치과기공사들의 호흡기 자각증상 및 관련요인

정희선,이무식,김남송 대한보건협회 2002 대한보건연구 Vol.28 No.2

본 연구는 치과기공사들의 호흡기 및 근골격계 자각증상에 관한 호소율과 관련요인을 조사 분석하여 직업성 질병을 예방하고 효율적인 건강관리와 작업 환경 개선을 위한 기초자료를 제공하고자 실시하였다. 연구대상을 전국의 치과기공소(실)에 근무하고있는 치과기공사를 무작위로 추출하여 우편 설문조사에 응답한 265명 이었으며 조사기간은 2000년 12월부터 2001년 3월 까지였다. 수집된 자료는 Spss 8.0프로그램을 사용하여 X2-test와 로지스틱 회기분석을 통하여 다음과 같은 결론을 얻었다. 조사대상자의 성별에 따른 일반적 특성을 분석한 결과 연령, 결혼상태, 흡연여부, 음주여부와 유의성이 있었고 직무특성 분포에서는 치과기공경력, 담당업무, 직위에 따라 유의성이 있었다. 호흡기 장애 호소율을 분석한 결과 평소시침 호소율(55.5%)이 가장 높게 나타났고 다음은 담.가래(52.5%), 숨참.숨헐떡임(42.6%), 콧물.코감기(39.2%), 숨쉴 때 소리(23.4%)순이었다. 로지스틱 회귀분석에서 평소기침 호소율에 유의한 영향을 준 요인으로는 직위였고, 담.가래는 직장소재지였으며, 콧물.코감기는 성별, 연령, 결혼상태, 직위였다. 이상의 결과로 볼 때 치과기공사들의 신체 자각증상 호소율은 비교적 ?? 나타났으며 효율적인 건강 관리와 작업환경 개선을 위해 치과기공과 재학생들에게도 치과기공 재료들의 유해성에 대한 보건관리 교육 실시 및 재료등의 유해성 방지를 위한 전문 연국기관이 요구되며 치과기공사들의 적극적 자기관리와 치과기공소 운영자의 정기적인 작업환경 측정으로 쾌적한 환경유지가 필요하다. 또한 치과기공사들의 직업적 특성을 고려한 건강관리 교육 및 전용의료기관을 지정하고, 정기 건강검진을 실시하여 질병 예방의 제도적 장치가 필요할 것으로 판단된다. The purpose of this study was to serve as a basis for the protection of dental technicians from occupational diseases, more successful health care for them, and the betterment of working environment, by examining their complaints about respiratory subjective symptom and the relevant factors. The study subjects were 265 dental technicians who were randomly selected from dental technology shops nationwide and respondent to a mail survey. The survey was conducted from December 2000 to March 2001. The collected data were analyzed with SPSS 8.0 program, and X^2-test and logistic regression analysis procedures were utilized. Dental technicians suffered coughing in ordinary time(55.5%), phlegm and sputum(52.5%%), shortness of breath(42.6%), nasal discomfort(39.2%). Major predictors to suffer coughing in ordinary time on multiple logistic regression analysis were position in the office, phlegm and sputum were location of work area and nasal discomfort were sex, age, marital status and position in the office. The above-mentioned findings showed that the dental technicians suffered highly from physical subjective symptoms of respiratory system. S0 there are some suggestions about mere efficient health care and better working environment: dental technology students should receive healthcare education to leam the harmfulness of dental technology materials, and a specialized research institution is needed to make a deep study of addressing the harmfulness of the materials. Dental technicians have to pay more attention to their own health care, and dental technology manager should check out working environment on a regular basis to maintain a comfortable environment. In addition, healthcare education should be provided to dental technicians in consideration of their vocational characteristics, and specific medical institutions for dental technicians should be designated. And a regular health examination should be conducted to prevent any possible occupational diseaede.

간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의

김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.

