두경부 편평상피암에서의 MIB-1, p53, bcl-2와 apoptosis의 발현 및 상호 연관성

손용준,한지용,윤형기,장수원,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Squamous cell carcinoma of the head and neck represents approximately 2.0∼4.0% of all malignant tumors, with an etiology closely associated with smoking, drinking and various genetic alterations. The purpose of this study was to investigate the correlation of MIB-1, p53, bcl-2 and apoptosis according to degree of differentitation of squamous cell carcinoma. Methods and Material : forty-eight cases of squamous cell carcinoma of the head and neck were selected for this study. MIB-1, p53, bc1-2 expression rate were studied by iromunogistochemical staining and the number of apoptosis observed by TUNEL method. Results : The expressioins of MIB-1, p53, bcl-2 and apoptosis were found in 56.3%, 50.0%, 14.6%, 85.4%, of 48 cases of squamous cell carcinoma, respectively. The expression of MIB-1, p53 and apoptosis were more higher in poorly differentiated cases than well differentiated cases. MIB-1 expression was related with p53 mutation (p<0.05) and apoptosis rate(p<0.05). Conclusion : From these results. the expressions of MIB-1, bcl-2 and apoptosis were related with degree of differentiation of squamous cell carcinoma and correlation among these parameters.

골격성 Ⅲ 급 부정교합자의 두개안모 성장예측에 대한 평가

손우성,강은희,정미라,성지현 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.1

본 연구는 성장에 의한 변화를 예측하는 현재의 방법이 실제로 골격성 Ⅲ급 부정교합자의 진단과 치료계획에 적절히 사용될 수 있는 지를 판단해 보기 위해 초진 시 골격성 Ⅲ급 부정교합으로 진단받고 성장 종료 후 악교정 수술을 받기위해 재내원한 골격성 Ⅲ 급 부정교합자 25명(남자 13명, 여자 12명)을 대상으로 시행되었다. 초진시 채득된 측모 두부방사선 사진에서 Ricketts의 성장예측법을 통해 성장 종료 후의 상태를 예측한 후, 악교정 수술을 위해 재내원 했을 때 채득된 측모 두부방사선 사진에서 계측된 실제 성장량과 비교분석 함으로써 다음과 같은 결론을 얻었다. 1. 예측치와 관측치의 일치정도를 평가해본 결과 Porion Location, Ramus Position, Facial Depth, Facial Axis, Mandibular Plane angle, Maxillary Convexity에서의 예측치가 관측치와 차이를 보이고 있어 이 항목에 대한 Ricketts 성장예측법의 예측치가 실제 성장량을 잘 설명해주지 못함이 관찰되었다. 2. 하악골체의 성장량은 정상 성장량과 유사하였으나 Porion Location, Ramus Position이 정상적인 성장과정을 벗어나면서 하악골의 전방위치를 유도하였다. 3. 골격성 Ⅲ 급 부정교합자에서는 성장의 양과 방향이 비정상적인 성장변화를 나타내어 정상 성장에서라면 변화를 보이지 않을 하악지의 전방 위치, 하악이부의 전상방 회전 등이 일어난 하악 전돌의 경향이 악화될 수 있다. This study was performed to evaluate whether growth prediction method can be used to diagnose and make treatment plan in skeletal Class Ⅲ malocclusion patients or not. The sample was consisted of 25 patients(13 males, 12 females) who had been diagnosed with skeletal Class Ⅲ malocclusion at first visit and after that had returned to take orthognathic surgery. Growth prediction performed with Ricketts' growth prediction method from first cephalogram was compared with actual growth of the second cephalogram. The findings of this study were as follows ; 1. There was significant difference between actual growth and growth prediction in Porion Location, Ramus Position, Facial Depth, Facial Axis, Mandibular Plane angle, Maxillary Convexity. So, for these items Ricketts' growth prediction method is not proper to predict growth. 2. Although the growth amount of mandibular body was similar to normal growth amount, mandible was positioned anteriorly because of Porion Location and Ramus Position. 3. In skeletal Class Ⅲ malocclusion patients, the tendency of mandibular prognathism might be aggreviated because of anterior placement of ramus and anterosuperior rotation of pogonion.

치과교정환자의 치면세균막 관리교육 효과

손우성,김진범,제영지 대한치과교정학회 1994 대한치과교정학회지 Vol.24 No.1

The short-term effects of plaque control instruction were studied in 42 adolescent orthodontic patients under active fixed treatment. At first visit, all the patients were received plaque control instruction using materials such as oral hygiene education slides, dentiform, disclosing agents, tooth brush and interdental brush. After that, Pateints were asked to perform the tooth brushing according to instruction. Such a procedure was repeated every week for 3 weeks. Plaque index and bleeding index were scored once a week for 4 weeks and were compared according to ages, sex and duration with fixed appliance. The results were as follows : 1. Plaque control instruction was effective in reducing plaque accumulation and gingival inflammation of the orthodontic patients. 2. The effect of plaque control instruction was continued during 3 weeks among all groups of subjects, and it was prominent at the first week. 3. There was no statistically significant difference in the effects of the plaque control instruction according to sex, ages, or duration with fixed appliances.

