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한국어 판 WHO-CIDI(Composite International Diagnostic Interview)-Alcohol의 개발:신뢰도 및 타당도 검사
남궁기,유계준,조은영,송선미,이희상,길계선,조현상,우용일 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6
CIDI-Alcohol의 한국어 판 개발을 위해 이를 우리말로 번역, 수정하고, 정신병원에 입원한 환자 90명과 일반인 50명에게 시행한 후 임상 진단과 비교하여 일치도를 봄으로써 그 신뢰도 및 타당도를 조사하였다. 결과는 다음과 같다. 1) 주정 사용 각 진단 범주에 대한 한국어 판 CIDI-Alcohol의 일반 면담자간 진단 일치도는 97%∼100%의 높은 일치도를 보였다. 2) 임상 진단을 기준으로 한 한국어 판CIDI-Alcohol의 주정 사용 장애의 진단 일치도는 각 진단 범주별로 kappa치가 0.43∼0.55로 기존의 연구에 비해 비교적 낮았다. 3) CIDI-Alcohol의 진단 기준을 변화시켜, 각 진단 범주에 대한 임상 진단과의 일치도를 알아본 결과 ICD-10/harmful use는 진단 기준 항목의 수를 2개 이상으로 하였을 때, DSM-Ⅲ-R/주정 의존은 진단 기준 항목의 수를 4개 이상으로 하였을 때 임상 진단과 가장 일치하였다. 이런 결과는 한국어 판 CIDI-Alcohol의 진단 기준이 대체적으로 민감도는 높으나, 특이도가 떨어지는 것으로 생각할 수 있으며, 따라서 본 연구자들에 의해 작성된 한국어 판 CIDI-Alcohol는 일반인구 집단을 대상으로 하는 역학 조사보다는 주정 사용 장애로 이루어진 순수한 실험군의 연구에 적합하다고 생각된다. he authors translated a CIDI-Alcohol, a highly structured diagnostic interview, into Korean and examined the validity and reliability of the Korean version of CIDI-Alcohol. In order to examine the validity and reliability of CIDI-Alcohol, the authors calculated the degree of agreement of CIDI-Alcohol diagnoses between the two lay interviewers and sensitivity, specificity, kappa coefficient between clinical and lay CIDI-Alcohol diagnoses. The results were as follows: 1) Agreement rates of CIDI-Alcohol diagnoses between the two lay interviewers ranged from 97% to 100%. The kappa coefficient for each diagnosis was quite high(0.96-1.0). 2) The kappa value of agreement between clinical and lay CIDI-Alcohol diagnoses ranged from 0.43 to 0.55, which was lower than those of other studies. 3) With canging the diagnostic criteria of CIDI-Alcohol, The highest agreement rate between clinical and CIDI-Alcohol diagnoses was acquired when the authors used two or more diagnostic criteria of ICD-10/harmful use and four or more diagnostic criteria of DSM-Ⅲ-R/ alcohol dependence.
오병훈,권준수,남궁기,김승현,지익성,김창윤,하규섭,박원명,김성곤,오강섭,김정범,이수정,정한용,이창욱,박용천,이영문,김세주,이병욱 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5
Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation Processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.
