생쥐에 있어서 單一害球가 分離된 受精卵의 移植에 의한 새끼生産에 관한 硏究

崔有林,全益秀,金宣宜,崔光洙,朴修奉,辛明宰 慶北大學校農業科學技術硏究所 1991 慶北大農學誌 Vol.9 No.-

本 연구는 생쥐의 4細胞期胚에서 하나의 割球를 뽑아내는 새로운 割球分離技術인 biopsy에 대한 효율성과 分離된 受精卵과 分離한 割球의 생존성 및 새끼생산율을 검토한 結果이다. 그 結果를 要約하면 다음과 같다. 1. 4細胞期胚에서 分離한 單一割球와 4細胞期胚를 M2 배양액에 배양한 結果, 單一割球는 82.6%가 영양배엽을 형성한 割球로 發生하였고 4細胞期胚로 89.5%가 胚盤胞期胚로 發生하였다. 2. 4細胞期胚를 biopsy하여 하나의 割球가 分離된 受精卵과 대조구인 4細胞期胚를 M2배양액에서 배양한 결과 각각 83.3%와 90.4%가 胚盤細胞胚로 發生하였다. 3. Biopsy하여 4細胞期胚에서 分離한 單一割球와 대조구인 4細胞期胚에서 4개의 割球로 분리한 單一割球를 M2 배양액에서 배양한 결과 각각 80.8%와 83.3%가 영양배엽을 형성한 割球로 發生하였다. 4. 4細胞期胚에서 하나의 割球를 뽑아낸 受精卵과 대조구인 4細胞期胚를 수란생쥐에 이식한 결과 각각 36.0%와 48.6%의 새끼쥐 생산率을 얻었다. The study was carried out to investigate the viability and the offspring production rate of single blastomeres and biopsied 4-cell mouse embryos and, also to examine the efficiency of biopsy. The results obtained are summerised as follows : 1. The separated blastomeres from 4-cell embryos and intact 4-cell embryos which were cultured in Medium 2 were developed to trophoblastic vesicle and blastocyst embryo by 82.6% and 89.5%, respectively. 2. The biopsied embryos from 4-cell embryos and intact 4-cell embryos which cultured in Medium 2 were developed to blastocyst embryo by 83.3% and 90.4%, respectively. 3. The biospied blastomeres and the separated blastomeres from 4-cell embryos which were cultured in Medium 2 were developed to trophoblastic vesicle by 80.8% and 83.3%, respectively. 4. The biopsied embryos from 4-cell embryos and intact 4-cell embryos were transferred to recipients, and the offspring rate was 36% and 48.6%, respectively.

경지정리사업 환지업무 전산화 기본골격구조

최수명,한경수 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

This study aimed at designing the basic framework for the full computerization of replotting process in farm land consolidation project through the integrated evaluation works between its inner and outer environments. The basic framework developed in this study is consisted of 3 main systems ; 1) main replotting process system supporting for data collection/analysis, alternative planning/design formulation and determination, 2) data/information system for communication between interested groups, 3) process control system for orderly control/management of overall process.

TFD 소자의 전기적 특성에 관한 상위전극의 영향

최희동,이명재,고동완,곽성관,김동식,정관수 慶熙大學校 레이저 工學硏究所 2002 레이저공학 Vol.13 No.-

In this work, we examined the electrical and mechanical characteristics of TFD devices for various top electrode materials by measuring barrier height and performing ASE depth profile. It was found that the shift of current-voltage(Ⅰ-Ⅴ) characteristics of TFD device depends on the top electrode material. The main reason of the asymmetry in Ⅰ-Ⅴ curve was the differences in barrier height of top and bottom electrodes, and chemical composition at the interface region between top electrode and insulator layer also was important reason. The barrier heights(φ_B) evaluated from temperature dependence of the Ⅰ-Ⅴ relation are 0.7795(Al) 1.0287(Ti) and 1.2928(Ta) eV.

