트리메틸틴에 의해 유도된 흰쥐의 학습과 기억력 손상에 대한 육미지황탕가미방의 신경보호 효과

정희상 ( Hee Sang Jeung ),김근우 ( Geun Woo Kim ),구병수 ( Byung Soo Koo ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1

목적: 이 연구는 알쯔하이머 병에 대한 육미지황가미방의 효과를 조사하였다. 육미지황가미방은 산약, 산수유, 복령, 목단피, 구기자, 택사, 숙지황을 포함한 여러 가지 한약재의 전탕액으로 치매의 한약 치료제로 널리 사용되어 왔다. 방법: 이 약물의 신경보호 작용을 조사하기 위해, 수중미로를 사용하여 학습과 기억에 대한 육미지황가미방의 효과를 평가했고, 트리메틸틴으로 신경과 인지 장애를 유발시킨 쥐의 해마의 중추성 콜린계에서의 작용을 연구했다. 트리메틸틴은 강력한 유독물질로 선택적으로 중추신경계와 면역계의 세포를 파괴시킨다. 트리메틸틴(6.0 mg/kg, i.p.) 주입 후, 쥐에게 육미지황가미방(400 mg/kg, p.o.)를 2주 동안 날마다 복용시켰으며, 수중미로를 수행시켰다. 결과: 육미지황가미방을 트리메틸틴에 노출시킨 쥐에 투약했으며, 그들은 수중미로에서 학습과 기억의 향상을 보였고, 이는 육미지황가미방이 어떠한 환경에서는 트리메틸틴으로 유발된 신경퇴화 후 중추신경계의 결손을 감소시킬 수 있음을 보여준다. 결론: 이러한 결론은 육미지황가미방이 인지능력을 증가시키고, 트리메틸틴으로 유발된 신경퇴화에서 콜린 아세틸전환효소의 정도를 변화시킬 수 있음을 보여준다.

『방약합편(方藥合編)』에 수재된 신경정신과(神經精神科) 관련 주요 처방(處方)에 대한 연구(硏究)

김지훈 ( Jee Hoon Kim ),구병수 ( Byung Soo Koo ),김근우 ( Geun Woo Kim ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1

Objectives: The purpose of this study is to analysis of the herb medications corresponded with neuropsychiatry of 『Bang-Yak-Hap-Pyun』. Methods: The herb medications of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong(上·中·下統) and 『Enlargement side prescriptions』(增補方) are selected by comment on the chief virtue including reference word of corresponded with neuropsychiatry. Results and Conclusion: 『Bang-Yak-Hap-Pyun』is a book most people who have a background or career in Han Medicine(韓醫學) would pore over. They corresponded with neuropsychiatry among the herb medications of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong(上·中·下統) are 55 prescriptions that Sang-Tong(上統) is 8 prescriptions, Jung-Tong(中統) is 23 prescriptions and Ha-Tong(下統) is 24 prescriptions. And the herb medications corresponded with neuropsychiatry of 『Enlargement side prescriptions』(增補方) are 40 prescriptions. And then the herb medications corresponded with neuropsychiatry of 『Bang-Yak-Hap-Pyun』received much influence from 『Dong-Eui-Bo-Gam』. Incidentally the herb medications corresponded with neuropsychiatry of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong showed the high percentage in Neurosis. And the herb medications corresponded with neuropsychiatry of 『Enlargement side prescriptions』showed the high percentage in Psychosis. Besides not only put 『Enlargement side prescriptions』a premium on 『Dong-Eui-Bo-Gam』, but also made it the herb medications which were recorded on books flowed after 『Dong-Eui-Bo-Gam』known. It was entered up books quoted from『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong but the herb medications were that were not succeeded from 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong. Therefore 『Enlargement side prescriptions』 shows the efforts for supplement of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong.

