매개변수 연구를 수행하여 기술적 근거를 확립하고 연구 결과에 대한 회귀분석을 통해 확장된 매개변수 범위를 갖는 곡관부에 부착된 원형관 이음부의 이차응력지수 산출 상관관계식을 도출하였다. 본 연구를 통해 개발된 새로운 상관관계식에 대한 검증을 통해 현재 평가기준의 대체 기준으로써 적용할 것을 제안한다. The stress concentration of the integral welded attachments (IWA) often used to support piping system has been a big issue because it induces local stresses in piping. The method to evaluate local stresses associated with attachments on elbows has been suggested in EPRI TR-107453. However, there are limitations regarding specific parameters range in order to use correlation equation. In this paper, parametric study based on piping elbow size and attachment dimension was performed utilizing finite element analysis (FEA) to evaluate the secondary stress indices of hollow circular cross section welded attachments on piping elbows with the extended parameters range. The results of the FEA were used to develop correlation formulas for calculating secondary stress indices. The empirical equations in this study are suggested as an alternative evaluation method of EPRI TR-107453 by extending parameters range.

이미지스팸 필터링을 위한 영상 및 텍스트 데이터 기반 혼성 분류 모델

이건석(Keonseok Lee),배성호(Sungho Bae) 한국정보과학회 2020 한국정보과학회 학술발표논문집 Vol.2020 No.7

온도 변화에 따른 초전도케이블 전파특성 분석

이건석(Geon Seok Lee),지경환(Gyeong Hwan Ji),권구영(Gu-Young Kwon),방수식(Su Sik Bang),이영호(Yeong Ho Lee),박기준(Kijun Park),손송호(Song Ho Sohn),신용준(Yong-June Shin) 대한전기학회 2017 대한전기학회 학술대회 논문집 Vol.2017 No.7

한국판 역학연구 우울척도 개정판(K-CESD-R)의 표준화 연구

이산,오승택,류소연,전진용,이건석,이은,박진영,이상욱,최원정,Lee, San,Oh, Seung-Taek,Ryu, So Yeon,Jun, Jin Yong,Lee, Kounseok,Lee, Eun,Park, Jin Young,Yi, Sang-Wook,Choi, Won-Jung 한국정신신체의학회 2016 정신신체의학 Vol.24 No.1

