트리메틸틴에 의해 유도된 흰쥐의 학습과 기억력 손상에 대한 육미지황탕가미방의 신경보호 효과

정희상 ( Hee Sang Jeung ),김근우 ( Geun Woo Kim ),구병수 ( Byung Soo Koo ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1

목적: 이 연구는 알쯔하이머 병에 대한 육미지황가미방의 효과를 조사하였다. 육미지황가미방은 산약, 산수유, 복령, 목단피, 구기자, 택사, 숙지황을 포함한 여러 가지 한약재의 전탕액으로 치매의 한약 치료제로 널리 사용되어 왔다. 방법: 이 약물의 신경보호 작용을 조사하기 위해, 수중미로를 사용하여 학습과 기억에 대한 육미지황가미방의 효과를 평가했고, 트리메틸틴으로 신경과 인지 장애를 유발시킨 쥐의 해마의 중추성 콜린계에서의 작용을 연구했다. 트리메틸틴은 강력한 유독물질로 선택적으로 중추신경계와 면역계의 세포를 파괴시킨다. 트리메틸틴(6.0 mg/kg, i.p.) 주입 후, 쥐에게 육미지황가미방(400 mg/kg, p.o.)를 2주 동안 날마다 복용시켰으며, 수중미로를 수행시켰다. 결과: 육미지황가미방을 트리메틸틴에 노출시킨 쥐에 투약했으며, 그들은 수중미로에서 학습과 기억의 향상을 보였고, 이는 육미지황가미방이 어떠한 환경에서는 트리메틸틴으로 유발된 신경퇴화 후 중추신경계의 결손을 감소시킬 수 있음을 보여준다. 결론: 이러한 결론은 육미지황가미방이 인지능력을 증가시키고, 트리메틸틴으로 유발된 신경퇴화에서 콜린 아세틸전환효소의 정도를 변화시킬 수 있음을 보여준다.

『방약합편(方藥合編)』에 수재된 신경정신과(神經精神科) 관련 주요 처방(處方)에 대한 연구(硏究)

김지훈 ( Jee Hoon Kim ),구병수 ( Byung Soo Koo ),김근우 ( Geun Woo Kim ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1

Objectives: The purpose of this study is to analysis of the herb medications corresponded with neuropsychiatry of 『Bang-Yak-Hap-Pyun』. Methods: The herb medications of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong(上·中·下統) and 『Enlargement side prescriptions』(增補方) are selected by comment on the chief virtue including reference word of corresponded with neuropsychiatry. Results and Conclusion: 『Bang-Yak-Hap-Pyun』is a book most people who have a background or career in Han Medicine(韓醫學) would pore over. They corresponded with neuropsychiatry among the herb medications of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong(上·中·下統) are 55 prescriptions that Sang-Tong(上統) is 8 prescriptions, Jung-Tong(中統) is 23 prescriptions and Ha-Tong(下統) is 24 prescriptions. And the herb medications corresponded with neuropsychiatry of 『Enlargement side prescriptions』(增補方) are 40 prescriptions. And then the herb medications corresponded with neuropsychiatry of 『Bang-Yak-Hap-Pyun』received much influence from 『Dong-Eui-Bo-Gam』. Incidentally the herb medications corresponded with neuropsychiatry of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong showed the high percentage in Neurosis. And the herb medications corresponded with neuropsychiatry of 『Enlargement side prescriptions』showed the high percentage in Psychosis. Besides not only put 『Enlargement side prescriptions』a premium on 『Dong-Eui-Bo-Gam』, but also made it the herb medications which were recorded on books flowed after 『Dong-Eui-Bo-Gam』known. It was entered up books quoted from『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong but the herb medications were that were not succeeded from 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong. Therefore 『Enlargement side prescriptions』 shows the efforts for supplement of 『Bang-Yak-Hap-Pyun』Sang·Jung·Ha-Tong.

문무잡과(文武雜科) 방목(榜目)의 의사학적(醫史學的) 가치(價値)

유희영 대한한방신경정신과학회 1990 동의신경정신과학회지 Vol.1 No.1

한방신경정신과 영역의 Alzheimer형 치매 관련 연구현황

김태윤 ( Tae Yoon Kim ),금창준 ( Chang Jun Kum ),오재우 ( Jae Woo Oh ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.3

