자율신경계의 활성도 측정을 위한 Data Acquisition System의 개발 및 임상응용

신동구,박종선,김영조,심봉섭,이상학,이준하 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Power spectrum analysis method is a powerful noninvasive tool for quantifying autonomic nervous system activity. In this paper, we developed a data acquistion system for estimating the activity of the autonomic nervous system by the analysis of heart rate and respiratory rate variability using power spectrum analysis. Materials and methods: For the detection of QRS peak and measurement of respiratory rate from patient's ECG, we used low-pass filter and impedance method respectively. This system adopt an isolated power for patient's safety. In this system, two output signals can be obtained: R-R interval(heart rate) and respiration rate time series. Experimental ranges are 30∼240 BPM for ECG and 15∼80 BPM for respiration. Regults: The system can acquire two signals accurately both in the experimental test using simulator and in real clinical setting. Conclusion: The system developed in this paper is efficient for the acquisition of heart rate and respiration signals. This system will play a role in research area for improving our understanding of the pathophysiologic involvement of the autonomic nervous system in various disease states.

성인남성에서 심박동수 변이를 이용하여 측정한 자율신경계 활성도와 하부요로증상의 관계 분석

김일한,김진태,이수형,김세중,김영수,최종보 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.5

Purpose: Lower urinary tract symptoms (LUTS) are common, but their etiology and mechanism are still unclear. We believe that changes in autonomic nervous system (ANS) activity may be contributory, because the lower urinary tract is regulated through the sympathetic and parasympathetic nervous systems. Heart rate variability (HRV) is a tool by which autonomic nervous function can be measured, and therefore we measured and compared parameters of heart rate variability between men with LUTS and healthy subjects. Materials and Methods: Thirty-nine men with LUTS [mean age 56.9±8.9 years old, International Prostate Symptom Score (IPSS)≥8] and 23 healthy men (mean age 57.0±1.8 years old, IPSS<8) were included in the present study. HRV is known to be a useful tool for evaluating ANS activity, and we measured and compared HRV in the resting state. Results: The standard deviation of the N-N interval (SDNN) and total power (TP) for patients with LUTS revealed no significant differences from those in the control group. On frequency domain analysis, there was evidence of decreased high frequency (HF) in patients with LUTS (p< 0.05), but there were no significant differences in other parameters such as heart rate, square root of the mean squared differences of successive N-N intervals (RMSSD), very low frequency (VLF), low frequency (LF), or the LF/HF ratio. Conclusions: Patients with LUTS exhibited different HRV parameters compared with normal controls. Their decreased HF indicated that they may have had some kind of disease or imbalance in the autonomic nervous system, which may distinguish patients with LUTS from healthy men. Purpose: Lower urinary tract symptoms (LUTS) are common, but their etiology and mechanism are still unclear. We believe that changes in autonomic nervous system (ANS) activity may be contributory, because the lower urinary tract is regulated through the sympathetic and parasympathetic nervous systems. Heart rate variability (HRV) is a tool by which autonomic nervous function can be measured, and therefore we measured and compared parameters of heart rate variability between men with LUTS and healthy subjects. Materials and Methods: Thirty-nine men with LUTS [mean age 56.9±8.9 years old, International Prostate Symptom Score (IPSS)≥8] and 23 healthy men (mean age 57.0±1.8 years old, IPSS<8) were included in the present study. HRV is known to be a useful tool for evaluating ANS activity, and we measured and compared HRV in the resting state. Results: The standard deviation of the N-N interval (SDNN) and total power (TP) for patients with LUTS revealed no significant differences from those in the control group. On frequency domain analysis, there was evidence of decreased high frequency (HF) in patients with LUTS (p< 0.05), but there were no significant differences in other parameters such as heart rate, square root of the mean squared differences of successive N-N intervals (RMSSD), very low frequency (VLF), low frequency (LF), or the LF/HF ratio. Conclusions: Patients with LUTS exhibited different HRV parameters compared with normal controls. Their decreased HF indicated that they may have had some kind of disease or imbalance in the autonomic nervous system, which may distinguish patients with LUTS from healthy men.

