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치근단질환에서 Nitric Oxide Synthetase발현에 관한 연구
오수진,이흥수 원광대학교 치의학연구소 1999 圓光齒醫學 Vol.9 No.1
The periapical response to injury is a complex interaction of inflammatory, immune, neural, vascular and synthetic activity. Nitric oxide(NO), synthesized by nitric oxide synthetase(NOS) from L-arginine, is becoming recognized as an important bio-regulatory molecule in a variety of tissue, but little is known about its possible role in periapical tissue. The purpose of this study was to investigate the expression of nitric oxide synthetase(NOS) in tooth follicle, periapical abscess, granuloma and cyst. The expression of NOS in periapical lesions was evaluated by immunohistochemical staining for NOS_2, and NOS_3. The immunoreactivity was evaluated by staining intensity, and inflammatory cell infiltration. Correlationship between the periapical lesion in immunoreractivity were statistically analyzed by SPSS. The degree of NOS_2 and NOS_3 expression in periapical abscess was higher than in any other periapical lesions, and stastically significant. The expression degree of NOS_2 and NOS_3 was not correlated with periapical abscess and granuloma, but expression of NOS_2 showed very significiant in periapical cyst. The increased expression of NOS_2 and NOS_3 was correlated with inflammatory cell infiltration degree of the periapical cyst. These results suggested that NO should play an important role in progress and/or mediation of periapical lesions.
뇌 과학을 통해 셰익스피어의 『 리처드 3 세 』 읽기: 리처드의 사이코패스적 성향과 공감 결핍
오수진 한국고전중세르네상스영문학회 2022 중세근세영문학 Vol.32 No.2
This paper explores Richard’s psychopathic traits and lack of empathy in Shakespeare’s Richard III through reference to modern brain science. In the opening scene, Richard determines to be a villain, using his deformed body to justify his malice, as he unscrupulously plans his wrongdoings to take the throne. His psychological traits—namely his antisocial behavior, bold and guiltless attitude, lack of empathy for the suffering of others, and his insecure attachment bonding due to parental inadequacy—are similar to those exhibited by psychopaths with poorly functioning frontal lobes, involved in emotion. Without the benefit of modern-day technologies—such as CT, EEG, PET, SPECT, and fMRI brain scanning—Shakespeare provides us with an almost exact description of the clinical features of psychopaths as defined by present-day brain imaging. Like modern brain scientists, Shakespeare understands and explains human action involved in brain function, which suggests that literature and brain science can meet.
오수진,김인희,황유정,이석,김성훈,김상욱,이승옥,이수택 대한소화기내시경학회 2008 Clinical Endoscopy Vol.37 No.3
위에서 발생한 신경내분비암은 매우 드물게 발생하며 수술 전 진단이 어렵고, 진단 당시 종양의 크기가 크고 전이를 동반하여 예후가 매우 나쁜 것으로 알려져 있다. 위의 신경내분비암의 분류와 생물학적 특성에 대해서는 아직 이견이 있으나 일반적으로 형태학적 특성에 따라 대세포암과 소세포암으로 분류한다. 위의 신경내분비암은 발생빈도가 매우 낮아서 아직까지 자연경과 및 치료에 대해 확실히 정립되어 있지 않다. 저자들은 위에 발생한 신경내분비암 중 대세포암과 소세포암 각 1예를 문헌 고찰과 함께 보고하는 바이다.
Chemotherapeutic Candidate Inducing Immunological Death of Human Tumor Cell Lines
오수진,이현아,류정규,최인학,백소영 대한면역학회 2012 Immune Network Vol.12 No.2
The immunological death induction by EY-6 on the human tumor cell lines was screened. Human colon carcinoma (HCT15, HCT116), gastric carcinoma (MKN74, SNU668), and myeloma (KMS20, KMS26, KMS34) cells were died by EY-6 treatment with dose-dependent manner. CRT expression, a typical marker for the immunological death, was increased on the EY-6-treated colorectal and gastric cancer cells. Interestingly, the effects on the myeloma cell lines were complicated showing cell line dependent differential modulation. Cytokine secretion from the EY-6 treated tumor cells were dose and cell-dependent. IFN-γ and IL-12 secretion was increased in the treated cells (200% to over 1000% of non-treated control), except HCT116, SNU668 and KMS26 cells which their secretion was declined by EY-6. Data suggest the potential of EY-6 as a new type of immuno-chemotherapeutics inducing tumor-specific cell death. Further studies are planned to confirm the efficacy of EY-6 including in vivo study.
오수진,정연 한국보건사회연구원 2019 보건복지포럼 Vol.270 No.-
최근 우리나라는 ‘과로 사회’라고 해도 과언이 아닐 정도로 장시간 노동으로 인한 여러 사회적 부작용이 속출하고 있다. 그러나 우리나라 과로사 예방 정책은 사실상 정부의 방치하에 사업주의 자율적 노력에 의존하는 형태로 이루어지고 있으며, 보건관리지침 이행이나 위험도 평가 혹은 건강 진단에 따른 사후 조치 등을 강제할 법적 근거가 부재한 상황이다. 또한 과로사나 과로로 인한 건강 문제가 발생한 경우에도 엄격한 인정기준과 제한된 보장성 등으로 인해 산재보험이 근로자들에 대한 사회적 안전망으로서의 제 역할을 제대로 하지 못하고 있다는 점에서 개선이 요구된다. 과로와 과로사는 근로자들의 건강하게 일할 권리를 침해하는 중대한 사회적 문제라는 점에서 국가 차원의 적극적인 관리가 필요하다.
셰익스피어의 에크프라시스: 언어의 시각화와 “마음의 눈”
오수진 한국고전중세르네상스영문학회 2019 중세근세영문학 Vol.29 No.2
This paper aims to explore how ekphrasis is employed in Shakespeare’s plays. As recent critics have defined, ekphrasis is a verbal representation of visual representation. Shakespearean ekphrasis means linguistic capacity or possibility to make the audience see. First, The Taming of the Shrew and Antony and Cleopatra suggest Shakespeare’s interest in pictorial art, emphasizing the vividness and seductiveness of his description. Second, Henry V and Pericles represent many absent and important events through Chorus’s ekphrasis and ask the audience to create images with the mind’s eye and imagination. Finally, Othello and The Tempest explore an ideal relationship between verbal and visual representations, or between narrative and drama. Eventually, Shakespearean ekphrasis highlights not only the fascination with the visualization of language, but also the interplay between different forms of representation, blurring the distinction between representation and reality.