Objectives: Alzheimer`s Dementia is somewhat common in clinical stages, and there are many reports and papers regarding this subject. We explain the present state of Alzheimer`s Dementia in JON (The Journal of Oriental Neuropsychiatry) for the benefits of clinical practice. Methods: We searched for articles in JON from 1990 to 2014 and selected ones that were related to Alzheimer`s Dementia; then, we analyzed the data and placed it in four categories, like experimental study, case study, Clinical Data-Analysis study, and clinical trial. Results: 1) We found 47 articles relating to Alzheimer`s Dementia in JON from 1997 to 2014: 41 experimental studies, 1 case study, 1 Clinical Data-Analysis study, and 4 Clinical trials. 2) There were Chung-kyung Acupuncture Method, Auricular acupuncture, and Cha-rak Acupuncture Method to treat Alzheimer`s Dementia. 3) There were many additional treatments, like aroma therapy. 4) In the experimental study, they reported on several herbs, including herbal prescriptions that affected the suppression of related mRNAs and genes. 5) There were 4 clinical trials regarding herbal prescription that was effective for treating Alzheimer`s Dementia. Conclusions: In JON, regarding Alzheimer`s Dementia, the majority dealt with experimental studies. Therefore, we also have to expand our sight into other fields of study. We need more clinical trials and case studies for the treatment of Alzheimer`s Dementia in Oriental Neuropsychiatry.

반하후박탕(半夏厚朴湯)의 사회, 심리적 스트레스에 대한 실험적 연구(實驗的 硏究)

원호영 ( Ho Young Won ),김하나 ( Ha Na Kim ),송영길 ( Young Gil Song ),김경옥 ( Kyeong Ok Kim ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.3

Objectives: This study is designed to investigate the effects of Banhahubak-Tang Extract (BHTe) on stress. Methos: BHTe was fed to ICR male mice (20±2 g) orally with the dose of 100 mg/kg/day for five days. Mice were then exposed to sociopsychological stress by observing foot shock stressed mice for one hour for five days while restrained. Results: 1) The BHTe-administered group showed a tendency of decreasing of serum corticosterone secretion compared with the control group. 2) The BHTe-administered group showed an increase in noradrenalin secretions in the dorsal cortex of the brain, but it was not significant. 3) BHTe administration had no effect on the brain level of lipid peroxidation. 4) BHTe administration decreased the serum level of lipid peroxidation. 5) BHTe administration decreased the Cu,Zn-SOD in the brain. 6) BHTe administration had no effect on catalase activity in the brain. 7) BHTe administration had no effect on the brain level of GSH. 8) BHTe administration increased the serum level of DPPH free radical scavenging activity, but not significantly enough to make a comparison with BHT. 9) The elevated plus-maze test is designed to detect the effect of anxiolytic drugs. The BHTe group showed a significant increase in latency time. Conclusions: These results suggest that BHTe can effectively rid the subject of the effects of sociopsychological stress.

노인성우울증에 대한 한방 집중치료 프로그램의 효과

김가나 ( Ka Na Kim ),황의완 ( Wei Wan Hwang ),조성훈 ( Seung Hun Cho ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.4

Objectives: As the elderly population grows and the prevalence of depression increases, the incidence of geriatric depression disorder will continue to increase. The effect of an intensive Korean medicine treatment program on geriatric depression disorder was studied. Methods: Geriatric depression disorder patients who received treatment over a period of three years were reviewed, with the geriatric depression score (GDS) used as the primary outcome. The intensive Korean medical treatment program applied to the geriatric depression disorder patients consisted of herbal medicine, acupuncture, pharmacopuncture, moxibustion, meditation, qigong exercises, and reminiscence therapy. Results: The GDS scores of patients who received the intensive Korean medical treatment program decreased from an average of 19.57 (±5.52) to 15.76 (±6.99) and there was a significant difference. Conclusions: When the intensive Korean medical treatment program was applied to geriatric depression disorder patients, the symptoms of depression improved. This treatment program will be helpful for improving symptoms in patients and can be applied by trained clinicians.

마음챙김 명상과 이정변기요법을 이용한 공황장애 그룹치료 효과에 대한 임상적 고찰

이성용 ( Seong Yong Lee ),유소정 ( So Jung Lyu ),최성열 ( Sung Youl Choi ),유영수 ( Yeoung Su Lyu ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.4

Objectives: This study was conducted to evaluate the clinical effects of group therapy for Panic disorder patients based on Mindfulness & Li-Gyeung-Byun-Qi therapy. Methods: The FFMQ, BDI, STAI, STAXI, Panic attack, Anticipatory anxiety and subjective improvement of three Panic disorder patients were compared pre- and post-treatment when given Mindfulness & Li-Gyeung-Byun-Qi therapy. Results: 1) After the patient in case 1 underwent 5 weeks of group therapy for Panic disorder, the Mindfulness meditation score was slightly improved, anxiety and depression were significantly decreased, and expression of anger was also improved. In addition, the Panic attack and Anticipatory anxiety became more stable in the objective evaluation, while ``Extreme improvement`` was shown in the subjective evaluation. 2) After the patients in case 2 and 3 underwent 5 weeks of group therapy for Panic disorder, Mindfulness meditation scores were slightly improved, anxiety and depression were significantly decreased, and expression of anger was also improved. In addition, the Panic attack and Anticipatory anxiety became more stable in the objective evaluation, while ``Moderate improvements`` were shown in the subjective evaluation. Conclusions: As per the results in these cases, it was shown that group therapy for Panic disorder utilizing Mindfulness & Li-Gyeung-Byun-Qi therapy was effective to maintain meditation and control the emotions of anxiety, depression, anger and so on. Therefore, it was considered that expansion of clinical utilization through the standardization of a group therapy program for Panic disorder is needed. Furthermore, it was also considered that a comparative study of the effects of previous cognitive programs for Panic disorder according to the objectified and standardized manual is needed in the future.

