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MoS2 코팅된 치과용 임플란트의 표면특성과 생체적합성
최한철,권민기,이준식,김미은 한국부식방식학회 2024 Corrosion Science and Technology Vol.23 No.1
The Ti-6Al-4V alloy is widely used as an implant material due to its higher fatigue strength and strengthto-weight ratio compared to pure titanium, excellent corrosion resistance, and bone-like properties that promote osseointegration. For rapid osseointegration, the adhesion between the titanium surface and cellular biomolecules is crucial because adhesion, morphology, function, and proliferation are influenced by surface characteristics. Polymeric peptides and similar coating technologies have limited effectiveness, prompting a demand for alternative materials. There is growing interest in 2D nanomaterials, such as MoS2, for good corrosion resistance and antibacterial, and bioactive properties. However, to coat MoS2 thin films onto titanium, typically a low-temperature hydrothermal synthesis method is required, resulting in the synthesis of films with a toxic 1T@2H crystalline structure. In this study, through high-temperature annealing, we transformed them into a non-toxic 2H structure. The implant coating technique proposed in this study has good corrosion resistance and biocompatibility, and antibacterial properties.
신생아 외과환아의 술후 합병증 및 사망율에 관한 임상적 분석
최한철,윤영국,이영하,장수일 慶北大學校 醫科大學 1992 慶北醫大誌 Vol.33 No.2
1981년 1월부터 1990년 12월까지 만 10년간 경북대학교 의과대학 소아외과에서 수술받은 생후만1개월 미만의 신생아수술 92예에 대하여 신생아수술의 합병율, 사망율 및 이에 관여하는 인자를 관찰한 결과를 요약하면 다음과 같다. 성별비는 남아 67예, 여아 25예로(남:여=2.9:1)로 남아에 많았고 입원당시 연령은 24hr 이내가 30.4%, 72hr 이내가 58.7%, 일주일이내가 73.9%였다. 질환별로는 복벽균열이 평균 1.18일로 가장 빨랐으며 유문협착증이 24.5일로 가장 늦은 경우였으며 가장 흔한 질환은 항문직장기형(30.4%)이었다. 미숙아는 92예중 12예(13.0%)였으며 입원시 체중으로 저체중아는 19예(20.6%)였고, 전체환자의 평균체중이 2825gm였으며 질환별 평균체중은 식도무공증이 2338gm으로 가장 낮았다. 술후합병증은 92예의 환자중 29예(31.5%)에서 있었으며 가장 흔한 술후합병증은 창상감염으로 12예(13.0%)에서 있었으며, 질환별 합병증발생율은 식도무공중이 75.0%로 가장 높은 합병증 발생율을 보였으며, 그 다음이 복벽균열로 66.7%였으며 항문직장기형이 28예중 3예로 (10.7%)로 가장 낮았다. Stage Ⅰ이 41.4%(34예중 14예), Stage Ⅱ가 25.8%(58예중 15예)의 술후합병율로 Stage Ⅱ가 낮은 경향을 보였으나 유의한 차이는 없었다. 92예중 16예(17.4%)가 사망하였으며, 질환별사망율로는 공장 및 회장폐쇄증이 9예중 4예(44%)로 가장 높았으며 항문직장기형이 28예중 3예(10.7%)로 가장 낮았으며, 가장 흔한 사망원인은 폐혈증이었다(41.3%). Stage Ⅰ이 26.4%(34예중 9예), Stage Ⅱ가 12.0%(58예중 7예)의 술후사망율로 Stage Ⅱ가 낮은 경향을 보였으나 유의한 차이는 없었다. 사망에 영향을 미치는 요인으로는 미숙아, 저체중아, 저체온이 있었다(P<0.05). A clinical analysis on ninety-two surgical neonates who underwent neonatal surgery from Jan. 1981 to dec. 1990 at Kyungpook National University was carried out in order to observe factors which affected the postoperative morbidity and the mortality. Of these 92 patients, the male and female ratio was 2.9:1. Age on admission was younger in cases with gastroschisis or with omphalocele or with jejunoileal atresia. Average body weight on admission was 2825gm and was lowest in patient with esophageal atresia, 2338gm. The postoperative complications appeared 29cases(31.5%) among 92 cases and the most common complication was wound infection, 12cases(13.0%). Esophageal atresia presented highest morbidity (75%), secondly gastroschisis (66.7%) and anorectal malformation presented lowest morbidity(10.7%). The complication rate of Stage Ⅰ, 41.1%(14 cases among 34 cases) seemed to be higher than that of Stage Ⅱ, 25.8% (15 cases among 58 cases) but statistically not significant. The mortality rate was 17.4%(16 deaths among 92 cases) and jejunoileal atresia presented highest mortality (44%), and anorectal malformation presented lowest mortality(10.7%). The most common cause of death was sepsis, 7 cases(41.3%). The mortality rates of Stage Ⅰ, 26.4% (9 cases among 34 cases) seemed to be higher than that of Stage Ⅱ 12.0% (7 cases among 58 cases) but statistically not significant. The present results suggested that factors which significantly affected the postoperative mortalities were prematurity, low birth weight and hypothermia.