알코올이 Dynamic Posturography에 미치는 영향

이진춘,고의경,장민호,이병주,백무진,노환중,왕수건,전경명 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

矮小條蟲(Hymenolepis nana)에 대한 Albendazole의 영향에 관한 電子顯微鏡的 硏究

王辰聲,金洙鎭,林漢鍾 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3

Newly developed albendazole (Zentel®) is a broad spectrum anthelmintic with high activity against intestinal nematodes as well as trematodes and cestodes infections. The present study was undertaken to observe the morphological changes of Hymenolepis nana which obtained from experimentally infected mice after treatment with albendazole. For this study 20 mice were artificially infected with eggs and 16 of them were given albendazole (1×100mg/kg) four weeks after infection. The worms were collected from the small intestine of the mice which were autopsied at 1 and 2 hours after treatment. The fine structure of the collected worms were studied by means of scanning and transmission electron microscopies. The findings were compared with those of untreated worms. The results are as follows: 1. The worms obtained from non-treated mice showed that the whole surface is covered with many microtriches. Microtriches of H. nana may be divided into three anatomical regions; a base, junctional region and cap. Tegumental layer showed well developed syncytium which included a lot of number of discoidal secretory bodies. 2. Many blebs were formed on the surface of the damaged tegument of the worm at 1 hour after treatment with albendazole. The bleb was packed by plasma membrance and included matrix which uniform electron density. Some bleb surface has microtriches. 3. The destruction of tegumental syncytium was recognized at 2 hours after treatment with albendazole. Therefore the blebs on the worm sufrace caused to the death by the tegumatal bursing.

운동성 산화 스트레스와 항산화비타민의 보충이 말초단핵세포의 NF-kB 활성에 미치는 영향

진영수,박건구,박준영,김미정,이왕록,김혜영,이한준,박은경 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2

Reactive oxygen species(ROS) are implicated in the pathogenesis of a wide variety of human diseases. Numerous studies indicate that ROS may serve as common intracellular molecules that contribute to the process of nuclear factor(NF)κB activation in response to a diverse stimuli. In our laboratory, we have demonstrated tat antioxidants could reverse the decline of immune function caused by exercise-induced ROS. Furthermore, it in necessary to understand a mechanism underlying ROS-dependent disorder in biological system. Recent studies have been shown that several gene expression were regulated by oxidants, antioxidants and other determinants of the intracellular reduction-oxidation(redox) state. In this process, NF-κB have been shown to play a important role. The purpose of the present investigation was to evaluate the effect of exercise-induced oxidative stress and antioxidnt supplementation on NF-κB activation in peripheral mononuclear cells. Forty male SD rats(4 weeks old) were randomly divided into noraml diet group and antioxidants(ATO) supplement group, and then ATO groups were treated with antioxidants(VE: 2001U/kg, VC: 50mg/rat, β-carotene: 300mg/kg, vitamin B6: 250㎍/100g, selenomethionine: 0.1mg/kg) for 16 weeks. After 16 weeks breeding at each condition, each group divided into two groups: Control group(CR) fed generally, Exercise group(CE) fed generally and followed by acute exercise 16 weeks later. Antioxidant Antioxidants and Exercise group(AE) fed with antioxidants and followed by acute exercise. The activation of NF-κB binding activity was increased after exhaustive exercise bout in both group. In addition, pretreatment of ATO group with the antioxidants mixture lead to the inhibition of NF-κB binding activity. This results suggest that NF-κB activation should be further studies in response to a variety of exercise.

중공사 형태의 막여과 공정에서 압력 강하 및 에너지 소비에 관한 연구

왕진수,김병직 崇實大學校 生産技術硏究所 1995 論文集 Vol.25 No.2

Pressure difference is required to purity the untreated water in a membrane-based process. It affects the initial cost and operating cost of the system. Generally, the greater the pressure difference is, the more expensive the water filtration system is. From the experimental data and the derived equations, several design parameters that affect the pressure drop were investigates. The effect of temperature, crossflow velocity, and internal diameter of a fiber on the pressure drop was studied. Within the temperature range of 0℃ to 40℃, as feed water temperature increased, pressure drop required to purify the quantity of the untreated water decreased. And as the crossflow velocity increased, the pressure drop increased. The diameter of 1mm was thought to be a critical size. Below that size, as decreasing the diameter the pressure drop increased sharply. On the other hand, above that size, the pressure drop did not change much with increasing the diameter. Also, the energy cost to produce 1 ton of water was calculated for various modes of membrane-based water treatment systems.

