한인진 추출물의 간장보호 작용에 관한 연구

이순복,조태순,윤기욱,이종찬,이선미,심성보 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was investigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 ㎎/㎏ b.wt. in CCl_4-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 ㎎/㎏ b.wt. in CCl_4-induced chronic liver disease, 30 ㎎/㎏ b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.

정상 관동맥을 가진 심장 점액종 환자에서 발생한 급성 심근 경색증 1예

이정민,이현승,전은정,윤호중,정욱성,오용석,김철민,김재형,최규보,홍순조,이교영,심상인 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

창상 치유에 있어서 메피텔 (Mepitel)??의 효과에 대한 임상적 연구

이승욱,양순재,김용배 순천향대학교 1994 논문집 Vol.17 No.4

The wound healing is one of the oldest concerns of the medical profession. Local wound care in the cutaneous injury, burns, split thickness graft and donor site has been the long standing problem. In a superficial wound, the healing is accomplishied by reepithelialization and migration of epithelial cells which originate from the intact epithelium that surround the wound and from the undestroyed portion of epidermal appendages (hair follicles, sebaceous glands, and sweat glands) within the wound. Dressing materials for superficial wounds should ideally meet the following requirements. As mechanical displacement of the dressing material from the wound bed is impossible it must allow drainage of serous wound exudate and hematoma, and also allow antibacterial solutions to reach the wound. At the time of removal, the dressing should not adhere to the graft and open areas of the wound. For years, fine mesh gauze, vaseline gauze has been the main dressing materials for the cutaneous injuries in our hospital. But, recently we have used a new dressing materials, Mepitel?? which consists of a polyamide net, impregnated with a silicone gel. It has an open structure with 14 pores/cm² each with a diameter of 1.2mm. The advangtage of the material are ease of use, non-adhesion to the wound, very good tolerance, and abscence of pain during dressing changes. This product has been used in our hospital and this paper serves as a report on our early experiences with it.

정신분열증과 우울증의 지각결핍의 비교

이수형,송경의,이형영,하형욱 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4

정신분열증 환자의 지각결핍을 타 질환군과 비교해 보기 위하여 1983.6.1부터 동년 8월 31일 까지 전남의 대병원 정신과 외래에 다니는 우울증 환자 20명 국립나주정신병원에 입원한 정신분열증 환자 20명을 임의 선택하여 Garner의 모형을 이용 카드 분류를 시행하고 그 자료를 토대로 수정분류시간, 공제지수, 비율지수 등을 산출하여 변량분석한 결과 다음과 같은 결론을 얻었다. 1. 양 군의 수정시간을 변량 분석한 결과 유의한 차이를 발견할 수 없었다. 2. 공제지수와 비율지수를 변량분석한 결과 과다성 분류와 여과분류에서는 공제지수와 비율지수에서 아무런 유의차가 없었다. 3. 주사분류에서는 공제지수 비교에서 1% 수준에서 비율지수 비교에서 5% 수준으로 우울증의 분류시간이 긴 것으로 나타났다. 이상의 결과를 살펴볼 때 여과기능의 결함이라는 지각결핍은 정신분열증의 고유한 장애가 아닐 수도 있겠다. The perception of stimuli with two dimensions (size and figure) was investigated using Garners card sorting method into schizophrenic and depressive patients. The comparison of three performance indices (redundancy, filltering, scanning) between two study groups revealed that 1) the analysis of variance of the corrected time shows no significant difference between two groups, 2) in redundancy and filtering sorting the subtractive and ratio indices show no significant difference between two groups, 3) in scanning sorting the depressive group shows significantly longer sorting time than schizophrenic group(p<0.01 in subtractive index, p>0.05 in ratio index). The above findings suggest that the previously known perceptual deficit(mainly filtering deficit) may not be specific only to schizophrenia.

FET형 포도당 센서를 위한 PVP/DAST/GOD 고정화막 형성기술

조병욱,이수근,박이순,이종덕,손병기 경북대학교 센서기술연구소 1992 센서技術學術大會論文集 Vol.3 No.1

방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술

채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.

