Acylthiocholine의 합성

정두희,이지현,박유미,정대일,곽문정,신영주 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.2

Choline esters that are used with substrate of EE-AChE-catalyzed hydrolyses were synthesized by two methods. 2-Chloroethyl thiohexanoate 4a, 2-chloroethyl thioheptanoate 4c, and 2-chloroethyl thiooctanoate 4b were synthesized by treatment of hexanoyl chloride 3a, heptanoyl chloride 3c, and octanoyl chloride 3b with ethylene sulfide 2. Hexanoylthiocholine 6a and octanoylthiocholine 6b were synthesized by using 4a and 4b with trimethylamine 5. Secondly after reaction ethylene sulfide 2 with dimethyl amine 7 and acylation by acid anhydride 8, heptanoylthiocholine 6c, decanoylthiocholine 6d were synthesized by treatment of methyl iodide.

미니 임플란트 직경에 따른 피로파절강도의 비교 연구

허유리,손미경,김희중,최한철,정재헌 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: This study was conducted to obtain difference in fracture strength according to the diameter of one-body O-ring-type of mini implant fixture, to determine the resistance of mini implant to masticatory pressure, and to examine whether overdenture using O-ring type mini implant is clinically usable to maxillary and mandibular edentulous patients. Materials and methods: For this study, 13 mm long one body O-ring-type mini implants of different diameters (2.0 mm, 2.5 mm and 3.0 mm) (Dentis, Daegu, Korea) were prepared, 5 for each diameter. The sample was placed at 30 from the horizontal surface on the universal testing machine, and off-axis loading was applied until permanent deformation occurred and the load was taken as maximum compressive strength. The mean value of the 5 samples was calculated, and the compressive strength of implant fixture was compared according to diameter. In addition, we prepared 3 samples for each diameter, and applied loading equal to 80%, 60% and 40% of the compressive strength until fracture occurred. Then, we measured the cycle number on fracture and analyzed fatigue fracture for each diameter. Additionally, we measured the cycle number on fracture that occurred when a load of 43 N, which is the average masticatory force of complete denture, was applied. The difference on compressive strength between each group was tested statistically using one-way ANOVA test. Results: Compressive strength according to the diameter of mini implant was 101.5 ± 14.6 N, 149 ± 6.1 N and 276.0 ± 13.4 N, respectively, for diameters 2.0 mm, 2.5 mm and 3.0 mm. In the results of fatigue fracture test at 43 N, fracture did not occur until 2×106 cycles at diameter 2.0 mm, and until 5×106 cycles at 2.5 mm and 3.0 mm. Conclusion: Compressive strength increased significantly with increasing diameter of mini implant. In the results of fatigue fracture test conducted under the average masticatory force of complete denture, fracture did not occur at any of the three diameters. All of the three diameters are usable for supporting overdenture in maxillary and mandibular edentulous patients, but considering that the highest masticatory force of complete denture is 157 N, caution should be used in case diameter 2.0 mm or 2.5 mm is used. 연구 목적: 일체형의 o-ring type 미니 임플란트 고정체의 직경에 따른 파절강도의 차이를 비교하고자 한다. 연구 재료 및 방법: 길이 13 mm의 one body o-ring type의 미니 임플란트(Dentis, Daegu, Korea)를 직경2.0, 2.5, 3.0 mm 각각 5개씩 준비하였다. Instron universal testing machine 에 수직면에서 30도 각도로 샘플을 위치시키고 off-axis loading을 가하여 영구변형이 일어난 하중 값을 파절강도로 하고 5개의 시편의 평균을 구하여 각 직경에 따른 임플란트의 고정체의 파절강도를 비교하였다. 또한, 각 직경마다 3개의 시편을 준비하고 동적하중 피로 시험기를 이용하여, 파절이 발생할 때까지 파절강도의 80%, 60%, 40%의 loading 을 가하여 파절되는 cycle수를 측정하여 각 직경의 피로 파절을 분석하였다. 추가적으로 총의치의 평균 저작력인 43 N의 하중을 가하여 파절되는 cycle 수를 측정하였다. 각 군간의 차이를 검증하기 위해서 일원분산분석(one-way ANOVA test)을 시행하였고, 통계처리는 SPSS ver.12 (SPSS Inc. Chicago, IL, USA) 을 이용하여 실시하였다. 결과: 직경 3.0 mm 의 미니 임플란트는 평균 276.0 ± 13.4 N의 압축력을 받았을 때 영구 변형이 일어났고 직경 2.5 mm 미니 임플란트가 149.0 ± 6.1 N, 2.0 mm 미니 임플란트가 101.5 ± 14.6 N일 때 영구 변형이 일어났다. 각 군간의 파절강도에는 유의한 차이가 있었다(P<.001). 총의치의 평균 저작력 하중에서 실시한 피로 파절 실험 결과, 세직경 모두 5×106 cycle까지 파절이 일어나지 않았다. 결론: 미니 임플란트의 정적 하중 하에서 최대 압축강도는 직경이 증가할수록 유의적으로 증가하였다. 최대 압축강도는 세 직경 모두 총의치의 평균 저작력 보다는 크나 최대 교합력보다는 직경 3.0 mm에서만 크게 나타났다. 총의치의 평균 저작력 하중에서 실시한 피로 파절 실험 결과, 세 직경 모두 파절이 일어나지 않았다.