고위험 유방암환자에서 CPB(Cyclophosphamide, Cisplatin, BCNU) 고용량 화학요법과 자가조혈모세포이식술 : A Phase II Multi-Center Trial

최정혜,안명주,조은경,신동복,이재훈,이문희,김철수 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

배경: 림프절 전이가 많은 고위험군 유방암환자에서 CPB(cyclophosphamide, cisplatin, BCNU)를 이용한 고용량화학요법 및 자가조혈모세포이식술이 무병생존율에 미치는 영향과 안전성을 규명하기 위하여 연구를 시행하였다. 방법: 1998년 2000년 까지 한양대학병원, 가천의대병원과 인하대학병원에서 4개 이상 림프절을 침범한 유방암으로 근치적 절제술 시행 후 고용량 화학요법과 자가조혈모세포이식을 시행 받은 13명의 환자를 대상으로 하였고 대조군은 4개 이상 림프절을 침범한 유방암으로 보조화학요법을 받은 환자들 중 39명을 무작위로 선택하여 비교분석하였다. 고용량 화학요법은 제-6일에 BCNU 450 mg/m², 제-5일부터 3일까지 cyclophosphamide 2.0 g/m²와 cisplatin 55 mg/m²를 각각 투여하였다. 결과: 채집된 단핵구수의 중앙값은 8.5 x 10^(8)/kg (범위 2.44-17.90)이었고 CD34양성세포수의 중앙값은 11.0 x 10^(6)/kg (범위 0.8-78.35)이었다. 모든 환자가 이식 후 중앙치 10.0일(범위 8-15)에 말초혈액 과립구가 500 /mm³에 도달하였고 중앙치 9.0일(범위 0-18)에 혈소판이 20,000 /mm³에 도달하였다. 고용량 화학요법을 시행 받은 환자군의 추적기간의 중앙값은 24.6 개월 (범위 15.5-40.5)이었으며 총 13명의 환자 중 1명이 뇌전이로 인하여 사망하였으며 3명(23.1%)에서 재발이 관찰되었다. 대조군은 재발율이 25.6%이었고 무병생존율은 고용량 화학요법을 시행 받은 군(70.5%)과 대조군(78.8%) 사이에서 통계학적으로 의미 있는 차이를 나타내지 않았다 (P=0.744). 고용량 화학요법을 시행 받은 환자 중 10명 76.9%에서 발열이 관찰되었고 WHO 기준 3도 및 4도의 부작용은 혈액학적 부작용이 6예, 소화기적 부작용이 6예에서 관찰되었다. 결론: 고위험군 유방암 환자에서 CPB를 이용한 고용량화학요법 및 자가조혈모세포이식술은 안전하게 적용할 수 있는 치료의 한 방법이나 고용량 화학요법의 효과에 대해서는 앞으로 발표될 대규모 3상 연구의 결과를 주시해야 할 것으로 생각된다. Background: Despite the improvement of prognosis by multimodality therapy for the treatment of breast cancer, primary breast cancer patients with multiple involved axillary lymph node still have a high risk of recurrence. Methods: Between January 1998 and May 2000, we treated 13 women with histologically proven stage II or III breast cancer with 4 or more axillary lymph nodes at the time of primary mastectomy with high-dose chemotherapy and autologous stem cell transplantation. Results: The median age was 45 years (range: 32-57) and the median number of involved lymph node was 13 (range: 6-31). Ten patients were premenopausal state and 40 percent were positive hormone receptor. Seven patients received radiation therapy. Patients were treated with high-dose CPB (cyclophosphamide 2 g/m² D-5--3, cisplatin 55 mg/m² D-5--3, BCNU 450 mg/m² D-6) with autologous peripheral blood stem cell transplantation after 2-4 cycles of adjuvant chemotherapy (CAF, CEF or AC). We compared those patients with age and other clinical factors-matched 39 patients who received conventional adjuvant chemotherapy. The median follow-up for surviving patients who received high-dose chemotherapy was 25.6 months. The relapse rate and 2-year relapse-free survival was 23.1%, 25.6% and 70.5%, 78.8% for high-dose and conventional dose chemotherapy, respectively, but there was no significant difference between two groups (P>0.05). Conclusion: Further follow-up and additional studies are required to resolve the role of high-dose chemotherapy with autologous stem cell transplantation in high-risk breast cancer.

