The role of FGF-2 in smoke-induced emphysema and the therapeutic potential of recombinant FGF-2 in patients with COPD

Kim, You-Sun,Hong, Goohyeon,Kim, Doh Hyung,Kim, Young Min,Kim, Yoon-Keun,Oh, Yeon-Mok,Jee, Young-Koo Nature Publishing Group UK 2018 Experimental and molecular medicine Vol.50 No.11

<▼1><P>Although the positive effects of recombinant fibroblast growth factor-2 (rFGF-2) in chronic obstructive pulmonary disease (COPD) have been implicated in previous studies, knowledge of its role in COPD remains limited. The mechanism of FGF2 in a COPD mouse model and the therapeutic potential of rFGF-2 were investigated in COPD. The mechanism and protective effects of rFGF-2 were evaluated in cigarette smoke-exposed or elastase-induced COPD animal models. Inflammation was assessed in alveolar cells and lung tissues from mice. FGF-2 was decreased in the lungs of cigarette smoke-exposed mice. Intranasal use of rFGF-2 significantly reduced macrophage-dominant inflammation and alveolar destruction in the lungs. In the elastase-induced emphysema model, rFGF-2 improved regeneration of the lungs. In humans, plasma FGF-2 was decreased significantly in COPD compared with normal subjects (10 subjects, <I>P</I> <I>=</I> 0.037). The safety and efficacy of inhaled rFGF-2 use was examined in COPD patients, along with changes in respiratory symptoms and pulmonary function. A 2-week treatment with inhaled rFGF-2 in COPD (<I>n</I> = 6) resulted in significantly improved respiratory symptoms compared with baseline levels (<I>P</I> <I><</I> 0.05); however, the results were not significant compared with the placebo. The pulmonary function test results of COPD improved numerically compared with those in the placebo, but the difference was not statistically significant. No serious adverse events occurred during treatment with inhaled rFGF-2. The loss of FGF-2 production is an important mechanism in the development of COPD. Inhaling rFGF-2 may be a new therapeutic option for patients with COPD because rFGF-2 decreases inflammation in lungs exposed to cigarette smoke.</P></▼1><▼2><P><B>Lung disease: Inhaling a protein might help</B></P><P>Studies on the role of the protein ‘fibroblast growth factor-2’ (FGF-2) in chronic obstructive pulmonary disease (COPD) suggest that inhaled FGF-2 could help treat the emphysema linked to smoking. Researchers in South Korea led by Young-Koo Jee at Dankook University, Cheonan, and Yeon-Mok Oh at the University of Ulsan, Seoul, studied the role of the reduced FGF-2 levels found in mice with lung inflammation caused by exposure to cigarette smoke. They also uncovered details of a protective effect of inhaled FGF-2, identifying specific cellular and lung structure changes attributed to the administered FGF-2. Reduced FGF-2 levels were also found in patients with COPD. Initial trials revealed some improvement in patients treated with FGF-2, but not at a statistically significant level. Nevertheless, the authors suggest their results justify further investigation of the protein’s therapeutic potential.</P></▼2>

한국 어린이의 ABO혈액형 항체 생성에 대한 연구

윤영호,최효선,김덕언,박일규,김신규 대한임상병리학회 1997 대한임상병리학회지 Vol.17 No.6

疎風湯의 消炎·鎭痛作用에 관한 硏究

劉善美,林起龍,嚴基鎭,文永熙 조선대학교 약학연구소 1993 藥學硏究誌 Vol.15 No.1

This study was attempted to examine the effect of Sopung-Tang extract(STE) on anti-inflammatory action in rats, analqesic action and the acute, subacute toxicity in mice. In anti-inflammatory activity in rats, STE was shown to have significant preventive effect in the edema induced by Freund's conplete adjuvant and 5% acetic acid. In analgesic activity in mice, STE was shown to have significant analgesic action on the writhing syndrome in mice induced by 0.7% acetic acid. In acute toxicity test in mice, STE showed 10% mortality at 2000㎎/㎏ . and 1200㎎/㎏ i.p. In subacute toxicity test in mice, STE was not showed for 19 days. Serum uric acid in treated by adjuvant method rats were slightly decreaced by comparing with the control group. During the administration of extracts the body weight increased, but the liver and spleen weight was not changed.

노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성

유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.