연구목적 역학연구 우울척도 개정판은 우울 증상을 평가하는 데에 유용성이 입증된 척도로 알려져 있으며 '정신장애의 진단 및 통계 편람 제4판(DSM-IV)'에 기술되어 있는 주요우울장애의 주요한 우울 증상들을 포괄하고 있다. 이 연구에서는 한국판 역학연구 우울척도 개정판을 제작하여 척도의 신뢰도, 타당도와 특성을 평가하고자 하였다. 방 법 DSM-IV의 진단기준에 근거한 MINI를 사용하여 주요우울증, 기분부전증, 달리 분류되지 않는 우울장애로 진단된 48명의 환자군과 48명의 정상 대조군이 연구에 참여하였다. 연구 참여자들은 한국판 역학연구 우울척도 개정판, 몽고메리-아스버그 우울증 평가척도, 우울증 선별척도, 단축형 우울증상 평가 척도, 상태-특성 불안척도를 포함한 척도검사를 시행하여 교차 검증하였다. Cronbach's alpha 계수, Pearson 상관계수, 주성분 분석, Receiver Operating Characteristic(ROC) 곡선, 최적 절단점 산출을 위한 통계분석을 시행하였다. 결 과 한국판 역학연구 우울척도의 Cronbach's alpha 계수는 0.98이었으며, 한국판 역학연구 우울척도 개정판의 총점은 본 연구에서 시행하였던 다른 우울 및 불안척도의 점수와 높은 상관 관계를 보였다. 주성분 분석에서는 두 요인이 전체 분산의 76.29%를 설명하였으며, ROC 곡선을 이용하였을 때, 한국판 역학연구 우울척도 개정판의 최적 절단점은 13점이었다. 결 론 본 연구는 한국판 역학연구 우울척도 개정판의 표준화를 위한 첫 번째 연구로, 한국판 역학연구 우울척도는 우울 증상을 평가하는데 있어 신뢰성 있고, 타당한 척도임을 밝혔다. 또한 이 척도가 진료 및 역학 연구에서 유용한 선별검사 도구로 사용될 수 있을 것으로 기대한다. Objectives : The Center for Epidemiologic Studies Depression scale-Revised is a recently revised scale which has been reported as a valid tool for the assessment of depressive symptoms. It encompasses cardinal symptoms of depression described in the Diagnostic and Statistical Manual of Mental disorders, fourth edition. In this study, we assessed the reliability, validity and psychometric properties of the Korean version of the CESD-R(K-CESD-R). Methods : Forty-eight patients diagnosed as major depressive disorder, dysthymia, depressive disorder NOS according to the DSM-IV criteria using Mini International Neuropsychiatric Interview and 48 healthy controls were enrolled in this study. They were assessed with K-CESD-R, K-MADRS, PHQ-9, KQIDS-SR, STAI to check cross-validation. Statistical analyses were performed using calculation of Cronbach's alpha, Pearson correlation coefficient, Principal Component Analysis, ROC curve and optimal cut-off value. Results : The Cronbach's alpha of K-CESD-R was 0.98. The total score of K-CESD-R revealed significantly high correlations with those of K-MADRS, PHQ-9, KQIDS-SR(r=0.910, 0.966 and 0.920, p<0.001, respectively). Factor analysis showed two factors account for 76.29% of total variance. We suggested the optimal cut-off value of K-CESD-R as 13 according to analysis of the ROC curve which value sensitivity and specificity both equally. Conclusions : These Results showed that the K-CESD-R could be a reliable and valid scale to assess depressive symptoms. The K-CESD-R is expected as a useful and effective tool for screening and measuring depressive symptoms not only in outpatient clinic but also epidemiologic studies.

BART와 K-DOSPERT로 알아본 한국인의 위험감수경향

홍종인(Jong In Hong),이영렬(Young Ryeol Lee),김경희(Kyoung Hee Kim),박진영(Jin Young Park),박성혁(Sung Hyuk Park),이건석(Gunsuk Lee),이재원(Jaewon Lee) 대한사회정신의학회 2010 사회정신의학 Vol.15 No.1

