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김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
급성 조증에서 기분안정제와 리스페리돈의 병합 투여 효과 : 다기관 개방연구
김광수,배치운,윤진상,김영훈,이양현,지익성,이철,송혜경,최성구,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2
Ohjective : The primary purpose of this study was a replication of the effectiveness and tolerability of rispehdone in the treatment of patients with acute mania in very larger cohon in naturalistic treatment setting to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to Asian population. Methods : A total of 909 patients with DSM-TV criteria of bipolar disorder current manic and hypomanic episode, entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson-Angus Rating Scale (SARS) were measured at baseline and weeks 1, 3 and 6, for the assessment of effectiveness and extra-pyramidal symptom (EPS). Results : This study showed statistically significant reduction of scores on the YMRS and CGI-s (mean change=-23.5±11.8, p<0.0001 ; mean change=-2.7±1.5, p<0.0001, respectively) from the baseline to the endpoint (week 6). Number of patients with 50% reduction or more in the YMRS and CGI-s scores was 693 (77.8%) and 630 (70.7%) at endpoint, respec-tively. There were no statistically significant increments of scores on SARS. Risperidone was generally well tolerated. Conclusion : The present larger open study demonstrates that hsperidone add-on therapy is effective and tolerable in treat-ment of bipolar disorder, replicating results in various controlled and uncontrolled studies from Western countries.
Ku, Hye Jin,Kim, Hye Young,Kim, Hyeong Hoe,Park, Hee Ju,Cheong, Jae Hun WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.1
<P>To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon cooperative activation.</P>
( Hye-jin Ku ),( You-tae Kim ),( Ju-hoon Lee ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.5
Although the genus Leuconostoc, generally found in various fermented foods, has often been suggested to be a novel probiotic for food fermentation and health promotion, the strains in this genus showed low acid tolerance and low osmotic stress resistance activities, which are required for survival during food fermentation events. Recently, a novel species of Weissella, W. jogaejeotgali FOL01<sup>T</sup> (= KCCM 43128 = JCM 30580), was isolated from Korean fermented clams. To determine the genomic features of this new species, its genome was completely sequenced and analyzed. The genome consists of a circular chromosome of 2,114,163 bp of DNA with a G+C content of 38.8%, and the plasmid pFOL01 consists of 35,382 bp of DNA with a G+C content of 39.1%. The genome analysis showed its potential for use in food fermentation and osmotic stress resistance abilities for processing in food industries. In addition, this strain was predicted to have acid tolerance and adhesion to the mucosal layer for survival and colonization in the gut. Subsequent experiments substantiated these abilities, suggesting that W. jogaejeotgali may have probiotic potential and a high survival rate during food fermentation. Therefore, it may be suitable as a novel probiotic strain for various applications in food industries.
( Hye Jin Ku ),( Ju Hoon Lee ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.6
Metagenomic analysis of the human intestinal microbiota has extended our understanding of the role of these bacteria in improving human intestinal health; however, a number of reports have shown that current total fecal DNA extraction methods and 16S rRNA universal primer sets could affect the species coverage and resolution of these analyses. Here, we improved the extraction method for total DNA from human fecal samples by optimization of the lysis buffer, boiling time (10 min), and bead-beating time (0 min). In addition, we developed a new longrange 16S rRNA universal PCR primer set targeting the V6 to V9 regions with a 580 bp DNA product length. This new 16S rRNA primer set was evaluated by comparison with two previously developed 16S rRNA universal primer sets and showed high species coverage and resolution. The optimized total fecal DNA extraction method and newly designed long-range 16S rRNA universal primer set will be useful for the highly accurate metagenomic analysis of adult and infant intestinal microbiota with minimization of any bias.
