구순구개열 환자의 Le Fort I 골절단술 후 상악골의 위치적 안정성에 관한 연구 ; 예비보고

김명진,유호석,김종원,김규식,Kim Myung-Jin,Yu Ho-Seok,Kim Jong-Won,Kim Kyoo-Sik 대한구순구개열학회 1999 대한구순구개열학회지 Vol.2 No.1

It is well known that the postoperative skeletal instability after Le Fort I osteotomy for advancement of maxilla in the cleft patients is one of the major surgical problems. So we had tried to compare the amount of relapse after Le Fort I advancement surgery in the horizontal and vertical positional change, angular change of reference points between cleft patients and non-cleft patients. Longitudinal records of 10 consecutive cleft patients (test group) and 20 non-cleft patients (control group) were analyzed. Lateral cephalograms were taken preoperatively, immediately postoperatively, and 2, 6, 12 months postoperatively. We measured horizontal and vertical changes (ANS, PNS, AI) and angular change (SNA) of the reference points and lines. In the test group, horizontal relapse of ANS, PNS, AI point are 36.4%, 37.5%, 32.0% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 25.3%, 32.3%, 39.1% respectively at 12 months postoperatively. The angular change of SNA is 33.6% at 12 months postoperatively. In the control group, horizontal relapse of ANS, PNS, AI point are 23.8%, 30.2%, 21.7% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 22.7%, 27.3%, 25.1% respectively at 12 months postoperatively. The angular change of SNA is 22.2% at 12 months postoperatively. The cleft patients have a larger tendency of skeletal and dental relapse compared with non-cleft patients after Le Fort I surgery. So the oral and maxillofacial surgeons must keep in mind these facts in order to minimize the relapse phenomenon from the beginning of surgical planning to postoperative care.

Sequential ¹H MR Spectroscopy(MRS) Studies of Kaolin-Induced Hydrocephalic Cat Brain

김명진,황성규,황정현,장용민,김용선,김승래,Kim, Myung Jin,Hwang, Sung Kyoo,Hwang, Jeong Hyun,Chang, Yongmin,Kim, Yong Sun,Kim, Seung Lae The Korean Neurosurgical Society 2000 Journal of Korean neurosurgical society Vol.29 No.11

