폐경 여성에서 호르몬대체요법 후 유방 엑스선 사진의 변화

조수현,정창영,김봉수,정대현,조삼현,주경빈,류기영,황윤영 대한폐경학회 1998 대한폐경학회지 Vol.4 No.1

"Objectives: In the present retrospective study, we aimed to determine mammographic changes of breast parenchyme after hormone replacement therapy(HRT) in postmenopausal women. Methods: One-hundred fourty eight women were 'included into the study and devided into two groups.(HRT group: 129 women, No HRT group: 19 women) Prior to the start of HRT, an initial mammography was performed and repeated at 12 month intervals. HRT group included estrogen only(n=21), cyclic estrogen and progestin(n=52) and continuous estrogen and progestin(n=56) treated women. Mammograms were evaluated by two observers without knowledge of women's hormone treatment status. Results: Fifteen(12%) of 129 hormone treated women and 1(5.2%) of non-treated women developed increased parenchymal density during 1 year. Marginally significant increase in mammographic density after 1 year treatment was demonstrated according to age(6.6%, 12.2%, 30.0% in their fourties, fifties, sixties, respectively). Eleven percent of women showed increased density at the time of 12 month treatment but no one have increasment of density after 12 month of treatment in women whose menopausal duration was less than 5 years. A greater percentage of women treated with continuous combined estrogen-progestin showed increased mammographic density than cyclic combined estrogen-progestin treated women (71.4% vs 14.3%, p=0.001). Conclusions: An increase in mammographic density was demonstrated only in subjects undergoing continuous combined estrogen-progestin tteatment, in their sixties and less than one year treatment period. "

S-284 Prognostic impact of Left Ventricular Mass Change in ST-elevation Myocardial Infarction

( Ji-yeoun Seo ),( Jin-sun Park ),( Kyoung-woo Seo ),( Hyoung-mo Yang ),( Hong-seok Lim ),( Byoung-joo Cho ),( So-yeon Choi ),( Myeong-ho Yoon ),( Gyo-seung Hwang ),( Seung-jea Tahk ),( Joon-han Shin 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Background:?Prognostic significance between progression LVH and clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) is uncertain. This study aimed to investigate prognostic impact of progression of LV mass index (LVMI) in patients with STEMI.?Methods:?We analyzed the data and clinical outcomes of patients with STEMI who received successful coronary intervention. We finally enrolled 200 patients (166 males, 56 ±11 year-old) performed echocardiographic follow-up (F/U) between 12 and 36 months. According to the change in LVMI compared with baseline LVMI, patients were classified into progressed LVMI group and no progressed LVMI group. Progression of LVMI was defined as increment of LMVI greater than 10% compared with the baseline LVMI. Occurrence of major adverse cardiovascular events (MACE; death, recurrent MI, target vessel revascularization (TVR) within 5 years was evaluated. Results:?Progression of LVMI was occurred in 55 patients (42 males, 55±11 year-old). The event-free survival of all-cause mortality and recurrent MI in the progressed LVMI group was significantly worse than the no progressed LVMI group (log-rank p=0.002 and 0.005 figure). In a cox-regression model, the progressed LVMI group was associated with increased risk for recurrent MI (HR, 5.794; 95% CI, 1.445-23.239, p=0.013). By multivariate logistic regression, initial LVMI (odds ratio [OR], 1.012; 95% confidence interval [CI], 1.000-1.023; p=0.047] and F/U LVMI (OR, 1.016; 95%CI, 1.000-1.032, p=0.049) were independent predictors for MACE. Progression of LVMI was only independent predictor of MI (OR, 6.069; 95% CI, 1.426-25.822, p=0.015).?Conclusions:?In present study, increased LVMI was an independent predictor for adverse events, especially for recurrent MI, in patients with STEMI who received successful coronary intervention.

多發性腎囊腫 가족례 2례 : 蜘蛛膜下出血을 동반한 1례 포함

최연극,김순덕,조동규,김능수,김용주 慶北大學校 醫科大學 1985 慶北醫大誌 Vol.26 No.4

We experienced two families of polycystic kidney disease. Of the two families one case was associated with subarachnoid hemorrhage. We have reviewed the literatures of familial occurrence of polycystic kidney disease, and of the case associated with subarachnoid hemorrhage.

