심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

심근경색 모델 흰쥐에서 스트레스가 B-type Natriuretic Peptide 발현 및 심박변이율 변화에 미치는 영향

이삼윤(Sam Youn Lee),이미경(Mi Kyoung Lee),김남호(Nam-ho Kim),주민철(Min Cheol Joo),조항정(Hyang Jeong Jo),강지숙(Ji Sook Kang),김병숙(Byung Sook Kim),윤선식(Sun Sik Yoon),최을식(Eul Sig Choi),이문영(Moon Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

심박변이율의 감소는 심근 경색 환자에서 예후의 악화와 관련되어 있다. 심박변이율 중 very low frequency가 심부전환자의 예후를 판단할 수 있는 독립적 인자로서 사용이 가능하다고 보고된 바 있으며, 심실의 압력 증가에 반응해서 생성되는 B-type natriuretic peptide가 심근 경색의 예후 인자로서 사용할 수 있음 역시 보고된 바 있다. 본 연구에서는 심근경색 모델을 제작하여 일정의 회복 기간을 거친 다음 다시 일정 기간의 스트레스를 겪게 한 후 심박변이율의 변화 및 심실 조직에서의 BNP 발현 정도를 비교하여 스트레스에 의한 영향을 관찰하고자 하였다. Sprague-Dawley계 수컷 흰쥐 15마리를 대상으로 하였다. 실험동물은 인위적 스트레스 및 수술을 받지 않은 대조군(CON, n=5), 심근경색 수술을 받은 후 restraint stress를 받지 않은 군(MI+No Stress, n=5), 심근경색 수술을 받은 후 1주일 동안 restraint stress를 받은 군(MI+Stress, n=5)으로 분류하였다. 심근경색 모델 제작 직후 15분 이상 심전도의 변화를 기록하였으며, 2개월 정도 후 심근경색 수술을 받은 동물을 두 군으로 나누어 그 중 한 군에는 1주일 동안 restraint stress를 가한 후 restraint stress를 가하지 않은 동물과 심박변이율을 비교 분석하였다. 심실 조직은 좌심실 전벽 부위의 위축을 관찰할 수 있었고, 대식세포에 의하여 응고, 괴사된 심근세포의 탐식과 혈관이 풍부한 육아조직 및 섬유 변화를 볼 수 있었다. 심박변이율은 심근경색 수술을 받은 직후 심박수는 유의한 증가를 보였고, standard deviation of the normal to normal intervals (SDNN), very low frequency (VLF) 및 low frequency (LF)의 유의한 감소를 보였다. 심근경색 수술을 받았던 동물에서 두 달 정도의 회복 기간을 거친 후 스트레스를 받지 않은 군은 심박수 및 기타 심박변이율 분석에서 SDNN 값을 제외하고는 정상군과 유의한 차이를 관찰할 수 없었던 반면 1주일 동안 스트레스를 받은 군에서는 심박수가 다시 유의하게 증가했을 뿐만 아니라 SDNN, VLF 및 LF 역시 정상군과 유의한 차이를 보였다. 이상의 결과를 종합하면 심근경색 동물에 대해 1주일 동안 스트레스를 가한 결과 심박변이율이 감소하고 심실에서의 BNP 발현은 더욱 증가하여 악화함을 보여주고 있다. Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI+No Stress), and MI followed by stress group (MI+Stress). MI+Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI+Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI+ Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model. (Korean J Str Res 2010;18:275∼285)

여성 연소노인의 지각연령과 사회무용지도자 실제에 따른 지도효율성

정문미(Jung Moon Mi),원영신(Won Young Shin) 글로벌시니어건강증진개발원 2011 글로벌시니어건강증진개발원 논문집 Vol.1 No.1