목 적 : 실험적으로 유발된 고양이 수두증 모델을 통하여 양자 자기공명 분광상의 수두증에서의 임상적 적응과 경시적 뇌 대사산물의 변화를 규명하는데 목적이 있다. 대상 및 방법 : 30마리의 고양이에서 뇌대조내에 kaolin을 주입후 수두증을 유발한후 양자 자기공명 분광상을 이용하여 kaolin 주입전, 주입후 1, 3, 7, 14, 21, 28일째에 주요 대사산물인 N-acetyl aspartate(NAA), creatine(Cr), choline (Cho), lactate(Lac)의 분광상을 분석하였다. 결 과 : 30마리의 고양이에서 모두 수두증이 유발되었고, 급성기에 NAA/Cr비가 감소하는 소견보였으며, 1마리에서 lactate peak이 관찰되었다. 만성기(>14 days)까지 생존한 4마리의 고양이에서 NAA/Cr비의 증가가 관찰되었으며 이는 임상적 증상의 회복과 상응하는 결과를 나타내었다. 결 론 : Kaolin 유발 수두증모델에서 양자 자기공명 분광상은 급성기의 진단적 정보의 제공과 수두증에서의 뇌대사 및 생화학적 결과를 반영해 준다. 그리고, 급성기에서 lactate peak없이 NAA/Cr비의 감소와 만성기의 NAA/Cr비의 회복은 수두증으로인한 뇌실질의 손상이 신경세포 자체보다는 축색손상을 의미한다. 급성기말까지 초기 NAA/Cr비 감소가 회복없이 lactate peak이 동반되는 경우는 불량한 예후인자가 된다. 만성기의 NAA/Cr비의 정상화는 NAA/ Cr비의 감소를 보이는 뇌피질위축의 경우와의 감별진단에 실마리를 제공한다. Objectives : The aim of this study is to evaluate the sequential metabolic changes in experimental hydrocephalus and the clinical applicability to the diagnosis and prognosis of hydrocephalus using proton MR spectroscopy. Methods : Hydrocephalus was experimentally induced in 30 cats(2-3kg body weight) by injecting 1ml of sterile kaolin suspension(250mg/ml) into the cisterna magna. Proton MRS was performed with a 1.5 T MRI/MRS unit (Vision Plus, Siemens) at pre-treatment and at 1, 3, 7, 14, 21, and 28 days after the kaolin injection. PRESS(TR/TE=1500/270msec) technique was employed. The major metabolites which include N-acetyl aspartate (NAA), creatine(Cr), choline(Cho), and lactate(Lac) were quantitatively analyzed and the relative concentrations ratios were evaluated. Multislice $T_2$-weighted images were also obtained using fast spin echo sequence(TR/TE= 2500/96msec) to monitor the morphologic changes along with progression of hydrocephalus. Results : Hydrocephalus was successfully induced in all 30 cats. Twenty five cats died within 3 days and one at the end of the second week. In all animals, the NAA/Cr ratios initially decreased during the acute stage. In 4 surviving cats, the NAA/Cr ratios initially decreased during the acute stage(<14 days) and then gradually increased to the prekaolin level as follows : pre-kaolin($1.49{\pm}0.04$), day 1($1.11{\pm}0.07$), day 7($1.17{\pm}0.04$), day 14($1.40{\pm}0.03$), day 21 ($1.46{\pm}0.06$), day 28($1.43{\pm}0.03$). These levels were relatively well correlated with the symptomatologic improvement. Lactate peak, which reflects the evidence of ischemia, did not appear throughout the entire period except in one case which expired at the end of the second week. Conclusions : The NAA/Cr ratio of the sequential proton MRS in kaolin-induced hydrocephalic cats reflects a metabolic aspect of the hydrocephalus at each stage. A decreased NAA level at the early stage is from both neuronal and axonal damage which may provide diagnostic information in the acute stage of hydrocephalus. In addition, the initial fall of NAA/Cr ratio and recovery in the late stage, when no lactate peak emerges, may suggest that the main insult of the parenchyma is not to the neuron itself but to the axon, which may be related to a good prognosis. However, emergence of the lactate peak and unrecoverable NAA/Cr at the end of the acute phase may be a poor prognostic factor. In the chronic stage, recovery of NAA/Cr ratio may provide a diagnostic clue for the differentiation between hydrocephalus and cortical atrophy.

제 II 형 치상돌기 골절에서 전방경유 나사못 고정술

김명진,황정현,성주경,황성규,함인석,박연묵,김승래,Kim, Myung-Jin,Hwang, Jeong-Hyun,Sung, Joo-Kyung,Hwang, Sung-Kyu,Hamm, In-Suk,Park, Yeun-Mook,Kim, Seung-Lae 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.11

Objective : The aim of this study is to evaluate clinical outcome of anterior screw fixation for type II odontoid fractures for the prliematim of atlanatoaxial mobility. Methods : Between 1995 and 1999, we treated 15 cases of type II odontoid fractures by anterior screw fixation among 44 cases of odontoid fractures. Thece included 14 males and 1 female aged from 23 to 63 years, with a mean age of 39.7 years. The causes of trauma were traffic accident in 13 cases, slip down in 1 and fall down in 1. The fracture type was type II-P in 7 cases, type II-A in 3, type II-N in 2 and type II-A and P in 3. The fracture line was oblique downward and backward in 6 cases, oblique downward and forward in 3 and horizontally in 6. The range of follow up was 4 to 47 months(mean 26.5 months). Results : Adequate reduction and fixation were obtained in 12 cases. Three cases in which fracture type and line were type II-A and oblique downward forward were failed, so posterior transarticular screw fixation was performed. All except 3 failed cases had adequate cervical movement and stability. There were no operative mortality nor morbidity. Conclusion : Anterior screw fixation provides the best anatomical and functional results for type II odontoid fracture with intact transverse ligament when fracture line is horizontal or oblique downward and backward. But it is limited when fracture line is oblique downward and forward.

