올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.

도재소부용 저금함유금합금에서 열처리에 따른 Sn의 영향

남상용,김치영,조현설 대구보건대학 1999 대구보건대학 論文集 Vol.19 No.-

This study was carried out by oberserving to compositions of oxide on the surface of dental porcelain low gold alloy with various Indium addtions according to the degassing and analysing the change composition of additional elements Sn on diffusion behaviors of porcelain-metal surfaces. The specimens used were Au-Pd-Ag alloys by small Tin addition. These specimens were treated for 10min at 1000℃ in vacuum condition. To investigate the micrstructure of oxidized alloy surface, SEM and EDAX were used and EPMA were used to investigate the diffusion behaviors of porcelain-metal surfaces. X-ray diffraction were used to observe the morphological changes in the oxidation zone. Te results of this study were obtained as follows: 1) The Tin oxidation increased with increasing Sn content after hear treatment. 2) In concentration of Sn on metal-porcelain surface, Sn-6 was most significantry increased 3) In thickness of Sn on metal-porcelain surface, Sn-9 was most significantry increased 4) The oxidations of alloy surface were mainly SnO₂.

Sertraline이 Bleeding Time에 미치는 영향

박현숙,장기용,김은남,강병조 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2

본 연구는 선택적 세로토닌 재흡수 억제제(SSRIs), 특히 sertraline이 출혈 시간에 미치는 영향을 알아봄으로써 선택적 세로토닌 재흡수 억제제의 안전성과 혈액학적 부작용 측면을 평가하고자 하였다. 선택적 세로토닌 재흡수 억제제의 치료적 적응증에 해당하는 95명의 환자를 무작위 할당으로 sertraline 50mg 투여군, sertraline 200mg, 투여군, nortriptyline100mg 투여군, 위약(thiamine 100mg) 투여군으로 분류하여 정해진 양을 4주간 투여한 후 출혈 시간을 약물 투여 전, 약물 투여 2주 후, 약물 투여 4주 후의 3회에 걸쳐서 측정하였다. 95명의 환자 중 78명이 실험을 마쳤다. Sertraline 50mg 투여군에서 실험 전과 비교하였을 때 시간에 따르는 출혈 시간의 증가가 있었다. 다른 군에서는 실험 전과 실험 2주 후, 4주 후의 출혈 시간을 비교하였을 때 시간에 따르는 출혈 시간의 증가가 없었다. 연구 기간 동안 지혈 이상을 보인 환자는 없었다. 결론적으로 Sertraline 투여 초기에 정상 범위 내에서 출혈 시간의 증가가 있었다. Objective : This study was designed to assess the safety and hematological complications of the selective serotonin reuptake inhibitors(SSRIs) by examining the effect of sertraline on bleeding time. Method : Ninety five patients included in therapeutic indications of SSRIs were divided into sertraline 50mg, sertraline 200mg, nortriptyline 100mg, placebo(thiamine 100mg) groups. Bleeding time was measured at baseline, and repeated 2 and 4 weeks after the initiation of treatment with sertraline, nortriptyline and placebo 78 patients completed the study protocol. Result : Bleeding time was prolonged within normal range after 2 and 4 weeks of treatment in sertraline 50mg administration group. Bleeding time was not prolonged in the other groups. No patient developed clinical signs of abnormal hemostasis during the study period. Conclusion : Bleeding time was prolonged within normal range at initial period of treatment with sertraline.

호박(Cucurbita pepo L.) 종자의 자엽조직을 이용한 체세포배형성

홍남주,박현용 조선대학교 부설생명과학 연구소 1999 생명과학 연구 Vol.7 No.-

호박종자의 자엽절편체를 20μM 2,4-dichlorophenoxy acetic acid (2,4-D)가 첨가된 Murashige와 Skoog(MS) 배지에 치상한 후, 24시간 낮은 광조건(3000Lux)에서 배양하여 callus와 체세포배형성을 유도하였다. 2,4-D가 첨가된 MS배지에서 유도된 캘러스를 동일 배지에 계대배양하는 동안 치밀하게 생장하는 embryogenic callus는 계대배양 횟수의 증가와 함께 더 높은 빈도로 출현하였다. 이러한 callus로부터 somatic embryos의 생성은 3차 계대배양 후, 생장조절제가 첨가되지 않은 MS 배지에 2주 배양 후에 embryo의 형성이 관찰되었으며, 계속되는 배양에서 embryo 형성이 증가되었다. Somatic embryogensis was induced from seed cotyledons of pumpkin (Cucurbita pepo L.). Seed cotyledonary explants were cultured on MS medium supplemented with 20μM 2,4-dichlorophenoxey acetic acid(2,4-D) by incubating at 25 ± 2℃ under 24 hrs photoperiod (3000 Lux) for 4 weeks. The explants were transferred (subcultured) to same medium and to growth regulator-free MS medium for 4 weeks. Three times subculture on the same medium containing 20μM 2,4-D was required for somatic embryogenesis. Somatic embryos was only observed on growth regulator-free MS medium after 2 week cultures in the 4th subculture.