문무잡과(文武雜科) 방목(榜目)의 의사학적(醫史學的) 가치(價値)

유희영 대한한방신경정신과학회 1990 동의신경정신과학회지 Vol.1 No.1

온담탕가미방(溫膽湯加味方)의 항산화와 Serotonin 대사 과정에 미치는 영향

설선희 ( Seon Hui Seol ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.2

Objectives: The purpose of this study is to examine the effects of antioxidant activities and serotonin activities of OnDam-tang- Kami-bang (ODK) on P815 Mast Cell. Methods: The effects of ODK on the activation of DPPH radical?scavenging and SOD in P815 mast cell were investigated. The effect of ODK on the content of serotonin in P815 mast cell was investigated. The effects of ODK on the activation of 5-HTT, TPH-1 mRNA in P815 mast cell were investigated. Results: It was found that the ODK increased SOD activities and DPPH radical?scavenging activities in the P815 mast cell. Also, the ODK decreased the intracellular concentration of serotonin in the P815 mast cell. Further, the ODK decreased 5-HTT and TPH-1 mRNA expression in the P815 mast cell. Conclusions: The results of this experiment reveal that ODK has significant antioxidative effects. However, ODK decreased the intracellular concentration of serotonin and mRNA expression of 5-HTT and TPH-1, which implies that ODK might not be effective for treating depression. Further research exploring the positive aspects of ODK is suggested such that ODK could adequately target symptoms that are to be treated.

화병 변증도구의 신뢰도, 타당도 평가와 활용 가이드라인 연구

김국기 ( Kook Ki Kim ),서복남 ( Bok Nam Seo ),강위창 ( Wee Chang Kang ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.4

Objectives: The purpose of this study is to examine the validity, the test-retest reliability and to provide guidelines for the Instrument on Pattern Identifications for Hwa-byung. Methods: Participants are 97 patients with Hwa-byung who were diagnosed by Hwa-Byung Diagnostic Interview Schedule. Participants were tested twice within one week. Results: The test-retest reliability of the Instrument on Pattern Identifications for Hwa-byung was examined for 97 patients and calculated to be 0.3146. The reliability of the Instrument on Pattern Identifications for Hwa-byung was 0.605 with a difference of 5% or more for the first and the second. To confirm the validity of the Instrument on Pattern Identifications for Hwa-byung, we analyzed the relevance between symptoms, Pattern Identifications that belong to the group and other Pattern Identifications that do not belong. Conclusions: It can be diagnosed in the first pattern identification by the Instrument of Pattern Identifications for Hwa-byung when there is a difference of 5% or more in the first and second pattern identification. Based on this result, we derived an Instrument for Pattern Identifications of Hwa-byung that has been further modified through additional studies.

치매예방을 위한 활동 프로그램이 지역사회 노인의 우울, 인지기능 및 삶의 질에 미치는 효과

박금숙 ( Kum Sook Park ),정헌영 ( Heon Young Jeong ),소선녀 ( Sun Yoe So ),박영희 ( Young Hee Park ),양희정 ( Hee Jung Yang ),정경란 ( Kyoung Ran Jung ),문순주 ( Soon Joo Moon ),김혜경 ( Hae Kyoung Kim ),조정희 ( Jung Hee Cho ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.4

Objectives: This study is conducted to identify the effects of the activity program for preventing dementia against depression, cognitive function, and quality of life for the elderly. Methods: A non-equivalent control group with pretest-posttest design was used on 50 elderly who were assigned to the experimental and control group (25 for each group). Results: Cognitive function was significantly different between the two groups of the pretest and posttest (Z=4.217, p<.001). There were significant differences between the two groups of the pretest and posttest (Z=-2.324, p=.020) for the quality of life on the EQ-5D index. Conclusions: These findings confirmed that the activity program for preventing dementia was effective for improving cognitive functions and quality of life for the elderly. Therefore, it is further encouraged to perform the activity programs for preventing dementia within other community health posts and community centers. It is necessary to study the emotional supports from community health posts in the future.

금연 이침과 경피적 니코틴 패치 및 병용 요법 간의 금연 효과에 대한 예비적 비교 연구

강희철 ( Hee Chul Kang ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.2

Objectives: The purpose of this study was to compare three therapies - auricular acupuncture, transdermal nicotine patch and therapy - in combination with auricular acupuncture and nicotine patch. Methods: The subjects of this study included 188 male smokers in their 20s, 30s, 40s and 50s, who visited Wonmi Public Health Center. They were evaluated with the Fagerstrom test for nicotine dependence, amounts of daily smoking and success rate of smoking cessation. The subjects decided on a therapy method strictly of their own choice. They were divided into three groups according to the therapy; auricular acupuncture group (62 persons), nicotine patch group (69 persons) and combination therapy group (57 persons). Results: All three groups resulted in statistically significant reducing effects of nicotine dependence and amounts of daily smoking. In the combination therapy group, nicotine dependence was significantly decreased by more than those of the other groups. There were no statistically significant differences in decrements of daily smoking and success rate of smoking cessation among the three groups. Conclusions: The above results suggest that auricular acupuncture and transdermal nicotine patch have significant effects of smoking cessation. If they are combined, it is expected that therapies for smoking cessation would be developed.

