돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

우리나라 대학교 관광관련 전공 재학생의 교육기대수준에 관한 연구 : 6개 대학교 재학생을 중심으로 : 강릉대학교, 경주대학교, 세종대학교, 숙명여자대학교, 순천향대학교, 한양대학교

최영민,이성근 한국문화관광학회 2001 문화관광연구 Vol.3 No.2

The main aim of this paper is to examine education expectation level of students majoring culture and tourism at universities in Korea. From the previous studies, Authors drew three general factors of educations of students (knowledge/humanity/ professional way). This study identifies the relation between three education factors mentioned and education environment of students(year/ sex/ major operation system). The data were collected from survey questionnaires on six universities for 3 month from late March to early July 2001. The empirical test is focused on discovering following points; - the efficiency of actual education operation system of universities - the differences of education expectation according to different academic year/ sex - the comparison of characteristics related to education expectation of university students

鐵筋콘크리트 土留構造物의 最適化에 關한 硏究

崔洪植,邊根周,李相旻 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2

A mathematical model is formulated for the minimum cost design of reinforced concrete earth structures. The design variables are selected to be the depth and steel ratio in the retaining wall, and the depth, steel ratio and footing sizes in the isolated column footings. An elastic analysis is performed and resulting designs are based on both the ultimate strength theory and the elastic theory of concrete design. Constraint requirements are imposed to insure structural strength and side constraints. The resulting mathematical model is a nonlinear constrained optimization problem. The modified Lagrange Multiplier method is suggested as a satisfactory algorithm for the optimum design of the R.C. earth structures.

運動種目別로 본 PWC_(170)時에 發現되는 運動能力에 관한 比較硏究

최영근,김상국,김정주 경희대학교 체육대학 한국체육과학연구소 1984 體育學論文集 Vol.12 No.-

With two Gymnastics players, three Basketball players, four Baseball players, four Football players as the Subjects, this study was made in order to reveal the degree of Physical Work Capacity (PWC) 170 by measuring how Heart Rate would change when they run on the Treadmill. The Results are as following: 1. In max Heart Rate, Baseball players were the highest as 209.00±4.90 beats/min, Gymnastics players were 195.50±3.54 beats/min, Football players were 192.00 ± 7.02 beats/min and Basketball players were the lowest as 187.00 ± 8.89 beats/min. 2. In max Running time and Running distance, Football players were the highest, 11.66 ± 0.59 minutes as Running time, 2450.3 ± 151.28m as Running distance, Basketball players were 11.21 ± 1.73 minutes and 2358.9 ± 381.77m, Baseball players were 10.69 ± 0.47 minutes and 2256.9 ± 104.60m and Gymnastics Players were the lowest, 8.50 ± 0.03 minutes and 1721.80 ± 9.90m. 3. In Heart Rate increase while they run on Treadmill, it was totally the highest in Baseball players, and was appeared orderly in Gymnastics players, in Football players, and in Basketball players. % HR max was appeared generally that Gymnastics players were appeared the highest, and was appeared orderly Baseball players, Basketball players, Football players. 4. In Heart Rate change while the Recovery, the Basketball players were appeared generally low Heart Rate at the Sometime, and was appeared orderly Football players, Gymnastics players, Baseball players. % H.R. max, Basketball players was recovered the fastest speed. Within 4min recovery it was appeared quickly that was orderly Basketball players, Baseball players, and after 4min was appeared orderly Basketball players, Gymnastics players, Baseball players, Football players. 5. In PWC 170 test, Basketball players were appeared superior that 9.09 min in Running time and 1781.0m in Running distance, and 240m/min in load and 6% in slope. And next Football players were appeared 7.27 min in Running time, 1463.4m in Running distance, 220m/min in load, and 5% in slope, Gymnastics players were appeared 5.53 min in Running time, 968.0m in Running distance, 200m/min in load and 4% in slope. Baseball players were appeared inferior that was 12 min in Running time, 704.0m in Running distance, 200m/min in load, and 4% in slope.

