韓國産 자작나무科의 系統分類學的 硏究(序論)

李相泰,蘇雄永,田寬培,李愚喆 全北大學校 生物學硏究所 1981 生物學硏究年報 Vol.2 No.-

The present paper is an introduction to the whole project of "The systematic studies on Korean Betulaceae". Three studies under the project were performed this year and presented in this report : a review of taxonomic literatures and the construction of distribution maps by Woo-Tchul Lee, pollen morphology by Sang-Tae Lee and Moo-Yeol Kim, and wood anatomy by Woong-Young Soh and Kwan-Bae Jeon.

In Vivo ^31P NMR Spectroscopy를 이용하여 젖산 운동시간과 유산소 운동시간에 따른 골격근 섬유의 고 에너지 인(P) 대사 변화

성기홍,임태환,이대근,문치웅,이정희,김상태,신명진,이덕분 대한스포츠의학회 1994 대한스포츠의학회지 Vol.12 No.1

Intracellular high energy phosphorus metabolism can be assessed noninvasively and dynamically by in vivo ^31P NMRS of skeletal muscle have shown various applications of this technique in evaluating the pathophysiology of diseased or normal muscles. High energy phosphate metavolsim in the human skeletal muscle was studies in the work. ^31P nuclear magnetic resonance spectroscopy allowed the evaluate of the lactic acid and aerobic energy system in the intracellular skeletal muscle by energy concentration of ^31P nuclear magnetic resonance spectroscopy allowed the evaluate of the lactic acid and aerobic energy system in the intracellular skeletal muscle by energy concentration of ^31P metabolite, (Pi), (PCr), (ATP). The ratio of Pi/PCr the spectra measured from normal volanteers and elite athleties indicated a signetifcant difference between the two group for each exercise protocal. It was generally ovserved that the all out time of normal volunteers in shorter that that of elite athletes, and the ration of Pi/PCr is samller for elite athlets than for normal volunteers.

BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells

Kim, Hee Kyung,Kim, Sun Young,Lee, Su Jin,Kang, Mihyeon,Kim, Seung Tae,Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Lee, Dong Woo,Park, Woong Yang,Kim, Sung Joo,Park, Se Hoon,Lee, Jeeyun Neoplasia Press 2016 Translational oncology Vol.9 No.3

<P><I>BACKGROUND:</I> Although pazopanib treatment has become the standard chemotherapy in salvage setting for metastatic sarcoma patients, most patients progress after pazopanib treatment in 4 to 6 months. After failure to pazopanib, patients have limited options for treatment. Therefore, subsequent therapy in patients who failed to pazopanib is urgently needed and the use of patient derived cells or patient derived tumors for accompanying testing with various pharmacological inhibitors could offer additional treatment options for these patients. <I>METHODS:</I> Patient derived tumor cells were collected from ascites at the time of progression to pazopanib and a 13-drug panel was tested for drug sensitivity. We confirmed the results using <I>in vitro</I> cell viability assay and immunoblot assay. We also performed the genomic profiling of PDX model. <I>RESULTS:</I> The growth of patient derived tumor cells was significantly reduced by exposure to 1.0 μM AZD2014 compared with control (control versus AZD2014, mean growth = 100.0% vs 16.04%, difference = 83.96%, 95% CI = 70.01% to 97.92%, <I>P</I> = .0435). Similarly, 1.0 μM BEZ235 profoundly inhibited tumor cell growth <I>in vitro</I> when compared to control (control versus BEZ235, mean growth = 100.0% vs 7.308%, difference = 92.69%, 95% CI = 78.87% to 106.5%, <I>P</I> < .0001). Despite the presence of CDK4 amplification in the patient-derived tumor cells, LEE011 did not considerably inhibit cell proliferation when compared with control (control vs LEE011, mean growth = 100.0% vs 80.23%, difference = 19.77%, 95% CI = 1.828% to 37.72%, <I>P</I> = .0377). The immunoblot analysis showed that BEZ235 treatment decreased pAKT, pmTOR and pERK whereas AZD2014 decreased only pmTOR. <I>CONCLUSION:</I> Taken together, upregulation of mTOR/AKT pathway in sarcoma patient derived cells was considerably inhibited by the treatment of AZD2014 and BEZ235 with downregulation of AKT pathway (greater extent for BEZ235). These molecules may be considered as treatment option in STS patient who have failed to pazopanib in the context of clinical trials.</P>

