안와골절 수술 후 발생한 두 가지 상피세포를 가진 안와 점액낭종 1예

김미진,이민정,김찬중,김남주,정호경,곽상인,Mijin Kim,MD,Min Joung Lee,MD,Chan-Joong Kim,MD,Nam Ju Kim,MD,Ho-Kyung Choung,MD,Sang In Khwarg,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.7

Purpose: The authors report a case of orbital mucocele lined with two types of histological epithelial cells developed after repair of the orbital wall fractures. Case summary: A 53-year-old man presented with proptosis of the left eye for two years. The patient had a history of left orbital inferomedial wall fracture repair ten years earlier at a different hospital. Examination revealed 4 mm proptosis and superior globe displacement of the left eye. Restriction of left ocular movements on elevation, depression and adduction were observed. A computed tomography scan demonstrated a large, non-enhancing, cystic tumor in the left inferior orbit with the inferior and medial wall displaced toward the paranasal sinus. An orbital cystic tumor was excised with the removal of previously-inserted orbital implant via a transconjunctival and transcaruncular approach. The inferior, and medial orbital walls were reconstructed using a MEDPOR® TITANTM implant. The initial pathologic diagnosis was epidermal cyst. Histopathologic re-review revealed an orbital cyst lined with both stratified squamous epithelium and pseudostratified ciliated columnar epithelium, thus diagnosis was changed to orbital mucocele. Proptosis and restriction in ocular motility improved postoperatively. Conclusions: Mucocele formation should be considered in patients in whom a cyst developed after orbital fracture repair.

타액선 질환의 세침흡인생검에 관한 세포학적 연구

김미진,이태숙,Kim, Mi-Jin,Lee, Tae-Suk 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2

Fine needle aspiration biopsy cytology is a widely recognized and useful technique which can provide diagnosis in lesions of the head and neck, enabling appropriate management plans for individual patient to be made. Fifty one fine needle aspirates from salivary gland masses were examined. Four aspirates (8%) were inadequate for examination. Of the remaning 47 samples, 42 cases (82%) were benign lesions which consist of 30 pleomorphic adenoma(58%), 7 inflammatory lesion (14%), 4 Warthin's tumor(8%) and 1 benign lesion(2%). Two cases(4%) were atypical lesions. Three cases(6%) were malignant lesions consisting of 2 adenoid cystic carcinomas(4%) and 1 mucoepidermoid carcinoma (2%). The cytologic diagnoses were compared with the subsequent histologic diagnosis of surgical resected specimen in 24 cases. 19 cases of 21 aspirates from benign tumors were correctly diagnosed by fine needle aspiration cytology, with a specificity of 90%. All 3 aspirates from the 3 patients with malignant tumor were correctly diagnosed by fine needle aspiration cytology, with a sensitivity at 100%. Overall acurracy was 88%. Diagnostic error was encountered in adenoid cystic carcinoma, mucoepidermoid carcinoma and Warthin's tumor Correct histologic diagnosis was made in 86% of benign tumors(84% for pleomorphic adenoma and 100% for Warthin's tumor) and in 100% of malignant tumors.

헤지의 표준화된 평균차를 이용한 프로폴리스의 항-당뇨 효과

김미진,최기헌,Kim, Mi-Jin,Choi, Ki-Heon 한국데이터정보과학회 2010 한국데이터정보과학회지 Vol.21 No.3

The present study was carried out to summarize the effect of propolis in the diabetic rats by meta-analysis related studies. The association measure to test effect of propolis was Hedges's standardized mean difference between group of rats induced streptozotocin(STZ) or alloxan and group of rats induced STZ or alloxan treated with propolis about the considered 4 effect factors. In this particular fixed-effect model, blood glucose, Cholesterol, Triglyceride were significantly reduce. The case of heterogenous variable such as body weight, blood glucose, cholesterol, triglyceride, random-effect model was applied. In this model, blood glucose, triglyceride were decreased significantly in propolis treated group. According to the meta-regression analysis, period of injection was significant for body weight and blood glucose, cholesterol. 본 연구는 메타분석에서 헤지의 표준화된 평균차를 이용하여 당뇨에 걸린 쥐들에게 프로폴리스를 투여하여 체중, 혈당량, 콜레스테롤, 트리글리세리드의 평균비교를 통해 프로폴리스의 항-당뇨 효과에 대해 알아보았다. 고정효과모형을 적용시킨 결과 혈당량의 감소, 콜레스테롤 농도의 감소, 트리글리세리드 농도의 감소에 대해 유의한 효과를 보였고, 동질성 검정을 통해 동질성을 만족하지 않은 모든 변수에 대해 랜덤효과모형을 적용시킨 결과 혈당량의 감소와 트리글리세리드 농도의 감소에 대해 유의한 효과를 나타냈다. 또한 프로폴리스의 투여기간과 투여량에 대해 메타회귀분석을 실시한 결과, 투여기간이 체중, 혈당량, 콜레스테롤에 유의한 변수로 나타났다.