북한이탈주민들의 병증발생시기 인식에 대한 질적 연구

조아람 ( A Ram Cho ),유춘길 ( Chun Gil Ryu ),박소임 ( So Im Park ),성우용 ( Woo Yong Seong ),서주희 ( Joo Hee Sue ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.4

Objectives: The purpose of this study is to understand the cognition of the initiation of diseases of North Korean refugees in South Korea. Methods: 9 North Korean refugees hospitalized in Oriental Neuropsychiatry of National Medical Center participated in the interview. The statements were analyzed by using the phenomenological research methodology and Giorgi`s analytical method, in particular, was applied. Results: A total of 4 categories and 15 sub categories were derived from the participants` descriptions. North Korean refugees who thought their diseases have begun while living in North Korea coming to South Korea, have fire disease because of the strict social system, limitations imposed on their actions, and the violence of their husbands. And who thought during escaping from North Korea, have anxiety about being killed, found and transferred to North Korea. They also suffered from a sense of guilt towards their family who were left behind as well as from depression. Consequently, they thought their skeletal diseases have begun during this period. Who thought during their period in Korea, their diseases like fire disease and depression have been worsen because of unfamiliar circumstances and doctors who said their problems had been caused by psychiatric disorder. Nevertheless, they did their jobs, felt happy and had a will to be cured thingking possibilities of overcoming diseases. Conclusions: These results suggest that various factors during different periods in the life of North Korean refugees could have an effect on their present diseases.

REM 수면 행동 장애의 치료에 대한 중의학 및 Kampo의 연구 경향

최윤희 ( Yoon Hee Choi ),정진형 ( Jin Hyeong Jung ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.4

Objectives: This study was performed to review the research trends in treatment for REM sleep behavior disorder (RBD) in Traditional Chinese Medicine (TCM) and Kampo in Japan. Methods: We searched articles in CNKI (China National Knowledge Infrastructure) under the key words, RBD, and Chinese words related with it in Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs and Combination of Traditional Chinese Medicine With Western Medicine`` field, and also in CiNii (Citation Information by NII); we also searched articles in Kampo Square in Japan under the key words, RBD and Japanese words related with it. We found 10 papers, and then selected 6 of them except the non-clinical and unrelated studies. We then analyzed their way of diagnosis, treatments, study type and etc. Results: 6 studies were divided into 4 case reports, one control study, and one literature review study. All of the studies reported that Herbal medicine for RBD was effective as much as Western medicine like clonazepam and paroxetine. However, the quality and the quantity of these clinical studies were not enough. Conclusions: It seems that the researches for RBD have gradually been performed in TCM and Kampo. We hope that our study can activate/push forward clinical research for this disorder in Korean traditional medicine.

사상체질별(四象體質別) 학습특성(學習特性)의 차이(差異) 연구(硏究)

최우창 ( Woo Chang Choi ),김우경 ( Woo Kyoung Kim ),송정모 ( Jeong Mo Song ),김락형 ( Lak Hyung Kim ) 대한한방신경정신과학회 2013 동의신경정신과학회지 Vol.24 No.2

Objectives: The purpose of this study is to investigate the characteristics of Sasang constitutional types in the university students. Methods: One hundred fifty students of Woosuk University participated in this study and their majors were Korean medicine, nursing science and pharmacy. The Sasang constitutional types were determined by the results of Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD). The subjects were also tested by Academic Motivation Tests (AMT), Multi-dimensional Learning Strategy Tests (MLST) and Learning Style Questionnaire of Sasang Constitution (LSQ-SC). The subscale scores of AMT, MSLT and each questions of AMT, MLST, LSQ-SC were compared among the different Sasang constitutions using analysis of variances (ANOVA). Results: There were no significant differences in AMT results between Sasang constitutions. In subscales of AMT, Feeling scales (FTF) scores of Soyangin was significantly higher than Taeeumin. Other subscales of AMT were not different between Sasang constitutions. There were no significant differences in MLST results between Sasang constitutions. Subscales of MLST were not different between Sasang constitutions. There were many questions between Soyangin and other constitutions in the analysis of questions of AMT, MLST, and LSQ-SC, and less between Taeeumin and Soeumin. Conclusions: These results suggest that the characteristics of Soyangin is more prominent compared with other constitutions in the learning style, and there were a little differences between Soeumin and Taeeumin.