본 연구는 여성 연소노인의 사회 인구학적 특성에 따른 사회무용 지도자 실제, 사회무용 지도자 실제에 따른 지도 효율성의 차이, 그리고 지각연령이 지도 효율성에 미치는 영향을 규명하는 데 목적이 있다. 이와 같은 연구목적을 달성하기 위하여 서울지역 소재 노인교육기관(노인교실, 노인대학, 노인학교, 노인복지회관, 사회복지회관, 대학부설 평생교육원 및 사회교육원, 종교기관 등)에서 사회무용 프로그램에 참여한 경험이 있는 여성 연소노인을 모집단으로 설정한 다음, 유의표본표집법을 이용하여 450명의 연구대상을 표집하였으며, 불성실하게 응답한 자료를 제외하고 총 428명의 자료를 최종분석에 사용하였다. 자료처리는 SPSS Windows 15.0 version을 이용하여 빈도분석, 탐색적 요인분석, 신뢰도분석, 카이검정, 상관관계, 다중 회귀분석, 공분산분석을 실시하였으며, 다음과 같은 결론을 도출하였다. 첫째, 사회 인구학적 특성에 따른 사회무용 지도자 실제는 참여기관 유형에 있어서만 사회무용 지도자 실제 하위특성 모두에 한 차이가 나타났다. 또한 결혼유지 상태는 지도자의 성별, 연령을 제외, 교육수준과 경제수준은 성별을 제외, 직업상태(현재)는 성별과 전공경력을 제외한 모든 사회무용 지도자 실제 하위특성에 유의한 차이가 나타났다. 역연령은 지도자의 전공경력에서만 유의한 차이가 나타났다. 둘째, 지각연령이 지도 효율성에 미치는 영향을 분석한 결과, 지각연령의 하위요소 중, 보이는 연령이 지도 효율성의 하위 요소 중, 인지된 지도만족(B=-.106)에 부적(-), 활동 연령이 인지된 기능향상(B=.109)과 인지된 지도만족(B=.178)에 있어 모두 정적(+) 영향을 미치는 것으로 나타났다. 셋째, 사회 인구학적 특성과 지각연령이 일정한(통제된) 경우, 실제 사회무용 지도자의 하위특성인 성별, 연령, 교육수준, 전공경력 모두에 따라 지도 효율성의 하위요인 모두에 유의한 차이가 있었다. The purpose of this study is to find the between the young-old woman the demographic characteristics and practice of social dance instructor, the difference of between practice of social dance instructor and coaching effectiveness, and tne effect of between the self-perceived age and oaching effectiveness. The subjects in this study were 450 women who were selected by purposive sampling from a population of the young-old woman who had ever participated in social dance programs in senior education institutions senior class, senior college, senior school, Senior welfare center, social welfare center, university, school of lifelong education, religion community) in Seoul. After a survey was conducted, the answer sheets from 428 respondents were analyzed except some incomplete ones. As for data handling, a SPSS Windows Ver. 15.0 program was employed, and a frequency analysis, exploratory factor analysis, reliability analysis, pearson chi-square, binary-logistic regression, ANCOVA and were utilized. The findings of the study were as follows: First, practice of the coaches according to social population characteristics shows the significant difference for all practical lower facts of the coaches only in types of participation institute. Also, marriage status without the coaches’ gender and age, educational and economic level without gender, and current job status without the gender and career show the significant difference in practical lower facts of all the coaches. Chronological age shows the significant difference only in the career of the coaches. Second, the analysis of the influence of elf-perceived age on the coaching effectiveness shows all recognized coaching satisfaction(B=-.106) of (-), function improvement(B=.109) with the recognition of activity age and recognized coaching satisfaction(B=.178) were influenced in (+) way. Third, in case of social population characteristics and self-perceived age are controled, all lower factors of coaching effectiveness shows significant difference according to the actual coaches’ gender, age, educational level and career.

여성 연소노인의 지각연령에 따른 사회무용 지도자 선호에 대한 연구

정문미(Jung, Moon Mi),원영신(Won, Young Shin),고대선(Ko, Dae Sun) 한국노년학회 2010 한국노년학 Vol.30 No.2

