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      • Ⅲ. Amaranth, Brilliant Blue 및 Tartrazine의 腸片에 미치는 影響

        李神雄,曺圭朴,金和雄,崔在圭 忠南大學校 1972 論文集 Vol.11 No.-

        Pharmacological effect of amaranth, brilliant blue and tartrazine was investigated in guinea pig ileum. Amaranth, brilliant blue and tartrazine over 100㎍/ml concentration induced contraction of guinea pig ileum. Hexamethonium, atropine and promethazine did not prevent amaranth, brilliant blue or tartrazine induced contraction. Tetracaine antagonized the contractile response to amaranth, brilliant blue or tartrazine. In the presence of amaranth, brilliant blue or tartrazine, contractile response to acetylcholine was increased and inhibitory response to norepinephrine decreased. Amaranth, brilliant blue and tartrazine augmented peristaltic movement and intraluminal pressure of guinea pig ileum.

      • 칼슘 길항제가 심장 β-Adrenergic Receptors에 미치는 영향

        이신웅,김정구 영남대학교 약품개발연구소 1993 영남대학교 약품개발연구소 연구업적집 Vol.3 No.-

        It has been known that calcium antagonists also inhibit the radioligand binding to muscarinic and α-adrenergic receptors and, in case of verapamil, these inhibitions may play a role in the effects of verapamil on the heart. In this study, the effects of nicardipine, nifedipine, nimodipine, diltiazem and verapamil on the binding of [³H]dihydroalprenolol (DHA) to dog cardiac β-adrenergic receptors were examined. A single uniform [³H]DHA binding site (K_(D)=5 nM and B_(max)=2600 fmol/mg protein) was identified in dog cardiac sarcolemma. [³H]DHA binding was not affected by the usual therapeutic concentrations of these calcium antagonists (nanomolar range) but in the "nonspecific" concentration ranges (28~180 μM) these drugs inhibited [³H]DHA binding to β-adrenergic receptors. Nicardipine, nifedipine, nimodipine and diltiazem competed for [³H]DHA binding to β-adrenergic receptors with dissociation constants (K_(i)) of 28 μM, 74 μM, 39 μM and 35 μM, respectively. Verapamil (K_(i)=176.5 μM) was less potent inhibitor than other drugs and this inhibition was noncompetitive; the maximal binding capacity (B_(max)) was decreased by 300 μM verapamil without change in the apparent dissociation constant (K_(D)) for DHA. These results indicate that the inhibitory action of calcium antagonists at high concentrations on β-adrenergic receptors is not involved in the therapeutic effects of these drugs by the calcium channel blocking action.

      • KCI등재

        Korean EFL Learners’ Productive Collocation Knowledge and Its Relationship to Their Writing Proficiency

        이신웅 한국영어어문교육학회 2015 영어어문교육 Vol.21 No.4

        The primary purpose of the current study was to investigate Korean university students’ productive collocation knowledge and examine its relationship to the students’ writing proficiency. Seventy four Korean university students, who were mostly freshmen majoring in English at a university located in Seoul, participated in the study. The productive collocation test (PCT) was administered to the students to assess the collocation knowledge and it was found that the verb-noun collocations were harder to retrieve and use than the adjective-noun collocations in general. Besides, the unpredictability from L1 and the existence of various synonyms were identified as the source of difficulties in retrieving and using the collocations. In an attempt to investigate the relationship between the students’ productive collocation knowledge and their writing proficiency, a one-way ANOVA was conducted and it was found that the students with more productive collocation knowledge tended to have high writing proficiency overall. In addition, the result of a hierarchical multiple regression analysis revealed that the students’ productive collocation knowledge could account for their writing proficiency significantly when controlling for their grammatical knowledge and productive vocabulary size. The knowledge of verb-noun collocations, in particular, was found to be significantly related to the students’ writing proficiency.