인공모래 부산물 재활용 방안

김경남,신대용,이현종 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

인공모래 제조시 부산물로 발생하는 석분슬러지에 의한 환경문제와 폐기되는 자원의 활용문제를 해결하기 위하여 석분슬러지와 점토 및 폐유리분말을 이용하여 900∼1,100℃로 소성하여 세라믹스 건자재를 제조하였다. 석분 슬러지는 평균입경 16.3㎛, 비표면적 0.42㎡/g, 화학조성은 CaO 46.43wt%, SiO_2, MgO 와 Al_2O_3가 7.83 wt% , 6.17 wt% 및 3.13 wt%이며, 주결정상은 calcite (CaCO_3)와 dolomite (CaMg(CO_3)_2)로서 약 800℃에서 CaCO_3나 CaMg(CO_3)_2의 열분해에 의한 32.52wt% 의 강열감량을 나타내었다. 석분슬러지와 점토를 이용한 시편(No. 1, 4, 7, 10 및 13)은 점토의 첨가량과 소성온도가 증가함에 따라 시편의 부피비중 및 압축강도는 증가하였으나 기공률과 흡수율은 감소하여 No. 1, 4, 및 7 시편은 부피비중 1.78∼1.98, 기공률 6.4∼12.5%, 흡수율 10.3∼12.7%, 압축강도 264∼370kgf/㎠을 나타내었다. 폐유리분말을 첨가한 시편(No. 2, 5, 6, 8, 9, 10 및 12)의 부피비중과 압축강도는 1.91∼2.63 및 213∼895kgf/㎠로서 폐유리분말의 첨가가 시편의 소결성과 압축강도의 향상에 기여하여 세라믹스 건자재로 사용이 가능하였다. The utilization of waste stone powder sludge produced secondarily from artificial sand plants of Ssangyoung resource development (Co.) and general waste, as was classified, became very important to solve the environmental problem and waste materials recycle. In the chemical composition of stone powder sludge, the amount of CaO was 46.43wt%, SiO_2, MgO and Al_2O_3 were 7.83 wt% 6.17 wt% and 3.13 wt%, respectively. The mean average particle size was 16.3㎛ and specific surface area was 0.42㎡/g. Main crystal phases were calcite (CaCO_3) and dolomite (CaMg(CO_3)_2) and ignition loss was 32.52wt% because of decomposition of CaCO_3 or CaMg(CO_3)_2. Specimens were fabricated by mixing the waste stone powder sludge, low-grade clay, waste glass powder and sintering at 900∼1,100℃ for 2 hours. The density and compressive strength of specimen increased with increasing the sintering temperature and the amount of clay. The specimen showed the bulk density of 1.78∼1.98, porosity of 6.4∼12.5%, water absorption 10.3∼12.7% and compressive strength of 264∼370 kgf/㎠. Those of the specimen heated at 1,050℃ increased with increasing the added amount of waste glass powder, bulk density was 1.91∼2.63 and compressive strength was 213∼895 kgf/㎠. Therefore, the waste stone powder sludge can be used as a constructional materials.

난소 임신 10예의 분석

김용진,이충일,이해혁,남계현,이임순,이권해 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Ovarian pregnancy is an uncommon form of the ectopic pregnancies. The ovarian vascularity results in maternal hemorrhage early in the first trimester, which disrupts the pregnancy and usually ruptures the ovary with sufficient hemoperitoneum to require emergency operation. This report presents 10 cases of ovarian pregnancy by retrospective review between January 1986 and December 1995 at the Department of Obstetrics and Gynecology, Soonchunhyang University Hospital. There was 19,849 deliveries and 637 ectopic pregnancies during same period. It showed that the incidence of ovarian pregnancy was 3.21 % of all ectopic pregnancies. The clinical features of ovarian pregnancy revealed that abdominal pain was the major symptom, and history of amenorrhea was obscure. Because of life-threatening course, the early diagnosis and treatment of ovarian pregnancy is important. The clinical diagnosis of ovarian pregnancy was more difficult than that of tubal pregnancy.