자율신경질환의 척도

조은빈,박기종 대한신경과학회 2021 대한신경과학회지 Vol.39 No.-

The autonomic nervous system plays an important role in maintaining homeostasis mediated by the parasympathetic, sympathetic and enteric systems. Autonomic failure adversely affects body function and may increase morbidity and mortality. Therefore, the scoring systems, such as Ewing’s classification and Composite Autonomic Scoring Scale (CASS), were developed to detect and quantify autonomic deficits, primarily focusing on the cardiovascular reflex system. Autonomic disorders manifest with a myriad of symptoms resulting from the dysfunction of the gastrointestinal, genitourinary, secretomotor, pupillomotor systems as well as cardiovascular system. Several self-report questionnaires, such as Composite Autonomic Symptom Scale (COMPASS), Scale for Outcomes in Parkinson’s disease for Autonomic Symptoms (SCOPA-AUT), Survey of Autonomic Symptom (SAS), were also used to support to detect various signs and symptoms of autonomic dysfunction in clinical settings. In this review, we introduce clinically useful assessment scales in autonomic nervous system disorders.

Comparing the Effects of Distilled Rehmannia glutinosa, Wild Ginseng and Astragali Radix Pharmacopuncture With Heart Rate Variability (HRV): A Randomized, Sham-controlled and Double-blind Clinical Trial

Yook Taehan,Yu Jungsuk,Lee Hwiyong,Song Beomyong,김락형,Roh Jungdu,Shin Jinchul,Lim Sungtaek 사단법인약침학회 2009 Journal of Acupuncture & Meridian Studies Vol.2 No.3

This study compared the effects of distilled Rehmannia glutinosa, Wild Ginseng and Astragali Radix pharmacopuncture on the autonomic nervous system and heart rate variability. The purpose of the trial was to observe the influence distilled Astragali Radix, Wild Ginseng and Rehmannia glutinosa pharmacopuncture have on the autonomic nervous system. 120 healthy male volunteers were divided into four groups, which consisted of three experimental groups and a control group. This study was a randomized, placebo-controlled, double-blind clinical trial. Volunteers in experimental groups were underwent pharmacopuncture at GB21 (Kyonjong), and volunteers in the control group were injected with normal saline at GB21 (Kyonjong). Heart rate variability was measured seven times: before and after injection, every 5 minutes for 30 minutes. The result was distilled Rehmannia glutinosa, Wild Ginseng and Astragali Radix pharmacopuncture in healthy adult males tended to activate the autonomic nervous system, particularly the sympathetic nervous system. This study compared the effects of distilled Rehmannia glutinosa, Wild Ginseng and Astragali Radix pharmacopuncture on the autonomic nervous system and heart rate variability. The purpose of the trial was to observe the influence distilled Astragali Radix, Wild Ginseng and Rehmannia glutinosa pharmacopuncture have on the autonomic nervous system. 120 healthy male volunteers were divided into four groups, which consisted of three experimental groups and a control group. This study was a randomized, placebo-controlled, double-blind clinical trial. Volunteers in experimental groups were underwent pharmacopuncture at GB21 (Kyonjong), and volunteers in the control group were injected with normal saline at GB21 (Kyonjong). Heart rate variability was measured seven times: before and after injection, every 5 minutes for 30 minutes. The result was distilled Rehmannia glutinosa, Wild Ginseng and Astragali Radix pharmacopuncture in healthy adult males tended to activate the autonomic nervous system, particularly the sympathetic nervous system.