여객선의 화재 안전 평가 : 화재, 연기 통제와 대피 분석

김수웅,왕진,권영섭 조선대학교 생산기술연구소 2007 生産技術硏究 Vol.29 No.1

여객선 화재 발생시, 대참사를 피하기 위한 가장 중요한 수단중의 하나는 승객들이 신속하고 안전하게 탈출 하는 것이다. 할 수 있는 여러 연기 확산 예방조치들 중 하나는 연기의 확산을 간단하고 믿을 수 있는 방법으로 통재하는 것이다. 이러한 방법은 사람들이 연기와 접할 수 있는 지역을 최소화 할 수 있고, 연기로부터 탈출할 수 있는 가시성을 보장할 수 있게 된다. 이 연구에서는 여객선 화재 안전에 실질적인 적용성과 실용성에 도달하기 위한 필요한 작업들을 다루고 있고, 화재 안전성 평가에 대한 가능성을 제공한다. 여객선에서 화재, 연기 통재와 대피 분석을 연구하기 위해 제안된 방법은 현재 이용 가능한 정보와 새로운 위험 평가 기술을 사용하였다. 제안된 방법을 설명하기 위해 사례 연구가 수행 되었다. 마지막으로 앞으로 여객선 안전 분야중의 화재 안전성 평가의 연구 진행 방향에 대해 자세히 설명했다.

난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

Campylobacter pylori 위장내 분리위치에 따른 병원성

한왕수,한상진,김정목,조양자 대한감염학회 1989 감염 Vol.21 No.1

Compylobacter pylori may cause gastritis and has been proposed as an etiologic factor in the development of peptic ulcer. However, it is unknown where is primary colonization sites of C. pylori. Isolation sites of C. pylori in stomach and duodenum and pathology in antrum were evaluated in 90 subjects endoscoped at Hanyang University Hospital in Seoul, Korea. C. pylori detected in biopsied specimens of 40 (74%) of 54 C. pylori-positive patients at antrum only, and 13 (24%) of the same patients at antrum and body, but did not detected in duodenal biopsied specimens. Antral pathology results were chiefly found in active chronic gastritis. These findings strongly suggest that antrum is a primary colonization sites of C. pylori and the agent may be spread within stomach from the antrum.

막여과공정에서의 비용계산식 모델링 및 조작변수에 따른 비용의 변화에 대한 연구

김병직,왕진수 崇實大學校 生産技術硏究所 1996 論文集 Vol.26 No.1

A cost model for water filtration system using membrane was studied. Capital cost was the sum of non-membrane cost and membrane cost. And Operating cost consisted of energy, chemical, and membrane replacement cost. Integrated mathematical model was developed to estimate the capital and operating cost of variouw size membrane systems. The mathematical medel was translated into C program for convenient and quick use. By use of the program developed, the effect of Permeate Flux, Membrane diameter and service life, cross-flow velocity on total cost was studied. The results of sencitivity analysis are as follows: The cost was inversely related to permeate flux since the number of modules increased as reducing thepermeate flux. The membrane life had a significant effect on the operating cost. Cost of membrane per module decreased with increasing membrane element diameter.The head-loss across the membrane module was inversely proportional to the diameter of the element. Also deposition of material on the membrane surface could be reduced by increasing cross-flow velocity.

