Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

21가지 장미꽃 품종의 페놀성 화합물 함량 및 항산화 활성

조연재(Yeon Jae Jo),서정현(Jeong Hyun Seo),홍채영(Chae Young Hong),김성태(Seung Tae Kim),최은경(Ehn-Kyoung Choi),김윤배(Yun-Bae Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.4

본 연구는 21품종의 장미꽃에 대한 식품 및 화장품 원료로 사용 가능성을 살펴보기 위해 페놀성 화합물과 항산화 활성을 평가하였다. 총 폴리페놀, 총 플라보노이드 및 타닌 함량은 러버샤이 품종에서 각각 379.70 mg GAE/extract g, 50.10 mg CE/extract g 및 339.44 mg TAE/extract g으로 높게 나타났으며, 칠백리 품종에서 각각 107.25 mg GAE/extract g, 9.46 mg CE/extract g 및 36.31 mg TAE/extract g으로 낮았다. 페놀산 함량은 총 폴리페놀 함량과 유사한 결과를 보였으며, 러버샤이 품종에서 27.40 mg/extract g으로 높았다. 안토시아닌은 대부분 cyanidin-3,5-diglucoside로 확인되었으며 총 안토시아닌 함량은 유니나 품종에서 8.80 mg/extract g으로 가장 높았다. ABTS 및 DPPH 라디칼 소거 활성은 각각 428.10 및 419.59 mg AAE/extract g로 러버샤이 품종에서 가장 높았으며, 항산화 활성과 페놀 화합물의 함량과 높은 양의 상관관계를 보였다. 이러한 결과는 러버샤이와 같은 항산화 활성이 뛰어난 품종들이 관상 목적뿐만 아니라 높은 기능성을 가진 식품 및 화장품의 원료로 사용 가능성이 있다고 판단된다. This study evaluated the functional components and antioxidant activities of 21 different rose flower extracts, to confirm their value as a food and cosmetics ingredient. The highest values of total polyphenol, flavonoid and tannin contents (379.70±1.64 mg GAE/extract g, 50.10±0.76 mg CE/extract g, and 339.44±1.20 mg TAE/extract g, respectively) were obtained in Lover Shy. The proanthocyanidin content ranged from 61.88 mg CE/extract g in the Unina cultivar to 5.34±0.13 mg CE/extract g in the Aileen cultivar. The phenolic acid content obtained was highest in the Lover Shy cultivar (27.40±0.26 mg/extract g), whereas highest levels of anthocyanin (8.83±0.03 mg/extract g) were obtained in the Unina cultivar. High ABTS and DPPH radical scavenging activities were determined in the Lover Shy cultivar (428.10±0.29 and 419.59±3.12 mg AAE/extract g, respectively). Taken together, these results indicate that the antioxidant activity and functional components of Lover Shy cultivar are superior, and this extract can potentially be applied as a food and cosmetic ingredient.

韓國産·中國産 운지(Coriolus versicolor(Fr.) Quel)의 抗腫瘍 成分에 관한 比較 연구

崔乘基,金泰均,林雄圭 서울대학교 농과대학 농업개발연구소 1993 서울대농학연구지 Vol.18 No.1

韓國産과 中國産 雲芝 Coriolus versicolor (Fr.) Quel의 抗腫瘍成分의 수율과 종양억제율을 비교하기 위해, 단백결합다당류를 유기용매침전과 ultrafiltration method에 의해 分離, 定量하였다. 한국산 Coriolus versicolor (Fr.) Quel의 항종양 성분의 수율은 13.8%였고, 중국산 Coriolus versicolor (Fr.) Quel의 항종양 성분의 수율은 12.7%였다. 한국산과 중국산 시료간에 종양억제율에는 유의성 있는 차이가 보이지 않았다. To Compare the yield and inhibition of ratio antitumor constituents of Coriolus versicolor (Fr.) Quel in Korea and China, protein-bound polysaccharides were isolated and quantitated by organic solvent precipitation method and ultrafiltration method. The yield of antitumor constituents of C. versicolor (Fr.) Quel in Korea was 13.8% and the yield of antitumor constituents of C. versicolor (Fr.) Quel in China was 12.7%. The inhibition ratio of both did not showed significant value..

