정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화

박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2

Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)

칼 바르트(Karl Barth)의 교회론에 터한 기독교교육의 한 시도

홍만조 釜山外國語大學校 1998 外大論叢 Vol.19 No.1

It is said that Postmodernism which can be regarded as the feature of contemporary thought, has a positive aspect in which it lays stress on the diversity and the spaciality of the contemporary society. However, as it is connected with theology and developed to pluralism in religion, it seems to go so far as to shake the truth that the love of God for the salvation of man appears as reconciliation through Jesus Christ. Recently, the issue on understanding of the church appears to be the issue on the crisis of identity. All thoughts in the world can be changed, but the Word of God which is eternal truth cannot allow any kind of compromise and concession. Truth includes exclusiveness to the others in itself. During the christian history of 2,000 years, whenever this sort of disorder appears, leaders in charge of education in the church have alleged new theology or have applied the earlier effective theological theory again in order to end the disorder. The aim of this study is to introduce Karl Barth's theology as an alternative proposal on today's situation and to suggest an attempt of christian education based on it. 1. Karl Barth throughly tried to establish theology as a study of the church. He thought three elements: 'Acts of Divinity', 'the Bible as a testimony of revelation', and 'Ecclesia as a field of theology', as a starting point in his theology. So he regarded Ecclesia as a house of theology. His theology has much contributed to the church since it was 'a study for the church' and 'a study of the church'. Barth's methodology of theology is based on revelation. He dealt well with an issue on the formation of christian education which is bound to the bible and an issue on godly community that takes charge of historical problems through his theology. 2. Barth's five basic elements in theology are like these: God as a subject of act, Jesus Christ as an objective act, Holy Ghost as a subjective act, Man as an object of act, and the Church as a field of act. According to his theology, when Man who was reconciled with God lives a responsive life, it is arranged by dint of relation among God, Man, and the world. In the light of this respect, we can find that christian education based on Barth's theology has to deal with God, Man the church, and the world at the same time. These four elements has to the contents and the scope of christian education. 3. When we recognize that the aim of contemporary christian education is individual communion by means of revelation of God, we can easily find that Barth's methodology of theology has much influenced on a reorientation of christian education. The church where takes place act of reconciliation of God is the place that each person receives it by dint of his own subjective act. Christian education which helps each person to reconcile with God must pay attention to the dynamic relation between these two elements. On is the relation between the whole community as a body of Christ and the individual, the other is the communion among the individuals in the community. 4. One of two methodological frames is the personal communion(Koinonia) between teacher and student, the other is personal dedication(Diakonia) to community life. Barth argued that as the church, community of Jesus Christ, was brought to the world by God, it has to be a being for the world in order to find the true meaning there. In this point, we must pay attention to the fact that the real methods of christian education are Koinonia by reconciliation and Diakonia to the community. 5. Karl Barth's theology suggests a desirable way toward the situation of contemporary Korean church to the extend that the view to the church as a practical field of theology shakes, and that comes to a crisis of identity. An attempt of christian education by dint of his theology can solve the problems: radical separated churches, sectarianism, the numeral corpulence of the church, the gulf of attitudes to the participation of the society, and so on It can also solve the rise of radical theological theory not based on the field of the church and serious bad influences by some various educational field depart from the organic church system. The heritages of his theology awaken a mission of the church that in the tradition of christian history, the church has to contribute to contribute to rehabilitation of true man according to the suggestion of the bible. As it did in the early twentieth century, I think the methodology of Barth's theology can suggest the right way toward loss of orientation of contemporary christian education. I'm looking forward to vitalizing new attempts of christian education based on Barth's theology.