골격성 Ⅲ 급 부정교합자의 악골 부조화가 구치부 치성보상에 미치는 영향

성지현,김성식,손우성 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.1

골격성 Ⅲ 급 부정교합자는 부적절한 악골 위치에서 기능 교합을 유지하기 위해 치아의 경사도와 수직적 위치가 변화하게 된다. 이러한 치성보상은 전치부 및 구치부 전반에 걸쳐 일어나며, 현재 보편적으로 시행되고 있는 악교정수술을 위한 술전교정시 이를 제거하여 각 골격 구조내에서 치아들이 적절히 위치되도록 하여야 한다. 전치부 치성보상에 관한 측모 두부방사선 사진을 이용한 연구는 많이 시행되어졌으나, 구치부 경사도에 관한 연구는 미미한 실정이다. 이에 본 연구는 성인 골격성 Ⅲ 급 부정교합자의 전후방적, 수직적 악골 부조화에 따른 폭경 부조화 및 구치 경사도 변화를 알아보기 위해 진단 모형상에서 상하악 견치, 제1소구치, 제1대구치 부위의 기저골 폭경을 측정하여 상악에 대한 하악의 비율을 구하였으며, 모형을 삭제하여 좌우 구치간 경사도를 측정하였다. 악골 부조화 심화에 따른 기저골 폭경 비율과 제1대구치 협설 경사도 변화의 상관관계를 조사하여 다음과 같은 결론을 얻었다. 1. 골격성 Ⅲ 급 부정교합자의 악공의 전후방적 부조화가 심화될수록 상하악 구치간 각도합이 증가하여 치성보상이 많이 일어났으며, 특히 하악 구치가 설측 경사되는 치성보상을 보였다(p<0.001). 2. 골격성 Ⅲ 급 부정교합자의 악골의 수직적 부조화 및 폭경 부조화와 구치부 치성부상 간에는 유의할만한 상관성이 없었다. 3. 골격성 Ⅲ 급 부정교합자의 전후방적, 수직적 부조화의 심화와 기저골 폭경 부조화는 유의할만한 상관성이 없었다. This study examined the relations between degree of posterior dental compensation and skeletal discrepancy in Class Ⅲ malocclusion. The pretreatment lateral cephalograms and dental casts of 87 skeletal Class Ⅲ adults were selected to provide a random sampling of skeletal Class Ⅲ malocclusion. Skeletal discrepancy was described with ANB angle, Wits appraisal, Sn-Mn plane angle, FMA and ratios of basal arch width. Degree of posterior dental compensation was described with macillary intermolar angle, mandibular intermolar angle and sum of intermoloar angle. The relationships between skeletal discrepancy and degree of posterior dental compensation were analyzed with simple correlation analysis, stepwise multiple regression analysis. The results were as follows : 1. A strong association was found between the variation in the anteroposterior measure, ANB angle and the variation of posterior dental compensation measures, sum of intermolar angle and mandibular angle and mandibular intermolar angle in skeletal Class Ⅲ malocclusion. 2. There was no statistically significant relationship between the variation in the vertical measures and the variation of posterior dental compensation measures in skeletal Class Ⅲ malocclusion. 3. There was no statistically significant relationship between the variation in the anteroposterior and vertical measures and degree of basal arch width discrepancy.

자동영상추적장치를 이용한 카드뮴 처리 Oryzias latipes의 행위독성연구

류지성,이철우,최필선,최성수,류홍일,이길철,정규혁,박광식 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.4

Changes in certain fish behaviors are known to be very sensitive indicators of sublethal exposure to environmental contaminants. Therefore, behavioral toxicity tests, if properly designed, can be very useful to assess the influence of hazardous chemicals on fish. However, quantitative analysis of xenobiotic -mediated changes in locomotor behavior in fishes are rare, due mainly to the methodological difficulties. In general, fish movement has been known to be hypertrophic or hypotrophic according to the chemicals. As a study of fish behavioral toxicities, we quatified the swimming movement of Orydas latipes using computer-automated video tracking system. Oryzias latipes was exposed to cadmium of 128 mg/L for 1 hour in a limited aquaria, then the total swimming distance, the average swimming velocity, the histogram of turning angles, and the turning frequency were analyzed. Fish treated with cadmium showed decreased swimming activities, decreased velocity, and decreased turning frequency, which means hypotrophic activity. From these results, the computer-automated video tracking system of this study seems to be a good tool for the evaluation of the potential ecotoxicological studies.