모듈화된 구조에 기반한 H.263 비디오 코덱 VLSI의 설계

김명진,이상희,김근배,Kim, Myung-Jin,Lee, Sang-Hee,Kim, Keun-Bae 대한전자공학회 2002 電子工學會論文誌-SP (Signal processing) Vol.39 No.5

본 논문에서는 H.263 비디오 코덱 구현을 위한 효율적인 하드웨어 구조를 제안하고, 이에 기반한 VLSI 구현을 기술한다. 제안 구조는 부호화 및 복호화에 사용되는 내부 하드웨어 블록들간의 연결 및 이 블록들과 내부 RISC 프로세서간의 연결에 단일화된 인터페이스 방법을 사용한다. 이러한 단일화된 인터페이스의 사용은 블록들의 모듈화된 설계를 가능하게 하며, 하드웨어/소프트웨어의 적절한 분할 및 효과적인 파이프라인 동작을 가능하게 한다. 개발된 VLSI는 H.263 버전 2의 프로파일 3 @ 레벨 10을 지원하고, 제어용 프로토콜인 H.245와 다중화 프로토콜인 H.223을 지원한다. 따라서 외부에 오디오 코덱 칩을 추가함으로써 완전한 ITU-T H.324 또는 3GPP 3G-324M 멀티미디어 터미널 기능 구현에 사용될 수 있으며, 하드웨어 블록들을 최대한 활용하면서 소프트웨어적으로 H.263++와 MPEG4 코덱을 구현 할 수 있는 구조이다. 구현된 H.263 코덱은 40MHz의 동작 주파수에서 초당 15 프레임 이상의 성능으로 QCIF 크기의 영상의 부호화 및 복호화를 동시에 수행할 수 있다. In this paper, we present an efficient hardware architecture for the H.263 video codec and its VLSI implementation. This architecture is based on the unified interface by which internal hardware engines and an internal RISC processor are connected one another. The unified interface enables the modular design of internal blocks, efficient hardware/software partitioning, and pipelined paralled operations. The developed VLSI supports the H.263 version 2 profile 3 @ level 10, and moreover, both the control protocol H.245 and the multiplexing protocol H.223. Therefore, it can be used for the complete ITU-T H.324 or 3GPP 3G 324M multimedia processor with the help of an external audio codec. Simultaneous encoding and decoding of QCIF format images at a rate greater than 15 frames per second is achieved at 40 MHz clock frequency.

목과(木瓜)가 CT105 와 ${\beta}A$로 유도(誘導)된 Alzheimer's Disease병태(病態) 모델에 미치는 영향(影響)

김명진,정인철,이상룡,Kim, Myung-Jin,Jung, In-Chul,Lee, Sang-Ryong 대한한방신경정신과학회 2005 동의신경정신과학회지 Vol.16 No.1

This research investigates the effect of the Chaenomelis fructus(CMF) on Alzheimer's disease. Specifically, the effects of the CMF extract on (1) >$IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CT-105; (3) the AChE activity and the APP production of PC-12 cell treated with CT-105; (4) the behavior of AD mice with ${\beta}A$; (5) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and ROS; (6) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. The results were summarized as follows; 1. The CMF extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-1 cells treated with LPS. 2. The CMF extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The CMF extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. A significant inhibitory effect on the memory deficit was shown on the CMF extract group of the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The CMF extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, $IL-1{\beta}$ protein, mRNA, $TNF-{\alpha}$ mRNA, CD68/GFAP, and ROS in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The CMF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer’s disease induced by ${\beta}A$. These results suggest that the CMF extract may be effective for the treatment of Alzheimer’s disease. Investigation into the clinical use of the CMF extract for Alzheimer's disease is suggested for future research.