1,2-Benzisothiazol-3-one-1,1-Dioxide 유도체의 합성

정대일,정희철,변석인,이용균,박유미,최순규,한정태 東亞大學校附設基礎科學硏究所 2002 基礎科學硏究論文集 Vol.19 No.1

사카린 유도체는 제초제, 항독성, 살균제 등에 광범위하게 연구되어져 오고 있다. 새로운 농략 활성을 가진 물질을 합성하기 위해 먼저 선도물질로 사카린 1을 산화, 염소화 시킨 3-chloro-1,2-benzisothiazol-1,1-dioxide(BID-CI) 2와2cholromethy-1,2-benzisohizol-3-one1,1-dioxide 4를 합성하였다. 선도물질, amines, imidazoles, trones등과 반응시켜 다음과 같은 물질들을 얻었다. ; 3-cyclohexylamino-1,2-benzisothiazol-1,1-dioxide 6, 3-furylamino-1,2-benzisothiazol-1,1-dioxide 8, 3-(3-imidazol)-1,2-benzisothiazol-1,1-dioxide 10, 3-(2-methy-3-imidazol)-1,2-benzisothaizol-1,1-dioxide 12, 2-(3-imidazol)methy-1-1,2-benzisothiazol-3-one-1,1-dioxide 13, and 2-(-3-imidazol)methyl- 1,2-benzisothiazol-1,1-dioxide 14.

석탄회 및 석고첨가가 퇴비화에 미치는 영향

유현철,김정섭,곽명화,윤철종,이희인,박승조 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Problems of wastes that pigs produce are increasing rapidly in the hog raising industry nowadays. consequently, the generation volume of excreta also is increasing but most of that is not disposed appropriately and exposed in eco-system therefore the disposal of stock excreta is becoming more and more serious. considering the physical and chemical characteristics of livestock excreta, the pollution loading rate - BOD, COD etc. - is very high. as alternative plan, that is, as one method kind of composisting, the utilization of the soil reformation agent will become one solution in managing the upper problems. also, the flyash of 3.7 million tons are producing every year and about 32.2% of that, 1.18 million ton is recycled as concrete, cement, cementassistance, road etc. consequently, the discharged flyash is not abandoned and a plan of recycling is needed acutely. gypsum of 4.16 million tons in 1998 presently was produced and about 57.2% of that, 2.38 million tons was recycled as cement, construction materials. the present stock is 25 million tons. therefore, in this study, because organic materials can be obtained in pig excreta and calciums can be obtained in gypsum, the small amount of elements can be acquired in flyash for the soil reformation agents, mixing the three materials - pig excreta, gypsum, flyash - adequately, investigated technique of making the soil reformation agents and described below in comparrision with the changes of temperature, PH TOC, T-N, TOC/T-N ratio etc.

