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네트워크 약리학을 이용한 소양증을 동반한 피부 염증에 대한 蒼朮 및 厚朴의 잠재적 치료기전 탐색
홍예은,서광일,김병현,김규석,남혜정,김윤범 대한한방안이비인후피부과학회 2023 한방안이비인후피부과학회지 Vol.36 No.4
Objectives : To investigate the active compounds and therapeutic mechanisms of Atractylodes Lancea(Thunb.) D.C. and Magnolia Officinalis Rehder et Wilson in the treatment of dermatitis accompanied by pruritus, as well as their potential to complement or replace standard drugs. Methods : We conducted the network pharmacological analysis. We selected effective ingredients among the active compounds of research target herbs. Then we explore pathway/terms of the common target proteins among research target herbs, fexofenadine and disease. Results : We selected 9 active compounds are selected from Atractylodes lancea and identified 231 target proteins. Among them, 74 proteins are associated with inflammatory skin diseases that cause pruritus. These proteins are involved in various pathways including, ‘Nitric-oxide synthase regulator activity’, ‘Hydroperoxy icosatetraenoate dehydratase activity, Aromatase activity’, ‘RNA-directed DNA polymerase activity’, ‘Arachidonic acid metabolism’, ‘Peptide hormone processing’, ‘Chemokine binding’ and ‘Sterol biosynthetic process’. Additionally, coregenes are involved in ‘IL-17 signaling pathway’. Similarly, we selected 2 active compounds from Magnolia officinalis and identified 133 target proteins. Among them, 33 proteins are related to inflammatory skin diseases that cause pruritus. These proteins are primarily involved in ‘Vascular associated smooth muscle cell proliferation’ and ‘Arachidonic acid metabolism’. There is no significant difference between the pathways in which coregenes are involved. Conclusions : It is expected that Atractylodes Lancea will be able to show direct or indirect anti-pruritus and anti-inflammatory effects on skin inflammation accompanied pruritus through suppressing inflammation and protecting skin barrier. Meanwhile, it is expected that Magnolia Officinalis will only be able to show indirect anti-inflammation effects. Therefore, Atractylodes Lancea and fexofenadine are believed to complement each other, whereas Magnolia Officialinalis is expected to provide supplementary support on skin disease.
공간 속 독립 오브제로서 배치된 칸의 벽난로에 대한 연구
홍예은(Hong, Ye-Eun),남성택(Nam, Sung-Taeg) 대한건축학회 2020 대한건축학회논문집 Vol.36 No.4
The fireplace has been inseparable from the wall. Therefore, the fireplace, which is independently revealed in the living room, is unusual and exceptional. According to the concept of “Served-Servant space” by Louis Kahn, “Servant space” is conceived as an inhabited thick wall and completely separated from “Served space.” The fireplace is an apparent servant element, but in Fisher house, it is considered as the single, remarkable and major element composing the house. Paradoxically, this scene of the living room is in conflict with Kahn’s ideas on “Servant space.” This study sheds new light on the independent fireplace in the conflicting relationship and suggests the similarities with the contemporary cases-Le Corbusier & Philip Johnson-in terms of the stand-alone “Servant element.” In the end, the independent fireplace of the Fisher house has transformed into an essential element of the house, as Kahn said that “I feel it[fireplace] represents the presence of a man and therefore is of home.”
홍예은(Hong, Ye-Eun),남성택(Nam, Sung-Taeg) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.1
This study is based on visitor"s praise that Genel house is far superior to the Weiss house. Two of houses has manu of similarities because of contemporaneity, on the contrary, Genel house has a unique fireplace that is triangle shape and stands on beyond orthogonal position. The paper aims to reveal the significance of fireplace, like objet, in Genel House and further in Kahn"s architecture. Also, Weiss house"s outdoor fireplace is related to Genel"s indoor fireplace in terms of beyond orthogonality. In Weiss, fireplace is unificated to the structure of house, however, in Genel, fireplace is completely separated with the structure and become a main. In the same logical connection, the fireplace of Genel is similar to Fisher"s, in the end it reaches at the main spaces freely positioned in Dominican Motherhouse. Kahn"s compositional collage resembles Le Corbusier"s free plan.