農業科學技術開發 및 普及의 投資效果分析

徐東均,鄭武男,閔勝奎 韓國農業政策學會 1994 농업경영정책연구 Vol.21 No.2

초기계태에서 valproic acid에 의한 신경관 기형 : 입체현미경적 관찰

김동호,조무연,정유남,최영주,이종선,민경수,이무섭 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

연구목적 ' 항경련제인 valproic acid가 초기계태의 신경관 형성에 영향을 주는 기형유발에 대해 입체현미경하에서 관찰하였다 연구재 료 및 방법 : 백색의 Leghorn의 신선한 수정란을 30-35시간 동안 배양하여 Hamburger & Hamilton 기 5-10기의 초기 계태를 천공 필터를 이용하여 분리하여 6-30시간 동안 CO2 세포 배양기에서 배양하였고 무작위로 대조군과 실험군을 분류하였다. 실험군은 valproic acid 의 RPMI culture media 의 농도에 따라 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ 네가지 군으로 분리하였다. 각각의 대조군과 valproic acid를 처치한 실험군에서 입체 현미경하에서 초기계태의 신경관 형성의 형태학적인 특징과 기형형성의 빈도를 비교하였다. 결과: valproic acid가 없는 RPMI media에서 배양된 대조군은 24개의 계태는 22(91.7%)개는 정상으로 자랐으며 2(8.3%)개는 비정상으로 자랐다 이에 반하여 valproic acid가 처치된 RPMI media에서 배양된 72개의 계태는 42(58.3%)개가 비정상으로 자랐다. 주로 확인된 이상 형태는 신경주름의 변형. 신경관 폐쇄부전, 체절의 장애 및 발육 정지 등 이었다. 계태의 기형 형성은 valproic acid의 농도에 비례하여 증가하였다. valproic acrid 의 농도가 100 ㎍/㎖인 경우 18개 계태 중 2(11.1%)개에서 경미한 신경관 기형이 나타났으며 200 ㎍/㎖인 경우 18개 계태 중 11(61,1%)개는 정상, 7(38.9%)개는 명백한 신경관 기형이 나타났으며 500 ㎍/㎖인 경우 18개의 계태 중 5(27.8%)개는 정상. 13(72.2%)개는 명백한 신경관 기형을 나타냈다. 1000 ㎍/㎖인 경우 18(100%)개 모두 심한 신경관 기형이 나타났다. 결론: valproic acid는 초기계태에서 신경관 기형을 유발 했는데 저농도에서는 일부 경미한 신경관 이상을 보였고 고농도에서는 대부분 심한 신경관 손상을 동반하고 성장 속도가 둔화되어 약 용량의 증가에 따라 기형이 증가되는 dose-dependent manner 로 그 영향이 나타났다. Purpose : The teratogeruc effects of valproic acid widely used as anticonvulsant on the neurulation of the explanted eraly chick embryos were observed by the stereoscope. Materials and Methods: Fresh fertilized white leghorn hen eggs were incubated for 30-35 hours in an e99 incubator. The Hamburger and Hamilton stage 5-10 chick embryos were explanted using the punched-out filter paper explantation technique and cultured in the CO2 cell culture incubator for 6-30 hours. They were randomly divided into a control group and an experimental group. The experimental group was divided into four subgroups according to the valproic acid concentrations of 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ with which the RPMI culture media were treated. The morphological characteristics and the incidences of teratogenic effects on the neurulation of early chick embryos in the control and experimental groups were compared with each other using the stereomicroscope. Results : Of the 24 chick embryos cultured in the RPMI media without valproic acrid, 22 embryos(91.7%) developed normally, and 2 embryos (8.3%) developed abnormally, in contrast, among 72 embryos cultured in the valproic acrid-treated media, 42 embryos(58.3%) developed abnormally. The frequent anomalous features were deformities of the neural folds, failure of neural tube closure, derangement of somites, and developmental arrest. Of 18 embryos cultured in the media treated each with 100㎍/㎖ of valproic acid, 2 embryos(11.1%) showed mild abnormality of neural tube defect on stereoscopic examination. Of 18 embryos cultured 7l the media treated each with 200㎍/㎖ of valproic acid, 11 embryos(61.1%) developed normally for 20 hours and 7 embryos (38.9%) showed definite neural tube defect. Of 18 embryos cultured in the media 7reated each with 500㎍/㎖ of vaIprolc acid, 5 embryos(27.8%) developed normally (or 20 hours and 13 embryos (72.2% ) showed definite neural tube defect. Of 18 embryos cultured in the media treated each with 1000㎍/㎖ of valproic acid, 1 embryo developed normally for 4 hours but all embryos (100%) showed severe neural tube defect on whole brain after 8 hours of culture. Conclusion : Valproic acid induced mild neural tube defects in low concentration and in high concentration of valproic acid, most chick embryos developed slowly and showed severe neral tube defects. The frequency and severity of abnormal embryos ulcreased in dose-dependent manner.