본 연구는 여성 연소노인의 사회 인구학적 특성에 따른 지각연령의 차이를 알아보고 지각연령이 사회무용 지도자 선호에 미치는 영향을 규명하는 데 목적이 있다. 이와 같은 연구목적을 달성하기 위하여 서울지역 소재 노인교육기관(노인교실, 노인대학, 노인학교, 노인복지회관, 사회복지회관, 대학부설 평생교육원 및 사회교육원, 종교기관 등)에서 사회무용 프로그램에 참여한 경험이 있는 여성 연소노인을 모집단으로 설정한 다음, 유의표본표집법을 이용하여 450명의 연구대상을 표집하였으며, 불성실하게 응답한 자료를 제외하고 총 428명의 자료를 최종분석에 사용하였다. 자료처리는 SPSS Windows 15.0 version을 이용하여 빈도분석, 탐색적 요인분석, 신뢰도분석, 카이검정, 독립표본 t-test, 일원분산분석, 이항 로지스틱 회귀분석을 실시하였으며, 다음과 같은 결론을 도출하였다. 첫째, 사회 인구학적 특성에 따른 지각연령은 역연령, 교육수준에 있어서 지각연령 하위요인(보이는 연령, 느끼는 연령, 관심사 연령, 활동 연령) 모두에 유의한 차이가 나타났다. 또한 결혼유지 상태는 관심사 연령과 느끼는 연령, 경제수준은 보이는 연령, 관심사 연령, 느끼는 연령에 있어서만 유의한 차이가 나타났다. 둘째, 사회 인구학적 특성에 따른 사회무용 지도자 선호는 교육수준에 있어서 사회무용 지도자 선호 하위특성(성별, 연령, 교육수준, 전공경력) 모두에 유의한 차이가 나타났다. 또한 역연령은 지도자의 전공경력을 제외, 경제수준은 지도자의 성별을 제외한 모든 사회무용 지도자 선호 하위특성에 유의한 차이가 나타났으며, 결혼유지 상태는 지도자의 교육수준에 있어서만 유의한 차이가 나타났다. 셋째, 지각연령이 사회무용 지도자 선호에 미치는 영향을 분석한 결과, 지각연령의 하위 요소 중 보이는 연령만이, 사회무용 지도자 선호하위특성 중 전공경력을 제외한 성별(B=.458), 연령(B=.483), 교육수준(B=.76) 모두에 유의한 정적(+) 영향을 미치는 것으로 나타났다. The purpose of this study was to examine the demographic characteristics of the female young-old to their self-perceived age and the impact of their self-perceived age on preference for a social dance instructor. The subjects in this study were 450 women who were selected by purposive sampling from a population of the female young-old who had ever participated in social dance programs in senior education institutions senior class, senior college, senior shool, Senior welfare center, social welfare center, university, school of lifelong education, religion community) in Seoul. After a survey was conducted, the answer sheets from 428 respondents were analyzed except some incomplete ones. As for data handling, a SPSS Windows Ver. 15.0 program was employed, and a frequency analysis, exploratory factor analysis, reliability analysis, pearson chi-square, independent-samples t-test, one-way ANOVA and binary-logistic regression were utilized. The findings of the study were as follows: First, self-perceived age by social population characteristics shows significant difference in all lower factors of self-perceived age(Look age, Feel age, Interest age, Do age) as chronological age, education level. Also, the marriage status shows significant difference only in interest age and feel age, the economic level shows only in look age, interest age and feel age. Second, the social dance instructor preference by social population characteristics shows significant difference in the all lower facts of social dance coaches preference(gender, age, education level, instructor career) up to educational level. Also, chronological age without the instructor career, economic level without instructor gender show the significant difference in the lower facts of all social dance instructor preference. Also, marriage status shows the significant difference in the educational level of the instructor. Third, the analysis of the influence of self-perceived age on the instructor preference shows all gender(B=.458), age(B=.483) and educational lever(B=.76) without career were influenced in significant (+) way.

신규간호사와 프리셉터가 인지하는 프리셉터의 교수효율성 비교

김지양,김영선,김춘실,박현숙,신미영,윤연숙,조유숙,박미미,유문숙 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.2

Objective: The purpose of this study was to compare preceptors and new graduate nurses on their perception of preceptor teaching effectiveness. Methods: The participants were 90 new nurses and 90 preceptors who worked in A medical center. The data were collected from July 1 to September 30, 2008. A cross-sectional descriptive survey was done using a structured questionnaire. Results: New nurses' perception (4.07±.44) of the preceptor teaching effectiveness was significantly higher than perception of the preceptors (3.57±.37). Fifty five percent of new graduate nurses reported a lack of coherence in the preceptor's practice guidelines. For 5 causal factors classified on the teaching effectiveness, the factor of 'Professional knowledge and ability' showed the highest score, but 'Interpersonal and communication skill' got lowest score for both group. Preceptors responded that they did not have enough time to teach well because of their heavy workloads. Conclusions: These results suggest that the preceptors need appropriate compensation and education opportunities, and new graduate nurses need consistent education by the teaching professionals. Therefore, it is important to give preceptors full charge of the preceptorship. Also, it will be necessary to develop education programs to enhance interpersonal and communication skill for preceptors and new nurses.