대안학교 인성교육과 마음공부

유선영,강일국 木浦大學校 敎育硏究所 2004 교육연구 Vol.16/17 No.-

The alternative schools, which is founded by Won Buddhism, have developed their own curriculum to improve their human characteristics by mentality training method based on religious philosophy. The curriculum is formed as no-grade and no-class. The student organize their own curriculum by applying a course of study at the each school period. Each student should get the required credit to complete the school course. This curriculum has been adopted in many schools. Here the true value of mentality training method is evaluated for the schools which adopt the mentality training program. The worth of this program is evaluated in terms of internal and external relationship, sociality, response to a stimulus, and acceptance a view of the future. The results show a reliable aspect of the mentality training method on improving the human characteristics, especially for the teenager.

민주지산 일대의 관속식물상 조사

이희선,유영한 西原大學校 基礎科學硏究所 2002 基礎科學硏究論叢 Vol.16 No.-

The flora of the vascular plants on Mt. Manjujisan and its surrounding regions was investigated from June, 2000 to October, 2001. In this investigation, 3 phyla, 105 families, 399 genera, 614 species, 1 subspecies, 90 varieties and 5 formaties, total 710 taxa were collected and identified. Leading families were Compositae(11.4%), Gramineae(6.9%), Liliaceae(4.9%), and Rosaceae(4.9%). The endemic species, rare species and naturalized species distributed 7 taxa, 10 taxa and 28 taxa, respectively.

사방격자에 의해서 만들어진 주기적인 무아레 무늬를 이용한 물체의 형상측정

조선미,김영유,류지욱,육근철 公州大學校 基礎科學硏究所 1997 自然科學硏究 Vol.6 No.-

사방격자를 이용해서 물체의 형상을 측정할 수 있는 방법을 제안하였다. 카메라와 광원의 위치좌표는 변화시키지 않고 사방격자의 피치 간격을 일정한 비율로 변화시키는 방법과, 사방격자의 피치간격은 변화시키지 않고 광원과 카메라 사이의 평면 위치좌표를 변화시켜서 주기적인 무아레 무늬를 얻었으며 이를 이용하여 무아레 무늬의 절대차수를 결정할 수 있는 새로운 방법을 제안하였다. We present a simple method of determining the absolute order using periodic moire fringe structures formed by criss-crossed gratings. We selected two experimental methods that one is fixed the position coordinates of light sources and camera, and than change the pitch distance of criss-crossed gratings. Another method are fixed the pitch distance of criss-crossed gratings and than change the position coordinates of light sources and camera. As a results. We could determined the absolute order only once a photographing the objects.

만뢰산 일대의 관속식물상 조사

이희선,유영한 西原大學校 基礎科學硏究所 2002 基礎科學硏究論叢 Vol.16 No.-

The flora of the vascular plants on Mt. Manroesan and its surrounding regions was investigated from June, 2000 to April, 2001. In this investigation, 3 phyla, 92 families, 338 genera, 478 species, 1 subspecies, 73 varieties and 5 formaties, total 557 taxa were collected and identified. Leading families were Compositae(65 taxa, 11.7%), Gramineae(48 taxa, 8.6%), Liliaceae(30 taxa, 5.4%), Leguminosae (29 taxa, 5.2%), Rosaceae(28 taxa, 5.0%), Polygonaceae(24 taxa, 4.3%), and Cyperaceae(20 taxa, 3.6%). The endemic species, rare species and naturalized species distributed 3 taxa, 1 taxon and 28 taxa, respectively.

Caffeic Acid의 ONOO^(-) 제거활성

이지영,성도유,노재경,김유정,제정환,김민선,최재수,정해영,이경희 대한암예방학회 2003 Journal of cancer prevention Vol.8 No.3

완전 방실차단을 동반한 급성 심근염

이유선,정진옥,박용규,박형서,노상필,정승현,김정희,이재환,최시완,성인환 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

급성 심근염환자에서 발행한 완전 방실차단을 영구 심장박동 조율기로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Myocarditis, an inflammatory process involving the myocardal wall, may be caused by most infectious agents. Irrespective of its etiology, it presents commonly with evidence of heart failure, hypotension, and various electrocardiographic abnormalities. Patient with myocarditis may be asymptomatic or may have a rapidly progressive fatal disease. Medical management of patients with myocarditis includes specific therapy for underlying infection and control of the complication of myocarditis such as congestive heart failure and arrhythmia. Recently we had experienced myocarditis with complete atrioventricular block in 37-year-old man. Although he had shown complete recovery of heart failure, he had shown complete atrioventricular block, so we inserted permanent pacemaker. We report it with review of the literature.