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치근단질환에서 Nitric Oxide Synthetase발현에 관한 연구
오수진,이흥수 원광대학교 치의학연구소 1999 圓光齒醫學 Vol.9 No.1
The periapical response to injury is a complex interaction of inflammatory, immune, neural, vascular and synthetic activity. Nitric oxide(NO), synthesized by nitric oxide synthetase(NOS) from L-arginine, is becoming recognized as an important bio-regulatory molecule in a variety of tissue, but little is known about its possible role in periapical tissue. The purpose of this study was to investigate the expression of nitric oxide synthetase(NOS) in tooth follicle, periapical abscess, granuloma and cyst. The expression of NOS in periapical lesions was evaluated by immunohistochemical staining for NOS_2, and NOS_3. The immunoreactivity was evaluated by staining intensity, and inflammatory cell infiltration. Correlationship between the periapical lesion in immunoreractivity were statistically analyzed by SPSS. The degree of NOS_2 and NOS_3 expression in periapical abscess was higher than in any other periapical lesions, and stastically significant. The expression degree of NOS_2 and NOS_3 was not correlated with periapical abscess and granuloma, but expression of NOS_2 showed very significiant in periapical cyst. The increased expression of NOS_2 and NOS_3 was correlated with inflammatory cell infiltration degree of the periapical cyst. These results suggested that NO should play an important role in progress and/or mediation of periapical lesions.
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일시적인 C1 Inactivator 활성도 감소와 맥관부종을 동반한 루푸스 신염 1예
오수진,강경표,장용범,남상우,강명재,이식,방성광,강성귀,김원 대한신장학회 2005 Kidney Research and Clinical Practice Vol.24 No.5
맥관부종은 다양한 원인에 의하여 발생하며 때로는 생명을 위협할 수 있는 질환으로 안면부, 기도, 성기 또는 사지 부종이나, 복부 장기의 부종으로 인한 복통을 특징으로 하는 질환으로 유전성과 후천성으로 구분할 수 있다1). 유전성 맥관부종은 C1 esterase inhibitor (C1 INH)의 결핍이나 기능 이상으로 비알레르기성 부종이 발생하는 것으로 상염색체 우성으로 유전된다. 반면에 후천성 맥관부종은 유전성과 달리 나이가 들어서 발생하며 맥관부종의 가족력이 없이 나타나고 C1 INH 결핍, 혈청병, 전신성 홍반성 루푸스와 같은 면역 질환, 알레르기 질환, 물리적 자극 등에 의해 발생할 수 있다1,2). 전신성 홍반성 루푸스와 동반되어 발생하는 맥관부종의 증례는 주로 유전성 C1 INH 결핍에 의한 경우가 주로 많으며 후천성 C1 INH 결핍과 연관된 경우는 비교적 드물다3,4). 저자들은 간헐적인 안면부종과 소변량 감소를 주소로 내원한 환자에서 후천성 C1 INH 결핍과 동반되어 발생한 맥관부종과 루푸스 신염 1예를 경험하고 prednisolone 치료를 통하여 C1 inactivator 활동성이 회복되면서 맥관부종이 호전된 증례를 문헌 고찰과 함께 보고하는 바이다. C1 esterase inhibitor deficiency with consequent angioedma is an uncommon condition. Nonhereditary C1 inhibitor deficiency includes underlying disorders; lymphoproliferative disorder, autoimmune disease, hypereosinophilia, drug-induced, allergic, and idiopathic forms. The association of hereditary C1 esterase inhibitor deficiency with systemic lupus erythematosus has been previously described. We experienced a case with transiently decreased C1 inactivator activity and angioedema in lupus nephritis. This present case is a previously healthy 22-year-old woman, who developed intermittent facial angioedema and decreased urine amount. After steroid treatment, the C1 inactivator activity was recovered and angioedema was disappeared. (Korean J Nephrol 2005;24 (5):828-831)
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Protein kinase A 억제제인 KT5720이 글루카곤 매개성 항산화 효소의 발현감소에 미치는 영향
오수진,조재훈,박창식,김상겸,김봉희,Oh Soo-Jin,Jo Jae-Hoon,Park Chang-Sik,Kim Sang-Kyum,Kim Bong-Hee 환경독성보건학회 2006 환경독성보건학회지 Vol.21 No.3
We reported previously that glucagon decreased alpha- and pi-class glutathione S-transferases (GSTs) and microsomal epoxide hydrolase (mEN) protein levels in primary cultured rat hepatocytes. The present study examines the effects of Protein kinase A (PKA) inhibitor, KT5720, on the glucagon-mediated decrease in expression of GSTs and mEN. To assess cell viability. lactate dehydrogenase release and MTT activity were examined in hepatocytes treated KT5720. Cell viability was significantly decreased in a concentration dependent manner after incubation with KT5720 at the concentrations of 1 $\mu$M or above for 24 h, which was inhibited by the cytochrome P450 inhibitor SKF-525A. In contrast, another PKA inhibitor H89 (up to 25 $\mu$M) was not toxic to hepatocytes. The glucagon-mediated decrease in expression of alpha- and pi-class GSTs and mEH was completely inhibited by 25 $\mu$M H89 and attenuated by 0.1 $\mu$M KT5720. This study demonstrates that KT5720 may cause cytotoxicity in rat hepatocytes through cytochrome P450-dependent bioactivation. The present study implicates PKA in mediating the inhibitory effect of glucagon on expression of alpha- and pi- class GSTs and mEH.
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뇌 과학을 통해 셰익스피어의 『 리처드 3 세 』 읽기: 리처드의 사이코패스적 성향과 공감 결핍
오수진 한국고전중세르네상스영문학회 2022 중세근세영문학 Vol.32 No.2
This paper explores Richard’s psychopathic traits and lack of empathy in Shakespeare’s Richard III through reference to modern brain science. In the opening scene, Richard determines to be a villain, using his deformed body to justify his malice, as he unscrupulously plans his wrongdoings to take the throne. His psychological traits—namely his antisocial behavior, bold and guiltless attitude, lack of empathy for the suffering of others, and his insecure attachment bonding due to parental inadequacy—are similar to those exhibited by psychopaths with poorly functioning frontal lobes, involved in emotion. Without the benefit of modern-day technologies—such as CT, EEG, PET, SPECT, and fMRI brain scanning—Shakespeare provides us with an almost exact description of the clinical features of psychopaths as defined by present-day brain imaging. Like modern brain scientists, Shakespeare understands and explains human action involved in brain function, which suggests that literature and brain science can meet.
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Exploring Antecedents of Consumers’ Willingness to Depend on E-Health Information
오수진 한국콘텐츠학회 2012 International Journal of Contents Vol.8 No.1
Previous research on online health (e-health) information was primarily focused on consumer information search behavior and information quality. Although studies addressing online information quality have flourished, they have yet to thoroughly examine whether consumers actually use the information they search. The purspose of this study suggests a conceptual framework that examines the potential antecedents of a consumers’ willingness to depend on e-health information as an indicator of the consumer’s trust of the provided e-health information. The proposed antecedents include healthcare product involvement, online skill level, perceived quality, and credibility of the source. Using structural equation modeling on online survey data, seven hypotheses, which describe the relationships between the variables of the model, were tested. The results indicate that consumer willingness to depend on provided e-health information was significantly influenced by the consumers’ perceived quality and credibility of specific e-health information. Consumer involvement in healthcare and their online skill-level, respectively, also positively related to perceived quality and credibility regarding e-health information.
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