Yong Wook Kim,Su Mi Bae,Keun Ho Lee,Joon Mo Lee,Sung Eun Namkoong,Chong Kook Kim,Yong-Wan Kim,Jeong-Sun Seo,Insu P. Lee,Jeong-Im Sin,Woong Shick Ahn 대한암학회 2004 Cancer Research and Treatment Vol.36 No.4
Purpose: An arsenical compound, As2O3, has been reported to be effective for treating acute leukemia and inducing apoptosis in many different tumor cells. In this study, the ability of As4O6 to suppress cell growth and induce gene expression patterns was tested using a cDNA microarray in HPV16 immortalized cervical carcinoma cells, SiHa cells, along with As2O3. Materials and Methods: A novel arsenical compound, As4O6, was designed and its ability to induce cell growth inhibition as well as gene expression profiles along with As2O3 in HPV16 infected SiHa cervical cancer cells was compared. Both As2O3 and As4O6 induced apoptosis in SiHa cells, as determined by DNA ladder formation. To further compare the gene expression profiles between these two drugs, a 384 cDNA microarray system was employed. Also, the gene expression profiles were classified into the Gene Ontology (GO) to investigate apoptosis-related cellular processes. Results: As4O6 was more effective i suppressing the growth of SiHa cells in vitro compared to As2O3. In the case of treatment with As2O3, 41 genes were up- or down- regulated at least 2 fold compared to non-treatment. However, 65 genes were up- or down-regulated by As4O6 treatment. In particular, 27 genes were commonly regulated by both arsenic compounds. Also, the GO analysis indicated that down-regulation of cell-regulatory functions, such as cell cycle, protein kinase activity and DNA repair, induced anti-tumor effect. Conclusion: These data support that As4O6 could be more effective than As2O3 in inhibiting the growth of HPV16 infected cervical cancer cells. This appears to be mediated through a unique, but overlapping regulatory mechanism(s), suggesting that the regulated genes and cellular processes could be further used as a new potential drug approach for treating cervical cancer in clinical settings.(Cancer Res Treat. 2004; 36:255-262)
Polymorphism of Coagulation Factor XIIIA and XIIIB Subunits of Plasma in Korean Population
NamKoong, Yong,Lee, Chung Choo,Hong, Seung Ho,Kim, Hyun Sup,Lee, Kyung Lyong 한국유전학회 1989 Genes & Genomics Vol.11 No.4
As a part of researches for identifying the genetic composition of Korean population, authors have studied the phenotypes and allele frequencies of Coagulation Factor XIIIA (FXIIIA) and Coagulation Factor XIIIB (FXIIIB) in the plasma of Korean using agarose gel isoelectric focusing followed by immunoblotting. In the study of 329 individuals of Seoul, Kangreung and Kwangju, the identified phenotypes of FXIIIA were FXIIIA 1 (75.99%), FXIIIA 2-1 (23.40%) and FXIIIA 2 (0.61%). The allele frequencies of FXIIIA^*1 and FXIIIA^*2 were 0.8769 and 0.1231, respectively. And the phenotypes of FXIIIB were FXIIIB 1 (8.6%), FXIIIB 3 (46.9%), FXIIIB 3-1 (41.0%) and FXIIIB 3-2 (3.4%). Allele frequencies of FXIIIB^*1, FXIIIB^*2 and FXIIIB^*3 were calculated to be 0.2914, 0.0172 and 0.6914, respectively. The frequencies of FXIIIA^*1 and FXIIIA^*3 in Whites was slightly higher in Blacks, but that in Korean people were much higher than that in Blacks and Whites.
NAMKOONG, YONG,KIM, YUNG JIN,LEE, CHUNG CHOO 충남대학교 기초과학연구소 1993 연구논문집 Vol.13 No.-
As a part of research for clarifying the genetic composition of Korean population, phenotypes and allele frequencies of Apo A-Ⅳ and Apo E in human plasma have been studied using polyacrylamide gel isoelectric focusing and immunoblotting techniques. Blood samples were obtained from healthy individuals living in Seoul. Kangnung and Cheju, Korea. Two phenotypes of Apo A-Ⅳ controlled by two alleles were appeared in Korean population. The calculated allele frequencies of Apo A-Ⅳ*1 and Apo A-Ⅳ*2 were 0.9851 and 0.0149, respectively. There were four phenotypes for Apo E in Korean population. On the basis of 3 alleles for Apo E, allele frequencies of Apo E*2, Apo E*3 and Apo E*4 were 0.0054, 0.8216, and 0.1730, respectively.
