간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

급성 백혈병 환자에서 수두양 피부병변을 보인 파종성 Fusarium 감염 1예와 국내 파종성 Fusarium 감염증에 대한 고찰

오수진,정희선,김준성,김태석,조병식,최수미,김명신,이연수,이석,신완식 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

최근 면역저하환자의 증가와 함에 국내에서도 점차 침습성, 파종성 Fusarium 감염증 보고가 증가하고 있다. Fusarium 감염은 아스페르길루스 감염과 유사한 임상양상을 보이지만 특징적인 피부병변을 동반하고 혈액배양에서 균이 분리되는 경우가 더 많다. 저자들은 급성 림프구성 백혈병으로 진단받고 치료중인 30세 남자 환자에서 중증의 호중구 감소 상태에서 비특이적인 피부병변을 동반한 파종성 Fusarium 혈류감염을 경험하였기에 국내 증례 고찰과 함께 보고하는 바이다. 환자의 초기 피부병변은 구진에서 시작하여 주로 소포성 병변과 일부 통증을 동반한 결절 등 여러 형태로 나타났고, Tzank 도말검사 양성으로 비정형 수두로 오인되었다. 이후 피부병변은 농포로 변하였고, 혈액배양 및 피부 조직검사에서 파종성 Fusarium 감염으로 진단받았다. 환자는 liposomal amphotericin B, voriconazole 병합요법과 G-CSF 투여, 과립구 수혈을 받았으나, 호중구 감소증에서 회복하지 못하고 급성 호흡곤란증후군과 다장기 기능부전으로 사망하였다. 본 증례는 파종성 Fusarium 감염의 경우에도 수두양 병변으로 비특이적인 양상으로 나타날 수 있으므로, 감별진단을 위해 적극적으로 혈액배양과 피부조직검사를 시행해야 함을 보여준다. Recently, we experienced a case of disseminated fusarial blood stream infection with varicelloid skin eruptions, who had suffered from persistent neutropenic fever after salvage chemotherapy for relapsed acute lymphocytic leukemia (ALL). Neutropenia continued in spite of G-CSF and granulocyte transfusion, and he failed to respond to conventional amphotericin B initially, and then liposomal amphotericin B and voriconazole combination therapy. Disseminated fusariosis can be diagnosed by blood cultures in 50% of patients and present skin lesions in more than 80% of patients. So, typical skin lesions are important clue to diagnose of the disseminated fusariosis. However, many skin lesions in immunocompromised hosts are due to various infectious and non-infectious causes. So, this case shows that it is important to obtain biopsy specimens of skin lesions for histopathologic examination, culture and staining. Here, we present our case with the review of the literatures reported in our country, so far.

Mouse의 血液像에 관한 硏究 : Rompun投與가 鎭靜狀態 및 血液像에 미치는 影響 Effect of the administration of rompun on the sedation and the hematological values

吳錫斗,姜奉泰,李乙熙 진주산업대학교 1986 論文集 Vol.24 No.-

晋州農林專門大學 附屬動物飼育場에서 飼育中인 Mouse를 공시하여 Rompun 投與前 血液像을 調査하여 處理前의 實驗値를 算定했고 處理區는 0.1, 0.2 및 0.3mg/kg 投與群으로 나누어 投與後 鎭靜狀態는 經時的으로 調査했고 血液像은 1, 2, 3 및 4時間에 調査하였던 바 다음과 같은 結果를 얻었다. 1. 鎭靜導入時間은 0.1mg/kg, 0.2mg/kg 및 0.3mg/kg 投與區에서 각각 20分, 14分, 7.5分이었고 鎭靜待續時間은 0.5時間, 1時間, 2時間이었다. 2. 血球容積, 血色素含量, 赤血球數 및 白血球總數는 鎭靜期에 다소 감소하는 경향을 보였다. 3. 平均赤血球容積은 鎭靜期에 0.1mg/kg投與區는 감소했고, 0.2mg/kg 및 0.3mg/kg投與區는 증가하였다. 4. 血淸總蛋白含量은 投與後 4時間까지 감소하였다. The effects of Rompun on the sedation and the hematological values of the mouse were studied. 3 Levels of Rompun were treated: 0.1, 0.2 and 0.3 mg/kg of body weight of the mouse. The changes of sedation of the mouse were observed with the passage of time and the hematological values were estimated 4 times(1, 2, 3 and 4 hrs after administration). The results are summarized as follows: 1. Times required to reach the sedation state were 20, 14 and 7.5 min. at the level of 0.1, 0.2 and 0.3mg/kg of body weight and the sedation times taken were 0.5, 1 and 2 hours, respectively. 2. Packed cell volume, hemoglobin concentration, erythrocyte counts and leucocyte counts were decreased during sedative periods. 3. Mean corpuscular volume were decreased at the level of 0.1mg/kg during the sedative time, whereas increased at the level of 0.2mg/kg and 0.3mg/kg. 4. Plasma protein contents were decreased continuously up to 4 hours after administration.

