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      • KCI등재

        원저 : 트리메틸틴에 의해 유도된 흰쥐의 학습과 기억력 손상에 대한 육미지황탕가미방의 신경보호 효과

        정희상 ( Hee Sang Jeung ),김근우 ( Geun Woo Kim ),구병수 ( Byung Soo Koo ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1

        목적: 이 연구는 알쯔하이머 병에 대한 육미지황가미방의 효과를 조사하였다. 육미지황가미방은 산약, 산수유, 복령, 목단피, 구기자, 택사, 숙지황을 포함한 여러 가지 한약재의 전탕액으로 치매의 한약 치료제로 널리 사용되어 왔다. 방법: 이 약물의 신경보호 작용을 조사하기 위해, 수중미로를 사용하여 학습과 기억에 대한 육미지황가미방의 효과를 평가했고, 트리메틸틴으로 신경과 인지 장애를 유발시킨 쥐의 해마의 중추성 콜린계에서의 작용을 연구했다. 트리메틸틴은 강력한 유독물질로 선택적으로 중추신경계와 면역계의 세포를 파괴시킨다. 트리메틸틴(6.0 mg/kg, i.p.) 주입 후, 쥐에게 육미지황가미방(400 mg/kg, p.o.)를 2주 동안 날마다 복용시켰으며, 수중미로를 수행시켰다. 결과: 육미지황가미방을 트리메틸틴에 노출시킨 쥐에 투약했으며, 그들은 수중미로에서 학습과 기억의 향상을 보였고, 이는 육미지황가미방이 어떠한 환경에서는 트리메틸틴으로 유발된 신경퇴화 후 중추신경계의 결손을 감소시킬 수 있음을 보여준다. 결론: 이러한 결론은 육미지황가미방이 인지능력을 증가시키고, 트리메틸틴으로 유발된 신경퇴화에서 콜린 아세틸전환효소의 정도를 변화시킬 수 있음을 보여준다.

      • KCI등재

        노인 불면에 대한 EFT 불면 치료 프로그램(EFT-1)의 효과 평가를 위한 예비적 연구

        이정환 ( Jung Hwan Lee ),서현욱 ( Hyun Uk Suh ),정선용 ( Sun Yong Chung ),김종우 ( Jong Woo Kim ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4

        Objectives: The aim of this study was to evaluate the effects of EFT-I(EFT program for insomnia) for insomnia in the elderly as a preliminary study. Methods: This study was a single group pre-post comparative study that involved 10 elderly women(mean age=76.3±4.29), who visited a senior welfare center, complained of insomnia symptoms. Subjects received 8 sessions(twice a week for 4 weeks and 1 hour for each session) of EFT-I group training. Insomnia severity, depression, state anxiety, and life satisfaction of each subject were evaluated twice at pre and post of EFT-I. Korean Sleep Scale, Short form of Geriatric Depression Scale(SGDS), State-Trait Anxiety Inventory(STAI), and life satisfaction scale were used as evaluation tools. The data were analyzed using paired-samples T-test. Results: Insomnia severity, life satisfaction, depression, and state-anxiety were significantly improved by EFT-I. Conclusions: Result of this study showed that EFT-I can be a useful treatment program for elderly insomnia. Larger Clinical trials are needed to verify effect of EFT-I as a community based insomnia management program for the elderly.

      • KCI등재

        심박변이도 지표에 나타난 자율신경 상태와 우울, 불안 및 분노 설문검사 척도 간의 상관성 평가

        김상영 ( Sang Young Kim ),서현욱 ( Hyun Wook Seo ),김종우 ( Jong Woo Kim ),정선용 ( Sun Yong Chung ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4

        Objectives: This study aims to evaluate the relationship between HRV indices and scores of emotional questionnaires and to find out the effective way to assess patients emotional and physical condition. Methods: We selected 144 patients who had both HRV data and BDI, STAL and STAXI scores on the chart among outpatients from July 2006 to December 2010. The relationship between the scores rated from the questionnaires and HRV indices are analyzed. And the HRV indices of patients included in the top 30 percent group and the bottom 30% group are compared. Results: 1. There were no significant correlations between HRV indices and scores of BDI, STAI and trait anger of STAXI. 2. SDNN and TP of HRV significantly decreased with higher state anger scores of STAXI. The top 30 percent group of state anger had lower SDNN, TP, LF, HF and HRV-index and higher pNN50 than bottom 30 percent group. 3. RMSSD of HRV significantly decreased with higher anger-in scores of STAXI. The top 30 percent group of anger-in had lower RMSSD than the bottom 30 percent group. Conclusions: HRV can be used to evaluate emotional and physical changes related to state anger and inappropriate anger expression.