株式會社의 發起人의 數 問題 : 商法 改正案과 관련하여 on the Revision Draft of the Korean Commercial Code

崔埈璿,蔡明洙 全北大學校 1994 論文集 Vol.38 No.-

Article 288 of the revision draft of the Korean Commercial Code which has been made public in last May at the occasion of the public hearing under the auspices of the Ministry of Justice stipulates the number of incorporators in stock company to be not less than 3 persons. This is a considerable difference from the homologous stipulation of the Commercial Code in force which requests not less than 7 persons. An explanatory on the draft dealt out at the public hearings reads ; "In Japan companies can be incorporated with every one incorporator. However, it does not fit in with the legal mind to allow stock company with only one incorporator, even though there is no countermeasure against the ex post facto one-man companies. 3 persons as the least number of incorporators seem to be optimum……." Not a few controversy is expected over the reasonability of regulating the number of incorporators. And, this is an attempt to show the inappropriateness of that kind of regulation, and to verify the legitimacy of incorporateness of that kind of regulation, and to verify the legitimacy of incorporation of one incorporator. The incorporator system is unique to stock company due to its nature. It is for to entrust the incorporator(s) to fulfill the due procedures needed to incorporate, and in order to make them take all the responsibility for any loss imposed to the third parties in the process of incorporation. Thus, the incorporator(s) in the legal sense is/are not always the promotor(s) of stock company who are actually taking part in the incorporating activities, but the (natural and/or legal) person(s) who sign and seal as incorporator in the form of articles of association. And in many cases, the strawmen are mobilized to fulfill the number of incorporators requested by law. Though jurists usually invent the theoretical grounds for the regulation for plural incorporators, the real motive of the Commercial Code to require the plural in corporators lies in the Commercial Code itself. The Commercial Code prescribes company to be association, association of plural persons. However, by the very existence of one-man company it has been proved already that being an association is not the essential nature nor the requisite of being company. Accordingly, the stipulation of the Commercial Code which requires the plural incorporators can not have any ground. Any restriction of the number of incorporators of stock company should be lifted to enlarge the freedom of incorporation of capitals who need legal personality for efficient competition, introducing at the same time the legal devices for the enrichment of capital of the companies into the Commercial Code for the safety of transactions.

가족유형에 대한 교사의 가치관과 청소년의 부적응 행동 인식간의 관계연구

최명구,이인수 한국아동교육학회 2004 아동교육 Vol.13 No.2

본 연구는 교사의 가족가치관과 청소년의 부적응 행동 인식간의 관계를 연구하고자 교사의 인구사회학적 변인과 가족 가치관, 이혼가정과 사별가정 청소년에 대한 인식을 분석하였다. 연구대상은 서울, 경기도에 거주하는 중·고등학교 현직 교사 242명을 대상하였다. 교사외 가족가치관에 따른 한부모가족 청소년의 부적응 문제행동에 대한 인식은 성별, 연령, 결혼형태에 따라 영향을 받는 것으로 나타났으며 교사의 가족가치관이 전통적일수록 한부모가족 청소년의 부적응 문제행동에 대한 인식은 이혼·사별가족청소년 모두 상관이 있는 것으로 나타났다. 교사의 이혼에 대한 가치관에 따른 한부모가족 청소년의 부적응 문제행동 인식은 교사의 성별에 영향은 받는 것으로 나타났으며, 연령, 결혼형태, 교지경력에서는 영향을 받지 않는 것으로 나타났다. The purpose of this study was to analyze how family value of teachers relates with the teacher's perceptions on the maladjustment of the adolescent. Socio-demographic variables of teachers and family value influence the perceptions on the adolescents in the single-parents family. The subjects are 242 teachers of the secondary schools who live in Seoul and Gyonggi. The results indicated that, sex; age and family-type of teacher were a significant variable of teachers' perceptions on the maladjustment of adolescents. The more the teacher's family value is a traditional, the more the perceptions on the maladjustment of adolescents relate. The teachers' divorce value influence the perceptions of maladjustment behavior of adolescents according to the teacher's sex.