원발성 폐암 환자의 생존율에 관한 보고

김현태,이상무,어수택,박춘식,정성환,허승재,남충희,강창희,김용훈 순천향대학교 1994 논문집 Vol.17 No.4

We analysed 404 patients with primary lung carcinoma who were treated at Soonchunhyang University Hospital from July, 1985 to september, 1993 in order to investigate the survival rate and epidemiolgical properties of primary lung cancer. They were 330 males and 74 females. The most prevalent decade was seventh. In terms of cell type, the squamous cell was 225 patients (55%), and adenocarcinoma, small cell, mixed type was 21%, 19%, 4%, respectively. Among non-small cell lung carcinoma, stage Ⅲa was the most prevalent one(92%). In case of small cell carcinoma, the limited stage was 64%. The 12-, 24-, 36- month survival rate of total patients was 57%, 31%, 22%, respectivley and median sruvival time was 15 months. The 36-month survival rate tended to be longer in non-small cell lung carcinoma than that of small cell lung cancer, but there was no difference between two groups, statistically. In non-small cell carcinoma, The 36-month survival rate and meidan survival time were longer in the stage Ⅰ and Ⅱ than those of Ⅲa, Ⅲb, Ⅳ (80% versus 38%, 22%, 0%, p<0.05). According to involvement of lymph node, the 36-month survival rate was longer in NO and N1 than those of N2, N3 (61.9%, 48.7% versus 17.7%, 17.3%, p<0.05). In small cell carcinoma, The 36-month survival rate and median survival rate were higher and longer in limited stage than those of extensive stage(16.1% and 13 month vs 10% and 8 month, p<0.05). In conclusion, we report here the incidence of primary lung carcinoma and the survival rate of paients with primary lung carcinoma who were treated in Soonchunhyang University Hospital.

로케트 工學에 관한 硏究 : 第1報 : 亞音速 亂流流動에서 飛行翼模型의 剝離現象 Ⅰst Report : Separation of Airfoils in Subsonic Turbulent Flow

朴煥奎,金鍾一,金鎭興,李茂錫,朴吉文,鄭洛奎,李行男,李東起 조선대학교 동력자원연구소 1984 動力資源硏究所誌 Vol.6 No.2

Separation, pressure and velocity distributions were studied fully developed two dimensinonal, incompressible flow over a flat airfoil in subsonic wind tunnel. Velocity and turbulence were measured with a two channel constant temperature hot wire anemometer and pressure with a pitot tube and pressure tranducer system. The experimental results were obtained as follow: (1) Turbulent intensity of shear layer just outside the separation point is considered to affect the size of separation bubble. (2) Static pressure coefficient is separated into three regions according to its value change. (3) Separation point is varied with the change of attack angle. (4) Velocity distributions and boundary layers normal to airfoil surface are changed as variation of attack angle of airfoil.