극초단파치료기를 사용하는 물리치료실의 환경이 물리치료사의 인체자율신경계에 미치는 영향

신한기 ( Han Ki Shin ),이태규 ( Tae Kyu Lee ),전재윤 ( Je Yoon Jun ),김주승 ( Ju Seung Kim ),강종호 ( Jong Ho Kang ) 대한물리의학회 2015 대한물리의학회지 Vol.10 No.1

PURPOSE: The purpose of this study is to investigate the effect of the physical therapy treatment room environment using microwave diathermy on the autonomic nervous system of human body. METHODS: Participants were 24 healthy adults. Standard deviation of all normal R-R intervals(SDNN), root mean square of successive differences(RMSSD), low frequency(LF), high frequency(HF), LF/HF ratio were compared in microwave irradiation and non-irradiation group. Data were analyzed in Wilcoxon’s signed-ranks test and Mann-Whitney U test. RESULTS: Standard deviation of all normal R-R intervals (SDNN), root mean square of successive differences (RMSSD), low frequency(LF), high frequency(HF), LF/HF ratio were not significantly different in microwave irradiation group. Standard deviation of all normal R-R intervals(SDNN), root mean square of successive differences (RMSSD), low frequency(LF), high frequency(HF), LF/HF ratio were not significantly different in microwave non- irradiation group. Standard deviation of all normal R-R intervals(SDNN), root mean square of successive differences (RMSSD), low frequency(LF), high frequency(HF), LF/HF ratio were not significantly different between two groups. CONCLUSION: There was no significant change in the sympathetic nervous system and parasympathetic nervous system regardless of the presence of microwave irradiation. There was no significant change in the autonomic nervous system adaptability regardless of the presence of microwave irradiation. According to this study, microwave diathermy does not have significant effect on the autonomic nervous system. Future study is necessary to investigate the long term effect of the physical therapy treatment room environment using microwave diathermy on the autonomic nervous system of the human body.

심박변이도(Heart Rate Variability) 측정을 통한 다한증(多汗症)환자의 자율신경계(自律神經系)기능 평가

이건영,이형구,정승기,정희재,Lee, Kun-Young,Lee, Hyung-Koo,Jung, Sung-Ki,Jung, Hee-Jae 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1

Objectives : Essential hyperhidrosis is a socially and occupationally disabling disorder. There are many suggestions that hyperhidrosis is associated with the autonomic nervous system. This study was designed to investigate the autonomic nerve system the patients with hyperhidrosis. Methods : 348 palmar and plantar hyperhidrosis patients and 20 systemic hyperhidrosis patients in the ambulatory care were investigated. All patients were inspected at the first medical examination, using the PSA of HRV. HRV was measured for 5 minutes after 5 minutes' bed rest. We checked the frequency domain analysis of HRV (i.e. TP, VLF, LF, HF and LF/HF) which were transformed into natural logarithm of patients against the standard measures of the HRV components. Then, we compared the means of patients with means and highest values of in the normal range of Koreans 1) between the patients with palmar and plantar hyperhidrosis and the healthy controls and 2) between the patients with the systemic hyperhidrosis and healthy controls, by the frequency domain analysis of heart rate variability (HRV), respectively. We then compared the results between 1) and 2). Results : The values of natural logarithmic measures of LF/HF ratio in the patients with palmar and plantar hyperhidrosis we examined were significantly higher than the values of healthy controls, but those in the patients with systemic hyperhidrosis were not higher. Conclusion : This study suggests that the autonomic nervous function did not simply increase but that the balance between sympathetic and parasympathetic nervous function did matter in patients with palmar and plantar hyperhidrosis. This balance included that the sympathetic nervous function aggravated comparatively with parasympathetic nervous function. On the other hand, we couldn't find any significance of the patients with the systemic hyperhidrosis as for the autonomic nervous function.