진단 초음파를 이용한 정상 성인의 정중신경 측정

이정아,임길병,이홍재,정웅태,황현오 최신의학사 2003 最新醫學 Vol.46 No.11-12

Hinman 증후군(비신경인성 신경인성 방광) 1예

이경욱,채정호,이승주,김세웅,박원명,전태연,김광수 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.3

Objectives : The Hinman Syndrome is a condition representing urinary voiding dysfunction in a neurologically intact child. This syndrome probably is an acquired behavioral and psychosocial disorders. We present a case presenting voiding dysfuntion with no neurologic etiology. Case : The departmcnt of urology consulted the department of psychiatry for a psychiatric evaluation of a 14-year-o1d girl with a history of recurrent urinary tract infections, enuresis, and urinary dribbling since early childhood. She visited the emergency room bccausc of severe abdominal pain and hematuria. She was admitted to the department of urology. Neurological tests showed no abnormality, but a retrograde cystogram showed free vesicoureteral reflux to the level of the dilated intrarenal collecting systems. Marked blunting and dilatation of the caliccs suggested longstanding urinary flow obstruction. She had a history of scparation anxiety disorder and was very competetive, perfectionistic, and nervous. She also had very poor relationships with her friends and had difficults in managing them. Afer admission, she had stent operation and cystostomy. Antidepressant and anxiolytic medications with supportive psychotherapy were administered to treat anxiety, tension and depression. Gradually, her depressive symptoms and voiding difficulties improved. Conclusions : Psychological factors such as a perfectionistic and obsessive personality, a history of severe separation anxiety, stressors from poor interpersonal relationships and Ihe failure of an entrance examination seem to have contributes to the development and exacerbation of the urinary dysfunction. Pharmacotherapy and supportive psycho-therapy may be efective in treating associated psychiatric problems of these patients with hinman syndrome.

쥐 심실에서 Digitalis Receptor Desensitization에 관한 연구

이신웅,이정수,장태수 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-

[³H]Ouabain binding parameters (K_(v) and B_(max)) to control rat ventricular strips and Langendorff preparations which were not previously exposed to ouabain were compared with those to both preparations that had been first exposed to a complete ouabain dose range of dose-response curve (10^(-5) M to 10^(-4) M). In rat ventricular strips and Langendorff perfused heart preparations, cumulative dose-response curves of ouabain revealed biphasic positive inotropic effects. a "low-dose" effect and a "high-dose" effect with ED_(50) values of 0.5 μM and 35 μM ouabain, respectively. The "low-dose" effect in ventricular strip disappeared or was diminished significantly when the ouabain dose-response curve was repeated after the washout of the effects of the first dose-response curve, whereas there were no significant differences in the maximal "high-dose" effect in both exposures to oubain. However, both of the control and ouabain-preexposed Langendorff perfused hearts revealed the same low-dose effects. The K_(D) value for [³H]ouabain binding and the ouabain binding site concentration (B_(max)) estimated by [³H]ouabain displacement assay in control preparations were 230 nM and 2 p㏖/㎎ protein, respectively. [³H]Ouabain binding parameters were not changed by repeated exposure to high concentrations of ouabain. These results suggest that digitalis receptor desensitization in the rat ventricular strip may due to the change of post-receptor events induced by ouabain binding to a high affinity site (a₂ isoform).