정신분열증 환자의 전산화 단층촬영상 대뇌 비대칭성과 대뇌 위축과의 관계

유태열,한진희,채영래,김광수,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.3

Since the advent of computed tomography(CT). there have been growing evidences of cerebral structural abnormalities in schizophrenics. Among them. reversed hemispheric asymmetry has been regarded as impaired cerebral lateralization of schizophrenics representing another pathology different from brain atrophy. To investigate the pattern and frequency of reversed cerebral asymmetry and their relationship with brain atrophy. we analyzed widths of frontal and occipital region on the brain CT scans of right-handed 56 schizophrenics and 52 normal controls by a manual method. Brain atrophies were assessed using fixed arm planimetry and visual lineat measurements. Compared to normal controls. the schizophrenics show significantly increased frequency of reversed occipital asymmetry. Dividing the schizophrenics into group according to the evidences of atrophy revealed more reversed occipital asymmetry than those with brain atrophy. These findings suggest that reversed cerebral asymmetry might be unrelated to brain process and would be a neuroanatomic evidence of abnormal asymmetry of schizophrenices.

대학생들의 다이어트 식습관 실태 조사

김연정,문진아,왕수경 대전대학교 기초과학연구소 2010 自然科學 Vol.21 No.-

대전대학교 교양과목으로 개설된 ‘식생활과 다이어트’ 교과목을 수강하는 남녀 학생 151 명을 대상으로 다이어트 경힘과 함께 그들의 식습관을 알아온 결과는 다음과 같다 조사대상자는 남학생 81 명과 여학생 70명으로 총 151 명이었다. 남학생들의‘식생활과 다이어트’ 수강동기는 식생활 전반에 대해 공부하고 싶다는 응답이 여학생들은 특히 다이어트에 관심이 있어서 라고 응답한 학생이 가장 높아 유의적 차이를 보였다 여학생 중 51 .4%, 남학생 중54.3%는 다이어트에 대한 경험이 있었으며, 다이어트 해 본 시기는 남학생은 대학교 때 여학생은 고등학교 때가 가장 높게 나타나 유의적 차이를 보였다. 다이어트 정보는 남학생과 여학생 모두 인터넷과 경험 있는 친구 나 선배를 통해서가 가장 높게 나타났다. 남녀 학생의 평균 운동 시간은 유의적 차이를 보여 남학생은 주 1 - 3시간 운동하는 학생이 가장 많았고 여학생들의 주 1 시간미만 운동하는 학생이 많았다. 식생활 태도에 대한 조사에서 아침 식사를 하지 않는 학생이 남녀 각각 19.6%. 18.6%로 나타났다. 남학생이 여학생보다 과식하는 경향을 보였으며 간식을 먹는 횟수는 여학생이 많았다. 조사대상자 자신의 식생활의 개선점으로 남녀 학생이 각각 56 .4%와 47.0%가 불규칙한 식사로 답하였다. 이상의 결과로 남녀 학생들이 다이어트에 대한 관심도가 높았고 식습관에 문제가 있어 “식생활과 다이어트”과목을 수강함으로써 식습관과 다이어트 과목을 통한 영양교육이 효과가 있을 것으로 본다. In th is study, 151 students(male were 81 and female were 70enrolled in ‘' Food and Diet course were asked about their diet experiences and food habits . In the question asking the reasons for taking this‘' Food and Diet'class , most male subjects answered they enrolled 'to learn about overall knowledge’, whereas female students answered ' special interest in diet’' led to taking th is class. 67 .1 %of women and 64.2% of men said they put effort to maintain weight. Also , 51 .4%of female and 54.3% of male have experience of diet. The period of diet was most frequent in University for men (33 .3%) and in high school for women (47.1 %). Diet information was gathered from internet of from friends with previous experiences for both genders . It showed students gain little through reading nutrition related books , percentage was low for men and women (3 .7%. 1.4%, respectively). For diet methods. 40% of the subjects in total said they do diet through exercise. Female subjects showed that they've tried many different methods such as yoga and diet therapy . 53 .1 % of male and55.7% of female answered the diet was effective and lost weight. In the questionnaire about the dietary life and habits. percentage of the subjects who do not eat breakfast was 19.6% for men and 18.6% for women. The frequency of excessive eating and taking snacks was higher in men and it showed statistically meaningful result. From above results , we can conclude that the interest in diet was high in both gender and they both have problems regarding eating habits. 80 by taking ‘' Food and Diet’' class , it is predicted that this course will have educational effect on students 'eating habits and their diet.