      • KCI등재

        외상 후 스트레스장애에 대한 한방중재 고찰 -재해정신보건 한의학적 치료 모델 연구-

        권용주 ( Yong Ju Kwon ),조성훈 ( Seung Hun Cho ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4

        Objectives: These days assaults and other natural and human disasters are increasing. But oriental medical treatment researches in Korea are limited in car accident PTSD patients only. Our object is to explore an oriental medical intervention model for the evidence-based approach to PTSD after diverse trauma including disasters. Methods: Domestic papers for Korean researches are obtained from oriental medical related journals by internet searching. International materials are obtained from Pub Med searching and a publication from Department of Veterans` Affairs. After assorting searched articles into RCTs and non-RCTs, we analyzed the articles according to the elapsed time from trauma. Results: We confirmed that acupuncture, CBT, and PMR were effective in acute stage after traumatic event. And EMD R, EFT, and relaxation therapy were effective in chronic stage after traumatic event. Building on the findings, we proposed a model of oriental medicine for Disaster Mental Health. Conclusions: Analyzing previous researches about oriental medicine on PTSD, several interventions were confirmed the effectiveness on specific treatment stage. We could find the possibility of Oriental Medicine as a Disaster Mental Heath and proposed a model of Oriental medicine for Disaster Mental Health.

      • KCI등재

        정서 관련 척도를 이용한 사상체질의 감정 특성 요인 연구

        김우철 ( Woo Chul Kim ),김경수 ( Kyeong Su Kim ),김경옥 ( Kyeong Ok Kim ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4

        Objectives: One`s mind is turned over by environment and personal relationship. This Emotion is called Chiljung in Oriental Medicine. Sasang Constitution is sorted each Emotion by Nature & Emotion(性情). So, this study aimed at figuring out the relations on Sasang Constitution, and emotion traits of oriental medicine students by EEQ and CISS(as named Mood scale). Methods: 199 students of Dongshin university oriental medicine were tested by Questionnaire for Sasang Constitution Classification II (QSCCII) and Mood scale. In this study is used 156 students` data, except 43 students one for research. 156 students are classified four groups by QSCC II. The degree of emotion was determined by Mood scale. These data ware analyzed by frequency, t test, ANOVA, Multiple comparison, Correlation, Regression with SPSS windows 15.0. Results: 1. Soeumin has high score on EEQ more than Soyangin. 2. Sasang constitution make no difference on CISS, except emotion-oriented coping in not classify group. 3. It has influence on Emotional express by Sasang constotution that Task-oriented coping, EEQ and CISS. Conclusions: Sasang constitution has significant difference on Emotional express.

      • KCI등재

        한의대생 46명의 지각된 모성애척도와 MMPI 척도와의 상관성에 관한 연구

        하지원 ( Ji Won Ha ),김태헌 ( Tae Heon Kim ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4

        Objectives: This study was to investigate the correlation of the Percepted Maternal Love and the characteristics of personality showed on MMPI scale, of the Oriental Medical University students. Methods: For this study we carried out the MMPI profiling and Percepted Maternal Love Scale on self-check test term, among 46 senior students who are attending Oriental Medical University. After collecting the data, we studied the correlation between the two measures. Results: 1. As the Percepted Maternal Love score increased, the Depression and Social Introversion score decreased conversely. 2. As the Percepted Maternal Love score increased, the Avoidant personality disorder score decreased. 3. As the Percepted Maternal Love score increased, Narcissistic personality disorder score increased as well. 4. As the scale of percepted mother`s increased, the depressed, socially introverted character, and avoidant personality of the children decreased, and the self loving personality character increased on the contrary. Conclusions: By the above results, we can come to the conclusion that in order to nurture the children to be self loving and not to be depressed or intimidated, the mother must try to make sure that her children actually do perceive how much they are loved.