      • KCI등재
      • KCI등재

        L2 Reading Strategies and Gender: A Study of Korean EFL University Students

        이신웅 한국영미어문학회 2008 영미어문학 Vol.- No.86

        The main purpose of the study is to investigate gender difference in the frequency and pattern of reading strategy use and to see if the gender difference exists, if any, across reading proficiency level. Four hundred sixty six university students who were enrolled in two Korean universities located in Seoul participated in the study. Two major instruments were utilized in the current study. First, the reading strategy survey adapted from Survey of Reading Strategies (SORS; Mokhtari & Sheorey 2002) was administered to the participants to measure their perceived use of reading strategies. Second, a reading comprehension test was used to assess the participants' English reading ability. It was found that there was no considerable differences in the pattern of strategy use between the two groups. However, the results of independent samples t-tests revealed that the female students used reading strategies significantly more often than the male students in general. Then, a multiple analysis of variance was conducted to see if there was gender difference in the three dependent variables (global, problem-solving, and support strategy). The results showed that there was no significant gender difference in the use of global and problem-solving strategies, but there existed a significant gender difference in the use of support strategy and the difference was consistent across the reading proficiency level. It was concluded that the female students showed a higher use of reading strategies in general, particularly in the use of support strategy than the male students, and this tendency was consistent across reading proficiency level.

      • Rat腎臟에서 High Affinity [³H]Ouabain Binding Site의 缺如

        李神雄 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

        I50 value for inhibition by ouabain, turnover number, and (3H) ouabain binding of cardiac sarcolemmal Na+, K+-ATPase were compared to those of kidney microsome in rat. The I50value (50~60?M) and turnover number were same for both subcellular fraction. The KD value and binding site concentration (Bmax) calculated by displacement assay for ouabain binding of cardiac sarcoleinma in presence of 0.1-0.2 ?M [3H] ouabain were 0.33±0.05?M and 8.7±0.6 pmol/mg protein, respectively, but the binding in vitro of [3H]ouabainto kidney microsomal Na+, Kl+-ATPase was not detected. These data suggest that rat kidney has low affinity site but not detectable high affinity site to ouabain which can be detected inrat heart.

      • KCI등재

        L1 influence on the processing of L2 collocation: An experimental study of Korean EFL learners

        이신웅 경희대학교 언어정보연구소 2016 언어연구 Vol.33 No.S

        The current study aimed to investigate the influence of L1 on the processing of L2 collocations utilizing a phrase-acceptability judgement task. The task was conducted on 39 English collocations with 21 native speakers of English and 45 Korean EFL learners. Their error rates and reaction times were measured both on the congruent collocations that have L1 translation equivalents and the incongruent collocations that do not have ones. It was found that the advanced EFL learners responded significantly faster to and made fewer errors on both the congruent and the incongruent collocations than the intermediate EFL learners. Meanwhile, both the advanced and the intermediate EFL learners made significantly more errors and responded slower under incongruent condition, indicating a strong congruency effect. The results implied that there exists a high degree of reliance on L1 intralexical knowledge in processing L2 collocations by the EFL learners, and acquiring incongruent L2 collocations seems still challenging even to the advanced learners. However, it was also suggested that once EFL learners notice incongruent collocations as valid ones and store them in their L2 mental lexicon, they may be able to processing incongruent collocations as efficiently as native speakers, directly linking L2 collocation forms to their concepts independently of L1 mediation.

      • KCI등재

        English Vocabulary Size of Korean University Students

        이신웅 한국응용언어학회 2006 응용 언어학 Vol.22 No.1

        The purpose of the study is to measure the receptive English vocabulary size of Korean university students and to see if there is any difference in the size according to gender and year in college. Four hundred and sixty six students in two Korean universities participated in the study and their receptive vocabulary size was measured by an expanded and revised version of Vocabulary Levels Test (Schmitt, 2000; Schmitt et al., 2001). The results showed that the students' receptive vocabulary size in general was over 3,000 word families, which is the threshold level necessary for reading authentic texts in English. It was also found that there was a significant difference in the vocabulary size according to year in college, but no gender effect on vocabulary size. On the basis of results, it is suggested that Korean university students need to expand and deepen their vocabulary knowledge through an extensive reading of diverse authentic texts and other vocabulary-learning activities during the college years. It is also suggested that the teachers need to incorporate vocabulary learning strategy training in their instruction so that students can expand their vocabulary size effectively on their own.

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