Callus distraction method를 이용한 하악골 신장술 : 계단골절단술식의 적용

김명진,윤필영,신동준,김수경,김종원,김규식 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Since callus distraction technique was applied clinically for the correction of dentofacial deformity to the patients with hemifacial dysplasia by McCarthy in 1992, many surgeons have tried to apply this method to the maxillofacial region. But this technique has some drawbacks. One of the disadvantages of this technique is extensive scar formation in the facial area, which is a sequelae of extraoral approach for supraperiosteal dissection of the periosteum overlying the mandible. Recently, we have made an effort to perform this technique through intraoral approaches to prevent scar formation on the submandibular area and modified the design of the osteotomy, that is step osteotomy technique, to increase the raw bone surface on both osteotomized segments. The rationale for the application of this step osteotomy technique is to increase the amount of regeneracted bone and the length of distraction, to avoid damage of inferior alveolar neurovascular bundle, and to increase initial stability of the splitted segments. Step osteotomy procedure can be done with fine micro-osteotomy saw through subperiosteal tunneling. Extraoral pins should be inserted before making the osteotomy. Since 1974 we have applied this technique at 8 sites In 5 patients with mandibular deficiencies: 2 cases of hemifacial microsomia, 1 case of developmental facial asymmetry and 2 cases of mandibular bony defect. Mandibular elongation have been achieved from 12 to 20mm in length. 1 out of 8 site, we experienced non-union in the case of mandibular body defect. Some skeletal relapse and growth retardation phenomenon have been observed in some cases with the longest follow-up of 48 months.

소아의 상완골 원위부 과간 골절

이우석,정환용,김우식,김용찬,전택수,김남현,김규태 대한골절학회 2004 대한골절학회지 Vol.17 No.4

상완골 원위부 과간 골절은 소아에서는 매우 드물게 발생되는 골절로 대부분 주관절의 굴곡상태로 주관절 후방부에 직접적인 충격에 의해 발생하는 것으로 보고되고 있다. 전위가 없거나 경미한 경우 도수적 정복술 혹은 도수적 정복술 후 경피적 핀고정술을 시행하며, 전위가 심한 골절이거나 도수적 정복술이 불가능한 경우 관혈적 정복술 후 핀고정술을 시행하는 것으로 알려져 있다. 저자들은 전위된 상완골 원위부 과간 골절 환아 2예에서 각각 도수적 정복술과 관혈적 정복술 후 K 강선 고정술을 시행하여 만족한 결과를 얻었기에 보고하는 바이다. Intercondylar fractures of the distal humerus are very rare in children. The pattern of the fracture would suggest that the mechanism of injury involves a fall directly on the flexed elbow. Most agree that the undisplaced fracture can be managed conservatively. With increasing displacement and comminution, the opinions tend to differ. We suggest that closed reduction with percutaneous K wire pinning and open reduction with percutaneous K wire pinning offer a satisfactory methods by which to treat displaced intercondylar fracture in children.