주사피부염의 최신 연구 동향 및 더욱 효과적인 한방치료를 위한 제언 - 자율신경 기능조절을 중심으로 -

이은경,김병현,홍예은,이희재,김규석,남헤정,김윤범 대한한방안이비인후피부과학회 2024 한방안이비인후피부과학회지 Vol.37 No.3

Objectives : The aim of this study is to explore the potential of oriental medicine in managing rosacea throug h the regulation of the autonomic nervous system. Methods : We reviewed studies on the pathophysiology and medical treatment (both western and oriental medicine) of rosacea, as well as the relationship between rosacea and the autonomic nervous system, using four databases: PubMed, OASIS, RISS, and NDSL. Results : Rosacea is a chronic recurrent inflammatory disease characterized by symptoms such as facial flushing, inflammatory papules, and pustules. In Western medicine, symptomatic treatments like vasoconstric tors, doxycycline, and anti-inflammatory drugs are primarily used. According to the pathophysiological mechanisms of rosacea, the autonomic nervous system is closely related, particularly with sympathetic overactivity causing vasodilation and local inflammation in rosacea patients. Additionally, recent studies report that rosacea patients frequently exhibit neuropsychiatric symptoms such as anxiety, depression, and insomnia, which are closely linked to autonomic dysfunction and contribute to the worsening of skin symptoms. However, current studies on the use of oriental medicine for rosacea focus mainly on anti-inflammatory effects at the local level, similar to conventional treatments. Conclusions : Based on the close involvement of the autonomic nervous system in the pathophysiological mechanisms of rosacea and numerous studies showing that oriental medicine can effectively regulate autonomic function, applying such treatments to rosacea patients may improve not only skin symptoms but also the frequently associated neuropsychiatric symptoms like anxiety, depression and insomnia.

Effects of Juniper Essential Oil on the Activity of Autonomic Nervous System

Jong-Seong Park 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.3

This study was designed to clarify the effect of juniper essential oil on the autonomic nervous system. Blood pressure and heart rate variability (HRV) reflecting autonomic nervous system activity were measured. The systolic and diastolic blood pressure were decreased by inhalation of juniper essential oil. High frequency (HF) power level, an indicator of parasympathetic nervous system activity was increased in the stimulation of juniper essential oil. High frequency/low frequency (HF/LF) ratio, an indicator of sympathetic nervous system activity was decreased by the juniper essential oil. These results suggest that juniper essential oil has a modulatory effect on the autonomic nervous system activity.

심박수 변이도(Heart Rate Variability)를 이용해 고찰한 자율신경실조증 환자의 치험례

김대필 ( Dae Feel Kim ),최유석 ( You Seok Choi ),박영회 ( Young Hoi Park ),금동호 ( Dong Ho Keum ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.3

Objectives: This study was performed to evaluate the effect of acupuncture treatment on the imbalance of autonomic nervous system in the patient with dysfunction of autonomic nervous system by heart rate variability. Methods: The patient was hospitalized Dong-guk univesity Bundang oriental medicine hospital from 20th, Oct., 2003 to 25th, Oct., 2003. To evaluate the effect of acupuncture treatment, the patient was treated on the Back-shu points with acupuncture and tested immediately before and after acupuncture treatment by heart rate variability. Results and Conclusions: In this case, acupuncture treatment on the Back-su points was able to suppress the sympathetic activities and enhance the parasympathetic activities in the patient with dysfunction of autonomic nervous system. So it is suggested that acupuncture treatment was able to improve the imbalance of autonomic nervous system.

요양시설에 거주하는 치매노인을 위한 웃음요법과 음악요법이 우울과 자율신경활성도에 미치는 영향

채경숙 기초간호학회 2015 Journal of korean biological nursing science Vol.17 No.3

Purpose: This study was to identify the effects of laughing and music therapy on depression and the activities of the autonomic nervous system in the elderly with dementia. Methods: The participants were 61 seniors over 65 years old with dementia, admitted to nursing homes. Twenty of them received laughing therapy, 21 received music therapy and 18 were in the control group. A total of 59 patients’ data were analyzed. Depression was measured by Cornell Scale for Depression in Dementia tool, and the activities of the autonomic nervous system by the heart rate variability measuring device. The data were analyzed by frequency and percentage, Chi-square test, t-test, ANOVA, and Tukey test. Results: The depression of the music therapy group was more significantly decreased than the laughing therapy group and the control group. The activities of the autonomic nervous system of the laughing therapy group were more significantly increased than the music therapy group. The magnitude of the activities of the autonomic nervous system of the laughing therapy group were more significantly increased than the music therapy group. Conclusion: This study showed that music therapy was more effective than laughing therapy for the decrease of depression. Laughing and music therapy were more effective than in the control group for increasing the activities of the para-sympathetic nervous system and decreasing the activities of the sympathetic nerve system.