우주개발프로그램에서의 전기지상지원장비 개발 동향

박주호(Park, Joo-Ho),조승원(Cho, Seung-Won),김영윤(Kim, Young-Yun),채동철(Chae, Dong-Chul),허윤구(Huh, Yun-Goo),최종연(Choi, Jong-Yeoun) 한국항공우주연구원 2013 항공우주산업기술동향 Vol.11 No.2

우주개발 프로그램은 다른 연구 개발 프로그램들과는 달리, 설계와 개발 등의 과정 외에 시험, 조립 및 검증에 많은 비용과 시간을 소요하고 있다. 이는 한 번 발사를 하면 회수나 수리가 거의 불가능한 우주개발 프로그램의 특수성에 기인한다. 지난 수년간, 우주개발 선진국들은 오랜 역사와 경험을 바탕으로 우주개발프로그램의 전 과정에서 경쟁력 제고를 위해 힘써왔다. 이러한 경향은 위성 시험, 조립 및 검증의 과정에서의 중복적인 장비 개발을 줄이고 효율적인 시험과 운용을 지향하는 노력으로 이어지고 있다. 본 논문은 선진국의 우주개발프로그램관련 시험과정 및 시험장비 개발 정보를 수집하고 분석함으로써 향후 우리나라의 우주프로그램이 나아가야할 방향을 제시하고 있다. Once the spacecraft are launched, it is almost impossible to bring back and repair them again. At this point of view, the AIT (Assembly, Integration and Test) on the ground before launch is very important for all of space programs. Usually, it takes several years and more for thorough examinations because it totally depends on the complexity of the space program. In today"s environment, as demands of cost effective and reliable spacecraft increase, there have been a lot of researches supporting it. Removal of duplicated work, design of efficient test procedure and re-use of test equipments can be good examples. This paper is aimed at describing the recent trends and technologies about electrical ground support equipments in several advanced countries.

瀉白散의 면역조절 효과

조성연(Seoung Yeoun Cho),이동주(Dong Joo Lee),정한솔(Han Sol Jeong),이상룡(Sang Ryong Lee),이광규(Kwang Gyu Lee) 한의병리학회 2004 동의생리병리학회지 Vol.18 No.1

Carcinoembryonic Antigen Level Can be Overestimated in Metabolic Syndrome

Kim, Kyu-Nam,Joo, Nam-Seok,Je, Sang-Yeon,Kim, Kwang-Min,Kim, Bom-Taeck,Park, Sat-Byul,Cho, Doo-Yeoun,Park, Rae-Woong,Lee, Duck-Joo The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.6

<P>Carcinoembryonic antigen (CEA) levels can be affected by many factors and metabolic syndrome is also a candidate. This study examined the relationship between CEA levels and metabolic syndrome using the data of 32,897 healthy Koreans. Fecal occult blood tests were also performed. Subjects with colorectal carcinoma were excluded. Subjects were classified by their smoking status, metabolic syndrome and its components. Prevalence of metabolic syndrome and its all components showed a significant increase according to the quartile of serum CEA concentration (<I>P</I> < 0.001). Increased numbers of metabolic syndrome components showed a positive association with CEA levels (<I>P</I>-trend < 0.001). The odds ratios for the highest CEA quartile vs the lowest serum CEA quartile significantly increased in the presence of metabolic syndrome and its components. After adjusting for age, gender and smoking status, metabolic syndrome, low high density lipoprotein cholesterol and elevated blood pressure had higher odds ratios (OR) of the highest CEA quartile compared with the lowest serum CEA quartile (OR = 1.125, 95% CI = 1.030 to 1.222, <I>P</I> = 0.009; OR = 1.296, 95% CI = 1.195 to 1.405, <I>P</I> < 0.001; OR = 1.334, 95% CI = 1.229 to 1.448, <I>P</I> < 0.001, respectively). These results indicate that metabolic syndrome is associated with CEA value, which may lead to a misunderstanding of the CEA levels.</P>

해외 부동산 개발형 도시재생사업의 사업구조 분석

조승연,주관수,김옥연,김주진,Cho, Seung-Yeoun,Joo, Kwan-Soo,Kim, Ok-Yeon,Kim, Joo-Jin 한국토지주택공사 토지주택연구원 2014 LHI journal of land, housing, and urban affairs Vol.5 No.4