성대마비환자를 대상으로 시행한 후두근전도검사의 임상적 유용성

최홍식,최영준,문상우,김태만,최홍식,최영준,문상우,김태만 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

Abstract

Hong,Sung-Man 外 고려대학교 아세아문제연구소 2002 亞細亞硏究 Vol.45 No.3

리비아 대수로공사 지역의 지반특성

홍원표,남정만,김시현,이재호 중앙대학교 기술과학연구소 1996 기술과학연구소 논문집 Vol.26 No.-

리비아 사막지역의 지반특성을 연구하기 위하여 리비아 1단계 대수로공사가 실시된 지역의 지반특성을 검토하였다. 본 연구에서는 Sarir 취수원에서 Ajdabiya 저수조를 경유하여 Sirt 저수조까지의 대수로 공사지역을 따라 실시된 실내시험과 현장시험결과를 포함하고 있다. 이 지역은 내륙지역(Sarir 취수원에서 Ajdabiya 저수조까지)과 해안지역(Ajdabiya 저수조에서 Sirt 저수조까지)으로 구분하여 연구된다. 본 연구결과, 지표면 부근에 있는 모암(Cap rock)은 주로 Caliche나 석회사암(Calcarenite) 성분을 많이 띠고 있고, 이들의 깊이에 따른 강도변화는 발견할 수 없었다. 또한 모래에 대한 Ncl도 깊이에 대한 변화를 발견할 수 없었으나 이들을 종류별로 분류하였을 경우, N치가 약간 증가하는 추세를 보였다. 끝으로 해안지역의 점토에서는 지표면부근에서 조금 과압밀된 경향을 볼 수 있었으며, 내륙지역의 점토에서는 대단히 높은 팽윤포텐셜이 관찰되었다. To study geotechnical properties on Sahara desert of Libya, geotechnical characteristics in the region of the Great Man-made River Project were reviewed. A series of field and laboratory tests were carried out along the route of the conveyance lines from Sarir well field to Sirt end reservoir through Ajdabiya holding reservoir. In the view of geotechnical aspect, the research subject area can be divided into two areas ; one is the inland area(from Ajdabiya holding reservoir to Sirt reservoir). The results of this study showed that the cap rocks nearby ground surface were generally composed of caliche or calcarenite and variation of its strength according to depth could not find. Also, N value in sand did not show a trend of variation with depth however, the N value in the classified soil reveals tendency to increased. The clay of ground surface in the coastal area was slightly overconsolidated due to the desiccation of the surface soils. The clay in the inland area had high swelling potential.

Species Associations with Spatial Autocorrelation Analysis of Pinus rigida and Pyrola japonica

Huh, Man-Kyu,Huh, Hong-Wook,Kim, Chang-Ho The Ecological Society of Korea 1999 Journal of Ecology and Environment Vol.22 No.6

The spatial distributions of allelic frequencies and ecological traits by randomization were studied in the natural population of two species (Pinus rigida and Pyrola japonica). Both species showed significant positive spatial autocorrelation as measured by Moran's I. In P. rigida, the genetic similarity was shown in individuals within up to a scale of 18 m distance and this is partly due to combination of pollen and seed dispersal by wind or men. In P. japonica, significant spatial autocorrelation was consisted of a scale of 8 m intervals. These population structure in the distribution of allelic frequencies is related to mating systems such as outcrossing and vegetative spread. The results also indicate that positive species associations between P. rigida and P. japonica can occur when both species select the same habitat or require the same environmental conditions.

광주시내 일부 중학생의 장내 기생충 감염과 환경조사 연구

문홍만 광주보건대학 1985 論文集 Vol.10 No.-

The auther studied the incidence of intestinal parasitic infections and surveyed the environment of 1,347 middle school boy and girl from March to May, 1985. The method employed was cellophane thick smear and the results obtained are as follows: 1. The prevalence rate of intestinal parasites of total was 5.2% among 1,347 middle school and 6.6% in. school boy, 3.8% in school girl. The infection rate of Ascaris lumbricoides was 1.4%, Trichuris trichiura 3.1%, Hymenolepis nana 0.7%. 2. The infection rate of intestinal parasites according to school years was the highest in 2 school year with 6.3% and the lowest in I school year with 4.4%. According to sex in school years, I and 2 school years was the highest in school boy than school girl, but 3 school year was similar. 3. The infection rate of intinal parasites according to degree of education was the highest in the primary school group with 7.1% and the lowest in the college group with 3.8%. According to sex was the highest in the middle school group of school boy with 9.4%, the lowest in college group of school girl with 3.8%. 4. The infection rate of intestinal parasites according to occupations was the highest in Agriculture with 8.5% and each 7.0% in Public officer, 6.3% in Labor, 6.0% in. Transportation business, 5.4% in Nonoccupation, 3.6% in Office man, 2.1% in Teacher, and 0% in Doctor respectively. In the posotive, according to sex was the highest in school boy of Agriculture with 11.4%, the lowest in school girl of Office man with 1.3%. 5. The infection rate of intestinal parasites by number of children was the highest in the family over 5 children with 5.7% and the lowest in I children with 0%. In the positive, according to sex was the highest in school boy of over 5 children with 8.5% and the lowest in school girl of 3 children with 2.4%.