精神障碍者 家族의 精神障碍에 對한 態度調査

金鐘碩,金容植,河圭燮,梁益弘,李符永 서울대학교 의과대학 정신과학교실 1989 서울醫大 精神醫學 Vol.14 No.1

琺瑯芽細胞腫 Ameloblastoma의 病理組織 및 臨床的 考察

金圭植 醫藥係社 1957 綜合 醫學 Vol.2 No.9

新局所痲醉劑 Baycain의 實驗的 硏究

金圭植 亞洲藥品 1988 臨床 醫藥 Vol.4 No.4

부신절제가 전기경련 충격에 의한 흰쥐 뇌의 조기유전자 발현에 미치는 영향

하규섭,강웅구,정희연,주연호,박주배,김용식 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

부신피질 호르몬이 뇌에서 전기경련 충격(ECS)에 의한 조기유전자(IEG)의 발현에 미치는 영향을 살펴보기 위하여 본 연구를 수행하였다. 양측 부신을 절제한 수컷 Sprague-Dawley 흰쥐에서 부신을절제한 지 3일 후에 ECS로 경련을 유발시켜 대뇌 피질, 해마 및 소뇌에서 c-fos, jun B, TIS 1의 발현 양상을 관찰하고 이를 대조군과 비교하여 다음과 같은 결론을 얻었다. 1) 부신절제 후 대뇌 피질에서 ECS에 의한 c-fos와 jun B 및 TIS 1 mRNA 발현은 대조군에 비하여 억제되었다. 2) 해마와 소뇌에서는 IEG의 종류에 상관없이 부신절제가 ECS에 의한 IEG의 발현에 별 영향을 미치지 않았다. 이상의 결과로부터 부신절제는 ECS에 의한 IEG의 발현에 영향을 미치며, 그 영향은 뇌의 부위에 따라 다름을 확인할 수 있었다. 부신피질 호르몬이 IEG 발현에 영향을 미치는 기전에 대하여 고찰하였다. The adrenocortical hormones have been known to be related with the pathogenesis of mental disorders and individual vulnerability to stress. To evaluate the influences of adrenocortical hormone on the signal transduction system in rat brain, the authors observed the effects of bilateral adrenalectomy on the induction of immediate early genes(IEGs) after electroconvulsive shock(ECS). Male Sprague-Dawley rats(200 - 250g) were treated with ECS(130V, 0.5sec) at day 3 after bilateral adrenalectomy. Rats were sacrificed at 0, 15, 30, 45, and 60 minutes after ECS, and cerebral cortex, hippocampus, and cerebellum were dissected from the brain. The induction of IEGs was assessed with northern hybridization. The band intensities of the autoradiographs measured with densitometer were compared between adrenalectomized group and sham-operated control group. After adrenalectomy, the c-fos, jun B, and TIS 1 induction by ECS was generally attenuated in the cerebral cortex. The induction of IEGs in the hippocampus and in the cerebellum was not influenced by adrenalectomy. These results suggest that adrenalectomy has differential influences on the induction of IEGs by ECS in the rat brain depending on the region of brain.

어떤 흰쥐 뇌에서 부신절제가 전기경련 충격에 의한 조기유전자 발현에 미치는 영향

하규섭,강웅구,정희연,주연호,조수철,박주배,김용식 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