본 연구는 영국과 일본의 부동산 개발형 도시재생사업의 사업구조에 대한 비교분석을 통해 국내 경제기반형 도시재생사업에의 시사점을 도출하는 것을 목적으로 한 연구이다. 부동산 개발형 도시재생사업은 1980년대의 신자유주의의 영향에 따라 등장한 사업수법으로 규제완화 및 공공지원과 민간주도의 거점 개발방식을 통해, 지역경제 활성화 등의 효과를 도모하고자 하는 방식이다. 특히 2000년대에 진행되고 있는 부동산 개발형 도시재생사업으로 영국의 스트라트포드 및 킹스 크로스, 일본 오오테마치와 시노노메 지구의 사례를 통해 국내에의 시사점을 도출하고자 하였다. 사례별 도시재생사업의 추진체계, 참여 주체별 역할, 공공의 지원 등에 대한 비교분석을 통해 다음과 같은 시사점을 도출할 수 있었다. 사업방식 측면에서는 국가적 대원칙에 따른 '선택과 집중'을 통한 국가적 자원의 효율적 배분, 추진체계 측면에서 토지 소유자등 직접적인 이해당사자 외에도 공공개발기관, 민간개발업체, 지자체, 국가, 관계기관 등 다양한 이해당사자가 참여하는 거버넌스 체계의 구축, 기반시설 정비에 대한 공공의 지원이 공통적 특징으로 나타나고 있었다. 이상의 부동산 개발형 도시재생사업에서 공공의 직접적인 사업시행은 감소하였으나 규제완화를 통한 민간자본 유치, 지역의 경제적 성장, 고용창출 등의 측면에서 효과적인 수법으로 평가받고 있다. 특히 경제기반형 도시재생사업의 성공적인 수행을 위해서는 공공시행자 및 지방정부의 역량강화에 주목할 필요가 있을 것으로 판단된다. This comparative analysis on the project scheme of property-led regeneration of UK and Japan aimed to suggest the implications for economy-based urban regeneration of Korea. Property-led regeneration attract private capital by deregulation and public investment since 1980s' neoliberalism. Its effectiveness for creating job and economic growth is demonstrated through last decades. The cases of property-led urban regeneration of 2000s, such as Stratford, King's Cross, Otemach and Shinonome, show decrease of public direct investment, promoting deregulation. It also proved that property-led urban regeneration has a great ripple effect to local economy. And the partnership among central and local governments, public development corporations, private developers and other local interest groups is emphasized for delivering successful urban regeneration. Especially, human empowerment of local government and responsibility of public organization are also required to deliver urban regeneration.

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-029 : Pulmonary Infection ; Comparison of Sensitivity of QuantiFERON-TB Gold In- Tube and T-SPOT.TB According to Age

( Won Bae ),( Se Joong Kim ),( Yeoun Joo Lee ),( Jong Sun Park ),( Young Jae Cho ),( Ho Il Yoon ),( Choon Taek Lee ),( Jae Ho Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Interferon gamma release assay (IGRA) has been used for detection of latent tuberculosis (TB) infection. There are two types of IGRA, one is the QuantiFERON- TB Gold In-tube (GFT-GIT) and the other one is the T-SPOT.TB. There were somecontradictory reports that result of IGRA was or was not associated with age. We aimed to evaluate whether there are different sensitivity of these tests according to age. Methods: We retrospectively reviewed the medical records of patients who were diagnosed with TB and examined by either QFT-GIT or T-SPOT.TB from Feb 2008 to Dec 2013. The positivity of two tests was analyzed and compared with true TB infection. True TB infection was defi ned as active TB that is positive mycobacterium culture or positive polymerase chain reaction (PCR) for TB.Results: QFT-GIT group included 192 and T-SPOT.TB group included 212 TB patients. The pulmonary TB patients were 76 (39.6%) and 143 (67.5%), pulmonary TB with extra-pulmonary TB were 34 (17.7%) and 31 (14.6%), and extra-pulmonary TB were 82 (42.7%) and 38 (17.9%) at each group. The overall sensitivity was 80.2% for QFTGIT and 91.0% for T-SPOT.TB. The sensitivity of QFT-GIT and T-SPOT.TB according to age group was that 93.3% and 96.7% below 29-year-old, 86.5% and 94.7% in 30 to 49-year-old, 76.8% and 87.5% in 50 to 69-year-old, and 68.3% and 85.7% above 70-year-old. Age-related changes in sensitivity was signifi cant in QFT-GIT (p=0.033) but not in T-SPOT.TB. Mean absolute lymphocyte count, level of serum protein and albumin were signifi cantly lower in older age group in both IGRA patients groups. Conclusions: This result suggests that T-SPOT.TB is more useful test for TB infection than QFT-GIT in old age group.

