표면곡률을 이용한 물체의 형상특징추출

조동욱,김지영,박웅규,윤상균,이성석,김태우 西原大學校 1992 西原大學 論文集 Vol.29 No.-

In this paper, a new shape feature extraction method of the objects using surface curvatures is described. First, the values of the H & K are calculated from range data as given input. Then objects are assigned in the form of 8 primitives by the signs of the H & K values. But existing methods have the difficulties with the complex object. Therefore, We propose the method for the complex primitives such as cone ridge and cone valley. Finally, the effectiveness of this paper is demonstrated by several experiment.

백서 해마에서 카이닌산 유도 경련에 의한 JNK 경유 신호전달경로 활성화의 발달 단계에 따른 변화

김종흔,정희연,노명선,안용민,강웅구,김용식,조수철 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 어린 백서의 해마에서 전기경련충격(electroconvulsive shock, ECS) 후 활성화되는 것으로 알려져 있는 MAPK계 신호전달경로가 카이닌산(Kainic acid, KA)에 의한 경련 후 어떤 양상으로 활성화되는 지를 초기 발달 단계에 따라서 관찰하고자 하였다. 방 법 : 생후 7일, 14일, 21일 된 어린 백서와 성년 백서의 해마에서 면역블롯 방법으로 MAPK계 효소의 인산화 효소 중 하나인 SAPK/ERK kinase-1(SEK-1), MAPK계 효소인 c-Jun N terminal protein kinase(JNK), 전사인자 c-Jun 및 조기유전자 단백질 Fos의 단백질 양과 기저 인산화를 측정하였고, 백서에게 KA를 주사하여 경련을 유발한 후 위 단백질들의 인산화 변화의 양상을 같은 방법으로 관찰하였다. 결 과 : SEK-1, JNK, c-Jun 모두 연령 증가에 따른 단백질 양 자체에는 변화가 없었다. JNK와 c-Jun은 기저 인산화의 양적 변화도 없었으나 SEK-1의 경우 기저 인산화 양이 생후 7일에 가장 높고 이후 연령이 높아짐에 따라 감소하였다. JNK의 경우 KA 주사 후 인산화 변화 양상이 관찰되지 않았으나 SEK-1과 c-Jun은 생후 14일부터 연령의 증가와 함께 인산화 양도 증가하였다. Fos 역시 생후 7일부터 발현되어 연령의 증가와 함께 발현양이 증가하였다. 결 론 : 백서 해마에서의 MAPK계 신호전달계의 성숙은 연령의 증가에 따라, 또 신호전달 물질에 따라 차이를 보였다. KA 유도 경련 후 JNK는 생후 21일까지도 활성화가 되지 않는 것으로 보아, 세포주에서 알려진 SEK-1 - JNK-c-Jun - Fos로 연결되는 신호전달 경로가 어린 백서의 해마에서는 적용될 수 없음을 시사한다. Objective : We observed the developmental pattern of activation of MAPK signal transduction pathways known to be activated by eletroconvulsive shock(ECS) in young rat hippocampus after kainic acid(KA)-induced seizure. Methods : We used the method of immunoblotting for examining the basal protein amount and basal level of phosphorylation of MAPK kinase(SAPK/ERK kinase -1, SEK-1), MAPK(c-Jun N terminal protein kinase, JNK), transcription factor(c-Jun) and immediate early gene proteins(Fos) in rat hippocampus at postnatal day 7, 14 and 21, respectively. We also examined the changes of phosphorylation of those proteins after kainic acid-induced seizure in the same way. Results : The basal protein amounts of SEK-1, JNK, and c-Jun did not show age-dependent changes and basal level of phosphorylation of JNK and c-Jun remains unchanged throughout the early developmental period. The basal level of phosphorylation of SEK-1 was peaked at postnatal 7 days and then decreased with aging. After kainic acid-induced seizure, the change of phosphorylation of JNK was not observed but those of SEK-1 and c-Jun increased after postnatal day 14. The expression of Fos was observed at postnatal day 7 and also increased with aging. Conclusion : These results show that the MAPK signal transduction system in rat hippocampus matures in accordance with aging, but the process of maturation differs depending specific proteins. This study suggests the signal transduction cascade(SEK-1 - JNK - c-Jun - Fos) which is well established in cell line studies may not be applied to rat hipposcampus because we could not observe the activation of JNK after KA-induced seizure in young rat hippocampus.