農漁村地域 定住生活圈 區分設定 : 全南 高興郡地域 事例硏究 A Case Study in Koheung County, Chonnam Province

崔洙明,黃漢喆 全南大學校 農漁村開發硏究所 1988 農業科學技術硏究 Vol.23 No.-

This study was carried out to try a methodological approach in planning of rural settlement hierarchy as a study in Koeung County. The propose method is consisted of three sub-steps: step Ⅰ analysis on the print hierarchical settlement patterns, step Ⅱ,analysis and estimation of settlement conditions in future, and step Ⅲ, design of rural settlement hierarchy in county level. In step I, theoretical division of the influential boundary of county-center using the radius of 16Km, analysis of market-use patterns and catchment area of middle schools were tried as analysis tools. Step Ⅱ, change-ability of settlement environment was detected by checking of planning view to county development in higher-rank plans just as provincial or national plans and by estimating the linkage patterns to higher-order center. The major results of this study are summarized as follows: 1. The settlement hierarchy of Koheung County has 4-order system: villege-lower order center (Myun)-low order center(Myun or Eup)-county center(Eup, the seat of county office). It is coincident with the current administrative hierarchy and the hypothetical settlement system propose in this study. 2. According to results of detailed survey, life-zones of Daesuh-, Donggang-, Bongrae, Myuns were divided into two or three parts with their higher order center being neighbouring towns in other county or cities. Koheung-Eup, Doyang-Eup and Kwayeog-Myun make central function fully to the neighbouring Myun-class areas. 3. There are four spheres of daily life in Koheung County : Beolgyo (Beoseong Country) Kwayeog, Koheung and Doyang zones, In future, because Kwayeog zones is estimated to be merged into Koheung zone, the area will be divided into three life zones. 4. Different from typical settlement patterns in rural counties, the highest center in Koheung County (Koheung-Eup) can not converge the total potentiality of subareas. The centers of other three life zones are not connected to Koheung-Eup as higher order center in living activities, but directly to Kwangju City which is the regional center of Chonnam Province respectively, So, there are some unsolved problems in harmonizing the centripetal forces for maximization of developmental potentialities in closed concept with the centrifugal forces for maximization of life convenience in open concept. 5. The methodologies proposed may be applied to the settlement planning in other rural counties having similar settlement condition as Koheung. However, as this study is only a trial to methodological approach in settlement planning, precies methods fer analysis and design works should be developed and studied continuously because planning of settlement system is very crucial to the life of residents living in rural counties.

고양이 위 평활근 수축에 대한 Vanadate와 Pervanadate의 효과

심상수,최효봉,심혜선,이덕주,윤신희,한상준,김명석,조양혁 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1

COMS 기준 전압 발생기의 설계에 관한 연구

최용,전일수,김명식 金烏工科大學校 産業技術開發硏究院 1999 産業技術開發硏究 Vol.15 No.-

CMOS Reference Voltage Generator(RVG) is designed to possible CMOS process without additional process steps. It is possible to compensate the temperature of RVG by using PTAT(proportional to the absolute temperature). Temperature compensation is profitable because ??(electron mobility) is used. When VDD sweeps from 3V to 7V, variation ratio of ?? is 0.3125mV/V. Also temperature variation ratio of ?? is -47.1ppm/˚C during sweeping from 0˚C to 100˚C The total current is 15.24μA, and the Power Consumption is 50.3μW.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.