TiO₂를 이용한 프로필렌 가스의 광촉매 산화반응

정대일,이동희,김용환,김현숙,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Photocatalyzed degradation of propylene gas was carried out over precoated titanium dioxide(anatase) illuminated W light in a flow reactor. photocatalytic oxidation of propylene gas indicated high conversion rates (78.0%) to CO₂ gas. And photocatalytic oxidation of gas according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂ gas showed.

철을 오염시킨 n-GaAs의Photoreflectance에 관한 연구

유재인,문영희,이동울,이정열,배인호,장광수 嶺南大學校 基礎科學硏究所 1998 基礎科學硏究 Vol.18 No.-

We investigated the variation of PR signals for n-GaAs surface treated with Fe as annealing method. The samples were annealed by isochronal(200∼600 ℃, 10 min) and isothermal(300 ℃, 10 ∼60 min) method. In PR signals measured from isochronal annealed samples, the rate of intensity decreasing for n-GaAs was 49%, and that for n-GaAs surface treated with Fe was 66%. We assumed that the large amount of decreasing intensity for Fe contaminated sample caused by decreasing carrier density due to increasing of ?? neutral acceptor at higher annealing temperature. In PR signals measured from isothermal annealed samples, the signals for annealed n-GaAs decreased with increasing annealing time, and the signals for n-GaAs surface treated with Fe continuously increased with increasing annealing time. It can be assumed that the increasing of PR intensity for Fe contaminated samples as annealing time caused by the diffusion of Fe atoms from the surface.

Nortropinone 유도체로부터 Nortropane Spirohydantoin 유도체의 합성

정대일,박유미,박종훈,김윤영,정두희,김인식 東亞大學校 1998 東亞論叢 Vol.35 No.-

The nortropinones 11 (tropinone lla, N-isopropylnortropinone 11b, N-Carbethoxynortropinone 11c, N-furfurylnortropinone 11d, N-(p-methoxyphenyl)nortropinone 11e) were respectively synthesized by the treatment of acetonedicarboxylic acid 8 with, 2, 5-dimethoxytetrahydrofurane 9 in various amines 10 (methylamine 10a, N-isopropylamine 10b, ethylcarbamate 10c, furfurylamine 10d, p-anisidine 10e). The nortropane spirohydantoins 14 (tropane spirohydanttoin 14a, N-isopropylnortropane spirohydantoin 14b, N-Carbethoxynortropane spirohydantoin 14c, N-furfurylnortropane spirohydantion 14d, n_(p-methoxyphenyl) nortropane spirohydantoin 14e) were respectively synthesized by the treatment of synthesized nortropinones 11 (tropinone 11a 54%, N-isopropylnortropinone 11b 50%, N-Carbethoxynortropinone 11c 58%, N-furfurylnortropinone 11d 31%, N-(p-methoxyphenyl) nortropinone 11e, 70%) with potassium cyanide 12, ammonium carbonate 13.