남성화를 보이는 여성에서 발견된 난소의 Steroid Cell Tumor 1예

조인호,정대훈,박영미,서영진,손영실,정철회,강영미,정수전,김영남,이경복,성문수,김기태 인제대학교 2006 仁濟醫學 Vol.27 No.-

Steroid cell tumor is a rare ovarian sex cord-stromal tumor which accounts for 0.1% of all ovarian tumors. Until now, only 4 cases have been reported in domestic literatures. Steroid cell tumor often secrets testosterone and presents virilization in adult women or precocious puberty in children. Treatment is often performed by surgical removal, adjuvant chemotherapy and radiation, but completely accepted treatment was not existed. We experienced a case of steroid cell tumor, which was manifested by typical virilization in a 43-year old patient, who was previously performed hysterectomy and unilateral oophorectomy. So, we present with a brief review of the literatures.

猪笭湯이 實驗的 賢贓障碍家兎에 미치는 影響

文永熙,金美淑,李炳柱,林起龍 조선대학교 약학연구소 1991 藥學硏究誌 Vol.13 No.1

This study was attempted to investigate the effect of Jueryeong Tang(JRT) on renal failure of the rabbit treated with folate. Serum creatinine, blood urea nitrogen and serum uric acid in folate-treated rabbits were markedly increased and creatinine clearance was decreased by comparing with the normal group. JRT(900㎎/㎏) given orally produced significant reduction in concentration of both serum creatinine and blood urea nitrogen by comparing with the corresponding folate-treated group. while did increased clearly in creatinine clearance. The morphological changes of arcuate arteries and glomeruli evoked by folate treatment were almost returned to normal state after administration of JRT. (900㎎/㎏). These experimental results suggest that JRT may greatly improve renal failure of the rabbit induced by folate treatment.

일간 신문의 기사와 광고에 나타난 식품영양정보의 현황 조사 (2002년)

문현경,용미진,장영주 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

The object of this study is to investigate and analyze the quantity and quality of information on health, food and nutrition reported by newspapers. Six different major domestic daily newspapers(Hankook Ilbo, Donga Ilbo, Chosun Ilbo, Kyunghyang Shinmun, Hankyoreh Shinmun, JoongAng Ilbo), were monitored from 1st of May to 31st of Oct. 2002. The results of monitoring in the newspapers were summarized as follows; 1. The total percentage of the articles on health, food and nutrition was 2.7% and the percentage of the advertisements on health, food and nutrition was 17.5% of total area of the newspaper. The ratio of the number of food and nutrition topic on the total number of health, food and nutrition topic was 35.8% for the articles, was 62.9% for the advertisements. Among advertisements on food and nutrition, the percentage of advertisements on healthy foods was the highest(3,481 or 55.0%). 2. Contents of 340 articIes(26.1%) were reported as suitable information. Contents of 259 articles(l9.9%) were reported as inaccurate information on health, food and nutrition. In the analysis of advertisements, the number of advertisements without sufficient reliable sources was 2,488 cases(23.0%), and with exaggerated contents was 2,268 cases(21.0%). The articles and advertisements should be backed by scientific research or reliable sources and also the opinions of people with expertise in order to report accurate information to the general public. In order to achieve these results, there should be continuing monitoring activity for the newspapers.

