건강한 성인 남녀에서 Apolipoprotein A-Ⅰ 유전자 다형성과 혈중 지질농도와의 연관성

문재연,박현영,이종호,이종은,장양수,조은영,김원호,최성훈,고영국 대한심장학회 2004 Korean Circulation Journal Vol.34 No.12

Background and Objectives:Apolipoprotein A-I is the major lipoprotein constituent of high density lipoprotein in plasma. In this study, the role of two polymorphisms in the apo A-I gene was investigated on the serum lipid profiles and apo A-I levels in healthy men and women. Subjects and Methods:Blood samples were obtained from 417 subjects (M:F=169:248, mean age 47.2 years). The apo A-I genotypes were determined by SNP-IT assays using the SNPstream 25KTM system. Results:The frequencies of the A allele at the XmnI restriction site and position -75 bp were 0.25/0.23 and 0.19/0.17 in men and women, respectively. A strong positive linkage disequilibrium (D’=0.990) between two polymorphisms was detected. In men, the A allele at the XmnI restriction site was associated with significantly lower levels of triglyceride (p=0.028) compared to the G/G subjects, but no significant associations were detected between the G-75A polymorphism and any of the lipid traits examined. In women, each A allele for the XmnI restriction site and -75 bp polymorphisms were significantly associated with higher levels of apo A-I (p=0.032 and p=0.012). In the multiple regression analysis, the HDL, being a current drinker and the A allele of the XmnI restriction site polymorphism were major determinants of the serum apo A-I levels in women (R2=0.272, p<0.05). Conclusion:Our study showed that the A allele at XmnI restriction site in the apo A-I gene was associated with decreased triglyceride levels in men. Each A allele of two polymorphisms was associated with an elevated apo A-I level in women. 배경 및 목적: HDL 콜레스테롤의 구성 단백질인 Apolipoprotein (apo) A-Ⅰ의 유전자 다형성은 지질 대사에 영향을 미치는 것으로 알려져 있다. 본 연구는 심혈관계 질환이 없는 한국인 성인남녀에서 apo A-Ⅰ 유전자 다형성과 혈중 지질 농도 및 apo A-Ⅰ 농도와의 관련성을 분석하였다. 방 법: 417명의(남:여=169:248, 47.2±10.4세) 건강한 성인 남녀를 대상으로 본 연구를 진행하였다. apo A-Ⅰ유전자의 Xmnl 작용부위와 G-75A 유전자 다형성 분석은 단일염기확장(Single base extension) 방법의 SNPstream 25K system을 이용한 SNP-IT assay 방법으로 실시하였다. 결 과: Apo A-Ⅰ의 XmnI 제한효소 작용부위의 유전자다형성의 A 대립인자 발현빈도는 남자와 여자에서 각각 0.25, 0.23으로 서양인들의 0.12-0.14에 비해서 높았으며, G-75A 유전자 다형성의 A 대립인자의 빈도는 남자에서 0.19, 여자에서 0.17였고 두 유전자 다형성은 상호 강하게 연관되어 있었다(D’:0.990, p=0.004). 남성에서 XmnI 작용부위 유전자 다형성의 A대립인자군의 중성지방 농도는 128±71.1 mg/dL로 GG 유전형의 중성지방 농도 154±81.1 mg/dL보다 유의적으로 낮았으나(p=0.028), 여성에서는 통계적으로 유의한 차이가 없었다. 그러나 여성에서는 A대립인자군의 apoA-Ⅰ 농도는 GG 유전형에 비해 유의적으로 높았다. G-75A 유전자 다형성의 A대립인자군의 HDL 콜레스테롤 농도는 남녀모두에서 유전형에 따른 유의적인 차이는 없었다. 그러나 여성에서 A대립인자군의 apo A-Ⅰ 농도는 141.7±37.3 mg/dL으로 GG 유전형에 비해 유의적으로 높았다. 다중회귀분석결과 apo A-Ⅰ 유전자의 두 가지 유전자 다형성은 남성에서는 혈중 apo A-Ⅰ 농도와 유의한 관련이 없었으나 여성에서는 HDL 콜레스테롤 농도, 현재 흡연, XmnI 작용부위의 유전자 다형성의 A 대립인자는 apo A-Ⅰ 농도를 유의적으로 증가시키는 인자로 분석되었다. 결 론: 건강한 한국인 성인에서 Apo A-Ⅰ XmnI 작용부위 및 G-75A 유전자 다형성은 유전자 다형성은 남성에서는 중성지방농도와 여성에서는 apo A-Ⅰ농도와 유의한 관련성을 나타냈으며 이 두 유전자 다형성은 상호연관되어 있었다.