Activity of Green Tea Polyphenol Epigallocatechin-3-gallate Against Ovarian Carcinoma Cell Lines
Yong Wook Kim,Su Mi Bae,Sung Eun Namkoong,Sei Jun Han,Sang Hee Kim,Yong-Wan Kim,Joon Mo Lee,Byoung Rai Lee,Young Joo Lee,Woong Shick Ahn,Insu P. Lee,Chong Kook Kim 대한암학회 2004 Cancer Research and Treatment Vol.36 No.5
Purpose: A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), is known to possess anti-cancer properties. In this study, the time-course of the anticancer effects of EGCG on human ovarian cancer cells were investigated to provide insights into the molecular-level understanding of the growth suppression mechanism involved in EGCG-mediated apoptosis and cell cycle arrest. Materials and Methods: Three human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells) were used. The effect of EGCG treatment was studied via a cell count assay, cell cycle analysis, FACS, Western blot and macroarray assay. Results: EGCG exerts a significant role in suppressing ovarian cancer cell growth, showed dose dependent growth inhibitory effects in each cell line and induced apoptosis and cell cycle arrest. The cell cycle was arrested at the G1 phase by EGCG in SKOV-3 and OVCAR-3 cells.In contrast, the cell cycle was arrested in the G1/S phase in PA-1 cells. EGCG differentially regulated the expression of genes and proteins (Bax, p21, Retinoblastoma, cyclin D1, CDK4 and Bcl-XL) more than 2 fold, showing a possible gene regulatory role for EGCG. The continual expression in p21WAF1 suggests that EGCG acts in the same way with p53 proteins to facilitate apoptosis after EGCG treatment. Bax, PCNA and Bcl-X are also important in EGCG-mediated apoptosis. In contrast, CDK4 and Rb are not important in ovarian cancer cell growth inhibition. Conclusion: EGCG can inhibit ovarian cancer cell growth through the induction of apoptosis and cell cycle arrest, as well as in the regulation of cell cycle related proteins. Therefore, EGCG-mediated apoptosis could be applied to an advanced strategy in the development of a potential drug against ovarian cancer. (Cancer Res Treat. 2004;36:315-323)
Regulation of Yolk Protein 2 Gene Expression in Drosophila immigrans
Yong, Namkoong,Chung, Yun Doo,Kim, Se Jae,Kwon, Hyeok Choon,Kim, Kyungjin,Lee, Chung Choo,Chung, Ki Wha,Choe, Oh Mok 濟州大學校 基礎科學硏究所 1995 基礎科學硏究 Vol.8 No.1
The three yolk protein genes (ypl, yp2 and yp3), encoding the three major polypeptide precursors of egg yolk, are developmentally regulated genes. The yps are expressed in sex-, stage-, and tissue-specific manners. It was reported that different cis-acting DNA regions are required for each of these tissue specificities in Drosophila melanogaster. In this paper, the developmental profile of yp2 expression was analyzed by northern blot and immunoblot analysis in Drosophila immigrans. The developmental profiles of mRAA and protein synthesis titers were very similar to those of D. melanogaster. The mRNA was first detected at more than 1 day after eclosion and the entire expression time of D. immigrans was longer than that of D.melanogaster. Electrophoretic mobility shift assay(EMSA) was carried out to identify the candidates for transacting factors that regulate the ovary-specific expression of yps. It revealed that only the crude extract from ovaries of adult females, not from fat bodies, could shift the mobility of the HindⅢ/PstI fragment of yp2. It suggests that this binding protein(s) may be an ovary-specific trans-acting factor(s). To purify the DNA binding protein, a glass bead binding purification method was devised. Using this method, we purified a putative DNA-binding protein with an apporximate molecular weight of 55-60 kDa.
NamKoong, Yong,Lee, Chung Choo,Hong, Seung Ho,Oh, Moon You 한국유전학회 1990 Genes & Genomics Vol.12 No.4
Genetic variations of human plasma α₁B-glycoprotein (α₁B) was observed using two-dimensional agarose gel electrophoresis (pH 5.4) - horizontal polyacrylamide gel electrophoresis (PAGE), pH 9.0 or one-dimensional PAGE (pH 9.0) followed Western blotting with specific antiserum to α₁B as alternative method. Among the 612 unrelated individuals living in Seoul (205 individuals), Kangreung (200 individuals) and Cheju (207 individuals) of Korea, four different α₁B phenotypes (1-1, 1-2, 2-2 and 1-3) were identified. Also, to conform whether each types are the same protein, peptide mapping of these proteins was performed. The frequencies of A1B^*1, A1B^*2 and A1B^*3 alleles were calculated to be 0.8897, 0.1021 and 0.0082, respectively. Mongoloid populations showed a higher degree (polymorphism information content) of α₁B variations than Caucasian populations that have been studied except Swedish Lapps population.