In vitro Screening of Jeju Island Plants for Cosmetic Ingredients

김미진,정택규,김무한,윤경섭,Kim, Mi Jin,Jung, Taek Kyu,Kim, Moo-Han,Yoon, Kyung-Sup Korean Society for Biotechnology and Bioengineerin 2018 KSBB Journal Vol.33 No.2

To identify new active cosmetic ingredients of natural origin, we screened the biological activities of 50 different kinds of plants from Jeju Island, the southernmost island of the Korean Peninsula. In this study, plant extracts were screened for inhibitory effects on elastase, nitric oxide, and melanin production, and for free radical scavenging effects. Eight plants, Viburnum erosum Thunb., Trachelospermum asiaticum var. intermedium Nakai, Sageretia theezans Brongn., Sorbus alnifolia var. hirtella T. Lee, Staphylea bumalda DC., Pourthicea villosa var. brunnea Nak., Illicium religiosum S. et Z., and Castanopsis cuspidata var. sieboldii Nakai were potent inhibitors of elastase (over 80% inhibition at 1 mg/mL). Elaeocarpus sylvestris var. Ellipticus (Thunb.) Hara ($IC_{50}$: $13.99{\mu}g/mL$), Sapium sebiferum (L.) ROXB. ($IC_{50}$: $14.27{\mu}g/mL$), and Castanopsis cuspidata var. sieboldii Nakai ($IC_{50}$: $16.46{\mu}g/mL$) showed good antioxidant effects. Eurya japonica Thunb., Quercus myrsinaefolia Bl., Caesalpinia decapetala var. japonica (S. et Z.) Ohashi, Weigela subsessilis L. H. Bailey, and Crinum asiaticum var. japonicum dose-dependently inhibited LPS-induced NO production on RAW 264.7 cells (at $50-200{\mu}g/mL$). Furthermore, Elaeocarpus sylvestris var. Ellipticus (Thunb.) Hara, Ilex integra Thunb., and Agastache rugosa (Fisch. et Meyer) O. Kuntze dose-dependently inhibited ${\alpha}-MSH$ stimulated melanin synthesis on B16 F10 cells (at $25-100{\mu}g/mL$). These results suggest that Jeju Island plants possess several biological activities and may be potent anti-aging, anti-inflammatory, skin-whitening, and anti-oxidative ingredients as functional cosmetic materials.

Sn-Bi도금 $Sn-3.5\%Ag$ 솔더를 이용한 Capacitor의 저온 솔더링

김미진,조선연,김숙환,정재필,Kim Mi-Jin,Cho Sun-Yun,Kim Sook-Hwan,Jung Jae-Pil 대한용접접합학회 2005 대한용접·접합학회지 Vol.23 No.3

Since lead (Pb)-free solders for electronics have higher melting points than that of eutectic Sn-Pb solder, they need higher soldering temperatures. In order to decrease the soldering temperature we tried to coat Sn-Bi layer on $Sn-3.5\%Ag$ solder by electroplating, which applies the mechanism of transient liquid phase bonding to soldering. During heating Bi will diffuse into the $Sn-3.5\%Ag$ solder and this results in decreasing soldering temperature. As bonding samples, the 1608 capacitor electroplated with Sn, and PCB, its surface was finished with electroless-plated Ni/Au, were selected. The $Sn-95.7\%Bi$ coated Sn-3.5Ag was supplied as a solder between the capacitor and PCB land. The samples were reflowed at $220^{\circ}C$, which was lower than that of normal reflow temperature, $240\~250^{\circ}C$, for the Pb-free. As experimental result, the joint of $Sn-95.7\%Bi$ coated Sn-3.5Ag showed high shear strength. In the as-reflowed state, the shear strength of the coated solder showed 58.8N, whereas those of commercial ones were 37.2N (Sn-37Pb), 31.4N (Sn-3Ag-0.5Cu), and 40.2N (Sn-8Zn-3Bi). After thermal shock of 1000 cycles between $-40^{\circ}C$ and $+125^{\circ}C$, shear strength of the coated solder showed 56.8N, whereas the previous commercial solders were in the range of 32.3N and 45.1N. As the microstructures, in the solder $Ag_3Sn$ intermetallic compound (IMC), and along the bonded interface $Ni_3Sn_4$ IMC were observed.