스트레스 반응 척도의 수정판 개발 및 타당화 연구 : 근로자 대상

최승미,강태영,우종민 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : The purpose of this study is to develop and validate a modified form of the Stress Response Inventory (SRI-MF) for workers. Methods : In study I, the Stress Response Inventory was conducted in 3,420 person, who worked for public institutions andlarge corporations. They were selected from 10 areas throughout the country. After we performed experimental factor analysis in order to select the items by internal consistency and factor loadings, we developed the short form of SRI (SRI-MF). In Study II, SRI-MF was validated by showing convergent/divergent validity with other stress-measuring instruments in another samples. Results : In study I, factor analysis yielded 5 factors, and two of them were excluded because of their low internal consistency. Consequently, total 22 items in the remaining 3 factors (somatization, depression, anger) were selected for the SRI-MF. Test-retest reliability of the SRI-MF was significantly high, ranging between .67-.71. Cronbach's α was also high. In study II, convergent validity was computed by correlating scores of other scales (GARS, SCL-90-R, PSQ) score. The correlations were all at significant levels. Discriminant validity was computed by comparing the total score and scores of 3 subscales in the patient and normal group. There were significant differences in the total and scores of 3 subscales between the two groups. Conclusion : The results of identifying factor structure in the SRI indicated 5 significant factors. Among them, 3 factors can be employed for the modified form of SRI with a high internal consistency. Thus, we suggest that the SRI-MF should be a effective and valid scale to evaluate stress response in work places.

SnO₂-TiO₂세라믹 복합체의 일산화탄소 감응특성

최우성,김태원,정승우 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

In order to promote CO sensitivity, 5, 10, 15, 20 mol% TiO_(2) added SnO_(2) composite ceramics were prepared. Using XRD and SEM, we investigated a phase analysis and microstructure, and mearsured the resistances as a function gas atmosphere of specimens by High Voltage Measure/Source Unit. The measured CO sensitivities of SnO_(2) -TiO_(2) composite ceramics were abou 3 times larger than that of pure SnO_(2) and showed the obvious temperature dependence of 500, 1000ppm CO sensitivity.

Langsat Tm 영상에 의한 원자력 발전소로부터의 온배수 확산의 추적조사

최승필,양인태 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

지금까지는 선박등을 이용하여 표본추출등으로 온배수 확산관측이 이루어져왔으나 온배수의 확산속도, 위상조건, 비용, 범위설정 및 위치 결정등의 여러가지 방해인자등 때문에 동시성, 광역성 및 경제성등의 문제에 있어서 새로운 탐사방법이 요구되어 왔다. 그러나 인공위성 영상을 이용하여 분석하면 단시간에 해양 환경을 감시 및 탐지 할수 있기 때문에 기종의 방법보다 상당히 신속하여 정확하게 수온 분포와 확산정도를 감지할 수 있다. 따라서 이연구는 인공위성 영상에 의 Observation for hot water spread has been carried out by such activites as sampling of water with ship, etc, until now. It was required further to have new probe methodologies in such issues as simultaneity, great-spheric nature, and economics due to many hindering ele- ments such as spread speed of hot waste water, weather conditions, cost and expenses, scope and location determinations. However, it was believed that stellite could be utilized to monitor spread of water temperature and spread level in more quick and correct way than existing one, because it would be possible to supervise and detect marine environment within significantiy short period if analyzed by means of satellite images. Therefore, this study is taken into account to flow and spread conditions of hot waste water, survey of water temperature, by means of satellite images.

방울토마토중 Dichlofluanid 및 Iprodione의 생산단계별 잔류농약 경시변화

최규일,성기용,정태균,이주환,허장현,고광용,이규승 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

방울토마토의 생산단계에서의 잔류허용기준 설정과 수확후 저장기간중 경시변화 및 세척에 의한 잔류농약의 감소양상을 파악하였다. 해당약제를 안전사용기준의 기준량 및 배량을 각각 시설재배 포장에서 살포후 10일간 잔류양상을 조사하였고, 실온 및 냉장조건 하에서의 저장실험 및 세척에 따른 전류농약의 잔소량을 파악하여 생산단계부터, 출하, 저장, 소비단계까지의 잔류량을 예측할 수 있는 모델개발을 위한 자료로 이용하고자 연구를 수행하였다. Dichlofluanid와 iprodione은 포장조건에서 반감일수가 기준량 2.2, 3.3일 이었으며, 배량은 3.5, 5.4일로 나타났다. 저장조건하에서의 약제별 반감기는 포장조건보다 잔류량의 감소속도가 느린 것으로 나타나 반감일수가 증가하였고, 세척방법에 의한 잔류농약의 감소량을 조사한 결과 세제 사용시의 평균제거율은 dichlofluanid는 73.7%, iprodione은 64.3%로 나타났고, tap-water 사용시에는 dichlofluanid 73.5%, iprodione 63.5%로 나타났다. 이러한 결과는 작물의 생산단계에서 구한 합리적인 희귀식을 이용하여 잔류농약의 경시변화를 파악하고, 저장 및 세척과정을 거쳐 최종 소비단계에서의 잔류농약의 수준을 평가할 수 있었다. We studied the residual patterns of two fungicides, dichlofluanid and iprodione, in cherry tomato greenhouse after applying with the recommended and double dose. Also, the degradation patterns during storage periods of up to ten days were compared between at room temperature (20℃) and at cold temperature (4℃). Removal rates of fungicides by washing with tap-water and detergent solution (0.1%, 0.2%) were measured. Half-lives of dichlofluanid and iprodione in greenhouse cherrytomato were 2.2~3.5 and 3.3~5.4 days, respectively. During the storage period, the residues were dissipated more slow. Removal rates were 62.8~80.3% by tap-water, 60.4~83.1% by 0.1% detergent solution, and 65.3~77.6% by 0.2% detergent solution. So, we can predict of terminal residues from cultivation period to marketing, storage and consuming.