비중격에서 발생한 근상피종1예

문재연,정지윤,김정수,허성재 대한이비인후과학회 부산,울산,경남 지부회 2020 임상이비인후과 Vol.31 No.2

Myoepithelioma is a rare benign tumor of the salivary glands and involvement of the nasal cavity is extremely rare. A 53-year-old male visited our department with a complaint of left nasal obstruction. A round shaped, space occupying mass was observed in the left nasal cavity under nasal endoscopic examination. Endoscopic excision was performed and the mass was completely resected with clear resection margin. Histopathological examination showed that the tumor was consistent with myoepithelioma. The nasal obstruction was completely resolved after surgery and no recurrence has been observed during the follow up period of 24 months.

랜섬웨어 분석과 피해 최소화 방안

문재연,장영현 국제문화기술진흥원 2016 The Journal of the Convergence on Culture Technolo Vol.2 No.1

랜섬웨어는 미국을 중심으로 활동하는 악성코드였으나 기하급수적인 컴퓨터 보급과 사용자의 증가를 매개체 로 하여 전 세계적으로 급속하게 유포되었으며 최근에는 국내에서도 출현하었다. 초기 랜섬웨어는 E-Mail을 공격매 개체로 사용하였으며 스팸메일을 통해 파일을 클릭하도록 유도하는 방식이 가장 일반적이나 SNS나 스마트폰 메시지 를 통해서도 유포되고 있다. 현재는 한글 버전으로 국내 대형 커뮤니티 사이트들을 공격하는 등 국내에서도 많은 피 해가 증가하는 추세이다. 랜섬웨어는 파일을 암호화하여 사용자에게 경고 메시지를 출력하며, 추적상태를 유추하기 어려운 비트코인 가상 화폐를 통한 결제를 요구하면서 금전적인 피해를 유도한다. 본 논문에서는 랜섬웨어로 인한 피 해 사례 분석과 해결방안을 제시한다. Ransomware was a malicious code that active around the US, but now it spreads rapidly all over the world and emerges in korea recently because of exponential computer supply and increase in users. Initially ransomware uses e-mail as an attack medium in such a way that induces to click a file through the spam mail Pam, but it is now circulated through the smart phone message. The current trend is an increase in the number of damage, including attacks such as the domestic large community site by ransomware hangul version. Ransomware outputs a warning message to the user to encrypt the file and leads to monetary damages and demands for payment via bitcoin as virtual currency is difficult to infer the tracking status. This paper presents an analysis and solutions to damage cases caused by ransomware.

Anomalous Origin of a Right Coronary Artery With Extrinsic Compression Between the Great Vessels: The Intravascular Ultrasound Images

문재연,정해창,심두선,박형욱,홍영준,김주한,안영근,정명호 대한심장학회 2008 Korean Circulation Journal Vol.38 No.7

The anomalous origin of the right coronary artery is a rare condition, but it has clinical importance because there have been reports of nonfatal or fatal myocardial infarction and sudden death associated with exercise for patients with this anatomy. We describe here a patient for whom 64 channel multi-detector row computed tomography was useful to identify this anomaly, and intravascular ultrasound was used to evaluate the myocardial ischemia by visualizing the coronary lumen. The anomalous origin of the right coronary artery is a rare condition, but it has clinical importance because there have been reports of nonfatal or fatal myocardial infarction and sudden death associated with exercise for patients with this anatomy. We describe here a patient for whom 64 channel multi-detector row computed tomography was useful to identify this anomaly, and intravascular ultrasound was used to evaluate the myocardial ischemia by visualizing the coronary lumen.