Propylthiouracil에 의한 중증 급성간염 1예

임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.

Generation of free radical by interaction of iron with thiols in human plasma and its possible significance

Chung, Ka-Young,Lee, Seung-Jin,Chung, Seung-Min,Lee, Moo-Yeol,Bae, Ok-Nam,Chung, Jin-Ho Elsevier 2005 Thrombosis research Vol.116 No.2

<P><B>Abstract</B></P><P>It has been reported that iron can generate reactive oxygen species (ROS) with thiols. In this study, we examined the interaction of iron with thiols in plasma and the generation of ROS. In human plasma, unlike with Fe<SUP>3+</SUP>, treatment with Fe<SUP>2+</SUP> increased lucigenin-enhanced chemiluminescence in a concentration-dependent manner, and this was inhibited by superoxide dismutase. Boiling of plasma did not affect chemiluminescence generation induced by Fe<SUP>2+</SUP>. Thiol depletion in plasma by pretreatment with <I>N</I>-ethylmaleimide (NEM) decreased chemiluminescence significantly. Consistent with these findings, albumin, the major thiol contributor in plasma, also generated ROS with Fe<SUP>2+</SUP>. Treatment with Fe<SUP>2+</SUP> resulted in significant reduction of oxygen radical absorbance capacity (ORAC value) in plasma followed by an increase in low-density lipoprotein (LDL) oxidation. These results suggest that generation of ROS by nonenzymatic reaction of Fe<SUP>2+</SUP> with plasma thiols could lead to reduction of total antioxidant capacity in plasma, thereby enhancing susceptibility of plasma LDL to oxidation under iron overload conditions.</P>

Current Status and Prospect of Rice Breeding in Korea

Moo-Nam Chung,Hae-Chune Choi 한국국제농업개발학회 2000 韓國國際農業開發學會誌 Vol.12 No.2

Pedigree Analysis of 17 High Quality Korean Rice Cultivars UsingWeb Database Systems

Min-Hee Nam,Gihwan Yi,Dong-Soo Park,Eun-Sook Chung,Song-Yi Song,Nam-Soo Jeon,Doh-Hoon Kim,Chang-Deok Han,Moo-Young Eun,Yeon-Chung Ku 한국작물학회 2006 Korean journal of crop science Vol.51 No.7

It is important to understand pedigree of rice cultivars commonly used for breeding. In this paper, pedigree tables for tracking the pedigree of 17 representative rice cultivars recommended by Rural development Adminstration (RDA) were completed and analyzed using two kinds of web database system; “IRIS” and “RRDB”. Seven cultivars, namely, “Sangmibyeo”, “Ilpumbyeo”, “Saegewhabyeo”, “Surabyeo”, “Shindongjinbyeo”, “Ilmibyeo” and “Jungwhabyeo” had “Koshihikari” on the pedigree of their ancestor. Besides “Koshihikari”, the most feguently used ancestral germplasms among the high quality rice cultivars were “Fujisaka 5”, “Kameno o” and “Asahi”. “Fujisaka 5” was used as ancestral parent in 12 out of 17 cultivars. Interestingly, “Kameno o” was used in pedigree of 16 out of 17 high quality varieties and “Asahi” was used in the ancestral pedigree of all 17 varieties. “Hwayeongbyeo” was used as one of parent in the breeding of “Dongjin 1”, “Hwabongbyeo”, “Saegewhabyeo” and “Junambyeo”. “Ilpumbyeo” was used in the breeding pathway of “Junambyeo” and “Saegewhabyeo”. “Man-geumbyeo” itself was not enlisted as one of high quality rice cultivars, but was used as a breeding parent of three high quality varieties, namely, “Saegewhabyeo”, “Hwabongbyeo” and “Nampyeongbyeo”. Incorporated with evaluation data, pedigree will provide a valuable chance to genealogical tracking of agronomic traits such as disease resistance, grain quality and etc.