Investigation of persistent infection with bovine viral diarrhea in Korean native cattle
Hye-Young Jeoung(Hye-Young Jeoung),Eun-Yong Lee(Eun-Yong Lee),Se-Jin Park(Se-Jin Park),Hyung-Woo Kang(Hyung-Woo Kang),Ji-Young Park(Ji-Young Park),Kyoung-Ki Lee(Kyoung-Ki Lee),Bok-Kyung Ku(Bok-Kyung K 한국예방수의학회 2022 한국예방수의학회 학술대회자료집 Vol.2022 No.-
( Hye-jin Ku ),( You-tae Kim ),( Ju-hoon Lee ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.7
To understand the formation of initial gut microbiota, three initial fecal samples were collected from two groups of two breast milk-fed (BM1) and seven formula milk-fed (FM1) infants, and the compositional changes in gut microbiota were determined using metagenomics. Compositional change analysis during week one showed that Bifidobacterium increased from the first to the third fecal samples in the BM1 group (1.3% to 35.1%), while Klebsiella and Serratia were detected in the third fecal sample of the FM1 group (4.4% and 34.2%, respectively), suggesting the beneficial effect of breast milk intake. To further understand the compositional changes during progression from infancy to childhood (i.e., from three weeks to five years of age), additional fecal samples were collected from four groups of two breast milk-fed infants (BM2), one formula milk-fed toddler (FM2), three weaning food-fed toddlers (WF), and three solid food-fed children (SF). Subsequent compositional change analysis and principal coordinates analysis (PCoA) revealed that the composition of the gut microbiota changed from an infant-like composition to an adult-like one in conjunction with dietary changes. Interestingly, overall gut microbiota composition analyses during the period of progression from infancy to childhood suggested increasing complexity of gut microbiota as well as emergence of a new species of bacteria capable of digesting complex carbohydrates in WF and SF groups, substantiating that diet type is a key factor in determining the composition of gut microbiota. Consequently, this study may be useful as a guide to understanding the development of initial gut microbiota based on diet.
어린이집 교사의 평가인증 참여 경험에 따른 영유아 식습관지도의 차이
구혜진(Hye Jin Ku),박선혜(Seon Hye Park) 한국보육학회 2020 한국보육학회지 Vol.20 No.1
본 연구는 어린이집 교사의 평가인증 참여 경험에 따른 영유아 식습관지도의 차이를 알아보는데 목적이 있다. 연구 대상은 경기도 소재 어린이집 교사 295명이고, 설문을 통해 자료를 수집하였다. 연구 도구는 김은희(2004)의 유치원 점심 급식 운영에 따른 식습관지도에 관한 연구에 사용한 질문지와 여윤재와 권수연(2015)의 어린이집 급식시간 중 영유아의 식사행동 실태 및 보육교사의 식사지도 방법에 관한 연구에 사용한 질문지를 수정 · 보완하여 사용하였다. 수집한 자료는 IBM SPSS WIN 25.0을 이용하여 빈도와 백분율을 산출하고 t-검증 및 카이제곱(χ² )검증을 이용하여 분석하였다. 연구 결과로 영유아 식습관지도빈도와 방법은 어린이집교사의 평가인증 참여 경험에 따라 차이가 있는 항목이 있었고, 평가인증 참여 경험에 따라 통계적으로 유의미한 차이가 나타났다. 이와 같은 연구 결과를 토대로 평가인증 참여 경험이 식습관지도에 도움이 된다는 결론을 도출하였다. 또한 평가인증지표 중에 영유아 식습관지도와 관련된 부분이 건강과 안전에 집중되어 있지만 평가인증 참여 경험이 있는 어린이집 교사가 평가인증 참여 경험이 없는 교사와 비교하였을 때, 평가인증 경험이 있는 경우가 음식의 필요성을 강조하고 몸에 좋은 음식을 조금 더 알 수 있게 하였을 뿐만 아니라 감사한 마음으로 스스로 식사 할 수 있게 지도하는 것을 확인할 수 있었다. Objective: The purpose of this study is to check the differences of daycare center teacher’s eating habits guidance according to the accreditation experiences of the teachers. Methods: For this purpose, a survey was conducted on 295 daycare center teachers in Gyeonggi-do. Based on the questionnaire developed by Kim(2004) for the study on the teaching of eating habits through the kindergarten meal program, it was modified according to the purpose of this study. And based on the research concept of Yeo and Kwon(2015), it was modified to suit the purpose of this study. The data collected in this study were analyzed using the IBM SPSS WIN 25.0 program. To calculate the basic statistics for each study subject, statistical values were conducted by frequency and percentage. T-test was verified with the frequency of eating habits guidance and Chi-verification was verified with the method of eating habits guidance. Results: The results showed that the frequency and method of eating habits guidance for toddlers and children differed according to the accreditation experiences of teachers. Conclusion/Implications: The above results showed that the accreditation experience is helpful in guiding eating habits for toddlers and children. In particular, teachers who experienced the accreditation emphasized the necessity of food and appreciation for food when guiding eating habits for toddlers and children.