건축위원회 심의 관련 정책추진 동향 연구 - 최근 10개년 국토교통부 보도자료를 중심으로 -
홍예은(Hong, Ye-Eun),김민지(Kim, Min-Ji),이여경(Lee, Yeo-Kyung) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.2
This paper aims to determine the recent policy enforcement trends of the Ministry of Land, Infrastructure and Transport (MOLIT) related to the architectural deliberation by analyzing MOLIT’s press releases. The “objects of deliberation” were the main subject that accounted for the largest portion (40.9%) of them. Specifically, press releases related to the objects of deliberation were mainly reported on the expansion, and the causes of the policy enforcement were not only follow-up actions for safety accidents but also introduction of new systems. Furthermore, 20.9% of the entire data was counted for cases of adding on to objects of deliberation due to “special cases and deregulation.” This trend of expansion on objects of deliberation continues to occur, thus it is necessary to enforce strategic policies to reasonably downsize the objects of deliberation so that they are not excessively burdensome to the architectural committee.
홍선화,강용훈,김민정,김예은,김유진,김지혜,윤영서,정유림,김옥진 한국동물매개심리치료학회 2017 한국동물매개심리치료학회지 Vol.6 No.1
As the population ages, the number of households raising companion animals is increasing. Companion animal industry has recently been diversified through a combination of various industries such as beauty, rest, and insurance, and the share of this industry in the economy is gradually increasing. Dandruid keratoses, ticks, and various pathogenic bacteria are parasitized on the skin and hair of a dog to damage the hair and cause skin diseases. The purpose of this study was to investigate the effects of natural ingredients on the oil and moisture content of dog skin when using natural shampoos and using these shampoos. In this study, we measured the water content of four poodles of 1 year and 4 years old. The natural shampoo used in 4 rats was prepared and used directly. The results of this study showed that the water content in the forelimb of the experimental dog was almost unchanged when using the ordinary shampoo, but it increased with the use of the natural shampoo. Especially, when using natural shampoo for 3 weeks, it was confirmed that the water content of ordinary shampoo increased about 55.71% over 3 weeks. On the other hand, when using a general shampoo, the water content of the neck of the experimental dog was almost unchanged, and even when using the natural shampoo, the moisture content was almost unchanged. These results suggest that natural shampoos will have a better effect on maintaining the moisture content of companion animals compared to ordinary shampoos.
음성 중심 리모컨 보이스틱(Voistick)의 음성 발화 추이 및 음성 기능 만족도 분석
홍민선,김진경,이후승,차명섭,양예은,이기훈,김영훈,유재상,유창민 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
IPTV 서비스 리모컨에 음성 사용자 인터페이스 (Voice User Interface)가 탑재됨에 따라, 사용자는 음성을 경유해 실시간 TV 채널과 VOD 콘텐츠를 자유자재로 탐색할 수 있게 되었다. 본 연구는 음성 발화를 유도하는 기술과 형태를 리모컨에 적용하여, 해당 리모컨을 통한 음성 발화 추이와 음성 사용성, 만족도 분석을 목적으로 한다. 기술 연구를 통하여 IPTV 서비스 내 음성 사용성을 높일 수 있는 음성인식 자동화 기술을 리모컨에서 구현하고, 음성 중심의 하드웨어 디자인을 적용하여 음성 중심 리모컨 보이스틱(Voistick)을 개발하였다. 화면과 연계되는 보이스틱 리모컨의 초기 사용자 경험을 개선한 후, 자사 IPTV 서비스 사용자 2,256 명에게 배포하여 일정기간 사용하게 하여 음성 발화 추이를 분석하였다. 이후 설문을 통해 보이스틱 음성 기능에 대한 의견과 만족도를 수집하여, 텍스트 분석으로 음성 기능과 관련한 주요 이슈를 도출하고 대응 표본 T 검정을 통해 음성 기능 만족도를 분석하였다. 연구 결과, 보이스틱은 기존 리모컨보다 음성 발화를 평균적으로 더 유도하는 것으로 나타났다. 음성 기능 만족도 또한 보이스틱이 기존 리모컨보다 높은 것으로 나타났으나, 주관식 설문의 텍스트 분석에서는 신규로 탑재한 음성인식 자동화는 기술은 안정화가 필요하고, 음성 인식률 및 서비스 고도화가 수반되어야 함을 확인하였다.