內燃機關의 排氣騷音이 性能에 미치는 影響

吳栗權,張熙碩,吳炯俊,車京玉 明知大學校 産業技術硏究所 1988 産業技術硏究所論文集 Vol.7 No.-

The theoretical analysis of the exhaust noise of an internal combustion entwine contains various difficult factors. The exhaust system is closely related with these problems, that is, the resistance of tile exhaust system is a factor governing the fuel economy and dynamic performance of an internal combustion engine, while exhaust noise and radiated noise from the system are one of the main factor affecting the quietness of an internal combustion engine and also one of the main sources of external noise of all internal combustion engine. Reducing tile resistance and lowering the exhaust and radiated noise are contracdictory requirements and it has been considered difficult to satisfy these requirements simultaneously. Almost all the studies on the attenuation characteristics of a muffler are an analysis based on the assumption that the time of intake-exhaust valve opening - closing is deadpoint. This paper introduces a practical exhaust system for internal combustion engine newly developed as the result of studies on the reduction of the exhaust system, pulsating noise and draft noise.

절골술을 이용한 안면교정

오석희,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The most important factor in the beauty of the face is the harmony of the facial skeleton and soft tissue. The postoperative result is not always satisfying after only classic soft tissue surgery. The reason for dissatisfaction is disharmony of the facial skeleton. Recently, the development of maxillofacial surgical techniques enable disharmony of the facial skeleton to be successfully corrected. The authors have had experience with 33 cases of congenital and acquired facial deformities, from March of 1986 to February of 1989, and have followed them from 6 months to 2 years. We used an intraoral approach in most cases and got good results. There were four wound disruptions which were treated conservatively and resolved without sequelae.

Estrogen이 가토의 이개변형에 미치는 영향

오경,김정희,김정태,김석권 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.1

Congenital auricular deformities such as lop ear, cup ear, prominent ear, and Stahl's ear can be corrected nonsurgically in the early neonatal period(first week after birth) obtaining satisfactory results. Auricular cartilage consists of chondrocytes and intercellular materials that are mainly assembled from collagen, elastin, and a proteoglycan aggergate. Cartilageelasticity is dependent upon the concentration of the proteoglycan aggregate. Hyaluronic acid, which is a constituent of proteoglycan aggregate and is increased by estrogens, has an important play on disconnecting the proteoglycan aggregate. So the increased estrogen results in the lack of elasticity. The circulating levels of free estradiol are higher during the first 72 hours after birth and decreases thereafter, so the ear is soft and easily malleable in this early neonatal period. In this study, we have applied aluminium splint(90 degree-angulated, 180 degree-angulated, and rolled) on rabbit ear. All of the rabbit was divided into 3 groups containing 3 types of deformities. In group 1, estrogen was applied to the deformed ear with regional injection to the perichondrium of auricular cartilage. In group 2. estrogen was applied topically with ointment. In group 3, as control group, saline was injected to the perichondrium. Four weeks later, in group 2, the shape of the deformed rabbit ear was maintained, and did not return to its original shape even after splint removal. From these results, we concluded that estrogen ointment could be tried as adjunctive therapeutic modalities to the nonsurgical treatment of the congenital auricular deformities.