Nitric Oxide가 인간 정자세포의 기능에 미치는 효과에 대한 연구

주보선,문화숙,박수진,문재연,조재동,김한도,Joo, Bo-Sun,Moon, Hwa-Sook,Park, Sue-Jin,Moon, Jae-Yeoun,Cho, Jae-Dong,Kim, Han-Do 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.1

This study was performed to determine the effects of nitric oxide on human sperm cell function. Semen samples were obtained from normal healthy volunteers. Motile spermatozoas collected by swim-up method were incubated up to 24 hours in Ham's F-10 medium supplemented with a various concentration of sodium nitroprusside (nitric oxide releasing agent). Sperm motility, hyperactivation, acrosome reaction rate, and acrosin activity were determined. The results are as follows; 1. 1mM of SNP resulted in a significant decrease in sperm motility ($44.8%{\pm}8.9%:78.1%{\pm}6.3%$, and hyperactivation $(10.4%{\pm}6.4%:47.7%:{\pm}9.5%)$ after incubation for 3 hours compared with the control group (Ham's F-10 alone), but had no effect on acrosome reaction. 2. At $100{\mu}M$ SNP, sperm motility was reduced after incubation for 6 hours $(54.8%{\pm}3.2%)$ compared with that of the control group $(82.7%{\pm}8.9%)$, but hyperactivation and acrosome reaction were not affected. 3. However, a lower concentration (less than $10{\mu}M$) of SNP had no effect on sperm motility and hyperactivation for 8 hours of incubation but significantly decreased them when incubation periods were increased up to 24 hours compared with the control group. On the other hand, $1{\mu}M$ and $10{\mu}M$ SNP significantly increased the acrosome reaction rate in both acrosomal status ($17.3%{\pm}5.2%$, $23.5%{\pm}4.7%$, respectively) and acrosin activity ($34.3{\mu}IU{\pm}10.5{\mu}IU,\;45.6{\mu}IU{\pm}5.6{\mu}IU$, respectively) as compared with the control group $(7.0%{\pm}4.0%,\;9.5{\mu}IU{\pm}3.4{\mu}IU)$. These results indicate that SNP, NO releasing agent, has a dose-dependent effects on the sperm cell function. Therefore it may positively affect the fertilization by promoting acrosomal reaction at a lower concentration (less than $10{\mu}M$).

Free Paper Presentation : OS-29 ; Comparison of Sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT.TB According to Age

( Won Bae ),( Se Joong Kim ),( Yeoun Joo Lee ),( Jong Sun Park ),( Young Jae Cho ),( Ho Il Yoon ),( Choon Taek Lee ),( Jae Ho Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Interferon gamma release assay (IGRA) has been used for detection of latent tuberculosis (TB) infection. There are two types of IGRA, one is the QuantiFERON-TB Gold In-tube (GFT-GIT) and the other one is the T-SPOT.TB. There were some contradictory reports that result of IGRA was or was not associated with age. We aimed to evaluate whether there are different sensitivity of these tests according to age. Methods: We retrospectively reviewed the medical records of patients who were diagnosed with TB and examined by either QFT-GIT or T-SPOT.TB from Feb 2008 to Dec 2013. The positivity of two tests was analyzed and compared with true TB infection. True TB infection was defined as active TB that is positive mycobacterium culture or positive polymerase chain reaction (PCR) for TB. Results: QFT-GIT group included 192 and T-SPOT.TB group included 212 TB patients. The pulmonary TB patients were 76 (39.6%) and 143 (67.5%), pulmonary TB with extra-pulmonary TB were 34 (17.7%) and 31 (14.6%), and extra-pulmonary TB were 82 (42.7%) and 38 (17.9%) at each group. The overall sensitivity was 80.2% for QFT-GIT and 91.0% for T-SPOT.TB. The sensitivity of QFT-GIT and T-SPOT.TB according to age group was that 93.3% and 96.7% below 29-year-old, 86.5% and 94.7% in 30 to 49-year-old, 76.8% and 87.5% in 50 to 69-year-old, and 68.3% and 85.7% above 70-year-old. Age-related changes in sensitivity was significant in QFT-GIT (p=0.033) but not in T-SPOT.TB. Mean absolute lymphocyte count, level of serum protein and albumin were significantly lower in older age group in both IGRA patients groups. Conclusions: This result suggests that T-SPOT.TB is more useful test for TB infection than QFT-GIT in old age group.