당뇨병 환자에서 비타민 E 영양제 보충이 체내 지질과산화 및 혈액 지방성분에 미치는 영향연구

강남이,민경완 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

We investigated the effects of vitamin E supplementation on lipid peroxidation and on the activities of antioxidative enzymes in diabetes mellitus. Vitamin E supplement doses consist of the amout 400 I.U./day (d-α-tocopherol. 268.5mg). After vitamin E supplementation. plasma levels of total cholesterol and LDL-cholesterol were decreased. and increased in plasma triglyceride. HDL-cholesterol. Plasma levels of lipid peroxide measured as thiobarbituric acid reactive substances(TBARs) before and after vitamin E supplementation was 0.271. 0.181 nmol/100ml plasma. respectively. Plasma level of TBARs. indicator of lipid peroxidation and increased susceptability of LDL towards lipid peroxidation. were elevated in diabetes before vitamin E supplementation. while the plasma level of TBARs was significantly decrease after vitamin E supplementation. indicating that decreased lipid peroxidation are associated with the antioxidative activities effects of vitamin E. In the present study the possible explanations for that diabetes have a higher risk of diabetic complications by cardiovascular disease include the changes of blood lipid and lipoprotein concentration, and vitamin E supplementation which might have protective functions against free radical against free radical-mediated lipid peroxidation.

강원도 지역의 초등학교 환경교육 실태 조사

노경주,김남일,이면우,추병완 춘천교육대학교 과학교육연구소 2004 과학교육연구 Vol.27 No.-

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

Manganese Oxide Film Electrodes Prepared by Electrostatic Spray Deposition for Electrochemical Capacitors

Nam, Kyung-Wan,Kim, Kwang-Bum The Electrochemical Society 2006 Journal of the Electrochemical Society Vol.153 No.1

Combining In Situ Synchrotron X‐Ray Diffraction and Absorption Techniques with Transmission Electron Microscopy to Study the Origin of Thermal Instability in Overcharged Cathode Materials for Lithium‐Ion Batteries

Nam, Kyung‐,Wan,Bak, Seong‐,Min,Hu, Enyuan,Yu, Xiqian,Zhou, Youngning,Wang, Xiaojian,Wu, Lijun,Zhu, Yimei,Chung, Kyung‐,Yoon,Yang, Xiao‐,Qing WILEY‐VCH Verlag 2013 Advanced Functional Materials Vol.23 No.8

<P><B>Abstract</B></P><P>The thermal instability of the cathode materials in lithium‐ion batteries is an important safety issue, requiring the incorporation of several approaches to prevent thermal runaway and combustion. Systematic studies, using combined well‐defined in situ techniques, are crucial to obtaining in‐depth understanding of the structural origin of this thermal instability in overcharged cathode materials. Here time‐resolved X‐ray diffraction, X‐ray absorption, mass spectroscopy, and high‐resolution transmission electron microscopy during heating are combined to detail the structural changes in overcharged Li<SUB><I>x</I></SUB>Ni<SUB>0.8</SUB>Co<SUB>0.15</SUB>Al<SUB>0.05</SUB>O<SUB>2</SUB> and Li<SUB><I>x</I></SUB>Ni<SUB>1/3</SUB>Co<SUB>1/3</SUB>Mn<SUB>1/3</SUB>O<SUB>2</SUB> cathode materials. By employing these several techniques in concert, various aspects of the structural changes are investigated in these two materials at an overcharged state; these include differences in phase‐distribution after overcharge, phase nucleation and propagation during heating, the preferred atomic sites and migration paths of Ni, Co, and Mn, and their individual contributions to thermal stability, together with measuring the oxygen release that accompanies these structural changes. These results provide valuable guidance for developing new cathode materials with improved safety characteristics.</P>

Synthesis and Electrochemical Investigations of Ni[sub 1−x]O Thin Films and Ni[sub 1−x]O on Three-Dimensional Carbon Substrates for Electrochemical Capacitors

Nam, Kyung-Wan,Lee, Eun-Sung,Kim, Jae-Hong,Lee, Young-Ho,Kim, Kwang-Bum The Electrochemical Society 2005 Journal of the Electrochemical Society Vol.152 No.11

대학생의 인구통계학적 특성에 따른 스포츠신발 브랜드자산 구성요소의 비교 분석

남경완 ( Kyung Wan Nam ),권욱동 ( Wook Dong Kwon ),조민행 ( Min Haeng Cho ),임승현 ( Seung Hyun Lim ),박재암 ( Jae Am Park ) 한국스포츠산업경영학회 2009 한국스포츠산업경영학회지 Vol.14 No.3