Increase of Metabolic Syndrome Score is an Independent Determinant of Increasing Pulse Pressure

문재연,박성하,안철민,조정래,박찬미,고영국,최동훈,정명호,장양수,정남식 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.1

Purpose: The objective of this study was to determine whether the progressive increase of metabolic syndrome (MetS) score, the number of components of MetS, is correlated significantly with increasing pulse pressure (PP). Materials and Methods: 4,034 subjects were enrolled from the Cardiovascular Genome Center of Yonsei University (M:F=2344: 1690, 55.2±10.5). Most of the study population were recruited from hypertension clinics, controlled with medications according to JNC7 guidelines. The Asian modified criteria of MetS were applied and MetS score was estimated. The HOMA index for insulin resistance, cholesterol profiles, and anthropometric measurements were assessed. Results: Among 4034 participants, 1690 (41.9%) were classified as MetS. Progressive increase in PP was demonstrated for increasing components of the MetS score. Multiple linear regression analysis with PP as the dependent variable showed that age (β=0.311, p<0.001), MetS score (β=0.226, p<0.001), male gender (β=-0.093, p <0.001) and HOMA index IR (β=0.033, p=0.03) are significantly associated with PP (R2=0.207, p<0.001). Conclusion: The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.

[교육 교수 탐구] 연구성학습을 어떻게 지도할것인가

문재연 길림성민족사무위원회 2004 중국조선어문 Vol.133 No.-

STAR FORMATION ACTIVITY OF GALAXIES UNDERGOING RAM PRESSURE STRIPPING IN THE VIRGO CLUSTER

문재연,황호성,Myung Gyoon Lee,정애리,Hyein Yoon,Jong Chul Lee 한국천문학회 2021 Journal of The Korean Astronomical Society Vol.54 No.1

We study galaxies undergoing ram pressure stripping in the Virgo cluster to examine whether we can identify any discernible trend in their star formation activity. We first use 48 galaxies undergoing different stages of stripping based on HⅠ morphology, HⅠ deficiency, and relative extent to the stellar disk, from the VIVA survey. We then employ a new scheme for galaxy classification which combines HⅠ mass fractions and locations in projected phase space, resulting in a new sample of 365 galaxies. We utilize a variety of star formation tracers, which include g - r, WISE [3.4]-[12] colors, and starburstiness that are defined by stellar mass and star formation rates to compare the star formation activity of galaxies at different stripping stages. We find no clear evidence for enhancement in the integrated star formation activity of galaxies undergoing early to active stripping. We are instead able to capture the overall quenching of star formation activity with increasing degree of ram pressure stripping, in agreement with previous studies. Our results suggest that if there is any ram pressure stripping induced enhancement, it is at best locally modest, and galaxies undergoing enhancement make up a small fraction of the total sample. Our results also indicate that it is possible to trace galaxies at different stages of stripping with the combination of HⅠ gas content and location in projected phase space, which can be extended to other galaxy clusters that lack high-resolution HⅠ imaging.

강독교수에서의 열독지도

문재연 길림성민족사무위원회 2002 중국조선어문 Vol.118 No.-

승모판막 치환술 후 뒤늦게 나타나는 기능성 삼첨판 폐쇄부전의 빈도 및 예측인자

문재연,심지영,안철민,심재민,권성우,최의영,정욱진,하종원,임세중,장병철,정남식,조승연 한국심초음파학회 2005 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.13 No.3

The Utility of Multi-detector Row Spiral CT for Detection of Coronary Artery Stenoses

문재연,정남식,최병욱,최규옥,서혜선,고영국,강석민,하종원,임세중,장양수,심원흠,조승연 연세대학교의과대학 2005 Yonsei medical journal Vol.46 No.1