2007년 서울 지역에서 판매되고 있는 반찬류의 세균 오염과 항생제 내성실태

김미진,이도경,장석,양환진,안향미,백은혜,하남주,Kim, Mi-Jin,Lee, Do-Kyung,Jang, Seok,Yang, Hwan-Jin,An, Hyang-Mi,Baek, Eun-Hye,Ha, Nam-Joo 대한약학회 2008 약학회지 Vol.52 No.6

The purpose of this research was to investigate the microbiological quality and antimicrobial susceptibilities of the ready-to-eat side dishes, which are were collected from the grocery stores, big markets, and department stores in Seoul throughout November, 2007. Of total 124 samples, presence of staphylococci and enteric bacilli was observed in 38 samples (31%) and 53 samples (43%), respectively. And 30 samples (24%) were shown to be of unsatisfactory quality for total bacterial count (>$10^5$). Antimicrobial susceptibilities of the staphylococci isolated from the side dishes were tested for six different antimicrobial agents, which are in widespread clinical use in Korea, as well as four new antimicrobials, daptomycin, linezolid, quinupristin/dalfopristin and tigecycline. As a result, the staphylococcal isolates were found to be resistant to oxacillin (${MIC}_{90}$, >128 ${\mu}g$/ml), teicoplanin (${MIC}_{90}$, >128 ${\mu}g$/ml), mupirocin (${MIC}_{90}$, >128 ${\mu}g$/ml), linezolid (${MIC}_{90}$, 128 ${\mu}g$/ ml) and quinupristin/dalfopristin (${MIC}_{90}$, 32 ${\mu}g$/ml). Especially, some of the staphylococcal isolates exhibited high level and multi-drug resistance. Moreover, these bacteria were also resistant to new antimicrobials, except tigecycline.

표고버섯 분말을 첨가한 쌀 쿠키의 품질 특성 및 항산화 활성

김미진,정해정,Kim, Mee-Jin,Chung, Hai-Jung 한국식품저장유통학회 2017 한국식품저장유통학회지 Vol.24 No.3

This study was conducted to investigate the effect of Lentinus edodes powder on the quality characteristics and antioxidant of rice cookies. The cookies for this experiment was made by 3 main ingredients including rice powder, flour, Lentinus edodes powder. The proportion of rice powder was fixed to 50% for the total amount of ingredients. The amount of reminded 2 ingredients (flour and Lentinus edodes powder) were varied. The amount of flour was decreased up to 38%, and the addition of Lentinus edodes powder was increased to 4%, 8% and 12%. Density of the dough, hardness, total polyphenol content, DPPH free radical scavenging activity, and reducing power increased with increasing Lentinus edodes powder content. Moisture content, pH of the dough, spread factor, loss rate, leavening rate, and L values of the cookies were decreased with increasing Lentinus edodes powder content. The result of consumer acceptance test revealed that there were no significant differences in smell, taste and overall acceptability, while the preference of color decreased as the amount of Lentinus edodes powder increased. To sum up, the cookies with 12% Lentinus edodes powder can produced the best results in terms of quality and antioxidant potential. 본 연구에서는 표고버섯 분말을 4%, 8%, 12%로 첨가하여 쌀 쿠키를 제조하고 품질 특성, 항산화 활성 및 기호도 조사를 실시하여 기능성 쿠키를 개발하고자 하였다. 쿠키반죽의 밀도는 표고버섯 분말 첨가량이 증가함에 따라 증가하였고 pH는 감소하였다. 쿠키의 수분 함량은 대조군이 8.32%로 가장 높았으며 첨가군은 4.73-5.56%로 대조군보다 낮았다. 표고버섯 분말 첨가량이 증가함에 따라 퍼짐성, 손실률, 팽창률 모두 감소하였다. 쿠키의 색도는 표고버섯 분말 첨가량이 증가함에 따라 L 값은 감소하였고 a 값은 증가하였으며 b 값은 대조군이 가장 높았다. 경도는 대조군이 가장 낮았고 12% 첨가군이 가장 높았다. 쿠키의 미세구조는 표고버섯 분말 첨가량이 증가할수록 표면과 내부 조직이 치밀해졌다. 총 폴리페놀 함량은 9.78-18.18 mg GAE/100 g의 범위로 표고버섯 분말 첨가량이 증가함에 따라 증가하였고, DPPH radical 소거능과 환원력도 증가하였다. 기호도 조사 결과, 색은 대조군이 높은 기호도를 나타내었으며 냄새, 맛, 전체적인 기호도는 대조군을 포함한 모든 시료들 간에 유의적인 차이가 없었다. 이러한 결과로 보아 쿠키에 표고버섯 분말을 첨가하는 것은 쿠키의 기호도를 증가시키고 동시에 항산화 활성을 증가시킴으로써 쿠키의 가치를 높여 줄 것으로 기대되며, 쿠키 제조 시 표고버섯 분말을 12% 첨가하는 것이 바람직할 것으로 사료된다.