관순법에 의한 휜-관 열교환기의 성능 해석

이태환,유충웅 진주산업대학교 1999 論文集 Vol.38 No.-

A cross-flow finned tube heat exchanger was investigated using a tube-by-tube method. The refrigerant R22 flows inside tubes while the air passes outside the finned tube. A self-constructed refrigerant circuitry was adopted. The refrigerant enthalpy at the exit of each tube and the average condensate layer thickness are investigated as a measure of the heat transfer and the observation with the quantity of condensation phenomenon respectively. The dependence of refrigerant enthalpy and the average condensate layer thickness on the refrigerant circuitry was also observed. It was confirmed that this method could be applied to the analysis of finned tube heat exchanger with condensation.

2종의 뒤영벌 여왕벌의 실내 정착율 비교

이상범,배태웅 東亞大學校 1999 東亞論叢 Vol.36 No.-

국내종 뒤영벌족 중 주요 우점종인 호박벌과 좀뒤영벌의 실내정착가능성을 조사하기 위하여 1997년 3월말에서 5월초까지 수원, 지리산과 인천영흥도에서 채집한 두 종의 여왕벌을 상자별로 사육한 결과 다음과 같은 결과를 얻었다. 호박벌과 좀뒤영벌 모두 상자의 재질이나 크기에 따른 산란율 및 성충출현율의 차이는 없었으나 호박벌이 좀뒤영별보다 산란율, 첫일벌 출현율, 50두 이상 일벌출현율, 새여왕벌 출현군체수, 여왕벌 수명 및 군체의 크기 등에서 좋은 성적을 보여 실내사육이 가능한 종이며 방화성 곤충으로서도 개발이 가능한 종이다. For survey of colony performance by foundation queens collected, collection of domestic species of Bombini was made from March to May of 1997 on Kyungki Suwon, Kyungnam Chiri-Mt. Area and Inchun Younghwung-Do in Korea. And queens of two Bombus species was reared at the 4 kinds of wooden case. The results obtained are as follows; Both of Bombus ignitus and B. ardeus were not a difference between the rate of egg-laid and of warker emergence according to the quality of material and size of all of ages. Bombus ignitus is better than Bombus ardens according to the rate fo egg-laid, rate of first worker emrgence, ≥50 heads of worker emergence, rate of new queen emergence, longivity of foundation queens, and size of colonies. So B. ignitus is possible to develop indoor rearing and foraging insect.

社會體育 活性化를 위한 施設의 開發 및 擴充 : 地域特性을 考慮한 Considered a regional distinction

李泰雄 釜山工業大學校 1990 論文集 Vol.32 No.-

I think that a social physical culture has to activate for people's health. By the way, first of all, the authorities have to secure facilities of athletes. Specially, Korea has mountainous district seventy percentage of whole land, and that, there are sea in the East, West and South. And most of Korea's city have river, hillock and mountain. Generally, we know that getting complete social facilities is to spend much expenses, however, I think that Korea can be furnished with inexpensives good facilities and athletic places if the government uses a gift of land nature well. Therefore, Korea needs to use topographical character, by the way, it would rather consider following three conditions; firstly, to park hillock, riverside around the city. second, to make a route for exclusive use of cycles and walkers. thirdly, to secure marine sports tools.

Ca-alginate 효모 겔 비드를 이용한 삼상 유동층 반응기의 동특성

이호원,김우식,최태웅,유인상 연세대학교 산업기술연구소 1989 논문집 Vol.21 No.2

This study was concerned with effects of gas velocity(0.23∼0.69 cm/sec), liquid velocity(0.42-0.71 cm/sec) and particle size(0.24-0.48cm/sec) on individual phase holdups, local solid holdups and axial dispersion coefficients. Ca-alginate yeast gel beads(s.g.=1.08) were used as the solid phase. In this experimental range, bed porosity decreased with increase in gas velocity but it increased with liquid velocity. And the correlations of axial dispersion coefficients with gas velocity, liquid velocity and particle size were as follows. ?? Especially, axial dispersion coefficients in this column were more increased of liquid velocity than gas velocity.