Guinea Pig의 血液像에 關한 硏究 : 絶食에 따른 血液像 Hematological values in the Starvation

李乙熙,姜奉泰,吳錫斗 진주산업대학교 1985 論文集 Vol.23 No.-

晋州農林專門大學 附屬動物飼育場에서 飼育되고 있는 姙娠中인 Guinea pig 20匹을 供試하여 絶食期間에 따른 血液像 및 正常管理 24時間後의 回復狀態를 調査하였던 바 다음과 같은 結果를 얻었다. 1. 赤血球數는 絶食期間이 길수록 增加幅이 크고 正常管理 24時間 後에는 12時間 絶食群은 增加되었고 24時間 및 48時間 絶食群에서는 減少되었다 2. Hemoglobin含量은 다소 增加하는 傾向이었고, Hematocrit値置는 減少하였으나 그 傾向은 뚜렷하지 않았다. 3. Plasma protein은 絶食中 若干 增加되었으나 正常管理 24時間後에도 回復되지 못했다. 4. 絶食後 MCV는 減少되었고 正常管理 24時間後에는 若干 增加했고 MCHC는 이와 반대 傾向이었다. 5. 白血球數는 絶食期間이 길 수록 減少幅이 컸고 正常管理 24時間後에는 12 및 24時間 絶食群은 本來의 數値와 비슷하였고 48時間의 경우는 적게 나타났다. 6. Neutrophils은 若干 增加되었고 Eosinophils및 Lymphocytes는 多少減少되었으나 그 경향은 不規則했다. 7. Basophils및 Monocytes는 變化幅이 輕徵하였다. This experiment was carried out to study the effect of hematological values of Guineapigs in the course of starvation at an interval of 12, 24, 48hr. and the restorative condition of 24hr, after normal feeding. It were raised at the animal farm in Chin-ju National Agricultural and Forestry Junior College. The results are summarized as follows. 1. The erythrocytes counts were gradualy increased by the process of starvation period and it were slightly decreased in both condition(24 and 48hr.) whereas increased 12hr. after normal feeding. 2. The hemoglobin contents increased and the hematocrit values decreased in the process of starvation periods, but the tendency make a no difference. 3. The plasma protein increased a little percentage in the stage of starvation and it was non-recovered initial values at 24hr. after normal feeding. 4. The mean corpusular volume decreased in the stage of starvation, whereas increased a little contents a 24hr. after normal feeding. But the mean corpusular hemoglobin concentration was contrary tendency. 5. The total leukocyte counts were on the decreased by the process of starvation periods, and it was recovered initial values at 12hr. and 24hr. in stage of starvation whereas non-recovered at 48hr. to 24hr. after normal feeding. 6. Neutrophils increased, Eosinophils and Lymphocytes decreased in stage of starvation, but showed irregula fluctuaction. 7. Basophils and Monocytes have not an effect on stage of starvation and 24hr. after normal feeding.

가변 링크전압을 이용한 영구자석 동기전동기의 토오크 리플 저감 제어

이동희,오석규 진주산업대학교 2000 論文集 Vol.39 No.-

Permanent magnet synchronous motors are widely used in high-performance drive applications such as industrial robots and machine tools because of their high-power density, high-torque/inertia ratio, and free maintenance. In recent sensorless and torque ripple reduction control are much studied for high-performance control. In this paper, A variable link voltage system is introduced for reduction of torque current ripple of PMSM. The PWM VSI inverter system with fixed high d.c. link voltage has high current ripple in low speed region because of voltage resolution and low back e.m.f. and dead-time effect more serious in the low speed range. The proposed variable link voltage inverter system controls the d.c. link voltage applied in the inverter input terminals according to the back e.m.f. of the motor and load conditions. In the low reference voltage command, variable link voltage system down the d.c. link voltage and up the d.c. link voltage in the high reference voltage command. So the time of the effective voltage vector in the SVPWM inverter remains constantly in the low speed range and voltage error and current ripple are decreased. The proposed algorithm is verified by simulation and experimental results.

Maillard 反應에 관한 연구 : Ⅰ. 아미노산과 6炭糖의 Maillard 反應 Ⅰ. Study on the Mailard Browning of Amino Acids and Hexoses

李乙熙,姜奉泰,金基元,文点東,吳錫斗 진주산업대학교 농업기술연구소 1989 農業技術硏究所報 Vol.2 No.-

아미노산과 7炭糖溶液을 121℃에서 15분간 열처리하였을 때 Maillard 反應의 發色强度를 비교한 결과는 다음과 같다. 1. 아미노산은 종류에 따라 갈변화 현상의 강도가 높은 것, 중간 것 및 낮은 것으로 대별되었다. 2. Ketose인 L-sorbose와 D-fructose가 aldose인 D-galactose, D-mannose 및 D-glucose 보다 갈변화현상이 높게 나타났다. 3. 반응액의 pH가 높아질 수록 반응성은 증가되었다. 4. D-glucose 및 D-fructose의 농도가 증가될 수록 반응성은 증가되었다. Common amino acids and hexoses have been ranked according to the intensity of Maillard Browning formed when heated in an autoclave for 15min, at 121℃. The results obtained as follows : 1. The amino acid compounds have been grouped into high, intermediate and low browning groups. 2. L-sorbose and D-fructose of ketose form showed higher velocity in this reaction than D-galactose, D-manose and D-glucose of aldose form. 3. As the pH values of reaction solutions increased, the color intensities of Maillard reaction increased. 4. As the concentrations of D-glucose and D-fructose increased, the color intensities of Maillard reaction increased.

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.