성심지황탕(醒心地黃湯)이 노화(老化) 백서(白鼠)의 혈액변화(血液變化) 및 혈청(血淸)과 뇌조직(腦組織)의 항산화물활성(抗酸化物活性)에 미치는 영향(影響)

김명진,이상룡,Kim Myung-Jin,Lee Sang-Ryong 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.2

This study was to investigate the effects of SUNGSIMJIHWANGTANG(SSJHT) on the blood and brain tissues of aged rats. For the experiment, the aged rats were divided into three groups : Non treated group(NC), distilled water fed group(PC), SSJHT fed group(SSJHT). Each group was fed for ten days before administration of scopolamine. Then, we injected scopolamine intraperitoneally to PC and SSJHT group for 5 days. We observed the changes of their blood cell(WBC, RBC, platelet), blood serum(BUN, creatinine, glucose, uric acid), erythrocyte hemolysis, and the activities of cholinesterase and measured the amounts of malondialdehyde in the serum, catalase, and SOD in the brain tissue. The main results of this investigation are as follows. 1. In respect of the number of WBC, SSJHT group exhibited significant increase in comparison with PC. 2. In respect of the amount of creatinine and uric acid in the blood serum, SSJHT group exhibited significant decrease in comparison with PC. 3. In respect of erythrocyte hemolysis, SSJHT group exhibited significant suppression in comparison with PC. 4. In respect of the activity of cholinesterase in the serum, SSJHT group exhibited significant activation in comparison with PC. 5. In respect of the amounts of malondialdehyde in the serum, SSJHT group exhibited significant decrease in comparison with PC. 6. In respect of the activity of catalase in brain tissue, SSJHT group didn't exhibit significant change in comparison with PC. 7. In respect of the activity of SOD in brain tissue, SSJHT group exhibited significant activation in comparison with PC. As a result of this study, SSJHT is expected to have antiaging effect by suppressing the formation of free radicals, the accumulation of antioxidants and further study needs to be carried on about SSJHT.

CONTOUR RECONSTRUCTION OF FACIAL DEFECT WITH SPLIT STERNOCLEIDOMASTOID MUSCULAR FLAP FOLLOWING PAROTIDECTOMY

김명진,김택경,유준영,KIM, Myung-Jin,KIM, Taek-Kyoung,YOU, Jun-Young Korean Association of Maxillofacial Plastic and Re 1991 Maxillofacial Plastic Reconstructive Surgery Vol.13 No.2

외상이나 종양의 적출 등으로 인하여 악안면부에 발생된 결손이나 안면 경부 기형의 교정을 위하여 여러 근피판을 이용하여 악안면부 재건술이 시행되어지고 있다. 흉쇄유돌근은 안면부의 일차적 혹은 이차적 재건에 안전하고 유용한 근피판 또는 근피부피판으로 널리 사용되고 있다. 이하선부에 발생된 종양의 적출술 후 나타날 수 있는 이하선부의 안모 변형 방지를 위하여 흉쇄유돌근 근피판을 이용하여 안모 재건이나 술후 가상형성으로 발생 가능한 적출부의 감염, 반흔조직 형성과 술후 천충으로 노출되는 안면신경을 보호하는데 사용할 수 있다. 전 흉쇄유돌근 근피판이나 다른 경부 근피판 사용시 이하선부의 과잉돌출, 안면경부 기형 및 경부운동 제한 등의 부작용이 발생될 수 있다. 이러한 단점을 보완하고자 저자등은 부분 흉쇄유돌근 근피판을 형성하여 기능적 이하선 적출술 후 노근피판 전위를 통하여 이하선부 연조직 결손으로 인한 안모 변형이나 사강형성 예방 등을 만족할 만한 결과를 얻었기에 문헌고찰과 함께 보고하고자 한다. Various muscular flaps are used in oral and maxillofacial reconstructive surgery for the defects caused by tumor resection and trauma or for the correction of head and neck deformities. The sternocleidomastoid(SCM) muscle may be widely used as a muscular or myocutaneous flap in these lesion. The authors used SCM muscular flap for the expected parotid defect following benign tumor related conservative parotidectomy in three cases. We expected that prevention of post-operative facial deformity, reduction of dead-space and protection of denuded facial nerve etc. is lead by SCM muscular flap. But the total SCM flap can lead to some complications such as "flat neck deformity", limitation of neck movement and overcontouring of parotid defect. Therefore, the authors used split pedicled SCM muscular flap and it lead good favorable results of post-operative functional and esthetic problems.