망막에서 기인한 기형성 수질상피종 1예

김미진,정호경,이민정,김영아,곽상인,Mijin Kim,Ho-Kyung Choung,Min Joung Lee,Young A Kim,Sang In Khwarg 대한안과학회 2010 대한안과학회지 Vol.51 No.12

Purpose: To report a rare case of medulloepithelioma originating from the retina. Case summary: A nine-year-old boy visited our clinic with conjunctival injection and decreased visual acuity in the left eye, which had developed two month previously. Slit lamp examination revealed a distorted pupil and an anteriorly protruding ciliary body displacing the peripheral iris toward the cornea on the inferonasal side. Funduscopic examination showed total retinal detachment accompanied by an inferior hypervascular mass. The examination of the right eye was unremarkable. On computer tomography imaging, a calcified mass was identified behind the iris of the left globe in the inferomedial aspect, and ultrasound biomicroscopy revealed a medium to high echogenic tumor with an uneven oval cystic cavity in the ciliary body. At the follow-up examination, the size of the mass was increased, so we performed enucleation of the left eye. Pathology demonstrated that the retrolental mass abutting the lens had arisen from the retina. Histological examination revealed that the tumor had originated from the retina and extended into the ciliary body, and most of the tumor was composed of hyaline cartilage with calicification. Tumor cells were identified in the periphery, forming elongated tubules and cord-like structures that were immunohistochemically positive for vimentin, neuron-specific enolase, and CD56 compatible with a teratoid medulloepithelioma. The patient was followed up for eight months without any metastasis in the orbit or elsewhere. Conclusions: Medulloepithelioma should be considered in the differential diagnosis of pediatric orbital mass accompanied by calcification. J Korean Ophthalmol Soc 2010;51(12):1665-1670

안내 섬모에 의한 안내염

김미진,허장원,정흠,Mijin Kim,Jang Won Heo,Hum Chung 대한안과학회 2010 대한안과학회지 Vol.51 No.6

Purpose: To report a case of intraocular cilium revealed by diagnostic vitrectomy in a case of stubborn uveitis that was unresponsive to steroid therapy. Case summary: A 39-year-old man was referred to our hospital due to decreased vision in his right eye that started two months prior to presentation. He had previously been treated for a diagnosis of iridocyclitis. The patient’s history revealed a blunt trauma to the right eye while wearing glasses after which he developed a microhyphema and was treated for traumatic iritis at another clinic 3 months ago. He was treated with topical and oral steroids after being diagnosed with iridocyclitis and had recently been prescribed additional oral cyclosporine because his condition had not improved. Ocular examination revealed inflammatory cells in the anterior chamber and vitreous cavity with hand motion vision. Ultrasonography revealed a hazy vitreous cavity but the retina was flat. Diagnostic vitrectomy with intravitreal antibiotic injection was performed and an intraocular foreign body presumed as a cilium was detected without an entrance wound on the exterior or interior surface of the eye. After removal of the foreign body, the patient’s vision was completely recovered. Conclusions: In cases of chronic uveitis that do not respond to immunosuppressive treatment without a clearly definable cause, diagnostic vitrectomy should be considered, keeping in mind the possibility of intraocular foreign body. J Korean Ophthalmol Soc 2010;51(6):904-907

이소성 췌장과 위점막을 가진 멕켈 게실에 의한 장중첩증 1예

김미진,김재영,설지영,강대영,Kim, Mi Jin,Kim, Jae Young,Sul, Ji Young,Kang, Dae Young 대한소아소화기영양학회 2006 Pediatric gastroenterology, hepatology & nutrition Vol.9 No.1

저자들은 장중첩증의 관장 정복 후 입원 관찰 기간 동안에 2차례 더 재발한 장중첩증을 가진 5세여 아에서 복부 CT 촬영으로 선두를 확인하고 복강경으로 치료한 이소성위점막과 췌조직을 동시에 가진 멕켈 게실에 의한 장중첩증 1예를 경험하였기에 문헌 고찰과 함께 보고한다. Intussusception is a frequent cause of intestinal obstruction in early childhood and most are idiopathic in origin. In a minority of cases a definite pathological lead point is identified by imaging studying or during surgery. As the pathologic lead point of intussusception, Meckel's diverticulum is the most common lesion. In symptomatic patients, 40~60% of Meckel's diverticulum contain ectopic tissue, with gastric mucosa being far the most common type. A few Meckel's diverticulum contain pancreatic tissue. Combined heterotopic pancreatic and gastric tissues in the Meckel's diverticulum especially causing intussusception is extremely rare. We report the case of 5-year-old girl with an intussusception caused by Meckel's diverticulum containing both heterotopic gastric and pancreatic tissues.