국소마취제의 피부수송체를 위한 제제개발 및 평가

조미현,김동우,박용근,지웅길 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-

For the dermal drug delivery system of local anesthetics (lidocaine HCl, and benzocaine), the drugs were formulated as hydrogel. The experiments of the formulation design were summarized as below, the lipid-water partition coefficients of drugs were evaluated and the vehicles with different concentrations of ethanol, glycerine and various enhancers were prepared for the formulation of hydrogel. After using these vehicles, hydrogel were formulated. The gelling agent was poloxamer 407. The resulting preparations were evaluated using in vitro drug permeation and drug accumulation in hairless mouse skin. The preparations were also evaluated by their viscosity and stability, In addition, using the tail-flick analgesia test, analgesic activity of the gel was compared with that of commercial cream.

교각의 세굴 방지에 관한 실험적 연구

조용진,김웅용 충주대 산업과학기술연구소 1999 産業科學論文集 Vol.7 No.2

This study based on the laboratory works, analyzes factors affecting local scour protection order to understand various charateristics of the local scour surrounding bridge piers. Attached with scour protection device as a method for decreasing local scour, it carries out the laboratory experiments and calculates the scour depth. From the expeiments attached with the scour protection devices, it seems possible to reduce the scour depth as the protecting plate and column are built in the same height with flume bed at paler or footing upstream interrupted falling flow. And then it could reduce scour depth. The paper presents the following research results: First, the decreasing degree of scour depth is in order of protecting column, protecting plate and non-protecting facilities. However, it shows no meaningful difference between protecting column and protecting plate. Second, Initiation of the local scour is frequently concided with protect device when v/ Vc is more than 0.6 and the beginning of scour around bridge piers wthout protection device is happened in v/Vc 〉0.4 Third, in Lp/b=0.5∼1, decreasing effect of scour depth is maximized Whose value approaches range the maximum 40 percents. Furthermore, the effect is not sever Lp/b 〉1.

산업대학 건축공학과 교육과정 개발에 관한 연구

임응찬,한인웅,이승준,박재호,조방현,서형수,정구용,한기원,김진원,임상규,이재윤 三陟大學校 1996 論文集 Vol.29 No.2

By impproving the educational program of the Department of Architectural Engineering and studying the theory of learning and the applied method necessary for the development of nation and society, we should develop a satisfying course of education to meet the demand and skill in the industralized society for the purpose of cultivating men of baility with great personalities and creative minds. Therefore, this study focused on classifying several kinds of occupations in the prart of architectured related to what graduates from the department of Architectural Engineering go with into the society. Accordingly after choosing some works adequate to each occupation by the proposed curricula, we tried to establish the scope of education and courses corresponding to the jobs and thus and develop a satisfying curriculum.

니코틴과 트리암시놀론 아세토니드를 함유하는 생분해성 마이크로스피어의 제조시 분무건조법과 용매증발법의 비교

박선영,조미현,이종화,김동우,지웅길 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.4

The microspheres have been developed as a new drug delivery system. Although many particulate drug carriers, such as liposome, niosome and emulsion, have been introduced, injectable and biodegradable microspheres appears to be a particularly ideal delivery system because the local anesthesia is not necessary for the insertion of large implants and for the removal of the device after the drug release is finished. Biodegradable microspheres with nicotine and triamcinolone acetonide are prepared and evaluated. As biodegradible polymers, PLA (M.W. 15,000, PLA-0015), PLGA (M.W. 17,000, RG 502) and PLGA (M.W. 8,600, RG 502H) are used. This study attempted to prepare and evaluate the nicotine and triamcinolone acetonide-incorporated microspheres, which were prepared by two methods, solvent-evaporation and spray-drying methods. The microspheres, as a disperse system for injections, were evaluated by particle size, size distribution, entrapment efficiency, and in vitro drug release patterns. The differences of preparation method, partition coefficient, types of polymer, and preparation conditions of microspheres influence the particle size, entrapment efficiency, and in vitro drug release patterns.