저출산･고령사회 이슈에 대한 정책대응 과제 : 인천시 사례를 중심으로

문은영,권미애,전혜정 이화여자대학교 젠더법학연구소 2016 이화젠더법학 Vol.8 No.1

This study was conducted with the need for preparing active measures of the central government and the local government to deal with low fertility and aging society issues and with the purpose of setting the related policy direction. The issues of recent low fertility and aging are experienced globally and the decline of population is detected in Korea as well. Therefore, multilateral efforts are taken to deal with the imminent phenomenon at the governmental level. Incheon Metropolitan City, with its population of 3 million, is one of the big cities in rapid progress of low fertility and aging phenomenon. While the total fertility rate of Incheon is 1.21 (Statistics Korea, 2015) which is the similar level with the national average, it is far below the population replacement level and has continuously been recording the low figures since 2000. Besides, the elderly population rate in 2014 was 10.3%, a 5.5% increase compared to the previous year. It is expected that the population aging would be accelerated for the next 30 years and it is forecasted that the elderly population rate of Incheon would reach around 30% by 2040. According to the survey results of general citizens on this population change, more than half of the respondents seriously recognized the shift to the low fertility and aging society and demanded the measures to deal with the issues. To set the policy direction in association with the central government within the local region, this study explores the tasks to deal with the policy and the demands for the policy in Incheon Metropolitan City. 본 연구는 저출산・고령사회 이슈에 대응하여 중앙정부와 더불어 지자체의 적극적 대책마련의 필요성과 정책방향성 수립을 위한 목적으로 시도되었다. 최근 저출산과 고령화의 문제는 전 세계적으로 경험되는 문제이며 또한 우리나라에서도 인구의 변화가 감지되고 있는 상황이다. 이에 정부차원에서 이미 저출산과 고령화 문제를 경험하고 대처하고 있는 선진국의 사례를 검토하면서, 다가올 현상에 대해 대응할 수 있기 위한 다각적 노력이 진행되고 있다. 인천시는 인구 300만 시대가 임박하는 상황에서 저출산과 고령화 현상이 빠르게 진행되고 있는 대도시중 하나이다. 인천시의 합계출산율은 1.21명으로 전국평균과 동일한 수준에 있지만 인구대체수준에는 크게 못 미치는 상황이며, 2000년 이래 지속적으로 낮은 수치를 기록하고 있다. 또한 2014년 노인인구 구성비는 10.3%로 전년대비 5.5% 증가되었으며, 향후 30년간 고령화가 빠른 속도로 진행될 것으로 전망되며 오는 2040년 인천의 고령인구비율이 약 30%로 예측되고 있다. 이러한 인구변화에 대해 일반 시민들에게 저출산・고령화 사회로의 변화는 실태조사결과 절반 이상이 심각하게 인지하고 있는 상황이며, 이에 대한 대책마련을 요구하고 있는 것으로 나타났다. 본 연구에서는 중앙정부와 연계성 있는 지역 내 정책방향 수립을 위해 인천시 사례를 들어 지역에서의 정책에 대한 시민체감도와 정책 수요, 또 정책대응의 과제를 살펴보고자 한다.

여성잡지에 나타난 식품영양정보의 양적·질적 현황 조사 (2002년)

문현경,용미진,장영주 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

The desire for the healthy life is increasing as a result of rapidly changing social and economic environment in Korea. Because of the need, information on health, food and nutrition are being introduced through the mass media. The object of this study is to investigate and analyze the quantity and quality of information about health, food and nutrition in women's magazines. Six representative domestic monthly magazines(Lady Kyunghyang, Women Donga, Women Chosun, Women JoongAng, Women sense, Jubu Senghwal) were selected for this study. The results of monitoring from June 2002 to September 2002 for the women's magazines were summarized as follows; 1. The percentage of the articles on health, food and nutrition by total area of the women's magazines was 23.1%. There were total 595 articles on health, food and nutrition. Among these, 400 articles(67.2%) were about food and nutrition. 2. The percentage of the advertisements on health, food and nutrition was 35.3% by total area of the woman's magazines. There were 2,353 advertisements on health, food and nutrition. Among these, 1,574(66.9%) advertisements were about food and nutrition. The most frequently advertised advertisements on food and nutrition were about processed foods (527 cases, 33.5%). The second most frequently advertised advertisements were about diet (374 cases, 23.8%). The third one was healthy foods (345 cases, 21.9%). 3. The contents of 215(53.8%) articles (the total number of articles was 400) was suitable. The contents of 89 advertisements(22.3%) did not have accurate information on health, food and nutrition. For the advertisements in women's magazines (the number of total articles was 2,203), the percentage of the advertisements which was not able to capture the feature of the advertisements was 27.9%, insufficiency of reliable sources was to 21.9%, and exaggeration of the contents in the advertisements was 16.0%. Articles and advertisements should be backed by scientific research or reliable sources and also the opinions of people with expertise in order to report accurate information to the general public. In order to achieve these results, there should be continuing monitoring activity for the women's magazines.