난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

급성 심근경색 : Gd-DTPA 조영증강 자기공명영상 Gd-DTPA Enhanced Magnetic Resonance Imaging

정경일,김제현,이창호,이영주,김한수,소동문,이영돈,박경주,왕희정,탁승제,이철주,김선용,김옥화,임태환,문창현,최병일,서정호 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

This study was undertaken to determine the value of gadolinium dimeglumine (Gd-DTPA) enhanced MRI in the diagnosis of acute myocardial infarction. Seven cats were subjected to 2 hours of left anterior descending coronary arteryocclusion (group 1) and 8 cats to 1 hour of occlusion (group 2). Reperfusion was followed by taking Tl-weighted MR images at 5, 15, 30, 45, 60 minutes after Gd-DTPA (0.2 mmol/kg) injection. Myocardial enhancement patterns were categorized into three zones (central ischemic, peripheral ischemic, and normal) or two zones (ischemic and normal) and the presence of injured myocardium in each zone was confirmed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Signal intensity (SI) of each zone was evaluated relative to back muscle in regard to its chronological changes and difference among the zones. Group 1 displayed three zones of enhancement in 6 cats whereas 1 cat in group 1 and all in group 2 showed two zones of enhancement. Intermediate SI central zone was compatible but smaller than TTC nonstained area, and determined to be a persistently occlusive injury. High SI peripheral zone in group 1 and high SI ischemic zone in group 2 were stained and determined as reperfused injury although reversibility was not definite. The peak SI, occurring 15 minutes after Gd-DTPA injection, of 2.47±0.48 at peripheral zone was greater than that of 1.66±0.36 at central zone in group 1 and of 1.81±0.41 at ischemic zone in group 2 (p < 0.05). SI of injured myocardium increased more rapidly and decreased more gradually than that of normal myocardium. That the features of SI change with time in injured myocardium was compatible with the results of other studies using different contrast agents. Gd-DTPA enhanced MRI differentiated persistently occlusive injury as central intermediate SI, and reperfused injury as homogenous high SI, with the maximal contrast between the two at 15 minutes after contrast injection, thus indicating the value of Gd-DTPA enhanced MRI in the diagnosis of acute myocardial infarction.

사업장(事業場) 근로자(勤勞者)의 사상체질(四象體質)에 따른 생활습관(生活習慣), 자각증상(自覺症狀), 건강인식(健康認識)에 관(關)한 연구(硏究)

서명효,강홍구,장두섭,왕명자,차남현,김삼태,권소희,정해경,송용선,이기남,Seo Muoung-Hoy,Kang Hong-Goo,Jahng Doo-Sub,Wang Myoung-Ja,Cha Nam-Hyun,Kim Sam-Tae,Kwon So-Hee,Jung Hae-Kyoung,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2003 대한예방한의학회지 Vol.7 No.2

The study was conducted to evaluate the difference of life style, subjective symptoms and health cognition depending on the Sasang Constitution in the industrial workers. The results were as follows ; Constitutional distribution among exposed group were Tae-eum In(38.4%), So-eum In(35.2%), and So-yang In(26.4%) and it was turned out that Tae-eum In took a higher portion of Sasang constitution than other constitutions in technician workers. 'Exercise' and 'Obesity' were found most in Tae-eum In, In So-eum In there were many 'Normal' weight and 'Having digestive disorders' were found most in So-eum In. There were no significant difference in the health cognition among the constitutions. The closer to 'normal' weight, the higher prevalence in 'having' concern about health condition and the more 'normal' condition in sleeping, the higher prevalence of 'having' self-confident in present health.

정상 성인에서 Amitriptyline이 REM 수면에 미치는 영향

김태범,왕성근,신석철 대한생물치료정신의학회 1995 생물치료정신의학 Vol.1 No.2

To investigate the effects of amitriptyline on REM sleep in normal adults, author applied polysomnography of sleep structure to the volunteer before and after administration of amitriptyline 25㎎. The subjects were 8 healthy young adults, aged from 20 to 24 years old. The results were summarized as follows. 1. Compaired with the baseline, the decrease of the absolute value of REM sleep, the decrease of total REM sleep period and duration, the increase of REM sleep interval occured in amitriptyline administration night. 2. Compaired with the baseline, the increase of the absolute value and the relative of REM sleep, the increase of total REM sleep duration, the decrease of REM sleep latency occured in the first recovery night. 3. Compaired with the baseline, the increase of the relative value of REM sleep, the increase of REM sleep efficiency occured in the second recovery night. 4. In amitriptyline administration night, REM sleep supression effect of amitriptyline occured and in the first and in the first and the second recovery night, rebound phenomenon of REM sleep occured. 5. REM sleep supression effect of amitriptyline occured in totally each REM period time rather in specific sequential REM period, but rebound phenomenon of REM sleep markedly occured in the first REM period in first recovery night.

영어 Crossword 퍼즐 문제 발생기

金旺錫,卞永泰 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-

While the Web grows rapidly, many people, especially young people, use it for the purpose of information retrieval, exchange of information, game playing, etc. On the other hand, a lot of web sites are operated to provide educational material to those who are interested in it. There are also internet broadcasting service channels for education. Most of students using the Web are mainly interested in games and hobby-related information services, but not interested in sites providing educational information and study material. Therefore, it may be nice to provide them with edutainment(education+entertainment) material through the Web. Crossword puzzle problems may have such features, since it is a kind of games, and it provides chances to study a language. We present in this paper the study and implementation results of how to generate English crossword puzzle problems by computer programs. One of important topics in AI is CSP(Constraint Satisfaction Problem) to which the crossword puzzle problems are related. Since there are several constraints in the crossword puzzle, we need to study traditional methods how to represent the problems, what kinds of search algorithms are appropriate, and what kinds of heuristics are helpful. In this paper, we present the summary of traditional approaches to the problems, discuss the design issue, show the implementation of an English crossword puzzle problem generator in which frames are generated automatically with probability, and solutions for them are found. The solutions become eventually the crossword puzzle problems to the public. Several combinations of different models and different algorithms are discussed along with their results.

