도장작업시 유해인자들의 노출수준과 작업환경관리실태

이세기,문덕환,이채관,황용식,선병관,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objectives: For the purpose of preparing the fundamental data and assessing the status of exposure level of chemical substances in painting process. Methods and Materials: The author determined the concentration of organic solvents, lead(Pb), Chromium(Cr), and Toluene-2, 4-diisocyanate(TDI) in air of painting process to 90 industries classified by 15 types of manufacturing industry during a period from Jan. 1st 2001 to Dec. 31st 2001. Results: The results were as follows: 1. The geometric mean level of each chemical substance was 0.1706 ppm for exposure index in organic solvents, 0.0019㎎/㎥ for Pb, 0.0024 ㎎/㎥ for Cr, and 0.0004ppm for TDI, respectively. 2. The exposure level of each chemical substances by type of painting was the highest in dipping and brush painting for organic solvent, in spray-painting for TDI, and in spray gun-painting for Pb and Cr, respectively. 3. The exposure level of each chemical substances by type of local ventilation equipment was higher in enclosed and booth type for organic solvents. Cr, and TDI, and in exterior type for Pb, respectively than those of other types. 4. The exposure level of each chemical substances by type of hazardous material arresting media was higher in using water for organic substances, in using bag filter for Pb, TDI, respectively than those of other types. Conclusion: According to above results, this study suggests that the exposure level by type of industry exceeded the exposure level in wooden furniture and metal furniture manufacturing industry for organic solvents and Pb, respectively.

부산지역 강하먼지 중 불용성 중금속 함유량

이용범,황용식,이창희,박명희,이채관,강동묵,김정원,전병일,문덕환 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

■ Objectives The purpose of this study was to estimate qualitatively various bulk deposition flux of insoluble heavy metal components by applying regional and seasonal distribution. our institution from January 1980 to December 31th, 2001. ■ Materials and Methods Dustfall particles were collected by the modified American dust jar (wide inlet bottle type) at 6 sampling sites in Pusan area from March, 1999 to February, 2000. Five chemical species (Cd, Cr, Mn, Ni and Pb) were analyzed by AAS(Perkin-Elmer 4100ZL). ■ Results The mean values of each heavy metal concentrations were Cd for 3.947 g/㎢/month, Cr for 0.191 ㎏/㎢/month, Mn for 0.375 ㎏/㎢/month, Ni for 0.176 ㎏/㎢/month, and Pb for 0.823 ㎏/㎢/month. ■ Conclusions Insoluble heavy metal amount of regional variations were found in order of industrial zone, coastal zone, commercial zone, agricultural zone and residential zone.

『베니스의 상인』재고

李龍官 水原大學校 1998 論文集 Vol.16 No.-

In The Merchant of venice, Shylock is a complex and powerful character, the villain and the victim coexist in him. As villain he is a threatening force against the Christian society. He is censured by all but Tubal, his Jew colleague and is called "devil" nine times. As victim, he is a scapegoat for the maintenance of the Christian society. In the trial scene, Antonio tries to force him to become a Christian; but it is impossible for Shylock, Jew to the core, to convert to Christianity. In the end, Shylock is involuntarily excluded from the comic community of the play. On the whole, he asks us to alternate between "particpant" and "spectator" of the action.