태권도 선수들의 운동 만족이 정신건강 및 생활 만족에 미치는 영향

한권상,손창남,임상호,류경희,장지현,김태우 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

The purpose of this study is to determine how a Taekwondo player's athletic satisfaction affects his/her psychological health and overall personal happiness. A questionnaire survey was carried out on a sample group of 200 students attending colleges located in Seoul and Gyeonggi Province. Then, 23 questionaries deemed not trustworthy were eliminated, leaving 178 questionaries for analysis. The questionnaire, which contained total 128 questions, showed the confidence level falling between .5241 and .8945 (Cronbach's alpha). The study, which relied on frequency analysis, t-test, One-way ANOVA, and Scheffe test, produced the following results. First, athletic satisfaction showed a statistically significant difference (5% range) depending on sex, school year or athletic experience. Second, psychological health resulted in a statistically significant difference (5% range) depending on sex or athletic experience while no difference was noticed regarding school year. Third, happiness in life showed a statistically significant difference (5% range) depending on sex or school year while no difference was noticed with regard to athletic experience.

점포내 VMD요소가 SPA 브랜드 정체성에 미치는 영향

김소영, 손지훈, 심효진, 신동훈, 정일호, 홍동우, 김은영 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.2

This study was to examine the effect of VMD factors on brand identity for SPA brands. As brand stimulus, four SPA brands(e.g., Basic House, Codes combine, Uniqlo, Zara) were selected by pretest. For collecting data, a self-administered questionnaire was developed based on the literatures and intercept survey was conducted. A total 508 usable responses were obtained from consumers who shopped at the selected brands' stores. For data analysis, descriptive statistics, factor analysis, and regression analysis were used. As perceived by consumers, VMD consisted of seven factors: lightening, scent, color, layout, music, window display, and item presentation. The VMD factor was significantly related to brand identity for the SPA brands. Specifically, brand awareness was predicted by color, layout and item presentation; brand association strength was predicted by color, layout, and widow display; favorable brand association was predicted by item presentation; salience of brand association was predicted by color and music; and brand image association was predicted by color, layout, music, and item presentation. Thus, this study discussed a managerial implication for SPA retailers to develop a visual merchandising strategy in the competitive marketplace.

폐광산 주변의 목본 식생 현황 및 오염 토양에 대한 목본 종자의 발아 특성

서경원,손요환,김래현,구진우,노남진,경지현,김정규 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

시각적 피드백을 병행한 어깨복합운동프로그램이 어깨비대칭 청년들의 어깨 근력과 정렬에 미치는 영향

강순희, 강은지, 목미경, 박지연, 손혜림, 연우정 한국교통대학교 2016 한국교통대학교 논문집 Vol.51 No.-

The purpose of this study was to identify whether shoulder complex exercise program with visual feedback could improve the shoulder muscular strength and postural alignment in adolescents with shoulder asymmetry. Twenty eight subjects were recruited from the K university and divided into three groups: experimental 1, 2group(Each n=10) and control group(n=8). For 4 weeks, the experimental group 1 performed shoulder muscle complex exercise program and the experimental group 2 performed shoulder complex exercise program with visual feedback. The control group did not perform exercises. The shoulder muscle strength and difference between the height of left and right shoulders were assessed before, after training using the hand-held dynamometer and Global Posture System. Subordination variables, general characteristics analysis, χ² test and Kruskal Wallis H test were conducted to evaluate differences between groups and training before, after changes were checked Wilcoxon signed rank test with using the PASW 18.0 statistical program. The results of the study were as follows. 1) Both the experimental 1, 2group showed improvements in muscle strength of several muscles following training (p<.01). The control group showed significant reduction in the left posterior deltoid (p<.05), and did not show significant changes in examining other muscles (p>.05). And there were differences among three groups in shoulder muscle strength (p<.001). Muscle strength changes in several muscles were greater in the experimental 1, 2group compared with the control group (p<.001). Muscle strength changes in the several muscles were greater in the experimental group 2 compared with the experimental group 1 (p<.001) 2) Both the experimental 1, 2group showed significant decreases in the difference between the left and right shoulder heights following training (p<.01). The control group did not show change (p>.05). Changes in the difference between the left and right shoulder heights were greater in the experimental 1, 2group compared with the control group (p<.001).

産業災害로 인한 手脂切斷 患者의 療養期間과 診療費의 變異

이종호,이종영,손지연,하영애,박순우,감신,이영숙,김건엽,강윤식 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.3

This study was conducted to analyze variation in patient days and medical care benefits among finger-amputated patients due to industrial injury. The 242 personal data on medical care for finger-amputated patients due to industrial injury(131 in 1994, 111 in 1995) of Regional Labor Office were analyzed. The major results of this study were as follows: Patient days per case were 69. And the ratio of the maximum and the minimum among patient days for case was 26.6. Patient days per case in university hospital were 134.8 and the longest than other medical facilites. The ratio of the maximum and the minimum among the patient days per case was higher in hospital(24.7) than in other medical facilities. Benefits per case were 1,258,000 Won. And the ratio of the maximum and the minimum among benefits of case was 232.0. Case benefits was higher in university hospital (2,685,000 Won) than in other medicl facilities. The ratio of the maximum and the minimum among the benefits per case was higher in hospital(232.0) than in other medical facilities. Variation in patient days and medical care benefits per finger-amputated patient in industrial injury was large. This study results indicated need for a new industrial injury compensation insurance policy initiative for efficient utilization of medical resources and quality assurance. And the author thought that the results of this study would influence the policy for the industrial injury compensation insurance policy.