打設式 管井의 Developing工法에 關한 硏究

權武男,李基明,金照雄 慶北大學校 1975 論文集 Vol.20 No.-

The purpose of this study is to develop the economic and effective Developing machine and method for the maintenance of function and development of tube wells. The results studied in these experiments are as follows: 1. The ability from various Developing instruments, Sand-Excluding(Dry Weight), is more than 2 times to compare air compressor and surge plunger method with hand pump method. 2. The thickness of the formed filter layer influenced largely on the ability of concentrating water is about 7 centimeters under the methods of the Developing and the gravel packing. 3. The possible pumping rates and the draw down of water table on the same pumping rates (100tons/day) equal to the Developing and gravel packing method.

강박증 환자에서의 인격장애 공존병리에 관한 연구

이동우,강웅구,류인균,정도언,조맹제,우종인,김용식,권준수 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 강박증의 동반인격장애에 관한 연구들은 기존의 개념과 달리 강박성 인격장애와 강박증 간에는 특이적인 관계가 없으며, 강박증 환자들은 다양한 인격장애를 동반한다는 결과를 보여주었다. 그러나 이러한 연구들은 동반 인격장애에 관한 기술적인 분석에 그쳤고, 강박증 환자군의 임상 증상과 동반 인격장애 양상간의 연관성에 관한 분석을 시행하지 않았다. 본 연구의 목적은 강박증 환자군에서의 동반 인격장애를 평가하고 강박증 환자의 다양한 증상과 동반 인격특성 간의 연관성에 대해 연구하는 것이다. 방 법 : DSM-IV의 강박증의 진단기준을 만족하는 59명의 환자군과 32명의 정상대조군을 대상으로 인격장애 질문지를 적용한 후 4∼6점의 절단점을 기준으로 인격장애의 진단이 내려졌다. 먼저 환자군과 정상대조군 간의 특정 인격장애 빈도의 차이를 알아보기 위하여 Fisher's exact test를 시행한 후, 두집단 간에 유의한 차이가 있는 것으로 밝혀진 인격장애 척도 점수에 미치는 Y-BOCS,BDI,BAI점수의 영향을 알아보기 위하여 다중선형회귀 분석을 시행하였다. 결 과 : 1) Fisher's exact test 결과 강박증 환자군은 정상 대조군에 비해 경계성 인격장애(18.6%vs 0%, p=0.007). 회피성 인격장애(55.9% vs 18.8%, p=0.001), 우울성 인격장애(40.7% vs 0%, p=0.000)의 비율이 유의하게 높았다. 2) 다중선형회귀분석 결과 Y-BOCS 점수 (t=2.10, p=0.043)와 BAI점수(t=2.60, p=0.014)는 경계성 인격장애 점수에 유의한 영향을 주는 것으로 나타났다. 또한 BAI점수(t=3.23, p<0.003)는 회피성 인격장애 저수에, BDI점수 (t=3.08, p=0.004)는 우울성 인격장애 점수에 유의한 영향을 주는 것으로 나타났다. 결 론 : 강박증 환자군은 정상 대조군에 비해 회피성 인격장애, 우울성 인격장애, 경계성 인격장애의 동반율이 높고, 강박증이 경계성 인격장애의 심각도에 유의한 영향을 미치는 것으로 사료된다. The purpose of this study was to assess the comorbid axis-Ⅱ disorders of obsessive compulsive disorder(OCD) patients and to investigate the relationship between symptoms of OCD and the comorbid personality traits. The subjects were 59 patients who met DSM-IV criteria for obsessive-compulsive disorder and 32 normal controls. All subjects completed personality Disorder Questionnaire-IV(PDQ-IV). The patients completed Beck Depression Inventory(BDI) and Beck Anxiety Inventory(BAI), and were rated with Yale-Brown Obsessive Compulsive Scale(YBOCS). The results were as follows. 1) The OCD patients showed significantly higher prevalence of avoidant, depresssive and borderline personality disorder(p<0.01) compared to controls. 2) The BAI score had significant effect on the avoidant personality score(t=3,23, p<0.003). The BDI score had significant effect on the depressive personality score(t=3.08, p=0.004). The YBOCS(t=2.10, p=0.043) and BAI(t=2.60, p=0.014) scores had significant effects on the borderline personality score. We found that OCD patients had higher prevalence of avoidant, depressive, and borderline personality disorders. We also found that obsessive-compulsive symptoms have significant effect on the severity of borderline personalty traits. We suggest that it would be very helpful to consider Axis-Ⅱ disorders for managing patients with obsessive-compulsive disorder.

Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus

Cho, Euna,Ryu, Eun Jin,Jiang, Fen,Jeon, Ung Bae,Cho, Mong,Kim, Cy Hyun,Kim, Miyoung,Kim, Nam Deuk,Hwang, Tae-Ho Dove Medical Press 2018 Drug design, development and therapy Vol.12 No.-

<P><B>Purpose</B></P><P>Oncolytic poxvirus has shown promise in treating various solid tumors, such as liver cancer, and administration of oncolytic poxvirus via the hepatic artery may provide more survival benefits than other routes of administration. However, there is a lack of safety information to guide the application of hepatic arterial infusion (HAI) of oncolytic poxvirus in human studies. To investigate the acute and chronic toxicity of HAI administration of oncolytic poxvirus in animals and provide safety information for future human studies.</P><P><B>Methods</B></P><P>VV<SUP>tk−</SUP>, a vaccinia poxvirus with inactivated <I>thymidine kinase</I> gene, was administered via HAI to rabbits with normal liver function under angiography (1×10<SUP>8</SUP> or 1×10<SUP>9</SUP> pfu), and rats with N-nitrosomorpholine-induced precancerous liver cirrhosis under open surgery (1×10<SUP>8</SUP> pfu). Body weights and survival were monitored and blood samples were collected for hematological and biochemical tests. Distribution of A56 (a specific marker for poxvirus infection) in rabbit organs was evaluated using immunofluorescence assays.</P><P><B>Results</B></P><P>HAI of high doses of VV<SUP>tk−</SUP> did not cause any acute or chronic changes in body weight, survival or in biochemical, hematological tests in the 2 animal models, and none of the changes showed dose dependency (in rabbit study), or were influenced by liver cirrhosis (in rat study). A56 was not detected in any of the major rabbit organs.</P><P><B>Conclusion</B></P><P>HAI may provide a safe alternative route of oncolytic poxvirus administration for human studies.</P>

Protective Effects of Lupeol against <small>d</small>-Galactosamine and Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice

Kim, So-Jin,Cho, Hong-Ik,Kim, Seok-Joo,Kim, Joon-Sung,Kwak, Jong-Hwan,Lee, Dong-Ung,Lee, Sang Kook,Lee, Sun-Mee American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.11

<P>This study examined the hepatoprotective effects of lupeol (<B>1</B>, a major active triterpenoid isolated from <I>Adenophora triphylla</I> var. <I>japonica</I>) against <SMALL>d</SMALL>-galactosamine (GalN) and lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were orally administered <B>1</B> (25, 50, and 100 mg/kg; dissolved in olive oil) 1 h before GalN (800 mg/kg)/LPS (40 μg/kg) treatment. Treatment with GalN/LPS resulted in increased levels of serum alanine aminotransferase, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, as well as increased mortality, all of which were attenuated by treatment with <B>1</B>. In addition, levels of toll-like receptor (TLR)4, myeloid differentiation primary response gene 88, TIR-domain-containing adapter-inducing interferon-β (TRIF), IL-1 receptor-associated kinase (IRAK)-1, and TNF receptor associated factor 6 protein expression were increased by GalN/LPS. These increases, except TRIF, were attenuated by <B>1</B>. Interestingly, <B>1</B> augmented GalN/LPS-mediated increases in the protein expression of IRAK-M, a negative regulator of TLR signaling. Following GalN/LPS treatment, nuclear translocation of nuclear factor-κB and the levels of <I>TNF-α</I> and <I>IL-6</I> mRNA expression increased, which were attenuated by <B>1</B>. Together, the present findings suggest that lupeol (<B>1</B>) ameliorates GalN/LPS-induced liver injury, which may be due to inhibition of IRAK-mediated TLR inflammatory signaling.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-11/np500296b/production/images/medium/np-2014-00296b_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np500296b'>ACS Electronic Supporting Info</A></P>