平和開發에 關한 序說的 硏究

金旺憲,李景泰 경북대학교 평화문제연구소 1988 평화연구 Vol.13 No.-

The main purpose of this paper is to identify the concept of the peace development and to analyze the various factors for it. The inter-disciplinary study and cross-fertilization study on a large volume of literature and the results of pervious studies was carried on for this purpose. The peace development means the process for preparing better lives to conquer critical situation in this global village. Maintenance of world peace, promotion of the welfare of man, security of basic rights, preservation of the ecosystem, and humanization of technology-those are set forth for the main factors of peace development. Through the realization of those tasks man is able to build the global village in which he enjoys a life of happiness in an unpolluted enviroment, impairing the dignity of man in the peaceful world without hunger. Peace in this paper does not mean restraining wars, but more positively, eliminating causes of war. Welfare implies, in a larger sense, the state in which material, spiritual and social needs of man are satisfied. The meaning of human basic rights lies in the natural human right based on the idea of the natural law. Preservation of the ecosystem means to preserve an unpolluted natural environment by preventing contamination and by eliminating its sources. Humanization of technology connotes the technological development which will contribute to the realization of humanism, viewing man as the ultimate value of all. Man is considered to have infinite potentialities to get through any crisis or challenge. It is therefore believed that the ideal gloval village can be built by pursuing the right direction of peace development proposed in this paper. The only problem is the determination of man himself.

정신분열증 환자의 전산화 단층촬영상 대뇌 비대칭성과 대뇌 위축과의 관계

유태열,한진희,채영래,김광수,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.3

Since the advent of computed tomography(CT). there have been growing evidences of cerebral structural abnormalities in schizophrenics. Among them. reversed hemispheric asymmetry has been regarded as impaired cerebral lateralization of schizophrenics representing another pathology different from brain atrophy. To investigate the pattern and frequency of reversed cerebral asymmetry and their relationship with brain atrophy. we analyzed widths of frontal and occipital region on the brain CT scans of right-handed 56 schizophrenics and 52 normal controls by a manual method. Brain atrophies were assessed using fixed arm planimetry and visual lineat measurements. Compared to normal controls. the schizophrenics show significantly increased frequency of reversed occipital asymmetry. Dividing the schizophrenics into group according to the evidences of atrophy revealed more reversed occipital asymmetry than those with brain atrophy. These findings suggest that reversed cerebral asymmetry might be unrelated to brain process and would be a neuroanatomic evidence of abnormal asymmetry of schizophrenices.

저온에서 혐기성 소화에 대한 온도영향

閔庚碩,金弘泰,姜玉熙 慶北大學校 1991 論文集 Vol.51 No.-

This study was conducted to show the possibility of application of anaerobic digestion process in low temperature. Laboratory single-stage anaerobic digester was operated at 15 to 80 days' HRT at the temperature of 15℃, 20℃, 25℃ and 35℃. The results of this study indicated that the organic removal efficiencies and gas productions were remarkably decreased in low temperature. Despite of the low organic loading of 0.67 ㎏-COD/㎥·day at 15℃ the gas production was very poor as 0.16㎥CH_4/㎏COD removed. The observed maximum F/Mv ratio which would get the organic removal efficiencies of 70% and 60% respectively at the temperature of 20℃ and 15℃ were 0.1 ㎏COD/㎏MLVS·day. The substrate removal rates(Km) had a tendency to become larger at higher temperature, and were critical at the temperature of 20 to 25℃.

전방십자인대 재건술 후 등속성 운동검사와 기능적 활동도

김명신,윤태식,노권재,왕진만 大韓再活醫學會 1997 Annals of Rehabilitation Medicine Vol.21 No.6

젊은 성인에서 신체 만족도에 따른 문제해결양식, 대인관계문제와 우울증상과 자살사고와의 관련성

차승민,김태성,강문희,권명진,김정란,왕성근,지익성 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:The aim of this study was to evaluate that problem solving styles, interpersonal problems, depression and suicidal ideation according to body image satisfaction. Methods:One hundred and nineteen young healthy normal subjects filled out administered the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR K-BDDE-SR), Problem Solving Style Scale(Korean version PSS), Korean Inventory of Interpersonal Problem(KIIP), Korean version of the Depression Anxiety Stress Scale(KDASS-21), Korean version of Beck Scale for Suicidal Ideation(Korean version SSI) and Korean version of Reynolds Suicidal Ideation Questionnaire(Korean version SIQ) for a month. Results:Out of the 119 subjects, 39%(N=46) was male and 61%(N=73) was female. In high K-BDDE-SR group (higher than 67), helplessness was significantly higher than low K-BDDE-SR group(lower than 67), and problem-solving confidence, creative style, approach style were significantly lower than low K-BDDE-SR group. Also, Higher level of all KIIP factors in High K-BDDE-SR group was significantly differ than low K-BDDE-SR group. In High K-BDDE-SR group, K-DASS-21, SSI, and SIQ were significantly higher than low K-BDDE-SR group. Using multiple regression analysis contributing variance toward the total factor score of K-BDDE-SR of participants were K-DASS-21 and SIQ. Conclusion:Our results indicates that high tendency of dissatisfied body images have differences in helplessness, problem-solving confidence, approach style, interpersonal problems, depression and suicidal ideation compared to low tendency of dissatisfied body images. It is necessary to study body dysmorphic disorder patients group in the future.