친환경 방염액의 연구

이순홍,김병량,문명욱,이대정,정영호 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

대구 지하철 참사 이후 사회 전반적으로 방염에 대한 관심이 증대되어 방염제에 대한 연구가 활발하게 진행되고 있는 실정이다. 기존의 할로겐화 방염제는 방염제 자체의 독성으로 인해 인간의 건강과 환경에 유해성이 확인됨에 따라 이를 대체할 친환경 방염제의 연구가 부각되고 있는 시점이다. 본 연구에서는 친환경 대체 방염제의 일환으로 인계와 무기계 방염제를 혼합 사용하여 우수한 방염성능 및 연소시 유독가스가 발생되지 않는 친환경 방염제의 조성을 설계하고자 하였다. 인계 방염제로서 제1인산암모늄, 제2인산암모늄을 사용하였으며, 무기계 방염제로서 붕산과 붕사를 사용하여 각 조성 배합비의 함량 변화 실험을 통한 방염 특성 평가를 수행하였다. 이와 더불어 방염제의 부착률에 따라서 방염효과가 달라지는데, 최적의 조성으로 부착률을 달리하여 경제성과 법적인 측면을 고려하여 가장 효율적인 부착률을 알아보았다. The purpose of this research is to make a non toxic flame retardants as a substitute material for toxic halogen type, and to evaluate burning area, adhesion rate and flammability of non toxic flame retardants. The non toxic flame retardants were prepared by mixing processes of ammonium phosphate monobasic, ammonium phosphate dibasic, boric acid and borax under the various preparation conditions. Flammability of polyester fabrics treated with these mixed flame retardants was investigated through measurement of burning area and adhesion rate. The burning area values were decreased with increase of the Ammonium phosphate monobasic and ammonium phosphate dibasic content of flame retardants. For economic and legal reasons, the optimum adhesion rate of flame retardants on the polyester fabrics was 50%.

Detergent가 NAD의존성 α-glycerophosphate 탈수소효소에 미치는 영향

박수언,이동욱,이희성 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.3

The physical properties and the effects of detergent on the activities of purified NAD-linked a-glycerophosphate dehydrogenase(EC 1.1.1.8, GPDH) from kidney, liver and skeletal muscle of the rat were studied. The activity of this enzyme was measured by the method of White and Kaplan. The enzyme activity of liver (9.65 units/g tissue) was higher than those of other organs, but the highest value of the specific activity was shown in skeletal muscle as 0.058 unit/㎎ protein. These enzymes were purified approximately 167, 286 and 216-fold from kidney, liver and skeletal muscle, respectively, by ammonium sulfate saturation and blue dextran Sepharose column chromatography. These enzymes were composed of two isozymes which have different isoelectric points. Isoelectric points of the two isozymes were 6.5 and 6.7, and the molecular weights were 62,000 and 60,000 daltons. The UV spectrums of the purified enzymes from three organs of the rat showed very simillar pattern. But the representative compounds from three classes of detergents showed different effects on these enzymes. The enzyme of the skeletal muscle was activated by all of the detergents which were studied expect for Triton X-100, whereas the enzymes of the kidney and the liver were not activated or strongly inhibited by all of the detergents. In conclusion, the purified a-glycerophosphate dehydrogenases from the three organs of the rat were the homogeneous proteins out of consideration for physical properties. But the differences in the interaction between enzymes and detergents revealed that there are unsimilarities in the three dimentional structure between the skeletal muscle and those of other two organs inspite of similarities between the enzyme of kidney and that of liver.

이중언어자에서 보인 두 형태의 실어증 : 증례보고 A Case Report

나해리,이정욱,박성민,박수열,권순용,이현정 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.2

Since many people in Korea know more than one language, bilingual aphasia is an important line of research in clinical and theoretical neurolinguistics. Nowadays we meet many people who speak other languages along with Korean, who are immigrants from foreign countries, especially from China. Differential recovery of language affected by an aphasic deficit is documented. In the present work, we introduced a patient with bilingual aphasia who showed different recovery patterns in Korean and Chinese. A 66-year-old man was presented with language disturbance and right hemiplegia. On past medical history, he had received a hematoma evacuation through burr-hole due to left basal ganglia hemorrhage. After the event, he showed nearly global aphasia in Korean, but he showed minimally preserved language function on comprehension and fluency in Chinese. This result suggests that aphasia in bilingual subject may show different pat-terns of recovery between two languages.