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多發性腎囊腫 가족례 2례 : 蜘蛛膜下出血을 동반한 1례 포함
최연극,김순덕,조동규,김능수,김용주 慶北大學校 醫科大學 1985 慶北醫大誌 Vol.26 No.4
We experienced two families of polycystic kidney disease. Of the two families one case was associated with subarachnoid hemorrhage. We have reviewed the literatures of familial occurrence of polycystic kidney disease, and of the case associated with subarachnoid hemorrhage.
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최연극,조현숙,조동규,정태훈,김능수 대한천식알레르기학회 1984 천식 및 알레르기 Vol.4 No.2
Development of hypersensitivity to polyurethane is one of important occupational problems, but the clinical report is still uncommon in Korea. We report here a case of polyurethane sensitive asthma and the changes of his lung functions with polyurethane challenges with and without cromoglycate premedjcation. A 39-yr-old furniture painter (Ht. 168cm, Wt. 59kg), who had been engaged in the job without any health problem for 10 years, started to use polyurethane in his painting for the first time in his life on Feb. 9 of 1984. One week after the use of polyurethane, he noticed rhinorrhea, headache, myalgia and chills, followed by shortness of breath and whitish productive cough, which were maximal during the work, especially in the afternoon. His colleagues had no problem in the same work. There was no birds, no animals at his home and no recent changes in his life. He felt inproved on weekends when he was away from work. Regimens for cold was administered, but symptoms rather aggravated. Two months later, he quitted the job because of his poor health. He lost about 7kg in the 2 months. Symptoms were almost completely freed when he visited the clinic in the early part of May 1984, one month after leaving the plant. No abnormality was found on his routine health checkup including blood cell count, blood chemistry, serum IgE level, urinalysis, sputum test, chest X-rays, ECG and pulmonary function tests. However, skin testing with a battery of common inhalant allergens showed strong positive on dermatophagoides, house dust, straw dust, white wool and wasp. The patient was asked to spray the painting material containing polyurethane for 1 hour in the plant as he had done. This challenge provoked rhinorrhea, eye discharge, shortness of breath and cough with profuse whitish sputum in 30 min. after he started spraying. With the challenge, FVC, FEV and FEF 25-75% decreased to 51.8%, 35.5%, and 23.6% of the prechallenge levels, respectively. These parameters were well responded to bronchodilator inhalation and recovered almost to the prechalienge levels 2 hours later. Among the parameters of lung function, the most sensitive one to reflect bronchial hypersensitiveness to polyurethane was Gaw/VL, which decreased to 8.3% of prechallenge level. Moreover, it did not recovered to prechallenge level till 2 hous after administration of bronchoidlator inhalation. Volume of thoracic gas (VTG) increased by 52% of prechallenge level, however, it recovered well to the prechaUenge level with the application of bronchodilator. Premedication of the patient with cromoglycate, 6 puffs just before the same challenge, compromise the symptoms and changes of parameters of pulmonary function. With the premedication, FVC, FEV, FEF25-75% and Gaw/VL were resulted as 81.5%, 47.0%, 21.4% and 27.3% of prechallenge levels, respectively. And the response to the bronchodilator was much better compared with that of without premedication. Those suggested that premedication with cromoglycate inhalation might have effectiveness in decreasing the bronchial hypersensitiveness to polyurethane in asthmatic person.
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조현숙,최연극,조동규,정태훈,김능수,이원식 대한천식알레르기학회 1984 천식 및 알레르기 Vol.4 No.2
Pirbuterol, a selective p, agonist, was evaluated for bronchodilator activity and side effects in 19 patients with a known history of bronchial asthma. Patients received 30 to 40mg orally (divided 3 or 4 times) a day for a period of 2 to 20 weeks. Pretreatment evaluation consisted of physical examination, pulmonary function test, ECG and blood chemistries which were then monitored after 2 to 4 weeks of multiple dosing with pirbuterol a greater than 30% increase over baseline FVC, FEV, and MMFR was noted in 6%, 12% and 23% respectively of the tested cases. This percentage of responders increased to 13%, 27% and 34% for FVC, FEV, and MMFR respectively after 8 to 12 weeks of treatment. Wheezes and rhonchi had compltely disappeared or improved after treatment in about one half of the cases. There were no significant changes in heart rate and ECG findings between pre and posttreatment, but systolic blood pressure decreased after the treatment. Side effect such as tremor, palpitation, epistaxis, skin rash, headache or slightly increased serum transaminase occurred transiently in 8 cases. Side effects were tolerated with continued pirbuterol use except in one patient with tremors who was relieved with dose reduction.
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조현숙,이관호,최연극,조동규,김능수 대한천식알레르기학회 1985 천식 및 알레르기 Vol.5 No.1
In order to evaluate the distribution of causative allergens in type I hypersensitivity, the results of allergy skin test (by prick method) with a battery of 74 common allergens done in 200 allergic cases were analizecL Ratio of male to female in the observed cases was 1: l. 1, and the age incidence was highest in the thirties followed by the twenties and forties. Most of the patients revealed positivity to more than one allergens on the skin test. Dusts and mites were the most common allergens with positive reactions in 79. 0% of 200 patients, followed by animal danders, pollens and molds with positivities of 58. 5%, 46. 0% and 24. 0% of the patients respectively. House dust and Dermatophagoides were major allergens among the dusts and mites, while maize and Chrysanthemum were most common among the pollens. Hairs of cats and rabbits were the leading animal danders on positivity, whereas Aspergillus had the highest positivity among the molds. Concerning the type of allergic diseases, dusts and mites were main causative allergens in asthma, rhinitis and conjunctivitis, however, animal dander was the leading allergen in urticaria. And the positivity to pollens was much higher in seasonal allergic conditions compared with that in perennial one s.
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단 clone 성 항체를 이용한 정상인의 흉선세포 및 말초혈액 T-림프구의 subsets
이관호,김능수,조동규,최연극 대한내과학회 1986 대한내과학회지 Vol.30 No.4
Human thymocyte and T-cell subsets were quantitated by using OKT4 and OKT8 monoclonal antibodies in thymuses from twelve immunologically healthy children and peripheral blood from twenty healthy adults. And also, a study was done to determine whether the OKT4+T8+ lymphocytes are present in peripheral blood of healthy persons. By the expression of only OKT4 and OKT8, there were four different subsets of thymocytes as OKT4+T8+, OKT4+T8-, OKT4-T8+ and OKT4-T8- with percentages of 63.9, 10.2, 15.6 and 10.2 respectively. The OKT4+ cells and OKT8+ cells in peripheral blood T-cells of healthy persons were present in 57.7% and 31.5%, respectively. The OKT4+T8+ cells were present in 14.5% of healthy human peripheral blood T-cells.
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