부신피질 호르몬이 70g 이내의 어린 흰쥐의 뇌에서 전기경련 충격에 의한 조기유전자(IEG)의 발현에 미치는 급성 효과 및 만성 효과를 살펴보기 위하여 본 연구를 수행하였다. 70g 이내의 생식선이 발달하지 않은 수컷 Sprague-Dawley 흰쥐에서 양측 부신을 절제한지 3일과 14일 후에 전기경련 충격으로 경련을 유발시켜 대뇌 피질과 해마에서 c-fos, jun B, TIS 1 의 발현 양상을 관찰하고 이를 대조군과 비교하여 다음과 같은 결과를 얻었다. 1) 부신절제 후 대뇌 피질에서 전기경련 충격에 의한 c-fos와 jun B mRNA 발현은 일찍 최대치에 도달하고 일찍 감소하는 경향을 보였으며, 초기의 발현이 강화되는 경향을 보였다. 이러한 경향은 jun B가 c-fos 보다 뚜렷하였으며, 부신절제 후 3일이 경과된 경우보다 14일이 경과된 경우가 뚜렷하였다. 2) TIS 1의 경우에는 대뇌 피질에서 이러한 초기 발현의 강화가 관찰되지 않았으며, 부신절제 14일된 어린 흰쥐에서만 발현이 억제되는 경향을 보였다. 3) 부신절제는 해마에서는 전기경련 충격에 의한 c-fos와 jun B의 발현에 영향을 미치지 않았다. 부신절제 3일 후 전기경련 충격에 의한 TIS 1의 발현은 억제되는 경향이 관찰되었으나, 부신절제 14일 후에는 이러한 경향이 관찰되지 않았다. 이상의 결과로부터 부신절제는 전기경련 충격에 의한 IEG의 발현에 영향을 미치며, 그 영향은 흰쥐의 뇌의 부위, IEG의 종류에 따라 차이가 있음을 알수 있었고, 흰쥐의 연령 및 부신피질 호르몬을 제거한 기간 등의 영향도 있음을 확인할수 있었다. To evaluate the influences of adrenocortical hormone on the signal transduction system in young brain, the authors observed the effects of bilateral adrenalectomy on the induction of immediate early genes(IEGs) such as c-fos, jun B, and TIS 1 by electroconvulsive shock(ECS) in the young rats. The young(70g) male Sprague-Dawley rats were treated with ECS(130V, 0.5sec) at day 3 or 14 after bilateral adrenalectomy. They were sacrificed at 0, 15, 30, 45, and 60 minutes after ECS and cerebral cortex and hippocampus were dissected from their brans . The induction of IEGs were assessed with northern by hybridization. The band intensities of the autoradiographs measured by densitometer were compared between adrenalectomized group and sham-operated control group. In the cerebral cortex, c-fos and jun B appeared and disappeared earlier, and enhanced in the earlier phase of the induction in the adrenalectomized group. These trends were more prominent for jun B than for c-fos, and were more prominent at day 14 than at day 3 after adrenalectomy. The induction of TIS 1 was attenuated at day 14 after adrenalectomy. In the hippocampus, the induction of c-fos and jun B by ECS was not influenced by adrenalectomy. The induction of TIS 1 was attenuated at day 3 after adrenalectomy. These results suggest that adrenalectomy has influences on the induction of IEGs by ECS in rat brain differently, depending on the brain region, the kind of IEGs, the age of the rats, and the time passed after adrenalectomy.

口腔領域에 發生한 囊腫에 關한 臨床 및 統計學的 硏究

李春根,金圭植,南日祐,申相澈 醫藥係社 1954 綜合 醫學 Vol.11 No.12

齒根囊腫에 關한 臨床 및 統計學的 硏究

李春根,金圭植,南日祐,河正洙 中央醫學社 1967 中央醫學 Vol.12 No.1

We have studied on clinical and statistical studies of periodontal cysts developed from 46 patients. The results were obtained as follows, 1) Periodontal cysts are more frequent in females (52.17%) than that in males (47.83%). 2) Predominant ages are third decade (34.78 % ), fifth decade (23. 91 % ), second decade and fourth decade (each other 17.39%) and sixth decade (6.52 %) in the orders. 3) In the etiological teeth of periodontal cysts, the upper central and lateral incisors, lower first and second molars are prevalent. 4) periodontal cysts are more frequent in maxilla (70 %) than that in mandible (30%). The predominant region of periodontal cysts are anterior region of maxilla and molar region of mandible. 5) The 46 periodontal cysts have been treated by means of direct enucleation technique of cyst walls in 43 cases and apicoectomy in 3 cases.

A New 5α,8α-Epidioxy Sterol from a Marine Sponge Psammocinia Species

Hye Jin Park1,,Xuan Luo1,,Jongki Hong2,,Dong-kyoo Kim3,,Kwang Sik Im1, and,Jee H. Jung1* 한국생약학회 2005 Natural Product Sciences Vol.11 No.4

An investigation of the MeOH soluble fractions of a marine sponge Psammocinia sp. (Order:Dictyoceratida) led to the isolation of a new epidioxy sterol (1) and four known sterols (2-5). Their planarstructures were defined by analyses of the spectroscopic data. The 27-nor-24-methylcholestan type side chain withan epidioxy nucleus (1) was unprecedented. Compounds 1-5 were isolated from a sponge Psammocinia sp. for the first time.