고정상세포분리기의 개발 및 Cyclosporin A 생산을 위한 고정화 연속배양공정에의 적용

이태호,박성관,장용근,전계택 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.6

균사형성 미생물인 고정상곰팡이의 연속배양공정에 필수적인 효율적인 고정상세포분리기를 개발하고 이를 실제로 면역억제제인 cyclosporin A(CyA) 연속생산공정에 적용하였다. 점성이 큰 고분자인 carboxymethyl cellulose 용액을 이용한 실험에서 개발된 고정상 세포분리기는 분리능이 우수하여 고점도·고유속의 경우에도 고정성담체가 거의 유실되지 않았다. 이는 고정상세포분리기내에 설치된 공기유출관과 분리관의 역할에 기인하는 것으로 보인다. 또한 실제 곰팡이 세포를 이용한 고정상 연속배양(IPRS)의 경우 고정상세포분리기를 설치함으로써 담체밀도의 감소와 배양액내의 고농도(10g/l) 현탁 곰팡이 세포의 존재에도 불구하고 안정한 조업가능성을 보였다. 고정상 연속배양의 높은 희석속도에도 불구하고 균체 및 CyA의 생산성이 높게 나타났으며, 담체가 반응기 밖으로 거의 유출되지 않은 점으로 보아 고정상세포분리기의 우수한 성능 및 조업안정성을 확인할 수 있었다. We have developed an efficient immobilized cell separator for continuous operation of immobilized fungal cell cultures, and applied this separator to actual fermentation process for the production of cyclosporin A (CyA), a powerful immunosuppressant. In the experiments employing highly viscous polymer (carboxymethyl cellulose) solution, the decantor showed good separating performances at high solution viscosites and fast dilution rates. Air duct and cylindrical separator installed inside the decantor turned out to play key roles for the efficient separation of the immobilized cells. By installing the decantor in an immobilized perfusion reactor system (IPRS), continuous immobilized culture was stably carried out even at high dilution rate for a long period, leading to high productivities of free cells and CyA. Almost no immobilized biomass existed in effuluent stream of the IPRS, demonstrating the effectiveness of the decantor system for a long-term continuous fermentation. It was noteworthy that we could obtain these results despite of the unfavorable fermentation conditions, i.e., reduced density of the biosupports caused by overgrowth of cells inside the bead particles and existence of high density of suspended fungal ells (10 g/l) in the fermentation broth.

전달행렬에 의한 탄성지반에 놓인 축대칭 원추-원통형 탱크 해석

이관희,정성태,박준용,남문희 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-

Even though there are many analysis methods of circular tanks on elastic foundation, the finite element method requires a number of memory spaces computation time to solve large stiffness equations, In this study many the simplified methods are applied to analyze a cone-cylinder tank on elastic foundation. By the given analysis methods, direct stiffness method and foundation matrix method, the con-cylinder tank was transformed into the skeletonized frame structure. The frame structure was drivided into several finite elements. The stiffness matrix of a finite element is related with the transfer matrix of the element. Thus, the transfer matrix of each finite element utilized the transfer matrix method to simplify the analysis of the tank. There were no significant difference in the results of two methods, the finite element method and the transfer matrix method. The transfer matrix method applied to a circular tank on elastic foundation resulted in four simultaneous equations to solve completely

백혈병 세포주에 대한 (±)-ar-Turmerone, 자근 및 황금추출물에 의한 항암제의 세포독성 증강효과

이윤영,유관희,김삼용,안병준 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

Using the colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide](MTT)assay, we evaluated the chemosensitivity of 8 anticancer drugs{vincristine(VCR), vinblastine(VBL), adriamycin(ADR), cisplatin(CPDD), etoposide(VP-16), cytosine arabinoside(ara-C), bleomycin(Bleo) and cyclophosphamide(CYC)} and the cytotoxicity-enhancing effects of (±)-ar-turmerone and the extracts of the crude drugs {Lithospermum erythrorhizon(LE) and Scutellaria baicalensis(SB)}on the above mentioned anticancer drugs against HL-60 and KG-1 cells among 8 anticancer drugs, VCR, VBL, ADR, and CPDD inhibited the growth of both cell lines by more than 50% while VP-16, ara-C, Bleo, and CYC were less effective. (±)-ar-Turmerone had significant inhibitory effects against both cell lines, showing the ID_50 values of 11.730 ㎍/㎖ and 0.292 ㎍/㎖ for HL-60 and KG-1 cells. respectively. But the extracts of LE and SB roots showed no significant cytotoxic effects. According to ID_50 values, the cytotoxicities of VCR, VBL and ADR against HL-60 were enhanced two, eight and three times by mixing (±)-ar-turmerone, five, seven and three times by adding the extract of LE root, and twenty, six and three times by mixing the extract of SB root, respectively. The cytotoxicities of the above mentioned drugs against KG-1 cell were enhanced two, seven and three times by mixing (±)-ar-turmerone, two, three and three times by conbining wilth the extract of LB root, and two, five and two times by adding the extract of SB root, respectively. The cytotoxicity-potentiating effects of (±)-ar-turmerone and the extracts of LE and SB roots against HL-60 cell were greater than KG-1 cell.