원발성 폐암 환자의 생존율에 관한 보고

김현태,이상무,어수택,박춘식,정성환,허승재,남충희,강창희,김용훈 순천향대학교 1994 논문집 Vol.17 No.4

We analysed 404 patients with primary lung carcinoma who were treated at Soonchunhyang University Hospital from July, 1985 to september, 1993 in order to investigate the survival rate and epidemiolgical properties of primary lung cancer. They were 330 males and 74 females. The most prevalent decade was seventh. In terms of cell type, the squamous cell was 225 patients (55%), and adenocarcinoma, small cell, mixed type was 21%, 19%, 4%, respectively. Among non-small cell lung carcinoma, stage Ⅲa was the most prevalent one(92%). In case of small cell carcinoma, the limited stage was 64%. The 12-, 24-, 36- month survival rate of total patients was 57%, 31%, 22%, respectivley and median sruvival time was 15 months. The 36-month survival rate tended to be longer in non-small cell lung carcinoma than that of small cell lung cancer, but there was no difference between two groups, statistically. In non-small cell carcinoma, The 36-month survival rate and meidan survival time were longer in the stage Ⅰ and Ⅱ than those of Ⅲa, Ⅲb, Ⅳ (80% versus 38%, 22%, 0%, p<0.05). According to involvement of lymph node, the 36-month survival rate was longer in NO and N1 than those of N2, N3 (61.9%, 48.7% versus 17.7%, 17.3%, p<0.05). In small cell carcinoma, The 36-month survival rate and median survival rate were higher and longer in limited stage than those of extensive stage(16.1% and 13 month vs 10% and 8 month, p<0.05). In conclusion, we report here the incidence of primary lung carcinoma and the survival rate of paients with primary lung carcinoma who were treated in Soonchunhyang University Hospital.

합기도 수련생의 수련 지속 요인에 관한 연구

김의영,남승현,김석일,정용우,정천규 龍仁大學校 武道硏究所 1998 武道硏究所誌 Vol.9 No.1

This study investigated participants who have taken part in Hapkido continuously, in view of age, carrier in exercise, and gender and then analysed how these factors affect continuous participation in Hapkido. 1) The significant factors which enable the participants to continue Hapkido were revealed as health/physical fitness(71.67%), enjoyment / interrest (58.13%), self-protetio / guard(48.28%), phychological benefits(20.94%) 2) The factors of continuing Hapkido were different in ages, which showed significant differences in phychological benefits, skill fulfilment / challenge, accomplishment / position, charm, recreational activity. The response represented specifically in one or two areas in case of younger participants. The more aged, it showed relatively even distribution to the various responses due to the broaden span of thoughts. 3) The factors of continuing Hapkido were different in carrier, which showed significant differences in self-protection / grard, skill fulfillment / challenge, accomplishment/ position in different experiences in exercise. By the time of reaching first phase and second phase, it is thought to show the psychological effect of continuing exercise unconsciously in various areas. 4) The factors of continuing Hapkido were not different in gender, which implicated the fact that the overall attitude and thoughts on Hapkido of female participants and male participants are similar.

중국산 식욕 억제제 복용으로 유발된 암페타민 의존 의증 1례

김석현,남정현,박용천 漢陽大學校 精神健康硏究 1999 精神健康硏究 Vol.18 No.-

고령 폐결핵환자(60세 이상)에서의 방사선학적 소견

박정희,진용현,임종남 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

In this elderly patients, incidence of pulmonary tuberculosis is very high because of the decreased function of the body immune system and combined diseases. We analysed radiographic findings of 51 patients with pulmonary tuberculosis to compare with the typical findings of reactivation pulmonary tuberculosis in the adult over 60 years old. The typical location of reactivation pulmonary tuberculosis is the apicoposterior segment of the upper lobe and the superior segment of the lower lobe. But in elderly patients of our study, 38cases(76%) showed lesions also in atypical location such as the anterior segment of the upper lobe, the middle lobe, or the basal segments of the lower lobe. Also 36cases(72%) showed multilobar extents, 30cases(59%) showed unusual findings and 26cases(52%) showed multiple cavities and in 19 cases(38%), differential diagnosis with lung cancer was difficult. Especially in patients with diabetes mellitus, involvement of the anterior segment of the upper lobe was significantly high compared with the patients without DM.