      • KCI등재
      • KCI등재

        Beck 우울 척도 점수가 요통 환자의 한방 치료 초기에 미치는 영향에 대한 후향적 연구

        홍남중 ( Nam Jung Hong ),이제균 ( Je Kyun Lee ),이태규 ( Tae Gyu Lee ),박종훈 ( Jong Hoon Park ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4

        Objectives: The purpose of this study is to know that Beck Depression Inventory(BDI) score to effect on improvement degree of low back pain after oriental medical treatment. Methods: We analyzed charts of 33 inpatients who were treated in Ja-Seng Hospital of Oriental Medicine and Bu-Cheon Ja-seng Hospital of Oriental Medicine. Subject is divided into Group A(BDI<10) and Group B(BDI≥10). Numerical Rating Scale(NRS) and Oswestry Disability Index(ODI) were checked on admission, after 1 week, NES and OUT were rechecked o estimate the efficacy of treatments. Results: 1. In both groups, NES was significantly decreased(p<0.05). Analyzed result of the interaction between the two groups didn`t show significant difference(p=0.197). 2. In Group A, ODI was significantly decresed(p<0.05). In Group B, ODI wasn`t significantly decreased(p=0.058). The interaction analysis between the two groups didn`t show significant difference(p=0.173). 3. Analyzing patients with chronic back pain longer than 6 months by the presence of depression tendency and NRS, ODI decrease after 1 week of ambulation, while the NRS reduction showed relevancy by the depression tendency (p<0.05), the ODI reduction didn`t(p=0.272). Conclusions: 1. Although improvement of pain before and after the treatment and degree of functional recovery in high level BDI group was less than low-level BDI group, but it was stastically insignificant. 2. High BDI score of patients with chronic low back pain is the factor of disturbing pain improvement.

      • KCI등재

        우울증에 대한 한약물 치료 문헌적 고찰 -무작위 대조군 임상연구를 중심으로-

        이재은 ( Jae Eun Lee ),권용주 ( Yong Ju Kwon ),조성훈 ( Seung Hun Cho ) 대한한방신경정신과학회 2011 동의신경정신과학회지 Vol.22 No.4

        Objectives: This study aimed to investigate frequently used herbal materials among herbal prescription for depression focusing on randomized controlled trial. Methods: Every article relevant to depression was initially obtained from China National Infrastructure(CNKI), Korean database and book hand searching. Searching keywords were ``depression``, ``herbal medicine`` and ``randomized controlled trial(RCT)``. Results: Among comorbidity with depression, the most accompanied disease was that of circulatory system. Among sixty-five articles, depression with cerebral vascular disease was twenty eight. Article about mood disorder was twenty-four. High frequently used herbal materials were Bupleuri Radix(4ltimes), Curcumae Radix(34 times), Acori Graminei Rhizoma and Cnidii Rhizoma(24 times). Conclusions: According to this study, we could know select frequent-used herbal medicine. In a clinical treatment, herbal materials can be added herbal prescription related to depression. As these results, it can be helpful to develop new drugs.

      • KCI등재

        MPTP로 유도된 Parkinson`s disease 동물 모델을 이용한 소합향원(蘇合香元)의 신경보호 효과 및 그 작용 기전 연구

        김인자 ( In Ja Kim ),이지현 ( Ji Hyun Lee ),송규주 ( Kyoo Ju Song ),구병수 ( Byung Soo Koo ),김근우 ( Geun Woo Kim ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.1

        Objectives : To evaluate the neuroprotective effects of the essential oil from Sohaphwangwon (SH), a Chinese traditional medicinal prescription in a Parkinson`s disease mouse model. Methods : 1. The neuroprotective effect of SH on primary neuronal cells was examined by using 1-methyl-4-phenylpyridinium ion (MPP+). 2. The neuroprotective effect of SH was examined in a Parkinson`s disease mouse model. C57BL/6 mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg/day), intraperitoneal (i.p.) for 5 days. SH inhalation was applied before MPTP treatment for 7 days and continued until 12 days after the first MPTP treatment. 3. To find out the intracellular target signal molecule(s) regarding the neuroprotective effect of SH essential oil, brain-derived neurotropic factor (BDNF) and synaptic protein SNAP25 were examined by Western blot analysis. Results : 1. MPP+ induced a concentration-dependent decrease in cell viability. However, in the presence of 3 and 5 ug/ml of SH, MPP+-induced cell death was significantly reduced. 2. SH inhalation in MPTP mice led to the restoration of behavioral impairment and rescued tyrosine hydroxylase (TH)-positive dopaminergic neurodegeneration. 3. In SH / MPTP mice, BDNF and SNAP25 increased. Conclusions : This experiment suggests that the neuroprotective effect of SH essential oil is mediated by the expression of BDNF. Furthermore, SH essential oil may serve as a potential preventive or therapeutic agent regarding Parkinson`s disease.

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