Coevaporation에 의한 cd₁-xZn_(x)S 박막 제작 및 특성에 관한 연구

李載亨,李虎烈,朴鏞冠,申成浩,申載爀,朴光子 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-

In this paper, structural optical and electrical properties of Cd_(1-x)Zn_(x)S thin films prepared by coevaporation method were studied. Also, effects of ZnS mole ratio(x) to CdS on properties of thin film Cd_(1-x)Zn_(x)S/CdTe solar cells were investigated. When the ZnS mole ratio was less than 0.85, the crystal structure of Cd_(1-x)Zn_(x)S films was hexagonal with the c axis aligned perpendicular to the substrate. For x>0.85, however, the Cd_(1-x)Zn_(x)S films were grown with cubic zincblende structire. As the ZnS mole ratio increased the lattice constant of Cd_(1-x)Zn_(x)S films rapidly increased with ZnS mole ratio. The open circuit voltage of Cd₁xZnxS/CdTe solar cells increased with x due to reducing of the electron affinity difference between Cd₁xZnxS and CdTe films. However, the increase of series resistance due to the high resistivity of Cd_(1-x)Zn_(x)S films results on reducing conversion efficiency.

Twelfth Night연구

李龍官 水原大學校 1995 論文集 Vol.13 No.-

In Twelfth Night, when Malvolio refuses to be reconciled with the others and goes off claiming, “I'll be revenged on the whole pack of you,” the union of the lovers in the mainplot gets suspended. For, on the literal level, the feminine attire by which Viola can resume her identity falls into Malvolio's hand. On the symbolic level, moreover, Malvolio personifies the “self-ignorance” of the lovers; so his blunt exit insinuates that the lovers have not yet reached “self-knowledge.” His alienation mars the comic resolution and makes Twelfth Night closer to “problem comedies” rather than to “early comedies”.

中, 長距離 選手의 體溫, 脈搏 變化가 記錄에 미치는 影響

李容寬,김종인 公州大學校스포츠科學硏究所 1999 스포츠科學硏究所論文集 Vol.- No.13

We measured how the temperature and the pulse change effects the middle and long distance racer's record with 5 high school athletes and 5 college athletes. The conclusion is as follows : 1. The temperature change by cross country appeared 35.79±0.23 after arise and the others were normal temperature and some concerned with this was appeared an intending level difference of P〈0.05. 2. The pulse change by cross country appeared high 136±9.94 after tough exercise and at this proof it appeared an intending difference of P〈0.05. 3. The temperature change by different ways at the fields seems to change by sweat following the outdoor surroundings and at this proof it appeared difference of P〈0.05 4. The pulse change by different ways at the fields is appeared to be 136.58±19.1 less changed than cross country and at this proof it appeared an intending difference of P〈0.05. 5. The temperature and pulse change after games and tough exercise which is compared with that after cross country and exercises at the fields appeared an intending difference of P〈0.01 at r=0.30 concerned. And at the field of r=0.51 there was a certain concerning and it appeared an intending difference of P〈0.01. After 3 minutes rest, there was a certain concerning of r=0.40 and an intending difference of P〈0.01 at cross country. At the fields, the certain concerning of r=0.61 seemed effect the records and it appeared an intending difference of P〈0.01.

두개저 골절 환자의 임상적 고찰

이용성,송시헌,김성호,김관태,김윤 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.9

The authors analyzed 147 cases of basal skull fracture which were treated in the Department of Neurosurgery, Chungnam National University Hospital from Janwuy 1989 to December 1992. These fractures are difficult to diagnose by ordinary X-ray examination and are freguently inferred by clinical signs. The clinical features and radiological findings were reviewed. The results of the analysis are summarized as follows 1) The basal skull fractures were more common in men than women-the ratio being 6 1 1. 2) In decreasing order of cause of basal skull fractures were traffic accident~(77%), fall down, assault and slipping. 3) The minor head injury, Glasgow Coma Scale Score(GCS) of 13 to 15, was 79 cases(54%), the moderate head injury 40 cases(27%) and the severe head injury 18 cases(1996). 4) In decreasing order of clinical features were otorrhea(71 I) rhinorrhea(4856) and raccoon eye(33%) etc. 5) In decreasing order of the combined pathologies were skull fracture(55I 1, subdural hema-toma(l7%), epidural hematoma(l6%) and intraerebral hematoma(l2I) etc. 6) The facial nerve, vestibulocochlear nerve and optic nerve were the most commonly injured cranial nerve. 7) CSF leakage was noted in 139 cases and among them immediate type was far more common(%%) than the delayed type. 8) The incidence of meningitis was 5.4% and most of them associated with CSF leakage and the prophylatic antibiotic treatment has no effect to decrease infection rate. 9) In decreasing order of the frequency associated injuries were facial bone fracture (47%), clavicle fracture(19%), lower extremitics fracture(9%) and upper extremcties fracture(7%) etc.