유치 상아세관에 관한 주사전자현미경적 관찰

김유희,김영진,정경원 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

유치 상아세관의 형태학적 특징을 관찰하기 위하여 정상탈락기의 유전치, 조기발거한 유전치, 정상탈락기의 유구치와 대조군으로 저기발거한 영구소구치 각 10개를 대상으로 치관부 상아질을 주사전자현미경적 관찰을 통해 치수측, 중앙부, 법랑상아경계부근의 각 부위별 상아세관의 직경과 단위면적당 수를 측정하여 각 군내에서의 부위별 차이와 각 부위에서의 각 군간의 차이을 비교평가하여 다음과 같은 결론을 얻었다. 1. 정상탈락기의 유전치, 조기발거한 유전치, 정상탈락기 유구치, 조기발거한 영구 소구치 각 군내에서의 부위별 상아세관의 직경은 치수측에서 법랑상아경계부근으로 갈수록 작게 나타났다.(p<0.01). 2. 각 군간의 부위별 상아세관의 직경은 조기발거한 영구소구치군이 모든 부위에서 다른 세 군에 비해 크게 나타났다.(p<0.05). 3. 치수측과 중앙부에서 상아세관의 직경은 정상탈락기의 유구치군이 정상탈락기의 유전치군과 조기탈락한 유전치군에 비해 크게 나타났다(p<0.01). 4. 정상탈락기 유전치, 조기발거한 유전치, 정상탈락기 유구치, 조기발거한 영구 소구치에서 부위별 단위면적당 상아세관의 수는 치수측에서 법랑상아경계부근으로 갈수록 작게 나타났다(p<0.01). 5. 각 군의 상아질 치수측, 중앙부, 법랑상아경계부근에서 단위면적당 상아세관 수의 차이는 없었다(p<0.05). The purpose of this study was to evaluate number and diameter of tubules in pulp side, middle side, dentinoenamel junction side of coronal dentin of normal exfoliated anterior primary teeth, early extracted anterior primary teeth, normal exfoliated posterior primary teeth and early extracted permanent premolar. Numbers of sample were 10 teeth in each group. The diameter and number of tubules were counted and measured in ×4000 magnified screen of scanning electron microscope. The comparison of diameter and number of tubules at three level in each group was done. The results of this study were as follow. When the diameters of tubules at three levels were compared, the diameters of tubules were graduately decreased from pulp side close to dentinoenamel juntion side in all groups. At pulp sidem middle side and dentnoenamel junction side, when the diameters of tubules of each group were compared, the diameters of tubules of early extracted permanent premolar were greater than other groups. At pulp side, the diameters of tubules of normal exfoliated posterior primary teeth were greater than that of other two primary teeth groups. When the number of tubules at three levels were compared, the number of tubules were graduately decreased from pulp side close to dentinoinamel junction side in all groups. A pulp side, middle side and dentinoenamel junction side, when the number of tubules of each group were compared, no significant difference was in each group.

림프부종 치료프로그램이 림프부종이 있는 말기 암 환자의 사지둘레와 신체증상에 미치는 영향

박명희,허수진,최은미,정유니 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study was performed to investigate the effects of lymphedema treatment program on extremities circumference and physical symptoms in terminal cancer patients with lymphedema. Method: The subject was 13 patients diagnosed with lymphedema and admitted to C Hospital, hospice unit from March 1 to August 31, 2004. The effects of treatment were evaluated by measuring extremities circumferernce and by assessing physical symptons. Data were analyzed by using repeated measures ANOVA, Scheffé multiple comparisons. Result: The results were as follows: Extremities circumference was reduced significantly 30.8cm after last treatment compared with 33.4cm pre-treatment. Physical sysptom, 'heaviness' was improved significantly 4.2 after last treatment compared with 7.8 pre-treatment and difficulty to mobility was improved significantly 4.5 after last treatment compared with 7.4 pre-treatment. Conclusion: These findings indicate that lymphedema treatment program could be an effective nursing intervention for reducing extremities circumference and improving physical symptoms in terminal cancer patient.

유산균을 이용한 경구용 항원 단백질 수송능 연구

조희정,최한곤,김정애,오유경 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2

A promising application of Lactococcus lactis is its use as live vehicles for production and delivery of heterologous proteins of vaccines and therapeutic substances. Because L. lactis has GRAS ("generally regarded as safe") status, use tested whether L. lactis could function as the carrier of the L1 protein of human papillomavirus (HPV) type 16. The RNA level expression of L1 gene was detected in L. Laois. The L1 protein was expressed in L. luctis with LI gene. The growth of strains L. lactis with an empty plasmid (pAMJ328) and L. lactis with L1-encoding plasmid (pAMJ328-L1) was slightly decreased in comparison with the growth of strains L. lactis (wild type). However, all the three strains of L lactis maintained the ability to ferment sugars primarily into lactic acid, indicating that L1 protein did not affect the biochemical property of L.. lactis. These results suggest that L. lactis. capable of carrying LI protein, might he further developed as a biocompatible oral protein delivery system.