서천 추동리 문화유적에서 채취된 숯의 수종식별과 물리적 특성

김명진,이종신,박순발,Kim, Myung-Jin,Lee, Jong-Shin,Park, Soon-Bal 한국문화재보존과학회 2008 보존과학회지 Vol.24 No.-

서천 추동리 문화유적내 토과목관묘에서 출토된 숯과 인근의 기와가마에서 연료로 사용되었던 나무의 숯을 채취하여 수종을 식별하고 각각의 흡습성과 가스 흡착성을 비교하였다. 총 23점의 숯 시료에 대해서 수종을 식별한 결과 토광목관묘에서 출토된 12점의 숯은 모두 활엽수 숯으로 9점이 참나무속의 상수리나무아속 계통, 3점이 팽나무속 숯인 것으로 밝혀졌다. 한편 기와가마에서 출토된 11점의 숯은 모두 침엽수로 경송류의 소나무류인 것으로 식별되었다. 출토 숯의 물리적 성질을 조사한 결과 토광목관묘의 활엽수 숯이 기와가마의 소나무류 숯보다 높은 흡습성을 나타냈으며 에틸렌 가스 흡착 시험에서도 상수리나무아속 숯이 소나무류 숯보다 높은 가스 흡착성을 보였다. 토광목관묘 유구에 활엽수 숯을 사용한 이유는 침엽수 숯에 비하여 활엽수 숯이 미세 세공이 많고 비표면적이 넓어 수분과 가스 흡착력이 우수하여 묘광 내에 보다 양질의 매장 환경을 조성할 수 있기 때문으로 판단된다. 한편, 기와가마에서 소나무류를 연료로 사용한 이유는 비중이 작아 재질이 연하여 연소가 잘되고 특히 재내에 다량의 수지(송진)를 함유하고 있어 발열량이 높고 비교적 화력 조절이 용이했기 때문으로 판단된다. The identification of species, hygroscopic property, and ability of ethylene gas absorption of 23 ancient charcoals excavated from wooden coffin burials and roof-tile kilns of Chudong-ri cultural site were investigated. All of the 12 charcoals excavated from wooden coffin burials were broad-leaved trees. Among the total 12 samples, 9 samples were Lepidobalanus and others were Celtis spp.. On the other hand, other 11 charcoals from roof-tile kilns were needle-leaved tree, Pinus spp.(hard pine). The broad-leaved tree charcoals from wooden coffin burials showed a higher moisture absorption capacity than needle-leaved tree charcoals from roof-tile kilns. The ethylene gas absorption was greater in the Lepidobalanus charcoal than that of Celtis spp. and Pinus spp. (hard pine) charcoal. The broad-leaved tree charcoal having high absorption ability of substances was due to a large microporous and specific surface area. Therefore, it was estimated that broad-leaved tree charcoals were filled in order to make favorable condition in tomb. The wood quality of pine is soft and easy to burn because of low specific gravity, as well as high calorific value by resin in wood. We could assume that the pine wood was used as fuel for roof-tile kilns because of easy control of heating and thermal power.