2-Methylisoborneol(2-MIB)제거를 위한 산화 및 흡착공정의 특성

최근주,김상구,류동춘,신판세,손인식,오광중 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

One of the Musty and earthy smell compounds in raw water is generally attributed to 2-methylisoborneol (2-MIB). It is well known that activated carbon and oxidants such as O_3, ClO_2 are effective ways to control 2-MIB. In isotherm equilibrium experiments, 2-MIB in distilled water was much more adsorbed to the activated carbon(A/C) than raw water containing dissolved organic carbon (DOC). The Freundlich constants(k) of distilled water and raw water were 3.36 and 0.049, and 1/n values were 0.80 and 0.42, respectively. The 2-MIB residual rate were Y = e^(0.55_x)~ e^(-0.54_x) with Ozone(O_3) dose by 5 minutes contact time at the 241 and 353 ng/L initial concentrations. The 2-MIB residual rate were Y = e^(-0.32_X)~ e^(-0.35_X) with Chlorine dioxide(ClO_2) dose by 15 minutes contact time at the 89 and 249 ng/L initial concentrations. 2-MIB was decreased from 1911 ng/L to 569ng/L by post-ozonation(70%removal efficiency) and removal efficiencies of 2-MIB by the following 4 kinds Granular Activated Carbon(GAC) process such as coal base, coconut base, wood base and zeolite+carbon base were 95.8, 89.5, 88.4, and 93.7% respectively.

농장 사육되는 타조에서 나타난 다리 기형의 증례 보고

최종윤,손화영,전무형,조성환,김혜성,류시윤,박배근,이영원,윤원기 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-

Two farmed young ostrich chicks were applied to pathology laboratory at Chungnam National University. Grossly, one ostrich showed rotated tibiotarsus, the other showed rolled toes. Case 1 ostrich was hypertrophy of fibualis longus and tibial cranialis tendon and gastrocnemius tendon in crus, inflammation of flexor digitorum longus. In histopathological views, myocytes of fiburalis longus were showed hypertrophy and hyperplasia. It is not found any specific feature in X-ray of the case 2 ostrich. Limb deformities were detected frequently in farmed ostrich chicks in 2- to 3 weeks old. Limb deformities were an important cause of mortality in farmed ostrich chicks during the first 10weeks after hatch. Cause of limb deformities were considered a nutrition problem.

기제와 피부투과촉진제가 아포모르핀의 피부투과에 미치는 영향

최영근,최옥,김건남,박은석,지상철 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of apomorphine, the skin permeation rates of apomorphine from vehicles of different composition were determined using Franz diffusion cells fitted with excised rat skins. Solubility of apomorphine in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of apomorphine. The solvents used were propylene glycol (PG), Transcutol^??, Labrasol^??, Labrafac hydro WL^??, Labrafil WL 2609 BS^?? and isopropyl alcohol. Even though permeation rates of apomorphine from each vehicle were low (0.08-0.36㎍/㎠/hr), the combination of PG and Labrafac^?? increased it significantly. The permeation rates of apomophine from PG/Labrafac^?? mixtures increased as the volume fraction of PG in the mixture increased. The maximum permeation rate of 18㎍/㎠/hr was achieved at 30% of PG, which decreased with further increase of PG fraction. A series of fatty acids, alcohols and monoterpenes were employed as penetration enhancers. Incorporation of each enhancer in the PG/Labrafac^?? (30:70) mixture at the level of 10% improved the skin permeation significantly. The highest permeation rate, 117㎍/㎠/hr, was attained with myristic acid.

