결핵 치료 중 발생한 부작용으로 약제 변경한 환자들에 대한 임상적 고찰

김호철,김호철,김이형,송재욱,고원중,전경만,송준휘,류연주,김우열,권용수,최재철,박소영 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

목적: 일차 항결핵제 치료 중 부작용으로 약제변경을 한 환자들의 임상적 특성과 치료 경과에 대하여 알아보고자 하였다. 방법: 2009년 1월부터 12월까지 국내 10개 병원에서 일차 항결핵제 치료를 시작한 환자들 중에서 부작용으로 인해 약제를 변경한 환자들을 대상으로 변경 원인과 임상적 특성, 치료경과에 대하여 후향적으로 조사하였다. 결과: 일차 항결핵제치료를 시작한 환자는 총 2,601명이었고, 남자는 1438명(55.3%), 평균나이는 49.8±19.1세였다. 이 환자들 중 부작용으로 약제 변경한 환자는 230명(8.8%)이었고 남자는 116명(50.4%)이었고, 평균나이는 50.9±19.6세였다. 발생한 부작용으로는 간독성이 99명(43.0%)으로 가장 많았고 피부 이상반응은 63명(27.4%), 위장관 증상 46명(20.0%), 시력장애 31명(13.5%), 발열 23명(10.0%%), 백혈구 또는 혈소판감소증 15명(6.5%) 신기능장애 8명(3.5%), 손발저림 5명(2.2%) 순이었다. 나이, 체질량지수는 관련이 없었고, 당뇨(19%, p=0.02), 만성간질환(9%, p=<0.001) 및 폐외결핵(40%, p=0.047)이 약제부작용 발생과 관련이 있었다. 치료기간은 평균 294.5±189.7일로 더 길었으나 최종 치료성적과 재발여부에는 차이가 없었다. 결론: 일차 항결핵제 치료를 받는 환자들 중에서 기저질환으로 당뇨, 만성간질환이 있거나, 폐외결핵의 환자들에서 약제 부작용이 더 많았고 이로 인해 약제변경이 필요하였다. 그러나 약제를 변경한 경우에도 치료 성적에는 큰 차이가 없었다.

經營計劃의 長期的 樹立에 對한 經營學的 考察

김호철 전주대학교 산업경영연구소 1985 産經論叢 Vol.- No.3

Normalized Mean Shapes and Reference Index Values for Computerized Quantitative Assessment Indices of Chest Wall Deformities

김호철,박만식,이성건,남기창,박형주,김민기,송재준,최혁 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.10

We previously proposed a computerized index (eccentricity index [EI]) for chest-wall deformity measurements, such as pectus excavatum. We sought to define mean shapes based on normal chest walls and to propose for computerized index reference values of that are used in the quantitative analysis of the severity of chest-wall deformities. A total of 584 patients were classified into 18 groups, and a database of their chest-wall computed tomography (CT) scan images was constructed. The boundaries of the chest wall were extracted by using a segmentation algorithm, and the mean shapes were subsequently developed. The reference index values were calculated from the developed mean shapes. Reference index values for the EI were compared with a conventional index, the Haller index (HI). A close association has been shown between the two indices in multiple subjects (r = 0.974, P < 0.001). The newly developed mean shapes and reference index values supply both reliability and objectivity to the diagnosis, analysis, and treatment of chest-wall deformities. They promise to be highly useful in clinical settings.

金銀花의 基原에 關한 文獻的 考察

金頀哲,李尙仁 대한본초학회 1990 大韓本草學會誌 Vol.5 No.1

Endobronchial Tuberculosis Presenting as Right Middle Lobe Syndrome:Clinical Characteristics and Bronchoscopic Findings in 22 Cases

김호철,김현식,이승준,정이영,전경녀,이종덕,황영실 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.4

Purpose: Endobronchial tuberculosis (EBTB) presenting as right middle lobe syndrome (RMLS) is an uncommon clinical condition. We investigated the clinical characteristics in patients with EBTB presenting as RMLS. Patients and Methods: We retrospectively reviewed the records of 22 patients with EBTB presenting as RMLS who were diagnosed at our hospital from 2003 to 2006. Results: Its occurrence was more common in females than males (F, 18; M, 4). The mean age was 70.3± 8.5 years, and 17 patients were above the age of 65 years. Cough with sputum was the most common manifestation and 2 patients were asymptomatic. In bronchoscopic analysis, the most common finding was edematous-type EBTB, which was found in 15 patients, followed by actively caseating type in 6 and tumorous type in 1. Acid-fast bacilli (AFB) staining for bronchial washing fluid was positive in only 5 patients: 1 with edematous type and 4 with actively caseating type. Bronchoscopic biopsy showed chronic granulomatous inflammation in 16 patients. Follow-up chest X-ray after treatment showed complete disappearance of the lesion in 2 patients, more than 50% improvement in 5, less than 50% improvement in 5, and no change of lesion in 4. Conclusion: Edematous-type EBTB was the most common type of EBTB presenting as RMLS, and it usually occurred in elderly patients. Culturing for mycobacterium and histologic examination by bronchoscopy are necessary for proper diagnosis in these patients.