다양한 치주 골내낭과 이개부 병변의 처치를 위한 $BBP^{(R)}$ 이식재의 임상적 효과

김명진,이주연,김성조,최점일,Kim, Myung-Jin,Lee, Ju-Youn,Kim, Sung-Jo,Choi, Jeom-Il 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.1

Purpose: Periodontal intrabony defects have great deal of importance since they contribute to the development of periodontal disease. Current treatment regimens for intrabony defects involve grafting of numerous bony materials, GTR using biocompatible barriers, and biomodification of root surface that will encourage the attachment of connective tissue. Xenograft using deproteinized bovine bone particles seems to be very convenient to adjust because it doesn't require any donor sites or imply the danger of cross infections. These particles are similar to human cancellous bone in structure and turned out to be effective in bone regeneration in vivo. We here represent the effectiveness of grafting deproteinized bovine bone particles in intrabony defect and furcation involvements that have various numbers of bony walls. Materials and methods: Open flap debridement was done to remove all root accretions and granulation tissue from the defects within persisting intrabony lesions demonstrating attachment loss of over 6mm even 3 months after nonsurgical periodontal therapy have been completed. Deproteinized bovine bone particles($BBP^{(R)}$, Oscotec, Seoul) was grafted in intrabony defects to encourage bone regeneration. Patients were instructed of mouthrinses with chlorohexidine-digluconate twice a day and to take antibiotics 2-3 times a day for 2 weeks. They were check-up regularly for oral hygiene performance and further development of disease. Probing depth, level of attachment and mobility were measured at baseline and 6 months after the surgery. The radiographic evidence of bone regenerations were also monitored at least for 6 months. Conclusion: In most cases, radio-opacities increased after 6 months. 2- and 3-wall defects showed greater improvements in pocket depth reduction when compared to 1-wall defects. Class I & II furcation involvements in mandibular molars demonstrated the similar results with acceptable pocket depth both horizontally and vertically comparable to other intrabony defects. Exact amount of bone gain could not be measured as the re-entry procedure has not been available. With in the limited data based on our clinical parameter to measure pocket depth reduction following $BBP^{(R)}$ grafts, it was comparable to the results observed following other regeneration techniques such as GTR.

베이지안 통계학을 이용한 청동기시대 주거지내 화덕자리들의 광자극발광(OSL) 연대 결정

김명진,양혜진,홍덕균,Kim, Myung-Jin,Yang, Hye-Jin,Hong, Duk-Geun 대한방사선방어학회 2011 방사선방어학회지 Vol.36 No.2

이 연구에서는 소골 유적 29호 및 29-1호 주거지 내부에 사용 시기를 달리하여 존재하는 3개의 화덕자리에 대한 광자극발광(OSL) 연대측정을 수행하였다. 연대측정에 앞서 석영 시료의 자연 OSL 신호 관찰 및 절대영년도 평가를 수행한 결과, OSL 신호는 광이온화 단면적이 커 열과 빛에 매우 민감한 fast 성분만으로 이루어졌으며 청동기인들의 일반적인 난방 및 취사 온도인 $300^{\circ}C$ 이하에서도 완벽히 절대영년 됨을 알 수 있었다. 각 시료의 고고선량은 단일시료재현법을 적용한 재현성 평가와 플래토우 평가로부터 산출되었고, 이를 연간선량율로 나누어 OSL 연대를 결정하였다. 이후 산출된 OSL 연대의 정밀도를 높이기 위하여 발굴조사를 통해 파악된 화덕자리의 사용 시기와 각 화덕자리의 OSL 연대를 베이지안 통계에 적용한 결과, 개별 화덕자리의 사용 및 폐기 시점에 대한 높은 정밀도를 갖는 OSL 연대가 최종적으로 확정되었다. OSL dating for three hearths having the sequence of use and discard in No. 29 and 29-1 dwelling sites at Sogol cultural site was carried out. Resulting from the deconvolution of natural CW-OSL decay curve and thermal zeroing test, it was turned out that OSL signal was entirely composed of the heat- and light-sensitive fast component with high photoionization cross-section and all quartz OSL signals were thermally bleached under $300^{\circ}C$ which is the minimum temperature related to heating and cooking in Bronze age. After dose recovery test and plateau test, paleodose of each hearth sample was evaluated by using SAR method, and OSL age was determined from the ratio of paleodose to annual dose rate. For the purpose of the precision improvement of OSL age, Bayesian statistics was applied to each hearth's age and the archaeological sequence information. Finally, it could be concluded to the accurate use period of each hearth from the resultant OSL ages.