이 연구는 대학생의 특성에 따른 스포츠신발 브랜드의 충성도, 이미지, 인지도, 선호도를 분석하여 스포츠신발 브랜드자산 구성요소가 주는 시사점을 도출하고, 스포츠신발 브랜드의 연계를 강화하여, 기업의 목표달성을 위한 중요한 도구로 활용할 수 있는 기초자료 제공에 목적이 있다. 이를 위하여 G시에 소재하는 대학교 3곳을 선정하여 편의추출법(convenience sampling)을 사용하여 표본을 추출하였다. 연구대상으로 총 500명을 표집하였고, 불성실하게 응답하였다고 판단되거나 기입이 누락된 경우와 같은 연구 자료로 부적합한 설문지를 제외하였으며, 최종 분석에 사용된 표본은 총 478명 이었다. 표집된 자료는 통계프로그램인 Window용 SPSS ver. 15.0을 이용하여 분석목적에 따라 빈도분석, 요인분석, 신뢰도분석, t test, 일원변량분석(one-way ANOVA)을 실시하여 얻은 결과는 다음과 같다. 첫째, 남자대학생이 여자대학생 보다 스포츠참여 및 관심도가 높기 때문에 스포츠신발 특정브랜드에 대한 브랜드 충성도의 태도적요인과 브랜드 인지도, 이미지, 선호도가 더 높은 것으로 나타났다. 둘째, 대학생의 학년이 높을수록 스포츠신발 특정 브랜드에 대한 충성도, 이미지, 인지도, 선호도가 높게 나타났다. 셋째, 대학생에게 인지도가 높은 스포츠신발 브랜드는 참여종목이 축구, 야구와 농구인 것으로 나타나 이 종목의 스포츠신발 브랜드 중 인지도가 높은 브랜드가 있고, 이 종목에 참여하는 대학생에게 인지도가 높은 브랜드가 존재하고 있음을 알 수 있었다. 넷째, 운동에 참여하는 시간이 많을수록 스포츠신발 브랜드의 태도적 충성도와 행동적 충성도가 높아지는 것으로 나타났다. 다섯째, 스포츠신발의 구입주기가 짧을수록 브랜드 충성도(태도적 충성도, 행동적 충성도), 인지도, 선호도가 높은 것으로 나타났다. The purpose of this study was to analyze the athletic shoes`` brand loyalty, image, awareness, preference according to university students`` demographic characteristics. In order to strengthen the connection of athletic shoes brand and attainment of enterprise´ goal, this research came to the following conclusions by analyzing data from 478 students drawn from 3 different universities in "G"city by applying descriptive analysis, factor, reliability analysis, independent samples t-test, one-way ANOVA with SPSS Windows 15.0. First, men showed the high level of attitude factor of brand loyalty and brand image, awareness, preference than women`` by reason of men`` high level of sport participation and interest. Second, upper grade students`` showed the high level of brand loyalty and brand image, awareness, preference of specific brand, by reason of their high level of self involvement. Third, students have high level of brand awareness about soccer and baseball by reason of these sports have specific favorite brand. Students who participate in weight training and badminton have low level of brand awareness. Fourth, students with considerable time of sport participation show high level of attitude factor of brand loyalty and behavioral brand loyalty. Fifth, short term of athletic shoes purchase gives high level of brand loyalty, awareness, preference. because students who have short term of athletic shoes purchase know specific brand``s merits and demerits. Due to increase of sport activity, new brand marketing activity and new component part will appear. In order to strengthen the value of brand equity, it needs development and systematization of factor of brand equity.

Antiphospholipid Antibody Positivity and the Clinical Outcomes of Patients with Systemic Lupus Erythematosus

( Seoung Wan Nam ),( Soo-kyung Cho ),( Dam Kim ),( Kyung-eun Lee ),( Dong-jin Park ),( Shin-seok Lee ),( Yoon-kyoung Sung ) 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.4

Objective. To identify the prevalence of antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) patients and determine the relationship between aPL and the clinical outcomes. Methods. SLE patients with aPL test results within 2 years of enrollment were selected from Korean lupus network study. They were classified into two groups: aPL (+) group, patients positive for at least one aPL, and aPL (-) group, patients without an aPL. The clinical characteristics of the two groups were compared and the role of aPL in the risk of chronic kidney disease (CKD) in SLE patients was examined. Results. Among the 469 SLE patients, 69 (14.7%) had at least one aPL. The prevalence of cerebrovascular disease and CKD was higher in the aPL (+) group than in the aPL (-) group (10.1% vs. 1.8% and 13.8% vs. 5.1%, p<0.05). Multivariable regression analysis showed that the aPL positivity (odds ratio=3.93, 95% confidence interval=1.48∼10.47) was associated with the risk of CKD after adjusting for age, disease duration, and lupus nephritis history. Conclusion. The prevalence of aPL in Korean SLE patients is 14.7%, and it is associated with a higher prevalence of cerebrovascular disease and CKD in SLE patients. The aPL positivity is independently associated with the risk of CKD in SLE patients. (J Rheum Dis 2018;25:239-247)

태권도와 검도 종목 초등학생 수련자의 신체만족도와 고객만족도 비교 분석

남경완(Kyung Wan Nam),권옥동(Wook Dong Kwon) 한국사회체육학회 2010 한국사회체육학회지 Vol.0 No.41

The purpose of this study was comparison analysis of Teakwondo and Kumdo trainee`s body satisfaction and customer satisfaction. In order to provide the basic information for establishment of marketing strategy, we came to following conclusions by analyzing data from 352 Taekwondo and 322 Kumdo elementary school student trainees drawn from Taekwondo and Kumdo Do-Jang in "D" and "G" city by applying descriptive analysis, factor, reliability analysis, t-test, one-way ANOVA, structural equation model analysis with SPSS Windows 15.0 and AMOS 7.0. First, boy kumdo trainee`s body satisfaction level is higher than girl`s. Second, Taekwondo is effective for 3th, 4th grade elementary school student. Third, 3th, 4th grade elementary school student Taekwondo trainee shows high level of instructor, program, facilities, location. Forth, In case of training period, students who have under 1-2 years Taekwondo training period show high level of body satisfaction. Fifth, students who have under 1 years Kumdo training period show highest level of instructor factor of customer satisfaction. Sixth, students who participate in Taekwondo over than 5 days a week show high level of body satisfaction. Seventh, students who have higher frequency of Taekwondo participation a week show high level of customer satisfaction.