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조보연,이문호,고창순,김병국,김광원,서일택 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.1
혈청 ferritin의 측정법중 상품화된 kit로 2-site immunoradiometric assay법을 검토하고 측정법의 정도관리를 위한 실험적 결론를 통하여 다음과 같은 결론을 얻었다. 즉 측정에 소요되는 시간은 6시간이며 total dose 대신 maximum binding을 이용하면 표준곡선의 slope가 이상적인 범위이내로 유지될 수 있었다. 세척의 효과는 Reaction I이 끝난후보다 Reaction Ⅱ가 끝난 후에 더욱 중요하였으며 bead를 tube에 둔체 세척할 때에는 5회씩 세척으로 충분하였다. 혈청을 희석 사용했을 때 예상치와 측정치 사이에는 좋은 비례식이 성립되었으나 혈청효과를 보기위왜 혈청을 많이 넣었을 때는 검체혈청이 총 용적의 50% 이상을 초과하면 high dose hook 현상이 관찰되었다. 이 방법으로 검정한 sensitivity는 2.77 ng/ml이었으며 within-assay precision의 변이계수는 21.7%(mean 6.9 ng/ml), 9.7%(mean 44.3 ng/ml) 및 8.0%(mean 178.4 ng/ml)이었으며 between-assay reproducibility의 변이계수는 7.4%이었다. 또한 방사면역측정법의 정도관리를 위한 문헌고찰을 통하여 이 실험적 고찰을 비교 검토하였다. A 2-Site immunoradiometric assay for serum ferritin was evaluated with commercially available kit. The assay required 6 hours. The slope of the standard curve kept up ideal range with the calculation of maxium binding instead of total dose until expire date. The stage II washing was more important than the stage I washing on the modified washing procedure as the bead keeping to remain in the tube. With this modified method, three times of tube washing was sufficient to reduce the significant errors. The measured values of serially diluted sample with standard diluting buffer was proportional to the predicted values. In the experiment of serum effect on the assay, a linear relationship from 5 to 50% serum, but beyond 50% there was reduction in measured ferritin concentration. It has a sensitivity of 2.77 ng/ml, within-assay precision (CV) of 8.0%, and between-assay reproducibility (CV) of 7.4% (mean 174.8 ng/ml). $quot;
99m Tc-tin colloid 를 이용한 간 스캔상 " Hot spot " 로 나타난 상대정맥증후군 1예
조보연,이명철,고창순,조경삼,김병태,신영태,권기익 대한핵의학회 1981 핵의학 분자영상 Vol.15 No.1
The hot spot on liver scan was demonstrated by many authors in various conditions such as SVC obstruction, Budd-Chiari syndrome, liver abscess, hemangioma of liver, hepatic venoocclusive diseases, IVC obstruction, and tricuspid insufficiency. And the appearance of hot spot in SVC obstruction is due to unsual collateral circulation. But there was no report of this hots pov t on liver scan in our country. We have recently observed one patient with SVC obstruction who shows well-defined area of increased radioactivity between right and left lobe of liver on liver scan using 99mTc-tin colloid, and demonstrated collateral circulations with RI venograghy using 99mTc-O4. The injection site of radiocolloid was left antecubital vein. This hot spot did not appear when the radiocolloid was injected into right leg vein. We report here this hoe spot on liver scan in SVC obstruction with review of some literactures.
조보연,이홍규,고창순,민헌기,김성연,김두만,이석인 대한내과학회 1992 대한내과학회지 Vol.43 No.3
Erythropoietic protoporphyria is an inherited disorer of heme synthesis characterized by deficiency of the mitochondrial enzyme, ferrochelatase. This enzymatic abnormality results in increased free protoporphyrin in erythrocytes and plasma, which in turn produces cutaneous photosensitivity, the primary clinical manifestation of the disorder. In some patients, protoporphyrin accumulation in the liver may be associated with hepatitis, portal fibrosis and cirrhosis and may lead to fatal hepatic failure. Recently we experienced a 28-year old man, who had a history of photosensitivity and abnormal liver function test, complaining upper abdominal pain and weight loss. He showed very high level of free erythrocyte protoporphyrin and red fluorescing erythrocyte on fluorescent microscopy. On histopathologic examination, 1iver biopsy spiciemen exhibits brown pigments in hepatocytes, some ballooning degeneration and necrosis of hepatocytes and periportal fibrosis. Birefringence (Maltese cross) was also observed on polarization microscopy. So we concluded that abnormal liver function test in this patient was caused by the hepatitis related to erythropoietic protoporphyria.