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산유체모델에 의한 Building downwash 현상 해석
구윤서,최상민,이진호,윤희영 안양대학교 산업기술연구소 2000 自然科學硏究 Vol.7 No.-
본 연구에서는 굴뚝주변에 위치한 건물에 의한 세류현상을 보다 정확히 모사하기 위해서 전산유체모델을 이용하였다. 계산 신뢰도를 검증하기 위해서 전산모델 계산치와 1993년 Thompson의 추적자 실험에 의한 실측치 및 대기 환경영향평가에 많이 사용되는 ISCST3 모델 계산치와 각각 비교하였다. ISCST3에서는 건물의 영향을 고려하기 위하여 BPIP을 이용, 건물의 높이와 폭을 결정하여 모델링을 수행하였다. 전산유체모델에서는 건물을 형상화시키고 굴뚝에서 오염물질을 배출시켜 확산 계산을 하였다. 전산유체모델로 모사한 결과, 건물의 후면에 wake가 발생하는 것을 볼 수 있었고, wake zone의 길이는 건물 높이의 약 2배가 되었다. 오염물질 농도를 비교한 결과 ISCST에서는 최대 농도값과 착지점이 일치하지 않았으나, 전산유체모델로 계산한 결과는 추적자 실험치와 거의 일치한 값을 나타냈다. This study used the computational fluid dynamic(CFD) for describing a dispersion influenced by building downwash. We compared calculated concentrations with Thompson's tracer experiment and ISCST3 models. In calculating ISCST3 model, BPIP(Building Profile Input Program) was used to estimate building heights & widths corresponding to a specific wind direction. Results show that ISCST3 model is not appropriate to describe the building downwash but CFD model, which calculates the flow fields and dispersions simultaneously, is in good agreement with tracer measurements. In order to describe the dispersion induced by building wake near the stack, it is recommended to use CFD model.
관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구
강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.
번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.
강동현(Dong Hyeon Kang),이시영(Si Young Lee),김종구(Jong Koo Kim),최홍기(Hong Ki Choi),박민정(Min Jung Park),연제성(Je Sung Yeon),손진관(Jin Kwan Son) (사)한국생물환경조절학회 2015 생물환경조절학회지 Vol.24 No.4
본 연구에서는 새만금 개발구역에서 환경조절 비용이 적게 드는 시설원예단지 적지선정에 앞서 기상환경을 분석하고 평가기준을 정립하였다. 연구대상지는 28,300ha에 조성계획 중인 새만금 지역을 중심으로 하였다. 12곳의 기상 자료를 평가등급 및 주제도 작성에 활용하였다. 전문가 설문조사를 통해 10개 주제를 선정하였다. 10개 주제는 여름철 20일간 최고온도 평균, 겨울철 20일간 최저온도 평균, 여름철 90일간 평균온도, 겨울철 90일간 평균온도, 연중 순간 최고풍속과 연중 평균풍속, 겨울철 일간 일사량의 평균, 연중 안개 발생일수, 연중 일간 최고 강수량, 봄철 평균습도 분포 등으로 주제를 선정하였다. 선정된 주제에 대한 평가 등급은 연구대상지 기상환경을 분석하여 10 등급화 하여 구분하였으며, 전문가의견을 반영하여 가중치를 설정하였다. This study was conducted to find the suitability site selection for the construction of Saemangeum horticulture complex taking into account cost-effective environmental management by analyzing and comparing meteorological conditions. The study sites were regions around the Saemangeum area in which the development of an industrial complex extending 28,300 ha is planned. We collected meteorological data in 12 candidate sites and established a rating scheme and thematic maps. We selected ten themes by consulting experts using a questionnaire. Selected ten themes is Summer, 20 days max. temp. mean, Winter, 20 days min. temp. mean, Summer, 90 days temp. mean, Winter, 90 days temp. mean, Year-round, max. wind velocity, Year-round, wind velocity mean, Winter, 90 days solar radiation mean, Year-round, number of foggy days, Yearround, 1 day max. rainfall and Spring. 90 days humidity mean. And we set ratio-based weights for the evaluation parameters.
Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis
Lee, Ji-Min,Seo, Woo-Young,Han, Hye-Sook,Oh, Kyoung-Jin,Lee, Yong-Soo,Kim, Don-Kyu,Choi, Seri,Choi, Byeong Hun,Harris, Robert A.,Lee, Chul-Ho,Koo, Seung-Hoi,Choi, Hueng-Sik American Diabetes Association 2016 Diabetes Vol.65 No.1
<P>The role of a glucagon/cAMP-dependent protein kinase-inducible coactivator PGC-1 signaling pathway is well characterized in hepatic gluconeogenesis. However, an opposing protein kinase B (PKB)/Akt-inducible corepressor signaling pathway is unknown. A previous report has demonstrated that small heterodimer partner-interacting leucine zipper protein (SMILE) regulates the nuclear receptors and transcriptional factors that control hepatic gluconeogenesis. Here, we show that hepatic SMILE expression was induced by feeding in normal mice but not in db/db and high-fat diet (HFD)-fed mice. Interestingly, SMILE expression was induced by insulin in mouse primary hepatocyte and liver. Hepatic SMILE expression was not altered by refeeding in liver-specific insulin receptor knockout (LIRKO) or PKB beta-deficient (PKB beta(-/-)) mice. At the molecular level, SMILE inhibited hepatocyte nuclear factor 4-mediated transcriptional activity via direct competition with PGC-1 alpha. Moreover, ablation of SMILE augmented gluconeogenesis and increased blood glucose levels in mice. Conversely, overexpression of SMILE reduced hepatic gluconeogenic gene expression and ameliorated hyperglycemia and glucose intolerance in db/db and HFD-fed mice. Therefore, SMILE is an insulin-inducible corepressor that suppresses hepatic gluconeogenesis. Small molecules that enhance SMILE expression would have potential for treating hyperglycemia in diabetes.</P>
Lee, So Jin,Huh, Myung Sook,Lee, Seung Young,Min, Solki,Lee, Seulki,Koo, Heebeom,Chu, Jun‐,Uk,Lee, Kyung Eun,Jeon, Hyesung,Choi, Yongseok,Choi, Kuiwon,Byun, Youngro,Jeong, Seo Young,Park, Kinam WILEY‐VCH Verlag 2012 Angewandte Chemie Vol.124 No.29
<P><B>Die kondensierte Fassung</B>: Thioliertes Glycolchitosan bildet durch Ladungs‐Ladungs‐Wechselwirkungen und Netzbildung mit polymerisierten siRNAs stabile Nanopartikel (siehe Schema). Die Poly‐siRNA/Glycolchitosan‐Nanopartikel (psi‐TGC) sind in vivo genügend stabil für den systemischen Transport von siRNAs. Das Abschalten von Tumorproteinen durch psi‐TGC resultierte in reduzierten Tumorgrößen und verminderter Tumorvaskularisation.</P>