소양호에서 총세균수의 분포

최승익,변명섭,안태석 江原大學校 附設 環境硏究所 1998 環境硏究 Vol.15 No.-

The total bacterial numbers were estimated by acridine orange direct count method in Lake Soyang monthly from January 1990 to 1992 The range of total bacterial number was from 0.4*10^(6) to 4.7*10^(6) cell*㎖^(-1). In epilimnion,the variation range was wider than other depths. while in hypolimnion was narrower. At August, when water temperature was highest. the bacterial numbers was also highest . This means that water temperature was highest the bacterial numbers was also highest. This means that water temperature was one of the factor governing the bacterial abundance. In metalimnion. the bacterial number was higher than other depths during stratigication. And spacially the bacterial numbers near aquaclture net-cages were higher than those of dam site. This means that allochthonous materials such as terrestorial originated particle, organics and microbes from watershed and fish feed stinmulated the bacterial growth.

Agrobacterium을 이용한 고추의 형질전환체계개발

최근원,박영두,박승국,전영주,유일웅,김인태,백운돈 경희대학교 생명자원과학연구원 1997 硏究論文集 Vol.18 No.-

본 실험은 고추의 형질전환체 선발을 위한 최소의 항생제농도를 결정하고 그 결과를 이용하여 형질전환체를 유기하고 효율을 최대화하기 위하여 수행한 바 그 결과는 다음과 같다. 1. 항생제 감응성 검정결과 kanamycin 40㎎/ℓ와 hygromycin 20 ㎎/ℓ에서 신초형성이 완전히 억제되었다. 2. Agrobacterium 제거에 사용되는 carbenicillin과 cefotaxime 처리시 재분화에 아무런 영향을 미치지 않았으며 cefotaxime 200㎎/ℓ 처리에서는 무처리구보다 신초형성이 더 활발하였다. 3. 회복친인 135Q와 276F에서는 형질 전환시 높은 재분화율을 보였으나 형질전환율은 각각 10%와 11.1%의 낮은 빈도를 보였다. 4. 재분화된 신초들을 대상으로 histochemical GUS assay를 실시한 결과 부분적으로 푸른발색이 확인되었다. 5. GUS활성을 보인 신초들에 대한 NPTⅡprimer를 이용한 PCR검정에서 NPTⅡ 유전자의 존재가 확인되었다. A transformation system using Agrobacterium tumefaciens was developed with different genotypes of hot peppers (Capsicum annuum). Four antibiotics commonly used in Agrobacterium-mediated transformation were tested for their effects on shoot regeneration. Shoot induction was completely inhibited by kanamycin at 40㎎/ℓ and hygromycin at 20㎎/ℓ or higher, but not by carbenicillin and cefotaxime. Cotyledon explants of hot peppers were cocultivated with Agrobacterium turnefaciens LBA4404 which carries a binary. vector pBI121 harboring the neomycin phosphotransferase, type Ⅱ (NPT Ⅱ) gene and β-glucuronidase (GUS) gene. For selection of transformed cells, 40㎎/ℓ kanamycin were used because the sensitivity test showed that 40㎎/ℓ kanamycin completely inhibited shoot induction from nontransformed cells. Histochemical GUS assay showed the presence of the GUS gene and PCR analysis confirmed the NP TⅡ gene was integrated. Transformation frequency was about 10.0% and 11.1% of total regenerants from 135Q and 276F, respectively.