흡착특성이 다른 내분비계 장애물질 3종, Amitrol, Nonylphenol, Bisphenol-A의 GACs에서의 흡착 특성

최근주,김상구,권기원,지용대,김승현,김창원 한국물환경학회 2004 한국물환경학회지 Vol.20 No.3

Adsorption characteristics of three endocrine disruptors, amitrol, nonylphenol, and bisphenol-A, were evaluated depending on the type and service duration of activated carbon (AC). Bituminous coal-, wood-, and coconut-based coals were tested. Bituminous coal-based AC (BCAC) had the greatest sorption capacity for the three chemicals tested, followed by wood-based AC (WAC) for nonylphenol and coconut palm-based AC (CAC) for bisphenol-A. During the column test, amitrol removal efficiency increased over time, indicating that hydrophilic endocrine disruptors are biodegraded in the AC column. Removal efficiencies of hydrophobic compounds such as nonylphenol and bisphenol-A decreased over time since the main removal mechanism was adsorption. The order of the amitrol removal was: BCAC-5.9 yr , CAC-3.1 yr > BCAC-2.2 yr > BCAC-virgin > CAC-virgin > WAC-virgin > WAC-3.1 yr. In general, used AC had greater removals than virgin AC. The order of the bisphenol-A removal was: CAC-virgin > BCAC-2.2 yr > CAC-3.1 yr > WAC-virgin > BCAC-5.9 yr > WAC-3.1 yr. The order of the nonylphenol removal was: BCAC-virgin > WAC-virgin > CAC-3.1 yr ,WAC-3.lyr> BCAC-2.2 yr > BCAC-5.9 yr > CAC-3.1 yr. Bituminous coal AC performed the best over time. Endocrine disruptors such as these three compounds appear to be removed effectively by activated carbon through biodegradation and adsorption. Wood and coal based among the virgin ACs and 3.1 years used wood base among the used ACs appeared the lowest carbon usage rate(CUR) for nonylphenol removal by prediction model. Virgin and used coconut base ACs except BCAC had the lowest CUR for removal Bisphenol-A. Biodegradation of nonylphenol and Bisphenol-A did not occurred during the 9,800 bed volume experiment period. BCAC had the highest biodegradation capacity of 46% for amitrol among virgin ACs and the used coal based ACs had 33-44% higher biodegradation capacity than virgin's for amitrol so biodegradation is the effective removal technology for hydrophilic material such as amitrol.

향토음식 인지도에 관한 실증적 연구 : 경남 하동군 지역을 중심으로 with respect to Hadong-Gun Area, Kyungsangnam-Do

최수근,이연정,박성수 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.3

Rather than focusing on the general recognition of the area and extensive preference about its native cuisine, this study carried out more practical examination on the recognition of the native cuisine by presenting the more detailed introduction of the native cuisine in Hadong area. The findings of this study can be used as basic materials to devise measures for the instillation and advertisement of Hadong area's image, the development and maintenance of its native cuisine benefiting the activation of the local economy, and the reestablishment of Hadong area's native cuisine culture. First, the overall recognition of Hadong area's native cuisine was low and more consumption needs to be boosted by merchandising its foods through the strengthening of recognition. Second, correlation between this area's native cuisine was revealed and tables need to be set and menus need to be organized with this correlation in mind. Basic materials for suggestion sale were garnered. Third, given that most outside tourists visit Hadong by word mouth of all the information sources available, it is highly likely that positive word of mouth through satisfaction with native cuisine will raise the overall recognition of the area. Fourth, precise subdivision market and target market need to be specified. Though the factors like economic costs and the time required cannot be overlooked in strengthening recognition, consistent advertisement to the middle-aged people who are over 40 and live in Kyungsang-Do area will contribute to the fast rise in the recognition of Hadong area's native cuisine, leading to the possibility of economic development in the process.

골다공증에 의한 압박 골절의 치료에 있어서 경피적 추세 성형술의 의의

최재영,윤승환,조준,문창택,장상근 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Percutaneous vertebroplasty has recently been introduced as a therapeutic alternative for the treatment of pain associated with osteoporotic compression fractures and performed popularly at a few centers by neurosurgeons. This technique allows marked pain relief through stabilization of microfractures and strengthening of weakened vertebral body. Authors retrospectively analyzed the clinical outcome of 100 patients with osteoporotic compression fractures for investigating the therapeutic effectiveness of percutaneous vertebroplasty. They were treated with vertebroplasty from April to August 1999. Plain X-ray of all patients showed osteoporotic compression fractures at more than one level.