Enhancing low radio-dosage thyroid imaging using deep learning and Monte Carlo-based absorbed dose measurement in nuclear medicine

김호철,박찬록 한국원자력학회 2025 Nuclear Engineering and Technology Vol.57 No.5

The acquisition of improved quality via the administration of low radioactivity is an important challenge in the field of nuclear medicine. Thus, we evaluated the image quality generated under low radioactivity using deeplearning algorithms. In addition, internal dosimetry for various organs was measured based on Monte Carlo simulation. The dataset comprised 500 slices of thyroid nuclear medicine images acquired at 370 MBq as high radioactivity and 18.5 MBq as low radioactivity. The residual neural network (ResNet) with 16 residual blocks and a U-Net model were used with various hyperparameters for learning. In addition, we measured the internal dosimetry in peripheral organs based on a Monte Carlo simulation. The peak signal-to-noise ratio (PSNR) results were 18.24 for the ResNet model and 18.85 for the U-Net model on average. The structural similarity index measurement (SSIM) results were also 0.995 and 0.994 for the ResNet and U-Net models, respectively. The average absorbed dose for radionuclides with 37 MBq was 3.98 times higher than that of the radionuclide with 18.5 MBq. In conclusion, it is possible to make a diagnosis based on the administration of low radioactivity when scanning thyroid nuclear medicine images.

經營組織에 關한 意思決定論의 考察

金鎬喆 전주대학교 산업경영연구소 1984 産經論叢 Vol.- No.1

TINA / COBRA 분산 망관리 체계의 CMIPSNMP 수용을 위한 Gateway 설계 ( A Design of Gateway for CMIP , SNMP interworking with TINA / CORBA Distributed Network Management )

김호철,김영탁,구수용,이경휴 한국통신학회 1998 한국통신학회 학술대회논문집 Vol.17 No.3

하이부시 블루베리의 품종별 과실 특성

김호철,김태춘,Kim, Ho Cheol,Kim, Tae-Choon 국제문화기술진흥원 2022 문화기술의 융합 Vol.8 No.6

This study was conducted to compare the internal and external fruit quality of highbush blueberry cultivars introduced in Korea. The fruit of blueberry showed a double S-shaped growth curve, and the fruit weight increased significantly per seed increased by 0.02 g. The sugar content ranged from 9.5 to 14.2°Bx, with a large difference between cultivars. And the free sugar was composed of glucose and fructose as a reducing sugar, and mannitol as a sugar alcohol. The organic acid content was 0.7~1.13%, and citric acid was higher than that of malic acid. Fruit hardness showed a berry characteristic that rapidly declined as the coloring progressed.

조선초기 여진 귀화인의 통혼과 통혼규정

김호철 만주학회 2025 만주연구 Vol.- No.39

본고는 조선정부가 개입한 통혼사례를 검토하고, 여진인의 통혼대상을 규정한 통혼규정이 제정된 시점의 조선정부 내 인식과 북방상황에 대해 분석하였다. 조선 건국 후 조선의 북방에서는 지역적 인접성으로 인해 여진인과 조선인의 통혼이 이루어지고 있었다. 통혼을 통해 조선은 대외적으로 여진인의 관할권을 주장하는 명분으로 이용하기도, 대내적으로는 여진인을 정착시킬 인적 네트워크를 형성하였다. 통혼규정이 제정된 배경은 북방경영과 밀접한 영향이 있다고 할 수 있다. 북방경영은 특히 세종의 적극적인 의지로 실행되었는데, 북방경영에 고려했던 요소 중 하나는 북방에 혼거하던 여진인과 그 정착이었다. 이 시기 통혼대상을 규정한 것 또한 이러한 맥락에서 이해되어야 된다고 생각한다. 여진 추장과의 관계가 약해진 여진인들은 이탈할 우려가 있었고, 조선이 통혼규정을 제정하여 조선과의 관계를 이어가도록 하였다. 결국 조선은 ‘오면 어루만지고, 가면 붙잡지 않는 것이 옳다.’는 정책과는 다르게 여진인의 정착에 적극 대응하였다. This article examines cases of intermarriage involving Joseon government intervention and analyzes government perceptions and northern frontier conditions at the time when regulations governing Jurchen marriage partners and their marital eligibilities were established. Following the founding of Joseon, intermarriage between Jurchens and Koreans occurred frequently in the northern regions due to geographic proximity. During King Sejong’s reign in particular, the Joseon government not only permitted such marriages but at times encouraged intermarriage among naturalized Jurchens. Externally, these unions served to justify Joseon’s juridical claims over the Jurchens, while internally, they fostered human networks that promoted the settlement of Jurchens within Joseon territory. The enactment of intermarriage regulations was closely tied to Joseon’s broader efforts to manage the northern frontier, an undertaking actively advanced under King Sejong’s leadership. One major consideration was the settlement of Jurchens who had been residing among northern communities. The regulation of marriage partners during this period should be understood within this broader context. Amid concerns that Jurchens, whose ties to tribal chieftains had weakened, might defect, Joseon implemented intermarriage regulations to sustain relations with them. In practice, Joseon actively pursued the settlement of Jurchens, diverging from the formal principle at the time that “those who come should be welcomed, but those who leave should not be restrained.”