한국인이 생각하는 나르시시즘(Narcissism)의 개념에 대한 예비연구

이만홍,육기환 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.3

Objects : In order to define different concepts of narcissism in Korean, this study was designed to compare the concept of narcissism by Korean laymen with that of DSM-Ⅲ-R. Methods : 1) Initially, 2 laymen & 4 psychiatric personnel were interviewed and made to describe in free association on narcissism. With these results and the DSM-Ⅲ-R diagnostic criteria of narcissistic personality disorder, we developed a semistructured interview. 2) Using this semistructured interview, authors interviewed 28 key informants(14 laymen, 14 psychiatric residents) an asked them to describe their own understanding of prototypical person of narcissism. Psychiatric residents were comparative subjects to laymen. Results : Laymen thought positively that narcissism was one part of personality, made them achieve self-confidence and a new vitality in life, and consequently made them more enthusiastic in one's work. Narcissism was thught to result in possible difficulties of interpersonal relationships espeually by psychiatric residents. There was a gender difference which concentrated on the differences-men thought level of education, job, success, fame and money more important whereas women took as important factors such as appearance, relationships with one's spouse or lover and his social standing. Men overtly require acceptance by others whereas women self-absorption and intellectual achievement. When one is denied, men directly show aggressive response whereas women show this indirectly and later. Laymen saw narcissism as normal, while some saw it as a personality disorder or mental disorder. Reasons contribute to narcissism were developmental factor and socioenvironmental factor. Conclusions : Concepts and psychopathology of narcissism did not seem little difference between opinions of laymen and DSM-Ⅲ-R. Laymen took narcissism more positively than psychiatric residents. It was taken as part of personality, required for normal development and professional capabilities are above average and have achievement and self-confidence. Narcissism did not require treatment or when necessary it would become better. Results suggested that narcissism has sex difference more or less.

신경섬유종증과 병발된 말단비대증 1예

김현만,홍욱균,한지영 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.4

Although it has been well recognized that the neurofibromatosis frequently associates with endocrine anomalies such as pheochromocytoma, thyroid tumor and hyperparathyroidism, there are very few instances of neurofibromatosis associated with acromegaly. The etiological basis of this association is not clear. We report one case of neurofibromatosis concurrently occurenored with acromegaly in a 17-year-old man. A diagnosis of neurofibromatosis had been made by typical skin manifestation on physical examination followed by pathological findings of biopsied tissue from the lesion. A diagnosis of acromegaly had been made by elevated serum growth hormone level followed by detection of mass lesion on brain CT scan. His growth hormone level became lower after bromocriptine therapy. The tumor will be regularly checked up by brain CT scan for growing or changing in nature. (J Kor Soc Endocrinol 6:371~376, 1991)

경막외 스테로이드 주입에 의한 경부 신경근증의 치료

신근만(Keun Man Shin),홍순용(Soon Yong Hong),최영 대한통증학회 1991 The Korean Journal of Pain Vol.4 No.2

N/A Cervical epidural steroid injection, although not as familiar to many anesthesiologists, can be useful in the management of patients with acute and chronic neck, shoulder and arm pain. My clinic personally contacted and interviewed thirty patients with cervical radiculopathy who re- ceived cervical epidural steroid injection. Twenty seven percent of the patients had a excellent response(greater than 75% improvement) and fifty percent of the patients had a good response (greater than 50% improvement) to an injection of steroid into the cervical epidural space. We have conciuded that cervical epidural steroid injection was very effective in the management of cervical radiculopathy and represented a possible alternative to surgery. Many anesthesiologists should add to their armamentarium the use of such techniques in the man- agement of cervical radiculopathy.