연구목적: 위험감수경향을 5개의 항목별로 평가할 수 있는 영역별 위험감수척도(Domain-specific Risk-taking Scale;DOSPERT)의 한국어판인 K-DOSPERT를 제작하여 표준화하고, 전산화된 위험감수경향 검사인 풍선위험검사(Balloon Analogue Risk Task;BART)와 K-DOSPERT를 사용하여 한국 정상인의 위험감수경향성을 알아보고자 하였다. 방 법: 150명의 성인 남녀가 K-DOSPERT 표준화 연구에 참여하였다. 신뢰도 평가를 위해 Cronbach's alpha 계수를 산출하였고 타당도 평가를 위해 제 11 판 한국판 바렛충동성검사(Barratt Impulsiveness Scale; BIS)와의 상관관계를 알아보았으며, 위험 행동 및 위험인지점수의 상관성을 기존 외국 연구와 비교하였다. 또한 41명의 성인 남녀를 대상으로 BART와 K-DOSPERT 를 시행하여 두 검사결과를 비교하고, 성별 및 손잡이에 따른 위험감수경향을 알아보았다. 결 과: K-DOSPERT의 Cronbach’ s alpha 계수는 위험감수 및 위험인지 모두 0.84였고, 항목별로는 사회성을 제외한 나머지 위험 항목이 0.6 이상으로 나타나 높은 내적 일치도를 보였고, BIS와 비교한 결과 위험감수경향이 높을수록 충동성이 높은 모습을 보였다. 위험행동과 위험인지점수는 서로 역 상관관계를 보여(r=-0.55, p<0.01) 외국의 결과와 유사하게 나타났다. BART와 K-DOSPERT를 함께 시행한 결과 BART지수가 높게 나타난 집단이 K-DOSPERT 결과 위험감수성이 높게 나타났고, 남자및 오른손잡이는 여자 및 왼손잡이를 포함한 양손잡이에 비해 위험감수경향이 높게 나타났다. 결 론: K-DOSPERT는 한국인의 위험감수경향을 평가하는 도구로 적합하며, 위험감수경향의 평가가 필요한 개인 및 특정 집단에 대한 BART와 K-DOSPERT의 이용을 통해 추후 사회문제의 예방 및 대책마련에 도움이 될 수 있을 것이라 기대된다. Objectives:This study aims to make and standardize Korean version of Domain-specific Risk-taking scale(KDOSPERT) that can evaluate risk-taking propensity according to five risk domains, and look into risk-taking propensity of Koreans by using computerized behavioral task Balloon Analogue Risk Task(BART) and K-DOSPERT. Methods:150 men and women participated in K-DOSPERT standardization study. For the reliability evaluation, the study calculated Cronbach’s alpha coefficient, looked into relations with Barratt Impulsiveness Scale(BIS), and compared relations with risk taking and risk perception with existing oversea researches. In addition, it conducted BART and K-DOSPERT to 41 men and women to compare results of the two tests and examine risk-taking propensity according to the gender and the handedness. Results:K-DOSPERT’s Cronbach’s alpha coefficient indicated that both risk taking and risk perception were 0.84, and risk domains except for social domain were shown more than 0.6 and had high internal consistency. According to the comparison with BIS, the higher risk-taking propensity was, the higher impulsiveness was found. As risk taking and risk perception showed negative correlation (r=-0.55, p<0.01) which is similar to foreign study result. BART and K-DOSPERT were carried out at the same time, and the result showed that the group with high BART index had higher risk-taking propensity according to K-DOSPERT results, and men and the right-handed had higher risk-taking propensity than women and the left-handed and the mixed-handed. Conclusion:K-DOSPERT is suitable as a tool to evaluate risk-taking propensity of Koreans, and it is expected to help prevent social problems and prepare for countermeasures by using BART and K-DOSPERT to individuals and specific groups that need the evaluation of risk-taking propensity.

충수의 점액낭종에 의해 유발된 충수돌기형 장중첩증

문선경(Sun Kyung Moon),박문기(Moon Gi Park),이건석(Geon Seok Lee),김성철(Sung Cheol Kim),이종명(Jong Myeong Lee),이미선(Mi Sun Lee),곽승수(Seung Soo Kwak) 대한외과학회 2006 Annals of Surgical Treatment and Research(ASRT) Vol.71 No.3

조현병 및 조현정동장애 입원환자에서 혈청 염증표지자와 정신병적 증상과의 관련성

김계환,이건석,김수진,이은규,송열매,박진영,Kim, Kye Hwan,Lee, Kounseok,Kim, Su Jin,Lee, Eun Kyu,Song, Yul-Mai,Park, Jin Young 대한생물정신의학회 2012 생물정신의학 Vol.19 No.4

Objectives Despite the growing research interest in the role of immunological markers in schizophrenia, a few studies, with conflicting results, have focused on the association between high sensitivity C-reactive protein (hs-CRP) levels and clinical characteristics in schizophrenia. The aim of the present study was to examine the association of serum hs-CRP with psychopathology in schizophrenia. Methods Fifty-five inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of hs-CRP were measured, and each patient was assessed with the Korean version of the Positive and Negative Syndrome Scale (PANSS). Results In correlation analysis of hs-CRP with PANSS subscales, positive subscale score has significant positive correlation (r = 0.271, p = 0.046). In independent t-test analysis, subjects with hs-CRP > 0.3 mg/dL (elevated CRP group, n = 43) had significantly higher PANSS positive subscale score (t = -3.273, df = 24.107, p = 0.003) than those with hs-CRP ${\leq}$ 0.3 mg/dL (normal CRP group, n = 12). Conclusions Elevated serum levels of high sensitivity C-reactive protein in schizophrenia are associated with the severity of psychotic symptoms.