니코틴 의존도와 정신 건강 수준의 연관성에 대한 조사 연구 - 간이 정신진단 검사 중심으로 -

강희철 ( Hee-Chul Kang ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.1

Objectives: The purpose of this study is to investigate the relationship of nicotine dependence and mental health. Methods: The subjects of this study were 153 male smokers in their 20s, 30s, 40s and 50s who visited Wonmi Public Health Center. They were evaluated with Fagerstorm’s test for nicotine dependence (FTND) and Symptom Checklist-90-Revision (SCL-90-R). Using the FTND score, the participants were divided into three groups; mild nicotine dependent group, moderate group and severe group. Results: In the SCL-90-R score, there were statistically significant differences in the characteristics of Somatization, Obsessive-Compulsive, Interpersonal Sensitivity, Depression, Global Severity Index (GSI) and Positive Symptom Test (PST) among the three groups. Comparing the values of FTND and the amounts of Daily Smoking to the values of Somatization, Obsessive-Compulsive, Interpersonal Sensitivity, Depression and GSI in this study resulted in positive correlations, thereby demonstrating a statistical significance. Conclusions: The above results suggest that there are significant relations between nicotine dependence and the level of mental health. These results can be used for planning the smoking cessation program and mental health promoting program based on Korean traditional medicine.

뇌과학에 기반한 연령별 학습법과 연령별 한의학적 학습방법론 비교고찰

조아람 ( A Ram Cho ),박소임 ( So Im Park ),강다현 ( Da Hyun Kang ),서주희 ( Joo Hee Sue ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.4

Objectives: The purpose of this study was to research learning based on brain science and the learning methodology of Korean Medicine according to disparity of age. Through this, the study aimed to provide a guideline to related Korean Medicine treatments as well as the common nurturing/educational institutions. Methods: All journals and dissertations on brain science based learning methods studied in Korea to date that could be found in the National Assembly Library and the RISS were implemented in the analysis. The terminology used for search was as follows: 1st search, ``Brain``; 2nd search, ``Learning``, ``Education``; 3rd search, ‘Baby, ‘Infant``, ``Child``. For the learning methodology of Korean Medicine according to disparity of age, the related contents were extracted from Donguibogam and Liuyi, Sasang constitutional medicine. Results: A total of 30 studies, were collected as data. In the baby stage, the development and myelination of brain neurons are accelerated by experience and learning, highly influenced by social, cognitive and emotional movement. In infancy, the frontal lobe actively develops, so education for development of the prefrontal cortex is suggested. The brain of the infant at this stage can be developed by arts and physical education. In the child stage, the parietal and temporal lobe develop actively. Thus, programs to stimulate brain activity including brain respiration would be helpful in enhancing learning ability, concentration, etc. As evidence for learning and nurturing methodology according to disparity of age from Korean Medicine prospective, the following are listed: Location and time for sexual intercourse before pregnancy, stabilization during pregnancy, baby nurturing methods for nurturing from Donguibogam. Also Liuyi and Sasanag constitutional medicine can be the learning methodology according to disparity of age. And there are acupuncture points on each head section according to age in Donguibogam. Conclusions: Studies on ``brain-science based learning`` are continuously being conducted. Based on these studies, diverse new brain-science based learning will be developed in the future. There is also a need to develop the learning methodology of Korean Medicine according to disparity of age in a more systematic and diverse way.

뇌파를 이용한 생기능자기조절(뉴로피드백) 훈련에 대한 임상연구 동향 - 2000년부터 2013년까지 국내 학술지 논문을 중심으로 -

임정화 ( Jung Hwa Lim ),성우용 ( Woo Young Seong ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.3

Objectives: The purpose of this study is to investigate the clinical trial research trends in regards to the neurofeedback training (NFT) in Korean journals. Methods: We researched articles published in Korean journals from 2000 up to 2013 and were related to the NFT. We searched six electronic databases to find relevant articles, using the term ‘neurofeedback’. Results: 1) 6 single group comparative studies and 31 randomized controlled trials were found. 2) Healthy volunteers and students were most frequently studied with neurofeedback training. Other studies included attention deficit hyperactivity disorder (ADHD), Poststroke, panic disorder, premenstrual dysphoric disorder (PDD), temporomendibular disorder (TMD), and obesity. NFT interventions were attempted in diverse training protocols and assessed with many different outcome measurements. 3) Most studies showed effective results after NFT. Conclusions: NFT is increasingly studied and used in various clinical fields. Also, there have been efforts to adopt NFT in Korean medical clinics and researches, and more rigorous and innovative studies are needed in the future.